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Bladder carcinoma in situ

MedGen UID:
57584
•Concept ID:
C0154091
•
Neoplastic Process
Synonyms: bladder Ca in situ; bladder carcinoma in situ; bladder flat carcinoma in situ; bladder flat CIS; Cancer in situ of urinary bladder; Carcinoma in situ of bladder; carcinoma in situ of bladder; carcinoma in situ of the urinary bladder; Carcinoma in situ of urinary bladder; carcinoma in situ of urinary bladder; flat carcinoma in situ of the bladder; flat carcinoma in situ of the urinary bladder; flat CIS of the bladder; flat CIS of the urinary bladder; high grade bladder Intraurothelial neoplasia; stage 0 urinary bladder carcinoma; stage 0is bladder cancer; stage 0is bladder carcinoma; stage 0is bladder urothelial cancer; stage 0is bladder urothelial carcinoma; stage 0is bladder urothelial carcinoma aJCC v6; stage 0is bladder urothelial carcinoma aJCC v6 and v7; stage 0is bladder urothelial carcinoma aJCC v7; stage 0is carcinoma of bladder; stage 0is carcinoma of the bladder; stage 0is carcinoma of the urinary bladder; stage 0is carcinoma of urinary bladder; stage 0is urinary bladder carcinoma; urinary bladder carcinoma in situ; urinary bladder flat carcinoma in situ; urinary bladder flat CIS; urinary bladder in situ carcinoma
SNOMED CT: Carcinoma in situ of bladder (92546004); Cancer in situ of urinary bladder (92546004); Carcinoma in situ of urinary bladder (92546004)
 
Monarch Initiative: MONDO:0004703

Definition

Also known as carcinoma in situ of the urinary bladder or high grade intraurothelial neoplasia, this is a flat lesion of the transitional cell epithelium characterized by severe cytologic atypia. This lesion is confined to the urothelium, and is a precursor of invasive transitional cell carcinoma of the bladder. Stage 0is includes: Tis, N0, M0. Tis: Carcinoma in situ: "flat tumor". N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.) [from MONDO]

Professional guidelines

PubMed

Intravesical and alternative bladder-preservation therapies in the management of non-muscle-invasive bladder cancer unresponsive to bacillus Calmette-Guérin.
Steinberg RL, Thomas LJ, Nepple KG
Urol Oncol 2016 Jun;34(6):279-89. Epub 2016 Jan 14 doi: 10.1016/j.urolonc.2015.12.004. PMID: 26777259
Diagnosis and management of urothelial carcinoma in situ of the lower urinary tract: a systematic review.
Casey RG, Catto JW, Cheng L, Cookson MS, Herr H, Shariat S, Witjes JA, Black PC
Eur Urol 2015 May;67(5):876-88. Epub 2014 Nov 14 doi: 10.1016/j.eururo.2014.10.040. PMID: 25466937
Treatment of carcinoma in situ with intravesical bacillus Calmette-Guerin without maintenance.
Griffiths TR, Charlton M, Neal DE, Powell PH
J Urol 2002 Jun;167(6):2408-12. PMID: 11992047

Recent clinical studies

Etiology

Contemporary outcomes of bladder carcinoma in situ treated with an adequate bacille Calmette-Guérin immunotherapy.
Subiela JD, Rodríguez Faba Ó, Aumatell J, Calderón J, Mercadé A, Balañà J, Esquinas C, Algaba F, Breda A, Palou J
BJU Int 2022 Apr;129(4):542-550. Epub 2021 Aug 23 doi: 10.1111/bju.15567. PMID: 34375494
Can random bladder biopsies be eliminated after bacillus Calmette-Guérin therapy against carcinoma in situ?
Takamatsu K, Matsumoto K, Kikuchi E, Ogihara K, Hayakawa N, Tanaka N, Takeda T, Morita S, Kosaka T, Mizuno R, Asanuma H, Mikami S, Oyama M, Oya M
Int Urol Nephrol 2021 Mar;53(3):465-469. Epub 2020 Oct 6 doi: 10.1007/s11255-020-02667-9. PMID: 33025406
Bladder carcinoma in situ (CIS) in Australia: a rising incidence for an under-reported malignancy.
Ranasinghe WK, Attia J, Oldmeadow C, Lawrentschuk N, Robertson J, Ranasinghe T, Bolton D, Persad R
BJU Int 2013 Nov;112 Suppl 2:46-52. Epub 2013 Apr 10 doi: 10.1111/bju.12052. PMID: 23573811
Carcinoma in situ of urinary bladder: incidence, treatment and clinical outcomes during ten-year follow-up.
Librenjak D, Novaković ZS, Milostić K
Acta Clin Croat 2012 Jun;51(2):201-7. PMID: 23115943
Bladder carcinoma in situ in 2003: state of the art.
Witjes JA
Eur Urol 2004 Feb;45(2):142-6. doi: 10.1016/j.eururo.2003.09.013. PMID: 14733997

