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Retinal microaneurysm

MedGen UID:
472899
Concept ID:
C0154834
Pathologic Function
Synonyms: Microaneurysm, Retinal; Microaneurysms, Retinal; Retinal Microaneurysm; Retinal Microaneurysms
SNOMED CT: Retinal microaneurysms (34037000); Microaneurysm of retinal artery (34037000); Retinal microaneurysm (34037000)
 
HPO: HP:0032416
Monarch Initiative: MONDO:0001257

Definition

A localized dilation of microvasculature formed due to disruption of the internal elastic lamina of a retinal capillary blood vessel. The lesions present as small circular, red dots having distinct margins and are no larger than a blood vessel width at the disk margin. This expansion disturbs the normal flow pattern, changing shear force and pressure along the vessel. Shear force plays a key role in promoting the differentiation and proliferation of endothelial cells. [from HPO]

Professional guidelines

PubMed

Sędziak-Marcinek B, Teper S, Chełmecka E, Wylęgała A, Marcinek M, Bas M, Wylęgała E
J Diabetes Res 2021;2021:6620122. Epub 2021 Feb 26 doi: 10.1155/2021/6620122. PMID: 33728349Free PMC Article
Melo T, Mendonça AM, Campilho A
Comput Biol Med 2020 Nov;126:103995. Epub 2020 Sep 18 doi: 10.1016/j.compbiomed.2020.103995. PMID: 33007620
Kozak I, Oster SF, Cortes MA, Dowell D, Hartmann K, Kim JS, Freeman WR
Ophthalmology 2011 Jun;118(6):1119-24. Epub 2011 Jan 26 doi: 10.1016/j.ophtha.2010.10.007. PMID: 21269701

Recent clinical studies

Etiology

Zhang Y, An X, Duan L, Jin D, Duan Y, Zhou R, Zhang Y, Kang X, Lian F
Front Endocrinol (Lausanne) 2022;13:799337. Epub 2022 Mar 14 doi: 10.3389/fendo.2022.799337. PMID: 35370950Free PMC Article
Borrelli E, Sacconi R, Brambati M, Bandello F, Querques G
Sci Rep 2019 Nov 14;9(1):16789. doi: 10.1038/s41598-019-53357-1. PMID: 31728070Free PMC Article
Sjølie AK, Klein R, Porta M, Orchard T, Fuller J, Parving HH, Bilous R, Aldington S, Chaturvedi N
Diabet Med 2011 Mar;28(3):345-51. doi: 10.1111/j.1464-5491.2010.03210.x. PMID: 21309844
Stitt AW, Gardiner TA, Archer DB
Br J Ophthalmol 1995 Apr;79(4):362-7. doi: 10.1136/bjo.79.4.362. PMID: 7742285Free PMC Article
Klein R, Meuer SM, Moss SE, Klein BE
Arch Ophthalmol 1995 Nov;113(11):1386-91. doi: 10.1001/archopht.1995.01100110046024. PMID: 7487599

Diagnosis

Steffi S, Sam Emmanuel WR
Int Ophthalmol 2024 Feb 17;44(1):91. doi: 10.1007/s10792-024-02982-5. PMID: 38367192
Du J, Zou B, Chen C, Xu Z, Liu Q
Comput Methods Programs Biomed 2020 Nov;196:105687. Epub 2020 Aug 8 doi: 10.1016/j.cmpb.2020.105687. PMID: 32835957
Dai L, Fang R, Li H, Hou X, Sheng B, Wu Q, Jia W
IEEE Trans Med Imaging 2018 May;37(5):1149-1161. doi: 10.1109/TMI.2018.2794988. PMID: 29727278
Sjølie AK, Klein R, Porta M, Orchard T, Fuller J, Parving HH, Bilous R, Aldington S, Chaturvedi N
Diabet Med 2011 Mar;28(3):345-51. doi: 10.1111/j.1464-5491.2010.03210.x. PMID: 21309844
Klein R, Meuer SM, Moss SE, Klein BE
Arch Ophthalmol 1995 Nov;113(11):1386-91. doi: 10.1001/archopht.1995.01100110046024. PMID: 7487599

