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Acute lichenoid pityriasis(PLEVA)

MedGen UID:
57997
•Concept ID:
C0162852
•
Disease or Syndrome
Synonyms: Mucha-Habermann disease; Pityriasis lichenoides et varioliformis acuta; PLEVA
SNOMED CT: Pityriasis lichenoides acuta (86487001); PLEVA - Pityriasis lichenoides et varioliformis acuta (86487001); Mucha Habermann disease (86487001); PLA - Pityriasis lichenoides acuta (86487001); Acute lichenoid pityriasis (86487001); Parapsoriasis varioliformis acuta (86487001); Pityriasis lichenoides et varioliformis of Mucha-Habermann (86487001); Mucha-Habermann syndrome (86487001); Mucha-Habermann disease (86487001); Pityriasis lichenoides et varioliformis acuta (86487001); Parapsoriasis lichenoides et varioliformis acuta (86487001); Parapsoriasis varioliformis (200985008)
 
Monarch Initiative: MONDO:0024250

Definition

A rare skin disorder of unknown etiology that is considered to be a more severe form of pityriasis lichenoides. It is characterized by itchy, burning papular lesions which form open sores with red-brown crusts. Low grade fever, headache, malaise, and arthralgias may occasionally precede or accompany the skin findings. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute lichenoid pityriasis

Professional guidelines

PubMed

Pityriasis Rosea: Diagnosis and Treatment.
Villalon-Gomez JM
Am Fam Physician 2018 Jan 1;97(1):38-44. PMID: 29365241
Febrile ulceronecrotic Mucha-Habermann disease: proposed diagnostic criteria and therapeutic evaluation.
Nofal A, Assaf M, Alakad R, Amer H, Nofal E, Yosef A
Int J Dermatol 2016 Jul;55(7):729-38. Epub 2015 Dec 23 doi: 10.1111/ijd.13195. PMID: 26695875
Pityriasis Lichenoides in Childhood: Review of Clinical Presentation and Treatment Options.
Geller L, Antonov NK, Lauren CT, Morel KD, Garzon MC
Pediatr Dermatol 2015 Sep-Oct;32(5):579-92. Epub 2015 Mar 26 doi: 10.1111/pde.12581. PMID: 25816855

Recent clinical studies

Etiology

Use of Phototherapy in Children.
Eustace K, Dolman S, Alsharqi A, Sharpe G, Parslew R
Pediatr Dermatol 2017 Mar;34(2):150-155. Epub 2017 Jan 30 doi: 10.1111/pde.13072. PMID: 28133819
Past, present and future of cutaneous lymphomas.
Cerroni L
Semin Diagn Pathol 2017 Jan;34(1):3-14. Epub 2016 Nov 28 doi: 10.1053/j.semdp.2016.11.001. PMID: 27979336
Paraviral exanthems.
Fölster-Holst R, Zawar VP, Chuh A
Expert Rev Anti Infect Ther 2016 Jun;14(6):601-11. doi: 10.1080/14787210.2016.1184084. PMID: 27144956
Pityriasis lichenoides and its subtypes.
Bowers S, Warshaw EM
J Am Acad Dermatol 2006 Oct;55(4):557-72; quiz 573-6. doi: 10.1016/j.jaad.2005.07.058. PMID: 17010734
Papulosquamous diseases: a review.
Fox BJ, Odom RB
J Am Acad Dermatol 1985 Apr;12(4):597-624. doi: 10.1016/s0190-9622(85)70084-9. PMID: 3157710

Diagnosis

Pityriasis Rosea: Diagnosis and Treatment.
Villalon-Gomez JM
Am Fam Physician 2018 Jan 1;97(1):38-44. PMID: 29365241
Paraviral exanthems.
Fölster-Holst R, Zawar VP, Chuh A
Expert Rev Anti Infect Ther 2016 Jun;14(6):601-11. doi: 10.1080/14787210.2016.1184084. PMID: 27144956
Mucha-Habermann disease.
Bica BE, de Barros Mda G, Spingola C Jr
Rev Bras Reumatol 2013 May-Jun;53(3):314-7. doi: 10.1590/s0482-50042013000300011. PMID: 24051916
Interface dermatitis.
Joshi R
Indian J Dermatol Venereol Leprol 2013 May-Jun;79(3):349-59. doi: 10.4103/0378-6323.110780. PMID: 23619439
Pityriasis lichenoides and its subtypes.
Bowers S, Warshaw EM
J Am Acad Dermatol 2006 Oct;55(4):557-72; quiz 573-6. doi: 10.1016/j.jaad.2005.07.058. PMID: 17010734

