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Carcinomatosis

MedGen UID:
104704
•Concept ID:
C0205699
•
Neoplastic Process
Synonym: Carcinomatoses
SNOMED CT: Carcinomatosis (7010000); Disseminated carcinomatosis (307593001); Carcinomatosis (307593001)

Definition

Carcinoma that has spread diffusely to an anatomic site or throughout the body. [from NCI]

Professional guidelines

PubMed

Evidence-based approach to diagnosis and management of abdominal tuberculosis.
Jha DK, Pathiyil MM, Sharma V
Indian J Gastroenterol 2023 Feb;42(1):17-31. Epub 2023 Mar 11 doi: 10.1007/s12664-023-01343-x. PMID: 36899289Free PMC Article
ESGO/ISUOG/IOTA/ESGE Consensus Statement on pre-operative diagnosis of ovarian tumors.
Timmerman D, Planchamp F, Bourne T, Landolfo C, du Bois A, Chiva L, Cibula D, Concin N, Fischerova D, Froyman W, Gallardo Madueño G, Lemley B, Loft A, Mereu L, Morice P, Querleu D, Testa AC, Vergote I, Vandecaveye V, Scambia G, Fotopoulou C
Int J Gynecol Cancer 2021 Jul;31(7):961-982. Epub 2021 Jun 10 doi: 10.1136/ijgc-2021-002565. PMID: 34112736Free PMC Article
Micronodular lung disease on high-resolution CT: patterns and differential diagnosis.
Kim J, Dabiri B, Hammer MM
Clin Radiol 2021 Jun;76(6):399-406. Epub 2021 Feb 7 doi: 10.1016/j.crad.2020.12.025. PMID: 33563413

Recent clinical studies

Etiology

Pharmacotherapy for leptomeningeal disease in breast cancer.
Bartsch R, Jerzak KJ, Larrouquere L, Müller V, Le Rhun E
Cancer Treat Rev 2024 Jan;122:102653. Epub 2023 Nov 7 doi: 10.1016/j.ctrv.2023.102653. PMID: 38118373
Leveraging Molecular and Immune-Based Therapies in Leptomeningeal Metastases.
Wilcox JA, Boire AA
CNS Drugs 2023 Jan;37(1):45-67. Epub 2022 Dec 6 doi: 10.1007/s40263-022-00975-5. PMID: 36474108Free PMC Article
A Palliative Approach to Management of Peritoneal Carcinomatosis and Malignant Ascites.
Bleicher J, Lambert LA
Surg Oncol Clin N Am 2021 Jul;30(3):475-490. doi: 10.1016/j.soc.2021.02.004. PMID: 34053663
Management of neoplastic meningitis.
Roth P, Weller M
Chin Clin Oncol 2015 Jun;4(2):26. doi: 10.3978/j.issn.2304-3865.2015.05.02. PMID: 26112812
US of the peritoneum.
Hanbidge AE, Lynch D, Wilson SR
Radiographics 2003 May-Jun;23(3):663-84; discussion 684-5. doi: 10.1148/rg.233025712. PMID: 12740467

Diagnosis

Leptomeningeal Metastasis: A Review of the Pathophysiology, Diagnostic Methodology, and Therapeutic Landscape.
Nguyen A, Nguyen A, Dada OT, Desai PD, Ricci JC, Godbole NB, Pierre K, Lucke-Wold B
Curr Oncol 2023 Jun 19;30(6):5906-5931. doi: 10.3390/curroncol30060442. PMID: 37366925Free PMC Article
Leptomeningeal Metastasis from Non-Small Cell Lung Cancer and Current Landscape of Treatments.
Ozcan G, Singh M, Vredenburgh JJ
Clin Cancer Res 2023 Jan 4;29(1):11-29. doi: 10.1158/1078-0432.CCR-22-1585. PMID: 35972437
Leptomeningeal metastases: the future is now.
Lukas RV, Thakkar JP, Cristofanilli M, Chandra S, Sosman JA, Patel JD, Kumthekar P, Stupp R, Lesniak MS
J Neurooncol 2022 Feb;156(3):443-452. Epub 2022 Jan 20 doi: 10.1007/s11060-021-03924-2. PMID: 35048267
Leptomeningeal disease.
Groves MD
Neurosurg Clin N Am 2011 Jan;22(1):67-78, vii. doi: 10.1016/j.nec.2010.08.006. PMID: 21109151
Neoplastic meningitis.
Chamberlain MC
Oncologist 2008 Sep;13(9):967-77. Epub 2008 Sep 5 doi: 10.1634/theoncologist.2008-0138. PMID: 18776058

