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Congenital cytomegalovirus infection

MedGen UID:
57644
•Concept ID:
C0158945
•
Disease or Syndrome
Synonyms: CMV Infection, Congenital; Congenital CMV Infection; Congenital CMV Infections; Congenital Cytomegalovirus Infection; Congenital Cytomegalovirus Infections; Cytomegalovirus Infection, Congenital; Infection, Congenital CMV; Infection, Congenital Cytomegalovirus
SNOMED CT: Congenital cytomegalovirus infection (59527008); Neonatal cytomegaloviral disease (59527008)

Definition

An infection with the Cytomegalovirus that is present from birth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCongenital cytomegalovirus infection

Professional guidelines

PubMed

Congenital cytomegalovirus infection diagnostics and management.
Pinninti S, Boppana S
Curr Opin Infect Dis 2022 Oct 1;35(5):436-441. Epub 2022 Aug 19 doi: 10.1097/QCO.0000000000000874. PMID: 35984001Free PMC Article
Congenital Cytomegalovirus Infection: Epidemiology, Timely Diagnosis, and Management.
Jenks CM, Hoff SR, Mithal LB
Neoreviews 2021 Sep;22(9):e606-e613. doi: 10.1542/neo.22-9-e606. PMID: 34470762
Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy.
Rawlinson WD, Boppana SB, Fowler KB, Kimberlin DW, Lazzarotto T, Alain S, Daly K, Doutré S, Gibson L, Giles ML, Greenlee J, Hamilton ST, Harrison GJ, Hui L, Jones CA, Palasanthiran P, Schleiss MR, Shand AW, van Zuylen WJ
Lancet Infect Dis 2017 Jun;17(6):e177-e188. Epub 2017 Mar 11 doi: 10.1016/S1473-3099(17)30143-3. PMID: 28291720

Recent clinical studies

Etiology

Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: systematic review and meta-analysis.
D'Antonio F, Marinceu D, Prasad S, Khalil A
Ultrasound Obstet Gynecol 2023 Apr;61(4):436-444. doi: 10.1002/uog.26136. PMID: 36484439
Congenital cytomegalovirus infection diagnostics and management.
Pinninti S, Boppana S
Curr Opin Infect Dis 2022 Oct 1;35(5):436-441. Epub 2022 Aug 19 doi: 10.1097/QCO.0000000000000874. PMID: 35984001Free PMC Article
Congenital Cytomegalovirus Infection.
Kabani N, Ross SA
J Infect Dis 2020 Mar 5;221(Suppl 1):S9-S14. doi: 10.1093/infdis/jiz446. PMID: 32134480Free PMC Article
Congenital and perinatal infections.
Ostrander B, Bale JF
Handb Clin Neurol 2019;162:133-153. doi: 10.1016/B978-0-444-64029-1.00006-0. PMID: 31324308
Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy.
Rawlinson WD, Boppana SB, Fowler KB, Kimberlin DW, Lazzarotto T, Alain S, Daly K, Doutré S, Gibson L, Giles ML, Greenlee J, Hamilton ST, Harrison GJ, Hui L, Jones CA, Palasanthiran P, Schleiss MR, Shand AW, van Zuylen WJ
Lancet Infect Dis 2017 Jun;17(6):e177-e188. Epub 2017 Mar 11 doi: 10.1016/S1473-3099(17)30143-3. PMID: 28291720

Diagnosis

Congenital cytomegalovirus infection diagnostics and management.
Pinninti S, Boppana S
Curr Opin Infect Dis 2022 Oct 1;35(5):436-441. Epub 2022 Aug 19 doi: 10.1097/QCO.0000000000000874. PMID: 35984001Free PMC Article
Congenital Cytomegalovirus Infection.
Kabani N, Ross SA
J Infect Dis 2020 Mar 5;221(Suppl 1):S9-S14. doi: 10.1093/infdis/jiz446. PMID: 32134480Free PMC Article
Congenital and perinatal infections.
Ostrander B, Bale JF
Handb Clin Neurol 2019;162:133-153. doi: 10.1016/B978-0-444-64029-1.00006-0. PMID: 31324308
Congenital cytomegalovirus infection.
Fowler KB, Boppana SB
Semin Perinatol 2018 Apr;42(3):149-154. Epub 2018 Mar 2 doi: 10.1053/j.semperi.2018.02.002. PMID: 29503048
Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy.
Rawlinson WD, Boppana SB, Fowler KB, Kimberlin DW, Lazzarotto T, Alain S, Daly K, Doutré S, Gibson L, Giles ML, Greenlee J, Hamilton ST, Harrison GJ, Hui L, Jones CA, Palasanthiran P, Schleiss MR, Shand AW, van Zuylen WJ
Lancet Infect Dis 2017 Jun;17(6):e177-e188. Epub 2017 Mar 11 doi: 10.1016/S1473-3099(17)30143-3. PMID: 28291720

