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Trabecular Adenoma

MedGen UID:
60000
•Concept ID:
C0205651
•
Neoplastic Process
Synonyms: Adenoma, Trabecular; Adenomas, Trabecular; Trabecular Adenomas
SNOMED CT: Trabecular adenoma (21930005)

Definition

A benign epithelial neoplasm characterized by the presence of a trabecular glandular architectural pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrabecular Adenoma

Professional guidelines

PubMed

Hyalinizing trabecular adenoma of the thyroid--morphology and differential diagnosis.
Schmid KW, Mesewinkel F, Böcker W
Acta Med Austriaca 1996;23(1-2):65-8. PMID: 8767518

Recent clinical studies

Etiology

GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland.
Nikiforova MN, Nikitski AV, Panebianco F, Kaya C, Yip L, Williams M, Chiosea SI, Seethala RR, Roy S, Condello V, Santana-Santos L, Wald AI, Carty SE, Ferris RL, El-Naggar AK, Nikiforov YE
Thyroid 2019 Feb;29(2):161-173. doi: 10.1089/thy.2018.0791. PMID: 30648929Free PMC Article
Thyroid Bethesda reporting category, 'suspicious for papillary thyroid carcinoma', pitfalls and clues to optimize the use of this category.
Mahajan A, Lin X, Nayar R
Cytopathology 2013 Apr;24(2):85-91. Epub 2012 Feb 22 doi: 10.1111/j.1365-2303.2012.00966.x. PMID: 22356185
Histopathological study of solitary nodules of thyroid.
Khadilkar UN, Maji P
Kathmandu Univ Med J (KUMJ) 2008 Oct-Dec;6(24):486-90. doi: 10.3126/kumj.v6i4.1740. PMID: 19483430
Thyroid pathologic findings in patients with Cowden disease.
Harach HR, Soubeyran I, Brown A, Bonneau D, Longy M
Ann Diagn Pathol 1999 Dec;3(6):331-40. doi: 10.1016/s1092-9134(99)80011-2. PMID: 10594284
Histology of familial thyroid tumours linked to a gene mapping to chromosome 19p13.2.
Harach HR, Lesueur F, Amati P, Brown A, Canzian F, Kraimps JL, Levillain P, Menet E, Romeo G, Bonneau D
J Pathol 1999 Nov;189(3):387-93. doi: 10.1002/(SICI)1096-9896(199911)189:3<387::AID-PATH443>3.0.CO;2-S. PMID: 10547601

Diagnosis

GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland.
Nikiforova MN, Nikitski AV, Panebianco F, Kaya C, Yip L, Williams M, Chiosea SI, Seethala RR, Roy S, Condello V, Santana-Santos L, Wald AI, Carty SE, Ferris RL, El-Naggar AK, Nikiforov YE
Thyroid 2019 Feb;29(2):161-173. doi: 10.1089/thy.2018.0791. PMID: 30648929Free PMC Article
The wonderful colors of the hematoxylin-eosin stain in diagnostic surgical pathology.
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626
A practical diagnostic approach to solid/trabecular nodules in the thyroid.
Volante M, Papotti M
Endocr Pathol 2008 Summer;19(2):75-81. doi: 10.1007/s12022-008-9023-5. PMID: 18409025
Thyroid paraganglioma: a clinicopathologic and immunohistochemical study of three cases.
LaGuette J, Matias-Guiu X, Rosai J
Am J Surg Pathol 1997 Jul;21(7):748-53. doi: 10.1097/00000478-199707000-00002. PMID: 9236830
Hyalinizing trabecular adenoma of the thyroid--morphology and differential diagnosis.
Schmid KW, Mesewinkel F, Böcker W
Acta Med Austriaca 1996;23(1-2):65-8. PMID: 8767518

Therapy

A case of trabecular adenoma of the thyroid with black pigmentation.
Sharma V, Cui H, Whalen G, Khan A, Torres M
Thyroid 2007 Jun;17(6):593-4. doi: 10.1089/thy.2006.0151. PMID: 17614784
Prevalence and incidence of cytoplasmic yellow bodies in thyroid neoplasms.
Rothenberg HJ, Goellner JR, Carney JA
Arch Pathol Lab Med 2003 Jun;127(6):715-7. doi: 10.5858/2003-127-715-PAIOCY. PMID: 12741896

Prognosis

Thyroid Bethesda reporting category, 'suspicious for papillary thyroid carcinoma', pitfalls and clues to optimize the use of this category.
Mahajan A, Lin X, Nayar R
Cytopathology 2013 Apr;24(2):85-91. Epub 2012 Feb 22 doi: 10.1111/j.1365-2303.2012.00966.x. PMID: 22356185
Histopathological study of solitary nodules of thyroid.
Khadilkar UN, Maji P
Kathmandu Univ Med J (KUMJ) 2008 Oct-Dec;6(24):486-90. doi: 10.3126/kumj.v6i4.1740. PMID: 19483430
Prevalence and incidence of cytoplasmic yellow bodies in thyroid neoplasms.
Rothenberg HJ, Goellner JR, Carney JA
Arch Pathol Lab Med 2003 Jun;127(6):715-7. doi: 10.5858/2003-127-715-PAIOCY. PMID: 12741896
Sclerosing haemangioma of the lung is positive for MIB-1 in cell membrane and cytoplasmic staining pattern.
Hattori H
Histopathology 2002 Mar;40(3):291-3. doi: 10.1046/j.1365-2559.2002.01330.x. PMID: 11895496
Histology of familial thyroid tumours linked to a gene mapping to chromosome 19p13.2.
Harach HR, Lesueur F, Amati P, Brown A, Canzian F, Kraimps JL, Levillain P, Menet E, Romeo G, Bonneau D
J Pathol 1999 Nov;189(3):387-93. doi: 10.1002/(SICI)1096-9896(199911)189:3<387::AID-PATH443>3.0.CO;2-S. PMID: 10547601

Clinical prediction guides

Non-hyalinizing trabecular thyroid adenoma: a novel thyroid tumor with diagnostic pitfalls of hyalinizing trabecular adenoma and medullary thyroid carcinoma.
Hirokawa M, Matsuse M, Mitsutake N, Suzuki A, Higuchi M, Hayashi T, Kamma H, Miyauchi A, Akamizu T
Diagn Pathol 2023 Jun 20;18(1):74. doi: 10.1186/s13000-023-01361-5. PMID: 37340328Free PMC Article
The wonderful colors of the hematoxylin-eosin stain in diagnostic surgical pathology.
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626
Hyalinizing trabecular adenoma of the thyroid revisited: a histologic and immunohistochemical study of thyroid lesions with prominent trabecular architecture and sclerosis.
Galgano MT, Mills SE, Stelow EB
Am J Surg Pathol 2006 Oct;30(10):1269-73. doi: 10.1097/01.pas.0000209858.13035.0a. PMID: 17001158
Histology of familial thyroid tumours linked to a gene mapping to chromosome 19p13.2.
Harach HR, Lesueur F, Amati P, Brown A, Canzian F, Kraimps JL, Levillain P, Menet E, Romeo G, Bonneau D
J Pathol 1999 Nov;189(3):387-93. doi: 10.1002/(SICI)1096-9896(199911)189:3<387::AID-PATH443>3.0.CO;2-S. PMID: 10547601
Immunohistochemical localization of keratin, vimentin and myosin in salivary gland tumors.
Matsushima R, Nakayama I, Shimizu M
Acta Pathol Jpn 1988 Apr;38(4):445-54. doi: 10.1111/j.1440-1827.1988.tb02318.x. PMID: 2456668

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