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Orofacial Pain

MedGen UID:
59822
•Concept ID:
C0178782
•
Sign or Symptom
Synonym: Pain, Orofacial

Definition

pain in the oral and/or facial regions; associated conditions include local inflammatory and neoplastic disorders and neuralgic syndromes involving the trigeminal, facial, and glossopharyngeal nerves. [from CRISP]

Professional guidelines

PubMed

Orofacial Pain: Molecular Mechanisms, Diagnosis, and Treatment 2021.
Matsuka Y
Int J Mol Sci 2022 Apr 27;23(9) doi: 10.3390/ijms23094826. PMID: 35563219Free PMC Article
Primary Headaches.
Mier RW, Dhadwal S
Dent Clin North Am 2018 Oct;62(4):611-628. Epub 2018 Aug 14 doi: 10.1016/j.cden.2018.06.006. PMID: 30189986
Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications: recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain Special Interest Group†.
Schiffman E, Ohrbach R, Truelove E, Look J, Anderson G, Goulet JP, List T, Svensson P, Gonzalez Y, Lobbezoo F, Michelotti A, Brooks SL, Ceusters W, Drangsholt M, Ettlin D, Gaul C, Goldberg LJ, Haythornthwaite JA, Hollender L, Jensen R, John MT, De Laat A, de Leeuw R, Maixner W, van der Meulen M, Murray GM, Nixdorf DR, Palla S, Petersson A, Pionchon P, Smith B, Visscher CM, Zakrzewska J, Dworkin SF; International RDC/TMD Consortium Network, International association for Dental Research; Orofacial Pain Special Interest Group, International Association for the Study of Pain
J Oral Facial Pain Headache 2014 Winter;28(1):6-27. doi: 10.11607/jop.1151. PMID: 24482784Free PMC Article

Recent clinical studies

Etiology

Burning Mouth Syndrome Etiology: A Narrative Review.
Russo M, Crafa P, Guglielmetti S, Franzoni L, Fiore W, Di Mario F
J Gastrointestin Liver Dis 2022 Jun 12;31(2):223-228. doi: 10.15403/jgld-4245. PMID: 35574619
Psychosocial oral health-related quality of life impact: A systematic review.
Su N, van Wijk A, Visscher CM
J Oral Rehabil 2021 Mar;48(3):282-292. Epub 2020 Aug 14 doi: 10.1111/joor.13064. PMID: 32761938Free PMC Article
Temporomandibular disorders: Old ideas and new concepts.
List T, Jensen RH
Cephalalgia 2017 Jun;37(7):692-704. Epub 2017 Jan 9 doi: 10.1177/0333102416686302. PMID: 28068790
Effectiveness of Manual Therapy and Therapeutic Exercise for Temporomandibular Disorders: Systematic Review and Meta-Analysis.
Armijo-Olivo S, Pitance L, Singh V, Neto F, Thie N, Michelotti A
Phys Ther 2016 Jan;96(1):9-25. Epub 2015 Aug 20 doi: 10.2522/ptj.20140548. PMID: 26294683Free PMC Article
Expanding the taxonomy of the diagnostic criteria for temporomandibular disorders.
Peck CC, Goulet JP, Lobbezoo F, Schiffman EL, Alstergren P, Anderson GC, de Leeuw R, Jensen R, Michelotti A, Ohrbach R, Petersson A, List T
J Oral Rehabil 2014 Jan;41(1):2-23. doi: 10.1111/joor.12132. PMID: 24443898Free PMC Article