Therapy

Zhang Y, An X, Duan L, Jin D, Duan Y, Zhou R, Zhang Y, Kang X, Lian F
Front Endocrinol (Lausanne) 2022;13:799337. Epub 2022 Mar 14 doi: 10.3389/fendo.2022.799337. PMID: 35370950Free PMC Article
Sjølie AK, Klein R, Porta M, Orchard T, Fuller J, Parving HH, Bilous R, Aldington S, Chaturvedi N
Diabet Med 2011 Mar;28(3):345-51. doi: 10.1111/j.1464-5491.2010.03210.x. PMID: 21309844
Takebayashi T, Nishiwaki Y, Uemura T, Nakashima H, Nomiyama T, Sakurai H, Omae K
Occup Environ Med 2004 Feb;61(2):127-34. doi: 10.1136/oem.2002.006858. PMID: 14739378Free PMC Article
Kinyoun JL, Martin DC, Fujimoto WY, Leonetti DL
Invest Ophthalmol Vis Sci 1992 May;33(6):1888-93. PMID: 1582794
Goto S, Hotta R, Sugimoto K
Int Arch Arbeitsmed 1971;28(2):115-26. PMID: 5570047

Prognosis

Sjølie AK, Klein R, Porta M, Orchard T, Fuller J, Parving HH, Bilous R, Aldington S, Chaturvedi N
Diabet Med 2011 Mar;28(3):345-51. doi: 10.1111/j.1464-5491.2010.03210.x. PMID: 21309844
Takebayashi T, Nishiwaki Y, Uemura T, Nakashima H, Nomiyama T, Sakurai H, Omae K
Occup Environ Med 2004 Feb;61(2):127-34. doi: 10.1136/oem.2002.006858. PMID: 14739378Free PMC Article
Klein R, Meuer SM, Moss SE, Klein BE
Arch Ophthalmol 1995 Nov;113(11):1386-91. doi: 10.1001/archopht.1995.01100110046024. PMID: 7487599
Klein R, Meuer SM, Moss SE, Klein BE
Arch Ophthalmol 1989 Dec;107(12):1780-5. doi: 10.1001/archopht.1989.01070020862028. PMID: 2597068

Clinical prediction guides

Du J, Zou B, Chen C, Xu Z, Liu Q
Comput Methods Programs Biomed 2020 Nov;196:105687. Epub 2020 Aug 8 doi: 10.1016/j.cmpb.2020.105687. PMID: 32835957
Borrelli E, Sacconi R, Brambati M, Bandello F, Querques G
Sci Rep 2019 Nov 14;9(1):16789. doi: 10.1038/s41598-019-53357-1. PMID: 31728070Free PMC Article
Lazar I, Hajdu A
IEEE Trans Med Imaging 2013 Feb;32(2):400-7. Epub 2012 Nov 21 doi: 10.1109/TMI.2012.2228665. PMID: 23192523
Sjølie AK, Klein R, Porta M, Orchard T, Fuller J, Parving HH, Bilous R, Aldington S, Chaturvedi N
Diabet Med 2011 Mar;28(3):345-51. doi: 10.1111/j.1464-5491.2010.03210.x. PMID: 21309844
Stitt AW, Gardiner TA, Archer DB
Br J Ophthalmol 1995 Apr;79(4):362-7. doi: 10.1136/bjo.79.4.362. PMID: 7742285Free PMC Article

Recent systematic reviews

Zhang Y, An X, Duan L, Jin D, Duan Y, Zhou R, Zhang Y, Kang X, Lian F
Front Endocrinol (Lausanne) 2022;13:799337. Epub 2022 Mar 14 doi: 10.3389/fendo.2022.799337. PMID: 35370950Free PMC Article

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