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Lumbosacral radiculopathy

MedGen UID:
509639
•Concept ID:
C0154738
•
Disease or Syndrome
Synonym: Lumbosacral root lesion
SNOMED CT: Lumbosacral root lesion (2415007); Lumbosacral radiculopathy (2415007)

Professional guidelines

PubMed

Medication recommendations for treatment of lumbosacral radiculopathy: A systematic review of clinical practice guidelines.
Price MR, Mead KE, Cowell DM, Troutner AM, Barton TE, Walters SA, Daniels CJ
PM R 2024 Oct;16(10):1128-1142. Epub 2024 Apr 17 doi: 10.1002/pmrj.13142. PMID: 38629664
Evaluation of Treatment Patterns and Direct Costs Associated with the Management of Neuropathic Pain.
Machado-Duque ME, Gaviria-Mendoza A, Machado-Alba JE, Castaño N
Pain Res Manag 2020;2020:9353940. Epub 2020 Mar 30 doi: 10.1155/2020/9353940. PMID: 32318131Free PMC Article
Pharmacologic management of neuropathic pain: evidence-based recommendations.
Dworkin RH, O'Connor AB, Backonja M, Farrar JT, Finnerup NB, Jensen TS, Kalso EA, Loeser JD, Miaskowski C, Nurmikko TJ, Portenoy RK, Rice ASC, Stacey BR, Treede RD, Turk DC, Wallace MS
Pain 2007 Dec 5;132(3):237-251. Epub 2007 Oct 24 doi: 10.1016/j.pain.2007.08.033. PMID: 17920770

Recent clinical studies

Etiology

Association between spinal manipulative therapy and lumbar spine reoperation after discectomy: a retrospective cohort study.
Trager RJ, Gliedt JA, Labak CM, Daniels CJ, Dusek JA
BMC Musculoskelet Disord 2024 Jan 10;25(1):46. doi: 10.1186/s12891-024-07166-x. PMID: 38200469Free PMC Article
A systematic review and network meta-analysis comparing different epidural steroid injection approaches.
Mahmoud AM, Shawky MA, Farghaly OS, Botros JM, Alsaeid MA, Ragab SG
Pain Pract 2024 Feb;24(2):341-363. Epub 2023 Sep 12 doi: 10.1111/papr.13297. PMID: 37700550
Alpha-Lipoic Acid, Palmitoylethanolamide, Myrrh, and Oxygen-Ozone Therapy Improve Pharmacological Therapy in Acute Painful Lumbosacral Radiculopathy due to Herniated Disc.
Latini E, Bonasia G, Petroselli L, Mazzola M, Musa F, Santoboni F, Trischitta D, Sveva MN, Vetrano M, Vulpiani MC
Pain Physician 2023 Jul;26(4):E363-E373. PMID: 37535783
Work-relatedness of lumbosacral radiculopathy syndrome: Review and dose-response meta-analysis.
Kuijer PPFM, Verbeek JH, Seidler A, Ellegast R, Hulshof CTJ, Frings-Dresen MHW, Van der Molen HF
Neurology 2018 Sep 18;91(12):558-564. Epub 2018 Aug 17 doi: 10.1212/01.wnl.0000544322.26939.09. PMID: 30120136Free PMC Article
Immunotherapy for idiopathic lumbosacral plexopathy.
van Eijk J, Chan YC, Russell JW
Cochrane Database Syst Rev 2013 Dec 31;2013(12):CD009722. doi: 10.1002/14651858.CD009722.pub2. PMID: 24379134Free PMC Article

