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Disseminated candidiasis

MedGen UID:
102260
•Concept ID:
C0153252
•
Disease or Syndrome
Synonyms: Systemic candida infections; Systemic candidiasis
SNOMED CT: Disseminated candidiasis (70572005); Systemic candidiasis (70572005); Disseminated candidosis (70572005); Invasive candidiasis (70572005); Disseminated candida (70572005)
 
Monarch Initiative: MONDO:0042233

Definition

A fungal infection by any of the Candida species in two or more non-contiguous sterile body compartments. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisseminated candidiasis

Professional guidelines

PubMed

BET-HDAC Dual Inhibitors for Combinational Treatment of Breast Cancer and Concurrent Candidiasis.
Huang Y, Liu N, Pan Z, Li Z, Sheng C
J Med Chem 2023 Jan 26;66(2):1239-1253. Epub 2023 Jan 9 doi: 10.1021/acs.jmedchem.2c01191. PMID: 36622852
Single or 2-Dose Micafungin Regimen for Treatment of Invasive Candidiasis: Therapia Sterilisans Magna!
Gumbo T
Clin Infect Dis 2015 Dec 1;61 Suppl 6:S635-42. doi: 10.1093/cid/civ715. PMID: 26567282
Current treatment strategies for disseminated candidiasis.
Spellberg BJ, Filler SG, Edwards JE Jr
Clin Infect Dis 2006 Jan 15;42(2):244-51. Epub 2005 Dec 2 doi: 10.1086/499057. PMID: 16355336

Recent clinical studies

Etiology

Invasive candidiasis.
Lass-Flörl C, Kanj SS, Govender NP, Thompson GR 3rd, Ostrosky-Zeichner L, Govrins MA
Nat Rev Dis Primers 2024 Mar 21;10(1):20. doi: 10.1038/s41572-024-00503-3. PMID: 38514673
Chronic Disseminated Candidiasis in Children and the Role of Corticosteroids Therapy.
Al Yazidi LS, Elsidig N, Wali Y, Nazir H
Pediatr Infect Dis J 2023 May 1;42(5):e146-e151. Epub 2023 Feb 16 doi: 10.1097/INF.0000000000003859. PMID: 36795580
Candida urinary tract infections in adults.
Odabasi Z, Mert A
World J Urol 2020 Nov;38(11):2699-2707. Epub 2019 Oct 25 doi: 10.1007/s00345-019-02991-5. PMID: 31654220
Invasive fungal infections in the ICU: how to approach, how to treat.
Paramythiotou E, Frantzeskaki F, Flevari A, Armaganidis A, Dimopoulos G
Molecules 2014 Jan 17;19(1):1085-119. doi: 10.3390/molecules19011085. PMID: 24445340Free PMC Article
Epidemiology of opportunistic invasive mycoses.
Kullberg BJ, Oude Lashof AM
Eur J Med Res 2002 May 31;7(5):183-91. PMID: 12069910

Diagnosis

Invasive candidiasis.
Lass-Flörl C, Kanj SS, Govender NP, Thompson GR 3rd, Ostrosky-Zeichner L, Govrins MA
Nat Rev Dis Primers 2024 Mar 21;10(1):20. doi: 10.1038/s41572-024-00503-3. PMID: 38514673
Chronic Disseminated Candidiasis in Children and the Role of Corticosteroids Therapy.
Al Yazidi LS, Elsidig N, Wali Y, Nazir H
Pediatr Infect Dis J 2023 May 1;42(5):e146-e151. Epub 2023 Feb 16 doi: 10.1097/INF.0000000000003859. PMID: 36795580
Candida urinary tract infections in adults.
Odabasi Z, Mert A
World J Urol 2020 Nov;38(11):2699-2707. Epub 2019 Oct 25 doi: 10.1007/s00345-019-02991-5. PMID: 31654220
Use of T2MR in invasive candidiasis with and without candidemia.
Zacharioudakis IM, Zervou FN, Mylonakis E
Future Microbiol 2018 Aug;13:1165-1173. Epub 2018 May 24 doi: 10.2217/fmb-2018-0079. PMID: 29792512
Invasive fungal infections in the ICU: how to approach, how to treat.
Paramythiotou E, Frantzeskaki F, Flevari A, Armaganidis A, Dimopoulos G
Molecules 2014 Jan 17;19(1):1085-119. doi: 10.3390/molecules19011085. PMID: 24445340Free PMC Article

