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Acquired thrombocytopenia

MedGen UID:
509570
•Concept ID:
C0154301
•
Disease or Syndrome
Synonym: Thrombocytopenia, secondary
SNOMED CT: Acquired thrombocytopenia (74576004); Secondary thrombocytopenia (154826009)
 
Monarch Initiative: MONDO:0001198

Definition

An instance of thrombocytopenia that is acquired during the lifetime of the individual. [from MONDO]

Professional guidelines

PubMed

Identifying and treating refractory ITP: difficulty in diagnosis and role of combination treatment.
Miltiadous O, Hou M, Bussel JB
Blood 2020 Feb 13;135(7):472-490. doi: 10.1182/blood.2019003599. PMID: 31756253Free PMC Article
Treatment of patients with immune thrombocytopenia admitted to the emergency room.
Bavunoğlu I, Eşkazan AE, Ar MC, Cengiz M, Yavuzer S, Salihoğlu A, Öngören Ş, Tunçkale A, Soysal T
Int J Hematol 2016 Aug;104(2):216-22. Epub 2016 Apr 29 doi: 10.1007/s12185-016-2003-5. PMID: 27129318
Treatment of splenic marginal zone B-cell lymphoma: an analysis of 81 patients.
Thieblemont C, Felman P, Berger F, Dumontet C, Arnaud P, Hequet O, Arcache J, Callet-Bauchu E, Salles G, Coiffier B
Clin Lymphoma 2002 Jun;3(1):41-7. doi: 10.3816/clm.2002.n.010. PMID: 12141954

Recent clinical studies

Etiology

How I use platelet transfusions.
Stanworth SJ, Shah A
Blood 2022 Nov 3;140(18):1925-1936. doi: 10.1182/blood.2022016558. PMID: 35926105
Why thromboembolism occurs in some patients with thrombocytopenia and treatment strategies.
Han X, Li C, Zhang S, Hou X, Chen Z, Zhang J, Zhang Y, Sun J, Wang Y
Thromb Res 2020 Dec;196:500-509. Epub 2020 Oct 8 doi: 10.1016/j.thromres.2020.10.005. PMID: 33091704
Identifying and treating refractory ITP: difficulty in diagnosis and role of combination treatment.
Miltiadous O, Hou M, Bussel JB
Blood 2020 Feb 13;135(7):472-490. doi: 10.1182/blood.2019003599. PMID: 31756253Free PMC Article
Etiology and complications of thrombocytopenia in hospitalized medical patients.
Fountain EM, Arepally GM
J Thromb Thrombolysis 2017 May;43(4):429-436. doi: 10.1007/s11239-016-1467-8. PMID: 28054307
Thrombocytopenia and infections.
Franchini M, Veneri D, Lippi G
Expert Rev Hematol 2017 Jan;10(1):99-106. Epub 2016 Dec 20 doi: 10.1080/17474086.2017.1271319. PMID: 27936979

Diagnosis

An update on pediatric ITP: differentiating primary ITP, IPD, and PID.
Grace RF, Lambert MP
Blood 2022 Aug 11;140(6):542-555. doi: 10.1182/blood.2020006480. PMID: 34479363
Identifying and treating refractory ITP: difficulty in diagnosis and role of combination treatment.
Miltiadous O, Hou M, Bussel JB
Blood 2020 Feb 13;135(7):472-490. doi: 10.1182/blood.2019003599. PMID: 31756253Free PMC Article
Thrombocytopenia and infections.
Franchini M, Veneri D, Lippi G
Expert Rev Hematol 2017 Jan;10(1):99-106. Epub 2016 Dec 20 doi: 10.1080/17474086.2017.1271319. PMID: 27936979
Hospital-acquired thrombocytopenia.
McMahon CM, Cuker A
Hosp Pract (1995) 2014 Oct;42(4):142-52. doi: 10.3810/hp.2014.10.1151. PMID: 25502138
Jacobsen syndrome.
Mattina T, Perrotta CS, Grossfeld P
Orphanet J Rare Dis 2009 Mar 7;4:9. doi: 10.1186/1750-1172-4-9. PMID: 19267933Free PMC Article

Therapy

How I use platelet transfusions.
Stanworth SJ, Shah A
Blood 2022 Nov 3;140(18):1925-1936. doi: 10.1182/blood.2022016558. PMID: 35926105
Impact of Acquired Thrombocytopenia on Cardiovascular Outcomes in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis.
Ahsan MJ, Fazeel HM, Haque SMU, Malik SU, Latif A, Lateef N, Batool SS, Kousa O, Ahsan MZ, Anwer F, Andukuri V, Smer A
Cardiovasc Revasc Med 2021 Jun;27:79-87. Epub 2020 Jul 24 doi: 10.1016/j.carrev.2020.07.014. PMID: 32800731
Identifying and treating refractory ITP: difficulty in diagnosis and role of combination treatment.
Miltiadous O, Hou M, Bussel JB
Blood 2020 Feb 13;135(7):472-490. doi: 10.1182/blood.2019003599. PMID: 31756253Free PMC Article
Etiology and complications of thrombocytopenia in hospitalized medical patients.
Fountain EM, Arepally GM
J Thromb Thrombolysis 2017 May;43(4):429-436. doi: 10.1007/s11239-016-1467-8. PMID: 28054307
Predictors and clinical impact of pre-existing and acquired thrombocytopenia following transcatheter aortic valve replacement.
Flaherty MP, Mohsen A, Moore JB 4th, Bartoli CR, Schneibel E, Rawasia W, Williams ML, Grubb KJ, Hirsch GA
Catheter Cardiovasc Interv 2015 Jan 1;85(1):118-29. Epub 2014 Sep 30 doi: 10.1002/ccd.25668. PMID: 25204308