Therapy

Lymphomatoid Papulosis and Other Lymphoma-Like Diseases.
Moy A, Sun J, Ma S, Seminario-Vidal L
Dermatol Clin 2019 Oct;37(4):471-482. Epub 2019 Aug 6 doi: 10.1016/j.det.2019.05.005. PMID: 31466587
A systematic review of treatments for pityriasis lichenoides.
Bellinato F, Maurelli M, Gisondi P, Girolomoni G
J Eur Acad Dermatol Venereol 2019 Nov;33(11):2039-2049. Epub 2019 Aug 8 doi: 10.1111/jdv.15813. PMID: 31318465
Pityriasis Rosea: Diagnosis and Treatment.
Villalon-Gomez JM
Am Fam Physician 2018 Jan 1;97(1):38-44. PMID: 29365241
Phototherapy in children: Considerations and indications.
Crall CS, Rork JF, Delano S, Huang JT
Clin Dermatol 2016 Sep-Oct;34(5):633-9. Epub 2016 May 24 doi: 10.1016/j.clindermatol.2016.05.018. PMID: 27638444
Paraviral exanthems.
Fölster-Holst R, Zawar VP, Chuh A
Expert Rev Anti Infect Ther 2016 Jun;14(6):601-11. doi: 10.1080/14787210.2016.1184084. PMID: 27144956

Prognosis

Lymphomatoid Papulosis and Other Lymphoma-Like Diseases.
Moy A, Sun J, Ma S, Seminario-Vidal L
Dermatol Clin 2019 Oct;37(4):471-482. Epub 2019 Aug 6 doi: 10.1016/j.det.2019.05.005. PMID: 31466587
Pityriasis Rosea: Diagnosis and Treatment.
Villalon-Gomez JM
Am Fam Physician 2018 Jan 1;97(1):38-44. PMID: 29365241
Paraviral exanthems.
Fölster-Holst R, Zawar VP, Chuh A
Expert Rev Anti Infect Ther 2016 Jun;14(6):601-11. doi: 10.1080/14787210.2016.1184084. PMID: 27144956
Mucha-Habermann disease.
Bica BE, de Barros Mda G, Spingola C Jr
Rev Bras Reumatol 2013 May-Jun;53(3):314-7. doi: 10.1590/s0482-50042013000300011. PMID: 24051916
Pityriasis lichenoides.
Patel DG, Kihiczak G, Schwartz RA, Janniger CK, Lambert WC
Cutis 2000 Jan;65(1):17-20, 23. PMID: 10664870

Clinical prediction guides

Dermatologists' Impressions of Spontaneously Regressing Verruca Plana Histopathology.
Choi SH, Park S, Kim DY
Am J Dermatopathol 2022 Jun 1;44(6):411-415. Epub 2022 Jan 7 doi: 10.1097/DAD.0000000000002140. PMID: 34999600
Lymphomatoid Papulosis and Other Lymphoma-Like Diseases.
Moy A, Sun J, Ma S, Seminario-Vidal L
Dermatol Clin 2019 Oct;37(4):471-482. Epub 2019 Aug 6 doi: 10.1016/j.det.2019.05.005. PMID: 31466587
Dermatoscopy in inflammatory and infectious skin disorders.
Lacarrubba F, Verzì AE, Dinotta F, Scavo S, Micali G
G Ital Dermatol Venereol 2015 Oct;150(5):521-31. PMID: 26333553
Macrolides in chronic inflammatory skin disorders.
Alzolibani AA, Zedan K
Mediators Inflamm 2012;2012:159354. Epub 2012 May 17 doi: 10.1155/2012/159354. PMID: 22685371Free PMC Article
Lichenoid eruptions in children.
Tilly JJ, Drolet BA, Esterly NB
J Am Acad Dermatol 2004 Oct;51(4):606-24. doi: 10.1016/j.jaad.2003.12.012. PMID: 15389198

Recent systematic reviews

Systematic review of the efficacies and adverse effects of treatments for pityriasis lichenoides.
Jung F, Sibbald C, Bohdanowicz M, Ingram JR, Piguet V
Br J Dermatol 2020 Dec;183(6):1026-1032. Epub 2020 May 10 doi: 10.1111/bjd.18977. PMID: 32112390
A systematic review of treatments for pityriasis lichenoides.
Bellinato F, Maurelli M, Gisondi P, Girolomoni G
J Eur Acad Dermatol Venereol 2019 Nov;33(11):2039-2049. Epub 2019 Aug 8 doi: 10.1111/jdv.15813. PMID: 31318465
Phototherapy for Pityriasis Lichenoides in the Pediatric Population: A Review of the Published Literature.
Maranda EL, Smith M, Nguyen AH, Patel VN, Schachner LA, Joaquin JJ
Am J Clin Dermatol 2016 Dec;17(6):583-591. doi: 10.1007/s40257-016-0216-2. PMID: 27502793
Lymphomatoid Papulosis in Children and Adolescents: A Systematic Review.
Wieser I, Wohlmuth C, Nunez CA, Duvic M
Am J Clin Dermatol 2016 Aug;17(4):319-27. doi: 10.1007/s40257-016-0192-6. PMID: 27138554

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