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Atypical depressive disorder

MedGen UID:
509593
•Concept ID:
C0154437
•
Mental or Behavioral Dysfunction
Synonyms: atypical depression; atypical depressive disorder
SNOMED CT: Atypical depressive disorder (191659001)
 
Monarch Initiative: MONDO:0001485

Definition

A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite ("comfort eating"), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection. [from MONDO]

Professional guidelines

PubMed

Diagnosis and Treatment of Bipolar Disorder: A Review.
Nierenberg AA, Agustini B, Köhler-Forsberg O, Cusin C, Katz D, Sylvia LG, Peters A, Berk M
JAMA 2023 Oct 10;330(14):1370-1380. doi: 10.1001/jama.2023.18588. PMID: 37815563
Diagnosis and management of bipolar disorders.
Goes FS
BMJ 2023 Apr 12;381:e073591. doi: 10.1136/bmj-2022-073591. PMID: 37045450
Augmentation strategies for treatment resistant major depression: A systematic review and network meta-analysis.
Nuñez NA, Joseph B, Pahwa M, Kumar R, Resendez MG, Prokop LJ, Veldic M, Seshadri A, Biernacka JM, Frye MA, Wang Z, Singh B
J Affect Disord 2022 Apr 1;302:385-400. Epub 2022 Jan 2 doi: 10.1016/j.jad.2021.12.134. PMID: 34986373Free PMC Article

Recent clinical studies

Etiology

High serum leptin levels in depressive disorders with atypical features.
Gecici O, Kuloglu M, Atmaca M, Tezcan AE, Tunckol H, Emül HM, Ustundag B
Psychiatry Clin Neurosci 2005 Dec;59(6):736-8. doi: 10.1111/j.1440-1819.2005.01445.x. PMID: 16401252
The longitudinal course of psychopathology in Cushing's syndrome after correction of hypercortisolism.
Dorn LD, Burgess ES, Friedman TC, Dubbert B, Gold PW, Chrousos GP
J Clin Endocrinol Metab 1997 Mar;82(3):912-9. doi: 10.1210/jcem.82.3.3834. PMID: 9062506
Moclobemide and clomipramine in the treatment of depression. A randomized clinical trial.
Larsen JK, Holm P, Mikkelsen PL
Acta Psychiatr Scand 1984 Sep;70(3):254-60. doi: 10.1111/j.1600-0447.1984.tb01206.x. PMID: 6388247

Diagnosis

The effect of major depression on sexual function in women.
Fabre LF, Smith LC
J Sex Med 2012 Jan;9(1):231-9. Epub 2011 Aug 30 doi: 10.1111/j.1743-6109.2011.02445.x. PMID: 21883948
The longitudinal course of psychopathology in Cushing's syndrome after correction of hypercortisolism.
Dorn LD, Burgess ES, Friedman TC, Dubbert B, Gold PW, Chrousos GP
J Clin Endocrinol Metab 1997 Mar;82(3):912-9. doi: 10.1210/jcem.82.3.3834. PMID: 9062506
Atypical depression among psychiatric inpatients: clinical features and personality traits.
Derecho CN, Wetzler S, McGinn LK, Sanderson WC, Asnis GM
J Affect Disord 1996 Jun 20;39(1):55-9. doi: 10.1016/0165-0327(96)00022-5. PMID: 8835654
Atypical depression: clinical aspects and noradrenergic function.
Asnis GM, McGinn LK, Sanderson WC
Am J Psychiatry 1995 Jan;152(1):31-6. doi: 10.1176/ajp.152.1.31. PMID: 7802117
Characterizing depression in borderline patients.
Soloff PH, George A, Nathan RS, Schulz PM
J Clin Psychiatry 1987 Apr;48(4):155-7. PMID: 3558327

Therapy

The longitudinal course of psychopathology in Cushing's syndrome after correction of hypercortisolism.
Dorn LD, Burgess ES, Friedman TC, Dubbert B, Gold PW, Chrousos GP
J Clin Endocrinol Metab 1997 Mar;82(3):912-9. doi: 10.1210/jcem.82.3.3834. PMID: 9062506
Rolipram versus imipramine in inpatients with major, "minor" or atypical depressive disorder: a double-blind double-dummy study aimed at testing a novel therapeutic approach.
Bertolino A, Crippa D, di Dio S, Fichte K, Musmeci G, Porro V, Rapisarda V, Sastre-y-Hernández M, Schratzer M
Int Clin Psychopharmacol 1988 Jul;3(3):245-53. doi: 10.1097/00004850-198807000-00006. PMID: 3153712
Moclobemide and clomipramine in the treatment of depression. A randomized clinical trial.
Larsen JK, Holm P, Mikkelsen PL
Acta Psychiatr Scand 1984 Sep;70(3):254-60. doi: 10.1111/j.1600-0447.1984.tb01206.x. PMID: 6388247

Prognosis

The longitudinal course of psychopathology in Cushing's syndrome after correction of hypercortisolism.
Dorn LD, Burgess ES, Friedman TC, Dubbert B, Gold PW, Chrousos GP
J Clin Endocrinol Metab 1997 Mar;82(3):912-9. doi: 10.1210/jcem.82.3.3834. PMID: 9062506

Clinical prediction guides

The effect of major depression on sexual function in women.
Fabre LF, Smith LC
J Sex Med 2012 Jan;9(1):231-9. Epub 2011 Aug 30 doi: 10.1111/j.1743-6109.2011.02445.x. PMID: 21883948
Atypical depression: clinical aspects and noradrenergic function.
Asnis GM, McGinn LK, Sanderson WC
Am J Psychiatry 1995 Jan;152(1):31-6. doi: 10.1176/ajp.152.1.31. PMID: 7802117

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