Therapy

Efficacy and Safety of Intraoperative Hyperthermic Intraperitoneal Chemotherapy for Locally Advanced Colon Cancer: A Phase 3 Randomized Clinical Trial.
Arjona-Sánchez A, Espinosa-Redondo E, Gutiérrez-Calvo A, Segura-Sampedro JJ, Pérez-Viejo E, Concepción-Martín V, Sánchez-García S, García-Fadrique A, Prieto-Nieto I, Barrios-Sanchez P, Torres-Melero J, Ramírez Faraco M, Prada-Villaverde A, Carrasco-Campos J, Artiles-Armas M, Villarejo-Campos P, Ortega-Pérez G, Boldo-Roda E, Sánchez-Hidalgo JM, Casado-Adam A, Rodríguez-Ortiz L, Aranda E, Cano-Osuna MT, Díaz-López C, Romero-Ruiz A, Briceño-Delgado J, Rufián-Peña S; Grupo Español de Carcinomatosis Peritoneal
JAMA Surg 2023 Jul 1;158(7):683-691. doi: 10.1001/jamasurg.2023.0662. PMID: 37099280Free PMC Article
Leptomeningeal Metastasis from Non-Small Cell Lung Cancer and Current Landscape of Treatments.
Ozcan G, Singh M, Vredenburgh JJ
Clin Cancer Res 2023 Jan 4;29(1):11-29. doi: 10.1158/1078-0432.CCR-22-1585. PMID: 35972437
Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis.
Yang JT, Wijetunga NA, Pentsova E, Wolden S, Young RJ, Correa D, Zhang Z, Zheng J, Steckler A, Bucwinska W, Bernstein A, Betof Warner A, Yu H, Kris MG, Seidman AD, Wilcox JA, Malani R, Lin A, DeAngelis LM, Lee NY, Powell SN, Boire A
J Clin Oncol 2022 Nov 20;40(33):3858-3867. Epub 2022 Jul 8 doi: 10.1200/JCO.22.01148. PMID: 35802849Free PMC Article
Management of ascites.
Rochling FA, Zetterman RK
Drugs 2009;69(13):1739-60. doi: 10.2165/11316390-000000000-00000. PMID: 19719331
Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer.
Verwaal VJ, van Ruth S, de Bree E, van Sloothen GW, van Tinteren H, Boot H, Zoetmulder FA
J Clin Oncol 2003 Oct 15;21(20):3737-43. doi: 10.1200/JCO.2003.04.187. PMID: 14551293

Prognosis

Cytoreduction and HIPEC for Gastric Carcinomatosis: Multi-institutional Analysis of Two Phase II Clinical Trials.
Green BL, Blumenthaler AN, Gamble LA, McDonald JD, Robinson K, Connolly M, Epstein M, Hernandez JM, Blakely AM, Badgwell BD, Davis JL
Ann Surg Oncol 2023 Mar;30(3):1852-1860. Epub 2022 Nov 8 doi: 10.1245/s10434-022-12761-0. PMID: 36348206Free PMC Article
Management of Peritoneal Disease in Colorectal Cancer.
Welten VM, Melnitchouk N
Hematol Oncol Clin North Am 2022 Jun;36(3):569-582. Epub 2022 May 13 doi: 10.1016/j.hoc.2022.02.008. PMID: 35577709
Peritoneal sarcoidosis mimicking peritoneal carcinomatosis.
Panaccio P, Bellobono M, Esposito L, Ricciardiello M, Cinalli S, Cotellese R
Ann Ital Chir 2019 Jan 10;8 PMID: 30938712
Palliative Management of Peritoneal Metastases.
Lambert LA, Wiseman J
Ann Surg Oncol 2018 Aug;25(8):2165-2171. Epub 2018 Jan 30 doi: 10.1245/s10434-018-6335-7. PMID: 29383612
Neoplastic meningitis.
Van Horn A, Chamberlain MC
J Support Oncol 2012 Mar-Apr;10(2):45-53. Epub 2011 Sep 23 doi: 10.1016/j.suponc.2011.06.002. PMID: 22005214

