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Acute posterior multifocal placoid pigment epitheliopathy

MedGen UID:
56348
Concept ID:
C0154884
Disease or Syndrome
Synonyms: Acute multifocal placoid pigment epitheliopathy; Acute placoid pigment epitheliopathy; Multifocal placoid pigment epitheliopathy
SNOMED CT: Pigment epitheliopathy, disseminated retinitis AND retinochoroiditis (89188001); Acute posterior multifocal placoid pigment epitheliopathy (89188001); Acute multifocal placoid pigment epitheliopathy (89188001); AMPPE - Acute multifocal placoid pigment epitheliopathy (89188001)
 
Monarch Initiative: MONDO:0043089

Definition

Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is an acquired, inflammatory eye condition affecting the retina, retinal pigment epithelium (pigmented layer of the retina), and choroid. It usually affects both eyes and is characterized by multiple, yellow-white lesions in the back of the eye. The condition can significantly impair visual acuity if the macula is involved. APMPPE typically resolves on its own in weeks to months. While the cause is unknown, about a third of cases appear to develop after a flu-like illness. Non-ocular symptoms are uncommon, but cerebral vasculitis can be present and may cause permanent and/or severe neurological complications. [from MONDO]

Professional guidelines

PubMed

Papasavvas I, Herbort CP Jr
Medicina (Kaunas) 2022 Jan 21;58(2) doi: 10.3390/medicina58020165. PMID: 35208488Free PMC Article
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:174-181. Epub 2021 Apr 9 doi: 10.1016/j.ajo.2021.03.056. PMID: 33845024Free PMC Article
Jyotirmay B, Jafferji SS, Sudharshan S, Kalpana B
Ocul Immunol Inflamm 2010 Jan;18(1):46-51. doi: 10.3109/09273940903402637. PMID: 20128650

Recent clinical studies

Etiology

Niederer RL, Samalia PD, Chen YH, Goh JK, Cornish EE, Guest S, McCluskey PJ, Lim LL, Sims JL, Lightman S, Tomkins-Netzer O
Br J Ophthalmol 2024 Feb 21;108(3):398-404. doi: 10.1136/bjo-2022-321517. PMID: 36657959
Papasavvas I, Mantovani A, Herbort CP Jr
Medicina (Kaunas) 2022 Aug 8;58(8) doi: 10.3390/medicina58081070. PMID: 36013537Free PMC Article
Papasavvas I, Herbort CP Jr
Medicina (Kaunas) 2022 Jan 21;58(2) doi: 10.3390/medicina58020165. PMID: 35208488Free PMC Article
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:174-181. Epub 2021 Apr 9 doi: 10.1016/j.ajo.2021.03.056. PMID: 33845024Free PMC Article
Brazis PW, Stewart M, Lee AG
Neurologist 2004 Jul;10(4):171-84. doi: 10.1097/01.nrl.0000131145.26326.ff. PMID: 15245583

Diagnosis

Papasavvas I, Mantovani A, Herbort CP Jr
Medicina (Kaunas) 2022 Aug 8;58(8) doi: 10.3390/medicina58081070. PMID: 36013537Free PMC Article
Vodopivec I, Lobo AM, Prasad S
Semin Neurol 2014 Sep;34(4):444-57. Epub 2014 Nov 4 doi: 10.1055/s-0034-1390393. PMID: 25369440
Brazis PW, Stewart M, Lee AG
Neurologist 2004 Jul;10(4):171-84. doi: 10.1097/01.nrl.0000131145.26326.ff. PMID: 15245583
Verougstraete C
Bull Soc Belge Ophtalmol 2001;(279):67-78. PMID: 11344717
Jones NP
Br J Ophthalmol 1995 Apr;79(4):384-9. doi: 10.1136/bjo.79.4.384. PMID: 7742290Free PMC Article

