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Malignant Neoplasm of Lingual Tonsil

MedGen UID:
509264
•Concept ID:
C0153356
•
Neoplastic Process
Synonym: Malignant tumor of lingual tonsil
SNOMED CT: Malignant tumor of lingual tonsil (363377003)

Definition

Evidence of a malignant neoplasm of the lingual tonsil. [from NCI]

Professional guidelines

PubMed

Psychosocial Oncology: Optimizing Outcomes through Interdisciplinary Care in Head and Neck Oncology.
Henry M
Curr Oncol 2023 Jul 19;30(7):6859-6861. doi: 10.3390/curroncol30070501. PMID: 37504361Free PMC Article
Surgical Treatment for Advanced Oropharyngeal Cancer: A Narrative Review.
Maniaci A, Hao SP, Cancemi F, Giardini D, Checcoli E, Soprani F, Iannella G, Vicini C, Cocuzza S, La Mantia I, Fakhry N, De Vito A
Medicina (Kaunas) 2023 Feb 7;59(2) doi: 10.3390/medicina59020304. PMID: 36837506Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Recent clinical studies

Etiology

Human Papilloma Virus-Infected Cells.
Cruz-Gregorio A, Aranda-Rivera AK
Subcell Biochem 2023;106:213-226. doi: 10.1007/978-3-031-40086-5_8. PMID: 38159229
Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis.
Mehanna H, Taberna M, von Buchwald C, Tous S, Brooks J, Mena M, Morey F, Grønhøj C, Rasmussen JH, Garset-Zamani M, Bruni L, Batis N, Brakenhoff RH, Leemans CR, Baatenburg de Jong RJ, Klussmann JP, Wuerdemann N, Wagner S, Dalianis T, Marklund L, Mirghani H, Schache A, James JA, Huang SH, O'Sullivan B, Nankivell P, Broglie MA, Hoffmann M, Quabius ES, Alemany L; HNCIG-EPIC group
Lancet Oncol 2023 Mar;24(3):239-251. Epub 2023 Feb 13 doi: 10.1016/S1470-2045(23)00013-X. PMID: 36796393
Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments.
Solomon B, Young RJ, Rischin D
Semin Cancer Biol 2018 Oct;52(Pt 2):228-240. Epub 2018 Jan 31 doi: 10.1016/j.semcancer.2018.01.008. PMID: 29355614
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
HPV-associated head and neck cancer: a virus-related cancer epidemic.
Marur S, D'Souza G, Westra WH, Forastiere AA
Lancet Oncol 2010 Aug;11(8):781-9. Epub 2010 May 5 doi: 10.1016/S1470-2045(10)70017-6. PMID: 20451455Free PMC Article

Diagnosis

Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis.
Mehanna H, Taberna M, von Buchwald C, Tous S, Brooks J, Mena M, Morey F, Grønhøj C, Rasmussen JH, Garset-Zamani M, Bruni L, Batis N, Brakenhoff RH, Leemans CR, Baatenburg de Jong RJ, Klussmann JP, Wuerdemann N, Wagner S, Dalianis T, Marklund L, Mirghani H, Schache A, James JA, Huang SH, O'Sullivan B, Nankivell P, Broglie MA, Hoffmann M, Quabius ES, Alemany L; HNCIG-EPIC group
Lancet Oncol 2023 Mar;24(3):239-251. Epub 2023 Feb 13 doi: 10.1016/S1470-2045(23)00013-X. PMID: 36796393
Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review.
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article
History of tonsillectomy and risk of oropharyngeal cancer.
Combes JD, Voisin N, Périé S, Malard O, Jegoux F, Nadjingar R, Buiret G, Philouze P, Garrel R, Vergez S, Fakhry N, Righini C, Mirghani H, Lerat J, Saroul N, Verillaud B, Bartaire E, Céruse P, Clifford GM, Franceschi S, Lacau St Guily J
Oral Oncol 2021 Jun;117:105302. Epub 2021 Apr 24 doi: 10.1016/j.oraloncology.2021.105302. PMID: 33905915
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Therapy

Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis.
Mehanna H, Taberna M, von Buchwald C, Tous S, Brooks J, Mena M, Morey F, Grønhøj C, Rasmussen JH, Garset-Zamani M, Bruni L, Batis N, Brakenhoff RH, Leemans CR, Baatenburg de Jong RJ, Klussmann JP, Wuerdemann N, Wagner S, Dalianis T, Marklund L, Mirghani H, Schache A, James JA, Huang SH, O'Sullivan B, Nankivell P, Broglie MA, Hoffmann M, Quabius ES, Alemany L; HNCIG-EPIC group
Lancet Oncol 2023 Mar;24(3):239-251. Epub 2023 Feb 13 doi: 10.1016/S1470-2045(23)00013-X. PMID: 36796393
History of tonsillectomy and risk of oropharyngeal cancer.
Combes JD, Voisin N, Périé S, Malard O, Jegoux F, Nadjingar R, Buiret G, Philouze P, Garrel R, Vergez S, Fakhry N, Righini C, Mirghani H, Lerat J, Saroul N, Verillaud B, Bartaire E, Céruse P, Clifford GM, Franceschi S, Lacau St Guily J
Oral Oncol 2021 Jun;117:105302. Epub 2021 Apr 24 doi: 10.1016/j.oraloncology.2021.105302. PMID: 33905915
Human papillomavirus and gastrointestinal cancer: A review.
Bucchi D, Stracci F, Buonora N, Masanotti G
World J Gastroenterol 2016 Sep 7;22(33):7415-30. doi: 10.3748/wjg.v22.i33.7415. PMID: 27672265Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Prognosis

Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis.
Mehanna H, Taberna M, von Buchwald C, Tous S, Brooks J, Mena M, Morey F, Grønhøj C, Rasmussen JH, Garset-Zamani M, Bruni L, Batis N, Brakenhoff RH, Leemans CR, Baatenburg de Jong RJ, Klussmann JP, Wuerdemann N, Wagner S, Dalianis T, Marklund L, Mirghani H, Schache A, James JA, Huang SH, O'Sullivan B, Nankivell P, Broglie MA, Hoffmann M, Quabius ES, Alemany L; HNCIG-EPIC group
Lancet Oncol 2023 Mar;24(3):239-251. Epub 2023 Feb 13 doi: 10.1016/S1470-2045(23)00013-X. PMID: 36796393
Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review.
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article
Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments.
Solomon B, Young RJ, Rischin D
Semin Cancer Biol 2018 Oct;52(Pt 2):228-240. Epub 2018 Jan 31 doi: 10.1016/j.semcancer.2018.01.008. PMID: 29355614
Global burden of human papillomavirus and related diseases.
Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, Vignat J, Ferlay J, Bray F, Plummer M, Franceschi S
Vaccine 2012 Nov 20;30 Suppl 5:F12-23. doi: 10.1016/j.vaccine.2012.07.055. PMID: 23199955
HPV-associated head and neck cancer: a virus-related cancer epidemic.
Marur S, D'Souza G, Westra WH, Forastiere AA
Lancet Oncol 2010 Aug;11(8):781-9. Epub 2010 May 5 doi: 10.1016/S1470-2045(10)70017-6. PMID: 20451455Free PMC Article

Clinical prediction guides

Single-cell analysis reveals cellular and molecular factors counteracting HPV-positive oropharyngeal cancer immunotherapy outcomes.
Cha J, Kim DH, Kim G, Cho JW, Sung E, Baek S, Hong MH, Kim CG, Sim NS, Hong HJ, Lee JE, Hemberg M, Park S, Yoon SO, Ha SJ, Koh YW, Kim HR, Lee I
J Immunother Cancer 2024 Jun 10;12(6) doi: 10.1136/jitc-2023-008667. PMID: 38857913Free PMC Article
Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments.
Solomon B, Young RJ, Rischin D
Semin Cancer Biol 2018 Oct;52(Pt 2):228-240. Epub 2018 Jan 31 doi: 10.1016/j.semcancer.2018.01.008. PMID: 29355614
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
HPV-associated head and neck cancer: a virus-related cancer epidemic.
Marur S, D'Souza G, Westra WH, Forastiere AA
Lancet Oncol 2010 Aug;11(8):781-9. Epub 2010 May 5 doi: 10.1016/S1470-2045(10)70017-6. PMID: 20451455Free PMC Article

Recent systematic reviews

Association between tonsillectomy and risk of oropharyngeal cancer: a systematic review.
Bai C, He M, Li S, Liu J, Zhong L, Chen F, Zhou L, Jiang Y
Acta Otorhinolaryngol Ital 2024 Jun;44(3):143-149. Epub 2024 May 3 doi: 10.14639/0392-100X-N2790. PMID: 38712770Free PMC Article
Characteristics of human papillomavirus infection among oropharyngeal cancer patients: A systematic review and meta-analysis.
Cui M, Cheng J, Cheng H, Zhao M, Zhou D, Zhang M, Jia J, Luo L
Arch Oral Biol 2024 Jan;157:105830. Epub 2023 Oct 31 doi: 10.1016/j.archoralbio.2023.105830. PMID: 37924712
Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Prevalence and prognostic impact of retropharyngeal lymph nodes metastases in oropharyngeal squamous cell carcinoma: Meta-analysis of published literature.
Tirelli G, Gardenal N, Zanelli E, Borsetto D, Phillips V, Marcuzzo AV, Fussey J, Polesel J, Boscolo-Rizzo P
Head Neck 2022 Oct;44(10):2265-2276. Epub 2022 Aug 1 doi: 10.1002/hed.27166. PMID: 35913029Free PMC Article
Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review.
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article

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