Therapy

Invasive candidiasis.
Lass-Flörl C, Kanj SS, Govender NP, Thompson GR 3rd, Ostrosky-Zeichner L, Govrins MA
Nat Rev Dis Primers 2024 Mar 21;10(1):20. doi: 10.1038/s41572-024-00503-3. PMID: 38514673
Chronic Disseminated Candidiasis in Children and the Role of Corticosteroids Therapy.
Al Yazidi LS, Elsidig N, Wali Y, Nazir H
Pediatr Infect Dis J 2023 May 1;42(5):e146-e151. Epub 2023 Feb 16 doi: 10.1097/INF.0000000000003859. PMID: 36795580
Candida urinary tract infections in adults.
Odabasi Z, Mert A
World J Urol 2020 Nov;38(11):2699-2707. Epub 2019 Oct 25 doi: 10.1007/s00345-019-02991-5. PMID: 31654220
Use of T2MR in invasive candidiasis with and without candidemia.
Zacharioudakis IM, Zervou FN, Mylonakis E
Future Microbiol 2018 Aug;13:1165-1173. Epub 2018 May 24 doi: 10.2217/fmb-2018-0079. PMID: 29792512
Invasive fungal infections in the ICU: how to approach, how to treat.
Paramythiotou E, Frantzeskaki F, Flevari A, Armaganidis A, Dimopoulos G
Molecules 2014 Jan 17;19(1):1085-119. doi: 10.3390/molecules19011085. PMID: 24445340Free PMC Article

Prognosis

The pathology of canine mammary candidiasis with embolic dissemination in a dog.
Headley SA, Gomes ALPL, Martinelli TM, Fritzen JTT, Teixeira Vanzela AL, Silva FHP, Gaspar T, Giordano LGP, Alfieri AA, Gomes LA
Microb Pathog 2023 Dec;185:106424. Epub 2023 Oct 31 doi: 10.1016/j.micpath.2023.106424. PMID: 37913829
Epidemiology, Clinical Characteristics and Risk Factors for Severity of Chronic Disseminated Candidiasis in Jerusalem, Israel.
Cohen N, Orenbuch-Harroch E, Olshtain-Pops K, Lachish T, Korem M
Mycopathologia 2023 Dec;188(6):873-883. Epub 2023 Jun 16 doi: 10.1007/s11046-023-00755-9. PMID: 37326819
Invasive candidiasis in pediatric intensive care units.
Singhi S, Deep A
Indian J Pediatr 2009 Oct;76(10):1033-44. Epub 2009 Nov 12 doi: 10.1007/s12098-009-0219-6. PMID: 19907936
Chronic disseminated candidiasis in patients with acute leukemia: emphasis on diagnostic definition and treatment.
Masood A, Sallah S
Leuk Res 2005 May;29(5):493-501. Epub 2004 Dec 30 doi: 10.1016/j.leukres.2004.10.003. PMID: 15755501
Hepatosplenic candidiasis. A manifestation of chronic disseminated candidiasis.
Kontoyiannis DP, Luna MA, Samuels BI, Bodey GP
Infect Dis Clin North Am 2000 Sep;14(3):721-39. doi: 10.1016/s0891-5520(05)70128-8. PMID: 10987117

Clinical prediction guides

The pathology of canine mammary candidiasis with embolic dissemination in a dog.
Headley SA, Gomes ALPL, Martinelli TM, Fritzen JTT, Teixeira Vanzela AL, Silva FHP, Gaspar T, Giordano LGP, Alfieri AA, Gomes LA
Microb Pathog 2023 Dec;185:106424. Epub 2023 Oct 31 doi: 10.1016/j.micpath.2023.106424. PMID: 37913829
Epidemiology, Clinical Characteristics and Risk Factors for Severity of Chronic Disseminated Candidiasis in Jerusalem, Israel.
Cohen N, Orenbuch-Harroch E, Olshtain-Pops K, Lachish T, Korem M
Mycopathologia 2023 Dec;188(6):873-883. Epub 2023 Jun 16 doi: 10.1007/s11046-023-00755-9. PMID: 37326819
Nicotinamide potentiates amphotericin B activity against Candida albicans.
Yan Y, Liao Z, Shen J, Zhu Z, Cao Y
Virulence 2022 Dec;13(1):1533-1542. doi: 10.1080/21505594.2022.2119656. PMID: 36068709Free PMC Article
Comparisons of the clinical and mycological characteristics of pediatric candidemia.
Chen WC, Chen PY, Yang SC, Yen TY, Lu CY, Chen JM, Lee PI, Chang LY, Chen YC, Huang LM
J Formos Med Assoc 2022 Sep;121(9):1668-1679. Epub 2021 Dec 4 doi: 10.1016/j.jfma.2021.11.009. PMID: 34876342
Anidulafungin: an echinocandin antifungal.
Pfaller MA
Expert Opin Investig Drugs 2004 Sep;13(9):1183-97. doi: 10.1517/13543784.13.9.1183. PMID: 15330749

Recent systematic reviews

Acute disseminated candidiasis with skin lesions: a systematic review.
Guarana M, Nucci M
Clin Microbiol Infect 2018 Mar;24(3):246-250. Epub 2017 Aug 25 doi: 10.1016/j.cmi.2017.08.016. PMID: 28847765

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