Diagnosis

Classification and Diagnosis of Temporomandibular Disorders and Temporomandibular Disorder Pain.
Klasser GD, Goulet JP, Moreno-Hay I
Dent Clin North Am 2023 Apr;67(2):211-225. Epub 2023 Feb 1 doi: 10.1016/j.cden.2022.12.001. PMID: 36965927
Orofacial Pain: Molecular Mechanisms, Diagnosis, and Treatment 2021.
Matsuka Y
Int J Mol Sci 2022 Apr 27;23(9) doi: 10.3390/ijms23094826. PMID: 35563219Free PMC Article
New International Classification of Orofacial Pain: What Is in It For Endodontists?
Pigg M, Nixdorf DR, Law AS, Renton T, Sharav Y, Baad-Hansen L, List T
J Endod 2021 Mar;47(3):345-357. Epub 2020 Dec 16 doi: 10.1016/j.joen.2020.12.002. PMID: 33340605
Chronic orofacial pain.
Ananthan S, Benoliel R
J Neural Transm (Vienna) 2020 Apr;127(4):575-588. Epub 2020 Mar 4 doi: 10.1007/s00702-020-02157-3. PMID: 32130516
Temporomandibular Joint Disorders and Orofacial Pain.
Ahmad M, Schiffman EL
Dent Clin North Am 2016 Jan;60(1):105-24. Epub 2015 Oct 21 doi: 10.1016/j.cden.2015.08.004. PMID: 26614951Free PMC Article

Therapy

Essential Hypertension and Oxidative Stress: Novel Future Perspectives.
Franco C, Sciatti E, Favero G, Bonomini F, Vizzardi E, Rezzani R
Int J Mol Sci 2022 Nov 21;23(22) doi: 10.3390/ijms232214489. PMID: 36430967Free PMC Article
Cannabis and orofacial pain: a systematic review.
Grossman S, Tan H, Gadiwalla Y
Br J Oral Maxillofac Surg 2022 Jun;60(5):e677-e690. Epub 2021 Jun 23 doi: 10.1016/j.bjoms.2021.06.005. PMID: 35305839
Effectiveness of exercise therapy versus occlusal splint therapy for the treatment of painful temporomandibular disorders: a systematic review and meta-analysis.
Zhang L, Xu L, Wu D, Yu C, Fan S, Cai B
Ann Palliat Med 2021 Jun;10(6):6122-6132. Epub 2021 May 10 doi: 10.21037/apm-21-451. PMID: 33977737
Trigeminal Neuralgia: Basic and Clinical Aspects.
Araya EI, Claudino RF, Piovesan EJ, Chichorro JG
Curr Neuropharmacol 2020;18(2):109-119. doi: 10.2174/1570159X17666191010094350. PMID: 31608834Free PMC Article
Effectiveness of Manual Therapy and Therapeutic Exercise for Temporomandibular Disorders: Systematic Review and Meta-Analysis.
Armijo-Olivo S, Pitance L, Singh V, Neto F, Thie N, Michelotti A
Phys Ther 2016 Jan;96(1):9-25. Epub 2015 Aug 20 doi: 10.2522/ptj.20140548. PMID: 26294683Free PMC Article

Prognosis

Effectiveness of the socket shield technique in dental implant: A systematic review.
Ogawa T, Sitalaksmi RM, Miyashita M, Maekawa K, Ryu M, Kimura-Ono A, Suganuma T, Kikutani T, Fujisawa M, Tamaki K, Kuboki T
J Prosthodont Res 2022 Jan 11;66(1):12-18. Epub 2021 Mar 9 doi: 10.2186/jpr.JPR_D_20_00054. PMID: 33692284
Bruxism definition: Past, present, and future - What should a prosthodontist know?
Manfredini D, Ahlberg J, Lobbezoo F
J Prosthet Dent 2022 Nov;128(5):905-912. Epub 2021 Mar 5 doi: 10.1016/j.prosdent.2021.01.026. PMID: 33678438
Trigeminal Neuralgia: Basic and Clinical Aspects.
Araya EI, Claudino RF, Piovesan EJ, Chichorro JG
Curr Neuropharmacol 2020;18(2):109-119. doi: 10.2174/1570159X17666191010094350. PMID: 31608834Free PMC Article
Effectiveness of mobilisation of the upper cervical region and craniocervical flexor training on orofacial pain, mandibular function and headache in women with TMD. A randomised, controlled trial.
Calixtre LB, Oliveira AB, de Sena Rosa LR, Armijo-Olivo S, Visscher CM, Alburquerque-Sendín F
J Oral Rehabil 2019 Feb;46(2):109-119. Epub 2018 Oct 26 doi: 10.1111/joor.12733. PMID: 30307636
Painful Temporomandibular Disorder: Decade of Discovery from OPPERA Studies.
Slade GD, Ohrbach R, Greenspan JD, Fillingim RB, Bair E, Sanders AE, Dubner R, Diatchenko L, Meloto CB, Smith S, Maixner W
J Dent Res 2016 Sep;95(10):1084-92. Epub 2016 Jun 23 doi: 10.1177/0022034516653743. PMID: 27339423Free PMC Article