Therapy

Kraemer LS, Montgomery JR, Baker KM, Colyer MH
Retin Cases Brief Rep 2022 Jan 1;16(1):16-19. doi: 10.1097/ICB.0000000000000959. PMID: 31990820
Li AL, Palejwala NV, Shantha JG, O'Keefe G, Lee CS, Albini T, Yeh S
PLoS One 2020;15(8):e0238080. Epub 2020 Aug 24 doi: 10.1371/journal.pone.0238080. PMID: 32834009Free PMC Article
Lee GE, Lee BW, Rao NA, Fawzi AA
Ocul Immunol Inflamm 2011 Feb;19(1):42-7. Epub 2010 Oct 31 doi: 10.3109/09273948.2010.521610. PMID: 21034311
Fiore T, Iaccheri B, Androudi S, Papadaki TG, Anzaar F, Brazitikos P, D'Amico DJ, Foster CS
Retina 2009 Jul-Aug;29(7):994-1001. doi: 10.1097/IAE.0b013e3181a0bd15. PMID: 19491729
Matsumoto Y, Haen SP, Spaide RF
Compr Ophthalmol Update 2007 Jul-Aug;8(4):179-200; discussion 203-4. PMID: 17999832

Prognosis

Niederer RL, Samalia PD, Chen YH, Goh JK, Cornish EE, Guest S, McCluskey PJ, Lim LL, Sims JL, Lightman S, Tomkins-Netzer O
Br J Ophthalmol 2024 Feb 21;108(3):398-404. doi: 10.1136/bjo-2022-321517. PMID: 36657959
Xerri O, Salah S, Monnet D, Brézin AP
BMC Ophthalmol 2018 Mar 20;18(1):76. doi: 10.1186/s12886-018-0744-z. PMID: 29554890Free PMC Article
Vodopivec I, Lobo AM, Prasad S
Semin Neurol 2014 Sep;34(4):444-57. Epub 2014 Nov 4 doi: 10.1055/s-0034-1390393. PMID: 25369440
Fiore T, Iaccheri B, Androudi S, Papadaki TG, Anzaar F, Brazitikos P, D'Amico DJ, Foster CS
Retina 2009 Jul-Aug;29(7):994-1001. doi: 10.1097/IAE.0b013e3181a0bd15. PMID: 19491729
Quillen DA, Davis JB, Gottlieb JL, Blodi BA, Callanan DG, Chang TS, Equi RA
Am J Ophthalmol 2004 Mar;137(3):538-50. doi: 10.1016/j.ajo.2004.01.053. PMID: 15013878

Clinical prediction guides

Steptoe PJ, Pearce I, Beare NAV, Sreekantham S, Mohammed BR, Barry RJ, Denniston AK, Murray PI
Ocul Immunol Inflamm 2024 Jul;32(5):683-689. Epub 2023 May 3 doi: 10.1080/09273948.2023.2195934. PMID: 37134304
Niederer RL, Samalia PD, Chen YH, Goh JK, Cornish EE, Guest S, McCluskey PJ, Lim LL, Sims JL, Lightman S, Tomkins-Netzer O
Br J Ophthalmol 2024 Feb 21;108(3):398-404. doi: 10.1136/bjo-2022-321517. PMID: 36657959
Brydak-Godowska J, Turczyńska M, Przybyś M, Brydak LB, Kęcik D
Ocul Immunol Inflamm 2019;27(4):545-550. Epub 2018 Feb 8 doi: 10.1080/09273948.2017.1423335. PMID: 29420099
Xerri O, Salah S, Monnet D, Brézin AP
BMC Ophthalmol 2018 Mar 20;18(1):76. doi: 10.1186/s12886-018-0744-z. PMID: 29554890Free PMC Article
Comu S, Verstraeten T, Rinkoff JS, Busis NA
Stroke 1996 May;27(5):996-1001. doi: 10.1161/01.str.27.5.996. PMID: 8623125

Recent systematic reviews

Abu Serhan H, Abu Suilik H, Hassan AK, AlSamhori JF, Hassan AR, Siddiq A, Ahmed N, Elnahry AG
Int Ophthalmol 2024 Apr 23;44(1):189. doi: 10.1007/s10792-024-03119-4. PMID: 38652153Free PMC Article

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