Prognosis

Spleen Size and Thrombocytopenia After Transcatheter Aortic Valve Implantation.
Sugiura A, Treiling L, Al-Kassou B, Shamekhi J, Wilde N, Sinning JM, Zimmer S, Kuetting D, Oldenburg J, Poetzsch B, Nickenig G, Sedaghat A
Am J Cardiol 2021 Oct 15;157:85-92. Epub 2021 Aug 14 doi: 10.1016/j.amjcard.2021.07.021. PMID: 34404506
Etiology and complications of thrombocytopenia in hospitalized medical patients.
Fountain EM, Arepally GM
J Thromb Thrombolysis 2017 May;43(4):429-436. doi: 10.1007/s11239-016-1467-8. PMID: 28054307
Thrombocytopenia and infections.
Franchini M, Veneri D, Lippi G
Expert Rev Hematol 2017 Jan;10(1):99-106. Epub 2016 Dec 20 doi: 10.1080/17474086.2017.1271319. PMID: 27936979
Predictors and clinical impact of pre-existing and acquired thrombocytopenia following transcatheter aortic valve replacement.
Flaherty MP, Mohsen A, Moore JB 4th, Bartoli CR, Schneibel E, Rawasia W, Williams ML, Grubb KJ, Hirsch GA
Catheter Cardiovasc Interv 2015 Jan 1;85(1):118-29. Epub 2014 Sep 30 doi: 10.1002/ccd.25668. PMID: 25204308
Acquired thrombocytopenia after transcatheter aortic valve replacement: clinical correlates and association with outcomes.
Dvir D, Généreux P, Barbash IM, Kodali S, Ben-Dor I, Williams M, Torguson R, Kirtane AJ, Minha S, Badr S, Pendyala LK, Loh JP, Okubagzi PG, Fields JN, Xu K, Chen F, Hahn RT, Satler LF, Smith C, Pichard AD, Leon MB, Waksman R
Eur Heart J 2014 Oct 7;35(38):2663-71. Epub 2014 Mar 4 doi: 10.1093/eurheartj/ehu082. PMID: 24598983

Clinical prediction guides

Downregulation of ADAM17 in pediatric immune thrombocytopenia impairs proplatelet formation.
Wang Q, Wei J, Jia X, Feng X, Ji Z, Ji X, Shao X
BMC Pediatr 2022 Mar 30;22(1):164. doi: 10.1186/s12887-022-03237-x. PMID: 35354403Free PMC Article
Incidence, clinical impact and predictors of thrombocytopenia after transcatheter aortic valve replacement.
Tirado-Conte G, Salazar CH, McInerney A, Cruz-Utrilla A, Jiménez-Quevedo P, Cobiella J, Gonzalo N, Carnero M, Núñez-Gil I, Mejía-Rentería H, Salinas P, Macaya F, Maroto LC, Vilacosta I, Fernández-Ortiz A, Escaned J, Macaya C, Nombela-Franco L
Int J Cardiol 2022 Apr 1;352:21-26. Epub 2022 Feb 4 doi: 10.1016/j.ijcard.2022.01.072. PMID: 35124106
Incidence, Predictors, and Outcomes of Acquired Thrombocytopenia After Percutaneous Coronary Intervention: A Pooled, Patient-Level Analysis of the CHAMPION Trials (Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition).
Groves EM, Bhatt DL, Steg PG, Deliargyris EN, Stone GW, Gibson CM, Hamm CW, Mahaffey KW, White HD, Angiolillo DJ, Prats J, Harrington RA, Price MJ
Circ Cardiovasc Interv 2018 Apr;11(4):e005635. doi: 10.1161/CIRCINTERVENTIONS.117.005635. PMID: 29632238
Predictors and clinical impact of pre-existing and acquired thrombocytopenia following transcatheter aortic valve replacement.
Flaherty MP, Mohsen A, Moore JB 4th, Bartoli CR, Schneibel E, Rawasia W, Williams ML, Grubb KJ, Hirsch GA
Catheter Cardiovasc Interv 2015 Jan 1;85(1):118-29. Epub 2014 Sep 30 doi: 10.1002/ccd.25668. PMID: 25204308
Acquired thrombocytopenia after transcatheter aortic valve replacement: clinical correlates and association with outcomes.
Dvir D, Généreux P, Barbash IM, Kodali S, Ben-Dor I, Williams M, Torguson R, Kirtane AJ, Minha S, Badr S, Pendyala LK, Loh JP, Okubagzi PG, Fields JN, Xu K, Chen F, Hahn RT, Satler LF, Smith C, Pichard AD, Leon MB, Waksman R
Eur Heart J 2014 Oct 7;35(38):2663-71. Epub 2014 Mar 4 doi: 10.1093/eurheartj/ehu082. PMID: 24598983

Recent systematic reviews

Impact of Acquired Thrombocytopenia on Cardiovascular Outcomes in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis.
Ahsan MJ, Fazeel HM, Haque SMU, Malik SU, Latif A, Lateef N, Batool SS, Kousa O, Ahsan MZ, Anwer F, Andukuri V, Smer A
Cardiovasc Revasc Med 2021 Jun;27:79-87. Epub 2020 Jul 24 doi: 10.1016/j.carrev.2020.07.014. PMID: 32800731
The effect of in-hospital acquired thrombocytopenia on the outcome of patients with acute coronary syndromes: A systematic review and meta-analysis.
Oikonomou EK, Repanas TI, Papanastasiou C, Kokkinidis DG, Miligkos M, Feher A, Gupta D, Kampaktsis PN
Thromb Res 2016 Nov;147:64-71. Epub 2016 Sep 24 doi: 10.1016/j.thromres.2016.09.026. PMID: 27689317Free PMC Article

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