Diagnosis

Can random bladder biopsies be eliminated after bacillus Calmette-Guérin therapy against carcinoma in situ?
Takamatsu K, Matsumoto K, Kikuchi E, Ogihara K, Hayakawa N, Tanaka N, Takeda T, Morita S, Kosaka T, Mizuno R, Asanuma H, Mikami S, Oyama M, Oya M
Int Urol Nephrol 2021 Mar;53(3):465-469. Epub 2020 Oct 6 doi: 10.1007/s11255-020-02667-9. PMID: 33025406
5-Aminolevulinic acid-mediated photodynamic therapy for bladder cancer.
Inoue K
Int J Urol 2017 Feb;24(2):97-101. doi: 10.1111/iju.13291. PMID: 28191719
Upper Urinary Tract Carcinoma In Situ: Current Knowledge, Future Direction.
Redrow GP, Guo CC, Brausi MA, Coleman JA, Fernandez MI, Kassouf W, Keeley FX Jr, Margulis V, Raman JD, Roupret M, Shariat SF, Spiess PE, Thalmann GN, Matin SF
J Urol 2017 Feb;197(2):287-295. Epub 2016 Sep 21 doi: 10.1016/j.juro.2016.03.194. PMID: 27664578
Diagnosis and management of urothelial carcinoma in situ of the lower urinary tract: a systematic review.
Casey RG, Catto JW, Cheng L, Cookson MS, Herr H, Shariat S, Witjes JA, Black PC
Eur Urol 2015 May;67(5):876-88. Epub 2014 Nov 14 doi: 10.1016/j.eururo.2014.10.040. PMID: 25466937
Bladder carcinoma in situ in 2003: state of the art.
Witjes JA
Eur Urol 2004 Feb;45(2):142-6. doi: 10.1016/j.eururo.2003.09.013. PMID: 14733997

Therapy

Contemporary outcomes of bladder carcinoma in situ treated with an adequate bacille Calmette-Guérin immunotherapy.
Subiela JD, Rodríguez Faba Ó, Aumatell J, Calderón J, Mercadé A, Balañà J, Esquinas C, Algaba F, Breda A, Palou J
BJU Int 2022 Apr;129(4):542-550. Epub 2021 Aug 23 doi: 10.1111/bju.15567. PMID: 34375494
Can random bladder biopsies be eliminated after bacillus Calmette-Guérin therapy against carcinoma in situ?
Takamatsu K, Matsumoto K, Kikuchi E, Ogihara K, Hayakawa N, Tanaka N, Takeda T, Morita S, Kosaka T, Mizuno R, Asanuma H, Mikami S, Oyama M, Oya M
Int Urol Nephrol 2021 Mar;53(3):465-469. Epub 2020 Oct 6 doi: 10.1007/s11255-020-02667-9. PMID: 33025406
5-Aminolevulinic acid-mediated photodynamic therapy for bladder cancer.
Inoue K
Int J Urol 2017 Feb;24(2):97-101. doi: 10.1111/iju.13291. PMID: 28191719
Diagnosis and management of urothelial carcinoma in situ of the lower urinary tract: a systematic review.
Casey RG, Catto JW, Cheng L, Cookson MS, Herr H, Shariat S, Witjes JA, Black PC
Eur Urol 2015 May;67(5):876-88. Epub 2014 Nov 14 doi: 10.1016/j.eururo.2014.10.040. PMID: 25466937
Bladder carcinoma in situ in 2003: state of the art.
Witjes JA
Eur Urol 2004 Feb;45(2):142-6. doi: 10.1016/j.eururo.2003.09.013. PMID: 14733997

