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Benign neoplasm of testis

MedGen UID:
57576
•Concept ID:
C0154007
•
Neoplastic Process
Synonyms: Benign Neoplasm of Testis; benign neoplasm of testis; Benign Neoplasm of the Testis; benign neoplasm of the testis; Benign Testicular Neoplasm; benign testicular neoplasm; Benign testicular tumor; Benign Testicular Tumor; benign testicular tumor; benign testicular tumour; Benign tumor of testis; Benign Tumor of Testis; benign tumor of testis; Benign Tumor of the Testis; benign tumor of the testis; benign tumour of testis; benign tumour of the testis; testis benign neoplasm
SNOMED CT: Benign tumor of testis (92428008); Benign testicular tumor (92428008); Benign neoplasm of testis (92428008)
 
Monarch Initiative: MONDO:0021447

Definition

A neoplasm that arises from the testis and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

The contemporary management of cancers of the sinonasal tract in adults.
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Testicular involvement of acute lymphoblastic leukemia in children and adolescents: Diagnosis, biology, and management.
Nguyen HTK, Terao MA, Green DM, Pui CH, Inaba H
Cancer 2021 Sep 1;127(17):3067-3081. Epub 2021 May 25 doi: 10.1002/cncr.33609. PMID: 34031876Free PMC Article
Testicular Cancer: Diagnosis and Treatment.
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528

Recent clinical studies

Etiology

Моlecular mechanisms of initiation of carcinogenesis in the testis.
Bazalytska SV, Persidsky Y, Romanenko AM
Exp Oncol 2019 Sep;41(3):224-234. doi: 10.32471/exp-oncology.2312-8852.vol-41-no-3.13527. PMID: 31569932
Epidemiology of mesothelioma of the pericardium and tunica vaginalis testis.
Mezei G, Chang ET, Mowat FS, Moolgavkar SH
Ann Epidemiol 2017 May;27(5):348-359.e11. Epub 2017 Apr 14 doi: 10.1016/j.annepidem.2017.04.001. PMID: 28527639
Infertility with Testicular Cancer.
Ostrowski KA, Walsh TJ
Urol Clin North Am 2015 Aug;42(3):409-20. Epub 2015 Jun 11 doi: 10.1016/j.ucl.2015.05.003. PMID: 26216827
Cryptorchidism --disease or symptom?
Toppari J, Rodprasert W, Virtanen HE
Ann Endocrinol (Paris) 2014 May;75(2):72-6. Epub 2014 Apr 29 doi: 10.1016/j.ando.2014.04.010. PMID: 24786701
Cryptorchidism.
Hutson JM, Balic A, Nation T, Southwell B
Semin Pediatr Surg 2010 Aug;19(3):215-24. doi: 10.1053/j.sempedsurg.2010.04.001. PMID: 20610195

Diagnosis

Epidemiology and Diagnosis of Testis Cancer.
Stevenson SM, Lowrance WT
Urol Clin North Am 2015 Aug;42(3):269-75. Epub 2015 Jun 11 doi: 10.1016/j.ucl.2015.04.001. PMID: 26216814
Cryptorchidism --disease or symptom?
Toppari J, Rodprasert W, Virtanen HE
Ann Endocrinol (Paris) 2014 May;75(2):72-6. Epub 2014 Apr 29 doi: 10.1016/j.ando.2014.04.010. PMID: 24786701
Idiopathic granulomatous orchitis.
Roy S, Hooda S, Parwani AV
Pathol Res Pract 2011 May 15;207(5):275-8. Epub 2011 Apr 1 doi: 10.1016/j.prp.2011.02.005. PMID: 21458170
Spermatocytic seminoma.
Aggarwal N, Parwani AV
Arch Pathol Lab Med 2009 Dec;133(12):1985-8. doi: 10.5858/133.12.1985. PMID: 19961257
Specific association of human telomerase activity with immortal cells and cancer.
Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW
Science 1994 Dec 23;266(5193):2011-5. doi: 10.1126/science.7605428. PMID: 7605428

Therapy

Cutaneous Melanoma and Hormones: Focus on Sex Differences and the Testis.
Cosci I, Grande G, Di Nisio A, Rocca MS, Del Fiore P, Benna C, Mocellin S, Ferlin A
Int J Mol Sci 2022 Dec 29;24(1) doi: 10.3390/ijms24010599. PMID: 36614041Free PMC Article
Preservation of fertility in patients with cancer (Review).
Del-Pozo-Lérida S, Salvador C, Martínez-Soler F, Tortosa A, Perucho M, Giménez-Bonafé P
Oncol Rep 2019 May;41(5):2607-2614. Epub 2019 Mar 14 doi: 10.3892/or.2019.7063. PMID: 30896846
Infertility with Testicular Cancer.
Ostrowski KA, Walsh TJ
Urol Clin North Am 2015 Aug;42(3):409-20. Epub 2015 Jun 11 doi: 10.1016/j.ucl.2015.05.003. PMID: 26216827
Cryptorchidism --disease or symptom?
Toppari J, Rodprasert W, Virtanen HE
Ann Endocrinol (Paris) 2014 May;75(2):72-6. Epub 2014 Apr 29 doi: 10.1016/j.ando.2014.04.010. PMID: 24786701
The undescended testicle.
Palmer JM
Endocrinol Metab Clin North Am 1991 Mar;20(1):231-40. PMID: 1674244