Diagnosis

Neurologic Approach to Radiculopathy, Back Pain, and Neck Pain.
Coker C, Park J, Jacobson RD
Prim Care 2024 Jun;51(2):345-358. Epub 2024 Mar 11 doi: 10.1016/j.pop.2024.02.003. PMID: 38692779
Work-relatedness of lumbosacral radiculopathy syndrome: Review and dose-response meta-analysis.
Kuijer PPFM, Verbeek JH, Seidler A, Ellegast R, Hulshof CTJ, Frings-Dresen MHW, Van der Molen HF
Neurology 2018 Sep 18;91(12):558-564. Epub 2018 Aug 17 doi: 10.1212/01.wnl.0000544322.26939.09. PMID: 30120136Free PMC Article
Delayed postirradiation camptocormia.
Kelly L, Perju-Dumbrava LD, Thyagarajan D, Lee YC
BMJ Case Rep 2013 Aug 19;2013 doi: 10.1136/bcr-2013-200083. PMID: 23960150Free PMC Article
Lumbosacral radiculopathy.
Tarulli AW, Raynor EM
Neurol Clin 2007 May;25(2):387-405. doi: 10.1016/j.ncl.2007.01.008. PMID: 17445735
Diabetic amyotrophy: current concepts.
Sander HW, Chokroverty S
Semin Neurol 1996 Jun;16(2):173-8. doi: 10.1055/s-2008-1040973. PMID: 8987131

Therapy

Medication recommendations for treatment of lumbosacral radiculopathy: A systematic review of clinical practice guidelines.
Price MR, Mead KE, Cowell DM, Troutner AM, Barton TE, Walters SA, Daniels CJ
PM R 2024 Oct;16(10):1128-1142. Epub 2024 Apr 17 doi: 10.1002/pmrj.13142. PMID: 38629664
A systematic review and network meta-analysis comparing different epidural steroid injection approaches.
Mahmoud AM, Shawky MA, Farghaly OS, Botros JM, Alsaeid MA, Ragab SG
Pain Pract 2024 Feb;24(2):341-363. Epub 2023 Sep 12 doi: 10.1111/papr.13297. PMID: 37700550
Alpha-Lipoic Acid, Palmitoylethanolamide, Myrrh, and Oxygen-Ozone Therapy Improve Pharmacological Therapy in Acute Painful Lumbosacral Radiculopathy due to Herniated Disc.
Latini E, Bonasia G, Petroselli L, Mazzola M, Musa F, Santoboni F, Trischitta D, Sveva MN, Vetrano M, Vulpiani MC
Pain Physician 2023 Jul;26(4):E363-E373. PMID: 37535783
Epidural adhesiolysis: an evidence-based review.
Jamison DE, Hsu E, Cohen SP
J Neurosurg Sci 2014 Jun;58(2):65-76. PMID: 24819483
Immunotherapy for idiopathic lumbosacral plexopathy.
van Eijk J, Chan YC, Russell JW
Cochrane Database Syst Rev 2013 Dec 31;2013(12):CD009722. doi: 10.1002/14651858.CD009722.pub2. PMID: 24379134Free PMC Article

Prognosis

Evaluation of persons with suspected lumbosacral and cervical radiculopathy: Electrodiagnostic assessment and implications for treatment and outcomes (Part II).
Dillingham TR, Annaswamy TM, Plastaras CT
Muscle Nerve 2020 Oct;62(4):474-484. Epub 2020 Jul 26 doi: 10.1002/mus.27008. PMID: 32564381
Lumbosacral Radiculopathy: Inciting Events and Their Association with Epidural Steroid Injection Outcomes.
Engle AM, Chen Y, Marascalchi B, Wilkinson I, Abrams WB, He C, Yao AL, Adekoya P, Cohen ZO, Cohen SP
Pain Med 2019 Dec 1;20(12):2360-2370. doi: 10.1093/pm/pnz097. PMID: 31099846
Immunotherapy for idiopathic lumbosacral plexopathy.
van Eijk J, Chan YC, Russell JW
Cochrane Database Syst Rev 2013 Dec 31;2013(12):CD009722. doi: 10.1002/14651858.CD009722.pub2. PMID: 24379134Free PMC Article
Neuroimaging in pediatric leukemia and lymphoma: differential diagnosis.
Vázquez E, Lucaya J, Castellote A, Piqueras J, Sainz P, Olivé T, Sánchez-Toledo J, Ortega JJ
Radiographics 2002 Nov-Dec;22(6):1411-28. doi: 10.1148/rg.226025029. PMID: 12432112
Diabetic amyotrophy: current concepts.
Sander HW, Chokroverty S
Semin Neurol 1996 Jun;16(2):173-8. doi: 10.1055/s-2008-1040973. PMID: 8987131