Clinical prediction guides

Evaluation of the efficacy of manual soft tissue therapy and therapeutic exercises in patients with pain and limited mobility TMJ: a randomized control trial (RCT).
Gębska M, Dalewski B, Pałka Ł, Kołodziej Ł
Head Face Med 2023 Sep 8;19(1):42. doi: 10.1186/s13005-023-00385-y. PMID: 37684652Free PMC Article
Mandibular advancement device design: A systematic review on outcomes in obstructive sleep apnea treatment.
Uniken Venema JAM, Rosenmöller BRAM, de Vries N, de Lange J, Aarab G, Lobbezoo F, Hoekema A
Sleep Med Rev 2021 Dec;60:101557. Epub 2021 Oct 1 doi: 10.1016/j.smrv.2021.101557. PMID: 34662769
Psychosocial oral health-related quality of life impact: A systematic review.
Su N, van Wijk A, Visscher CM
J Oral Rehabil 2021 Mar;48(3):282-292. Epub 2020 Aug 14 doi: 10.1111/joor.13064. PMID: 32761938Free PMC Article
Trigeminal Neuralgia: Basic and Clinical Aspects.
Araya EI, Claudino RF, Piovesan EJ, Chichorro JG
Curr Neuropharmacol 2020;18(2):109-119. doi: 10.2174/1570159X17666191010094350. PMID: 31608834Free PMC Article
Orofacial Pain and Mastication in Dementia.
Lobbezoo F, Delwel S, Weijenberg RAF, Scherder EJA
Curr Alzheimer Res 2017;14(5):506-511. doi: 10.2174/1567205013666160602233535. PMID: 28490315

Recent systematic reviews

Cannabis and orofacial pain: a systematic review.
Grossman S, Tan H, Gadiwalla Y
Br J Oral Maxillofac Surg 2022 Jun;60(5):e677-e690. Epub 2021 Jun 23 doi: 10.1016/j.bjoms.2021.06.005. PMID: 35305839
Exercise therapy for whiplash-associated disorders: a systematic review and meta-analysis.
Chrcanovic B, Larsson J, Malmström EM, Westergren H, Häggman-Henrikson B
Scand J Pain 2022 Apr 26;22(2):232-261. Epub 2021 Sep 27 doi: 10.1515/sjpain-2021-0064. PMID: 34561976
Oral frailty and its determinants in older age: a systematic review.
Dibello V, Zupo R, Sardone R, Lozupone M, Castellana F, Dibello A, Daniele A, De Pergola G, Bortone I, Lampignano L, Giannelli G, Panza F
Lancet Healthy Longev 2021 Aug;2(8):e507-e520. doi: 10.1016/S2666-7568(21)00143-4. PMID: 36098000
Prevalence of temporomandibular joint disorders: a systematic review and meta-analysis.
Valesan LF, Da-Cas CD, Réus JC, Denardin ACS, Garanhani RR, Bonotto D, Januzzi E, de Souza BDM
Clin Oral Investig 2021 Feb;25(2):441-453. Epub 2021 Jan 6 doi: 10.1007/s00784-020-03710-w. PMID: 33409693
Effectiveness of Manual Therapy and Therapeutic Exercise for Temporomandibular Disorders: Systematic Review and Meta-Analysis.
Armijo-Olivo S, Pitance L, Singh V, Neto F, Thie N, Michelotti A
Phys Ther 2016 Jan;96(1):9-25. Epub 2015 Aug 20 doi: 10.2522/ptj.20140548. PMID: 26294683Free PMC Article

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