Prognosis

Single-cell sequencing on CD8(+) TILs revealed the nature of exhausted T cells recognizing neoantigen and cancer/testis antigen in non-small cell lung cancer.
Komuro H, Shinohara S, Fukushima Y, Demachi-Okamura A, Muraoka D, Masago K, Matsui T, Sugita Y, Takahashi Y, Nishida R, Takashima C, Ohki T, Shigematsu Y, Watanabe F, Adachi K, Fukuyama T, Hamana H, Kishi H, Miura D, Tanaka Y, Onoue K, Onoguchi K, Yamashita Y, Stratford R, Clancy T, Yamaguchi R, Kuroda H, Doi K, Iwata H, Matsushita H
J Immunother Cancer 2023 Aug;11(8) doi: 10.1136/jitc-2023-007180. PMID: 37544663Free PMC Article
Imaging spectrum of NUT carcinomas.
Virarkar M, Saleh M, Ramani NS, Morani AC, Bhosale P
Clin Imaging 2020 Nov;67:198-206. Epub 2020 Aug 2 doi: 10.1016/j.clinimag.2020.07.025. PMID: 32866821
Causes of death among cancer patients.
Zaorsky NG, Churilla TM, Egleston BL, Fisher SG, Ridge JA, Horwitz EM, Meyer JE
Ann Oncol 2017 Feb 1;28(2):400-407. doi: 10.1093/annonc/mdw604. PMID: 27831506Free PMC Article
Cryptorchidism.
Hutson JM, Balic A, Nation T, Southwell B
Semin Pediatr Surg 2010 Aug;19(3):215-24. doi: 10.1053/j.sempedsurg.2010.04.001. PMID: 20610195
Paratesticular mesothelial proliferations.
Churg A
Semin Diagn Pathol 2003 Nov;20(4):272-8. doi: 10.1053/j.semdp.2003.08.003. PMID: 14694980

Clinical prediction guides

Single-cell sequencing on CD8(+) TILs revealed the nature of exhausted T cells recognizing neoantigen and cancer/testis antigen in non-small cell lung cancer.
Komuro H, Shinohara S, Fukushima Y, Demachi-Okamura A, Muraoka D, Masago K, Matsui T, Sugita Y, Takahashi Y, Nishida R, Takashima C, Ohki T, Shigematsu Y, Watanabe F, Adachi K, Fukuyama T, Hamana H, Kishi H, Miura D, Tanaka Y, Onoue K, Onoguchi K, Yamashita Y, Stratford R, Clancy T, Yamaguchi R, Kuroda H, Doi K, Iwata H, Matsushita H
J Immunother Cancer 2023 Aug;11(8) doi: 10.1136/jitc-2023-007180. PMID: 37544663Free PMC Article
Cancer/testis antigens: promising immunotherapy targets for digestive tract cancers.
Ai H, Yang H, Li L, Ma J, Liu K, Li Z
Front Immunol 2023;14:1190883. Epub 2023 Jun 16 doi: 10.3389/fimmu.2023.1190883. PMID: 37398650Free PMC Article
Clear cell carcinoma of testis: A review.
Lin M, Awalt H, Ayala AG, Ro JY
Ann Diagn Pathol 2019 Jun;40:26-29. Epub 2019 Mar 20 doi: 10.1016/j.anndiagpath.2019.03.002. PMID: 30921621
The regulation of testicular descent and the effects of cryptorchidism.
Hutson JM, Southwell BR, Li R, Lie G, Ismail K, Harisis G, Chen N
Endocr Rev 2013 Oct;34(5):725-52. Epub 2013 May 10 doi: 10.1210/er.2012-1089. PMID: 23666148
Cryptorchidism.
Hutson JM, Balic A, Nation T, Southwell B
Semin Pediatr Surg 2010 Aug;19(3):215-24. doi: 10.1053/j.sempedsurg.2010.04.001. PMID: 20610195

Recent systematic reviews

A Systematic Review and Meta-analysis on the Impact of Infertility on Men's General Health.
Fallara G, Pozzi E, Belladelli F, Boeri L, Capogrosso P, Corona G, D'Arma A, Alfano M, Montorsi F, Salonia A
Eur Urol Focus 2024 Jan;10(1):98-106. Epub 2023 Aug 10 doi: 10.1016/j.euf.2023.07.010. PMID: 37573151
Testis-sparing surgery in children with testicular tumors: A systematic review and meta-analysis.
Miao X, Li Y, Zhou T, Lv M
Asian J Surg 2021 Dec;44(12):1503-1509. Epub 2021 Apr 21 doi: 10.1016/j.asjsur.2021.03.016. PMID: 33893031
Epidemiology of mesothelioma of the pericardium and tunica vaginalis testis.
Mezei G, Chang ET, Mowat FS, Moolgavkar SH
Ann Epidemiol 2017 May;27(5):348-359.e11. Epub 2017 Apr 14 doi: 10.1016/j.annepidem.2017.04.001. PMID: 28527639
Testicular cancer: seminoma.
Chung P, Warde P
BMJ Clin Evid 2011 Jan 25;2011 PMID: 21477387Free PMC Article
Screening for testicular cancer.
Ilic D, Misso ML
Cochrane Database Syst Rev 2011 Feb 16;(2):CD007853. doi: 10.1002/14651858.CD007853.pub2. PMID: 21328302

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