Clinical prediction guides

Cytoreduction and HIPEC for Gastric Carcinomatosis: Multi-institutional Analysis of Two Phase II Clinical Trials.
Green BL, Blumenthaler AN, Gamble LA, McDonald JD, Robinson K, Connolly M, Epstein M, Hernandez JM, Blakely AM, Badgwell BD, Davis JL
Ann Surg Oncol 2023 Mar;30(3):1852-1860. Epub 2022 Nov 8 doi: 10.1245/s10434-022-12761-0. PMID: 36348206Free PMC Article
A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181
Management of neoplastic meningitis.
Roth P, Weller M
Chin Clin Oncol 2015 Jun;4(2):26. doi: 10.3978/j.issn.2304-3865.2015.05.02. PMID: 26112812
Meningeal carcinomatosis in solid tumors.
Martins SJ, Azevedo CR, Chinen LT, Cruz MR, Peterlevitz MA, Gimenes DL
Arq Neuropsiquiatr 2011 Dec;69(6):973-80. doi: 10.1590/s0004-282x2011000700024. PMID: 22297890
Meningeal carcinomatosis.
HAWKINS D, BROWN D
Can Med Assoc J 1963 Feb 2;88(5):225-8. PMID: 13953212Free PMC Article

Recent systematic reviews

Trastuzumab Deruxtecan-Induced Interstitial Lung Disease/Pneumonitis in ERBB2-Positive Advanced Solid Malignancies: A Systematic Review.
Abuhelwa Z, Alloghbi A, Alqahtani A, Nagasaka M
Drugs 2022 Jun;82(9):979-987. Epub 2022 Jun 27 doi: 10.1007/s40265-022-01736-w. PMID: 35759121Free PMC Article
Risk of Peritoneal Carcinomatosis After Risk-Reducing Salpingo-Oophorectomy: A Systematic Review and Individual Patient Data Meta-Analysis.
Steenbeek MP, van Bommel MHD, Bulten J, Hulsmann JA, Bogaerts J, Garcia C, Cun HT, Lu KH, van Beekhuizen HJ, Minig L, Gaarenstroom KN, Nobbenhuis M, Krajc M, Rudaitis V, Norquist BM, Swisher EM, Mourits MJE, Massuger LFAG, Hoogerbrugge N, Hermens RPMG, IntHout J, de Hullu JA
J Clin Oncol 2022 Jun 10;40(17):1879-1891. Epub 2022 Mar 18 doi: 10.1200/JCO.21.02016. PMID: 35302882Free PMC Article
Clinical studies in CRS and HIPEC: Trials, tribulations, and future directions-A systematic review.
Morano WF, Khalili M, Chi DS, Bowne WB, Esquivel J
J Surg Oncol 2018 Feb;117(2):245-259. Epub 2017 Nov 9 doi: 10.1002/jso.24813. PMID: 29120491Free PMC Article
Bowel obstruction and peritoneal carcinomatosis in the elderly. A systematic review.
Santangelo ML, Grifasi C, Criscitiello C, Giuliano M, Calogero A, Dodaro C, Incollingo P, Rupealta N, Candida M, Chiacchio G, Riccio E, Pisani A, Tammaro V, Carlomagno N
Aging Clin Exp Res 2017 Feb;29(Suppl 1):73-78. Epub 2016 Nov 11 doi: 10.1007/s40520-016-0656-9. PMID: 27837464
Laparoscopic robot-assisted major hepatectomy.
Boggi U, Caniglia F, Amorese G
J Hepatobiliary Pancreat Sci 2014 Jan;21(1):3-10. Epub 2013 Sep 30 doi: 10.1002/jhbp.34. PMID: 24115394

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