Clinical prediction guides

Medication recommendations for treatment of lumbosacral radiculopathy: A systematic review of clinical practice guidelines.
Price MR, Mead KE, Cowell DM, Troutner AM, Barton TE, Walters SA, Daniels CJ
PM R 2024 Oct;16(10):1128-1142. Epub 2024 Apr 17 doi: 10.1002/pmrj.13142. PMID: 38629664
Alpha-Lipoic Acid, Palmitoylethanolamide, Myrrh, and Oxygen-Ozone Therapy Improve Pharmacological Therapy in Acute Painful Lumbosacral Radiculopathy due to Herniated Disc.
Latini E, Bonasia G, Petroselli L, Mazzola M, Musa F, Santoboni F, Trischitta D, Sveva MN, Vetrano M, Vulpiani MC
Pain Physician 2023 Jul;26(4):E363-E373. PMID: 37535783
Lumbosacral Radiculopathy: Inciting Events and Their Association with Epidural Steroid Injection Outcomes.
Engle AM, Chen Y, Marascalchi B, Wilkinson I, Abrams WB, He C, Yao AL, Adekoya P, Cohen ZO, Cohen SP
Pain Med 2019 Dec 1;20(12):2360-2370. doi: 10.1093/pm/pnz097. PMID: 31099846
Clinical Course of Motor Deficits from Lumbosacral Radiculopathy Due to Disk Herniation.
Akuthota V, Marshall B, Boimbo S, Osborne MC, Garvan CS, Garvan GJ, Buzanowska M, Sauerwein K, Sridhar BV, Plastaras CT
PM R 2019 Aug;11(8):807-814. Epub 2019 Mar 28 doi: 10.1002/pmrj.12082. PMID: 30689304
Diabetic amyotrophy: current concepts.
Sander HW, Chokroverty S
Semin Neurol 1996 Jun;16(2):173-8. doi: 10.1055/s-2008-1040973. PMID: 8987131

Recent systematic reviews

Medication recommendations for treatment of lumbosacral radiculopathy: A systematic review of clinical practice guidelines.
Price MR, Mead KE, Cowell DM, Troutner AM, Barton TE, Walters SA, Daniels CJ
PM R 2024 Oct;16(10):1128-1142. Epub 2024 Apr 17 doi: 10.1002/pmrj.13142. PMID: 38629664
A systematic review and network meta-analysis comparing different epidural steroid injection approaches.
Mahmoud AM, Shawky MA, Farghaly OS, Botros JM, Alsaeid MA, Ragab SG
Pain Pract 2024 Feb;24(2):341-363. Epub 2023 Sep 12 doi: 10.1111/papr.13297. PMID: 37700550
Work-relatedness of lumbosacral radiculopathy syndrome: Review and dose-response meta-analysis.
Kuijer PPFM, Verbeek JH, Seidler A, Ellegast R, Hulshof CTJ, Frings-Dresen MHW, Van der Molen HF
Neurology 2018 Sep 18;91(12):558-564. Epub 2018 Aug 17 doi: 10.1212/01.wnl.0000544322.26939.09. PMID: 30120136Free PMC Article
The short and midterm outcomes of lumbar transforaminal epidural injection with preganglionic and postganglionic approach in lumbosacral radiculopathy: a systematic review and meta-analysis.
Pairuchvej S, Arirachakaran A, Keorochana G, Wattanapaiboon K, Atiprayoon S, Phatthanathitikarn P, Kongtharvonskul J
Neurosurg Rev 2018 Oct;41(4):909-916. Epub 2017 Feb 6 doi: 10.1007/s10143-017-0826-z. PMID: 28168618
Immunotherapy for idiopathic lumbosacral plexopathy.
van Eijk J, Chan YC, Russell JW
Cochrane Database Syst Rev 2013 Dec 31;2013(12):CD009722. doi: 10.1002/14651858.CD009722.pub2. PMID: 24379134Free PMC Article

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