Therapy

Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: systematic review and meta-analysis.
D'Antonio F, Marinceu D, Prasad S, Khalil A
Ultrasound Obstet Gynecol 2023 Apr;61(4):436-444. doi: 10.1002/uog.26136. PMID: 36484439
Congenital cytomegalovirus infection diagnostics and management.
Pinninti S, Boppana S
Curr Opin Infect Dis 2022 Oct 1;35(5):436-441. Epub 2022 Aug 19 doi: 10.1097/QCO.0000000000000874. PMID: 35984001Free PMC Article
Cytomegalovirus infection during pregnancy: state of the science.
Leruez-Ville M, Foulon I, Pass R, Ville Y
Am J Obstet Gynecol 2020 Sep;223(3):330-349. Epub 2020 Feb 24 doi: 10.1016/j.ajog.2020.02.018. PMID: 32105678
Congenital cytomegalovirus infection.
Fowler KB, Boppana SB
Semin Perinatol 2018 Apr;42(3):149-154. Epub 2018 Mar 2 doi: 10.1053/j.semperi.2018.02.002. PMID: 29503048
Congenital Cytomegalovirus infection: advances and challenges in diagnosis, prevention and treatment.
Marsico C, Kimberlin DW
Ital J Pediatr 2017 Apr 17;43(1):38. doi: 10.1186/s13052-017-0358-8. PMID: 28416012Free PMC Article

Prognosis

Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: systematic review and meta-analysis.
D'Antonio F, Marinceu D, Prasad S, Khalil A
Ultrasound Obstet Gynecol 2023 Apr;61(4):436-444. doi: 10.1002/uog.26136. PMID: 36484439
Congenital Cytomegalovirus Infection: Epidemiology, Timely Diagnosis, and Management.
Jenks CM, Hoff SR, Mithal LB
Neoreviews 2021 Sep;22(9):e606-e613. doi: 10.1542/neo.22-9-e606. PMID: 34470762
Congenital Cytomegalovirus Infection.
Kabani N, Ross SA
J Infect Dis 2020 Mar 5;221(Suppl 1):S9-S14. doi: 10.1093/infdis/jiz446. PMID: 32134480Free PMC Article
Outcome and management of newborns with congenital cytomegalovirus infection.
Nicloux M, Peterman L, Parodi M, Magny JF
Arch Pediatr 2020 Apr;27(3):160-165. Epub 2020 Feb 29 doi: 10.1016/j.arcped.2020.01.006. PMID: 32127242
Congenital Cytomegalovirus infection: advances and challenges in diagnosis, prevention and treatment.
Marsico C, Kimberlin DW
Ital J Pediatr 2017 Apr 17;43(1):38. doi: 10.1186/s13052-017-0358-8. PMID: 28416012Free PMC Article

Clinical prediction guides

Newborn cytomegalovirus screening: is this the new standard?
Gantt S
Curr Opin Otolaryngol Head Neck Surg 2023 Dec 1;31(6):382-387. Epub 2023 Oct 11 doi: 10.1097/MOO.0000000000000925. PMID: 37820202
Congenital Cytomegalovirus Infection.
Kabani N, Ross SA
J Infect Dis 2020 Mar 5;221(Suppl 1):S9-S14. doi: 10.1093/infdis/jiz446. PMID: 32134480Free PMC Article
Outcome and management of newborns with congenital cytomegalovirus infection.
Nicloux M, Peterman L, Parodi M, Magny JF
Arch Pediatr 2020 Apr;27(3):160-165. Epub 2020 Feb 29 doi: 10.1016/j.arcped.2020.01.006. PMID: 32127242
Cytomegalovirus infection during pregnancy: state of the science.
Leruez-Ville M, Foulon I, Pass R, Ville Y
Am J Obstet Gynecol 2020 Sep;223(3):330-349. Epub 2020 Feb 24 doi: 10.1016/j.ajog.2020.02.018. PMID: 32105678
Congenital cytomegalovirus infection: management update.
Khalil A, Jones C, Ville Y
Curr Opin Infect Dis 2017 Jun;30(3):274-280. doi: 10.1097/QCO.0000000000000368. PMID: 28338486

Recent systematic reviews

Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: systematic review and meta-analysis.
D'Antonio F, Marinceu D, Prasad S, Khalil A
Ultrasound Obstet Gynecol 2023 Apr;61(4):436-444. doi: 10.1002/uog.26136. PMID: 36484439
Congenital Cytomegalovirus Infection and Ophthalmological Disorders: A Systematic Review.
Gabrani C, Mitsikas D, Giannakou K, Lamnisos D
J Pediatr Ophthalmol Strabismus 2023 Mar-Apr;60(2):86-94. Epub 2022 May 25 doi: 10.3928/01913913-20220426-01. PMID: 35611826
The association between congenital cytomegalovirus infection and cerebral palsy: A systematic review and meta-analysis.
Ong LT, Fan SWD
J Paediatr Child Health 2022 Dec;58(12):2156-2162. Epub 2022 Oct 17 doi: 10.1111/jpc.16244. PMID: 36250689
Vestibular and postural impairment in congenital Cytomegalovirus infection.
Corazzi V, Hatzopoulos S, Bianchini C, Skarżyńska MB, Pelucchi S, Skarżyński PH, Ciorba A
Int J Pediatr Otorhinolaryngol 2022 Jan;152:111005. Epub 2021 Dec 7 doi: 10.1016/j.ijporl.2021.111005. PMID: 34894538
Cytomegalovirus Infection in Human Immunodeficiency Virus (HIV)-Exposed and HIV-Infected Infants: A Systematic Review.
Ellington SR, Clarke KE, Kourtis AP
J Infect Dis 2016 Mar 15;213(6):891-900. Epub 2015 Nov 23 doi: 10.1093/infdis/jiv549. PMID: 26597258Free PMC Article

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