Prognosis

Contemporary outcomes of bladder carcinoma in situ treated with an adequate bacille Calmette-Guérin immunotherapy.
Subiela JD, Rodríguez Faba Ó, Aumatell J, Calderón J, Mercadé A, Balañà J, Esquinas C, Algaba F, Breda A, Palou J
BJU Int 2022 Apr;129(4):542-550. Epub 2021 Aug 23 doi: 10.1111/bju.15567. PMID: 34375494
Can random bladder biopsies be eliminated after bacillus Calmette-Guérin therapy against carcinoma in situ?
Takamatsu K, Matsumoto K, Kikuchi E, Ogihara K, Hayakawa N, Tanaka N, Takeda T, Morita S, Kosaka T, Mizuno R, Asanuma H, Mikami S, Oyama M, Oya M
Int Urol Nephrol 2021 Mar;53(3):465-469. Epub 2020 Oct 6 doi: 10.1007/s11255-020-02667-9. PMID: 33025406
Upper Urinary Tract Carcinoma In Situ: Current Knowledge, Future Direction.
Redrow GP, Guo CC, Brausi MA, Coleman JA, Fernandez MI, Kassouf W, Keeley FX Jr, Margulis V, Raman JD, Roupret M, Shariat SF, Spiess PE, Thalmann GN, Matin SF
J Urol 2017 Feb;197(2):287-295. Epub 2016 Sep 21 doi: 10.1016/j.juro.2016.03.194. PMID: 27664578
Carcinoma in situ of urinary bladder: incidence, treatment and clinical outcomes during ten-year follow-up.
Librenjak D, Novaković ZS, Milostić K
Acta Clin Croat 2012 Jun;51(2):201-7. PMID: 23115943
Bladder carcinoma in situ in 2003: state of the art.
Witjes JA
Eur Urol 2004 Feb;45(2):142-6. doi: 10.1016/j.eururo.2003.09.013. PMID: 14733997

Clinical prediction guides

A paclitaxel-hyaluronan conjugate (ONCOFID-P-B™) in patients with BCG-unresponsive carcinoma in situ of the bladder: a dynamic assessment of the tumor microenvironment.
Tosi A, Parisatto B, Gaffo E, Bortoluzzi S, Rosato A
J Exp Clin Cancer Res 2024 Apr 10;43(1):109. doi: 10.1186/s13046-024-03028-5. PMID: 38600583Free PMC Article
Can random bladder biopsies be eliminated after bacillus Calmette-Guérin therapy against carcinoma in situ?
Takamatsu K, Matsumoto K, Kikuchi E, Ogihara K, Hayakawa N, Tanaka N, Takeda T, Morita S, Kosaka T, Mizuno R, Asanuma H, Mikami S, Oyama M, Oya M
Int Urol Nephrol 2021 Mar;53(3):465-469. Epub 2020 Oct 6 doi: 10.1007/s11255-020-02667-9. PMID: 33025406
Clinical outcome of primary versus secondary bladder carcinoma in situ.
Chade DC, Shariat SF, Adamy A, Bochner BH, Donat SM, Herr HW, Dalbagni G
J Urol 2010 Aug;184(2):464-9. Epub 2010 Jun 17 doi: 10.1016/j.juro.2010.03.134. PMID: 20620399Free PMC Article
Clinical outcomes of primary bladder carcinoma in situ in a contemporary series.
Chade DC, Shariat SF, Godoy G, Savage CJ, Cronin AM, Bochner BH, Donat SM, Herr HW, Dalbagni G
J Urol 2010 Jul;184(1):74-80. doi: 10.1016/j.juro.2010.03.032. PMID: 20546806Free PMC Article
Bladder carcinoma in situ in 2003: state of the art.
Witjes JA
Eur Urol 2004 Feb;45(2):142-6. doi: 10.1016/j.eururo.2003.09.013. PMID: 14733997

Recent systematic reviews

A systematic review and meta-analysis of CK20, CD44, Ki67 and p53 as immunohistochemical markers in bladder carcinoma in situ.
Straccia P, Fiorentino V, Martini M, Pierconti F
Actas Urol Esp (Engl Ed) 2022 Nov;46(9):521-530. Epub 2022 Aug 6 doi: 10.1016/j.acuroe.2022.08.013. PMID: 36216762
Diagnosis and management of urothelial carcinoma in situ of the lower urinary tract: a systematic review.
Casey RG, Catto JW, Cheng L, Cookson MS, Herr H, Shariat S, Witjes JA, Black PC
Eur Urol 2015 May;67(5):876-88. Epub 2014 Nov 14 doi: 10.1016/j.eururo.2014.10.040. PMID: 25466937

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