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Cholinergic urticaria

MedGen UID:
508939
•Concept ID:
C0152230
•
Disease or Syndrome
Synonym: cholinergic urticaria
SNOMED CT: Cholinergic urticaria (73098005)
 
Monarch Initiative: MONDO:0006534

Definition

A type of physical urticarias (or hives) that appears when a person is sweating. [from MONDO]

Professional guidelines

PubMed

Clinical Management of Exercise-Induced Anaphylaxis and Cholinergic Urticaria.
Geller M
J Allergy Clin Immunol Pract 2020 Jul-Aug;8(7):2209-2214. doi: 10.1016/j.jaip.2020.01.025. PMID: 32620433
Cholinergic urticaria: epidemiology, physiopathology, new categorization, and management.
Fukunaga A, Washio K, Hatakeyama M, Oda Y, Ogura K, Horikawa T, Nishigori C
Clin Auton Res 2018 Feb;28(1):103-113. Epub 2017 Apr 5 doi: 10.1007/s10286-017-0418-6. PMID: 28382552
Omalizumab in the Treatment of Chronic Inducible Urticaria.
Chicharro P, Rodríguez P, de Argila D
Actas Dermosifiliogr 2017 Jun;108(5):423-431. Epub 2016 Oct 5 doi: 10.1016/j.ad.2016.07.018. PMID: 27717421

Recent clinical studies

Etiology

Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020.
Maurer M, Eyerich K, Eyerich S, Ferrer M, Gutermuth J, Hartmann K, Jakob T, Kapp A, Kolkhir P, Larenas-Linnemann D, Park HS, Pejler G, Sánchez-Borges M, Schäkel K, Simon D, Simon HU, Weller K, Zuberbier T, Metz M
Int Arch Allergy Immunol 2020;181(5):321-333. Epub 2020 Mar 30 doi: 10.1159/000507218. PMID: 32224621Free PMC Article
How to Approach Chronic Inducible Urticaria.
Maurer M, Fluhr JW, Khan DA
J Allergy Clin Immunol Pract 2018 Jul-Aug;6(4):1119-1130. doi: 10.1016/j.jaip.2018.03.007. PMID: 30033913
Sweat Allergy.
Hiragun T, Hide M
Curr Probl Dermatol 2016;51:101-8. Epub 2016 Aug 30 doi: 10.1159/000446788. PMID: 27584969
Exercise-induced anaphylaxis.
Feldweg AM
Immunol Allergy Clin North Am 2015 May;35(2):261-75. Epub 2015 Feb 28 doi: 10.1016/j.iac.2015.01.005. PMID: 25841550
Unusual urticarias.
Black AK
J Dermatol 2001 Nov;28(11):632-4. doi: 10.1111/j.1346-8138.2001.tb00050.x. PMID: 11770721

Diagnosis

Cholinergic Urticaria: Subtype Classification and Clinical Approach.
Fukunaga A, Oda Y, Imamura S, Mizuno M, Fukumoto T, Washio K
Am J Clin Dermatol 2023 Jan;24(1):41-54. Epub 2022 Sep 15 doi: 10.1007/s40257-022-00728-6. PMID: 36107396Free PMC Article
Chronic inducible urticaria: classification and prominent features of physical and non-physical types.
Pozderac I, Lugović-Mihić L, Artuković M, Stipić-Marković A, Kuna M, Ferček I
Acta Dermatovenerol Alp Pannonica Adriat 2020 Sep;29(3):141-148. PMID: 32975301
Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020.
Maurer M, Eyerich K, Eyerich S, Ferrer M, Gutermuth J, Hartmann K, Jakob T, Kapp A, Kolkhir P, Larenas-Linnemann D, Park HS, Pejler G, Sánchez-Borges M, Schäkel K, Simon D, Simon HU, Weller K, Zuberbier T, Metz M
Int Arch Allergy Immunol 2020;181(5):321-333. Epub 2020 Mar 30 doi: 10.1159/000507218. PMID: 32224621Free PMC Article
How to Approach Chronic Inducible Urticaria.
Maurer M, Fluhr JW, Khan DA
J Allergy Clin Immunol Pract 2018 Jul-Aug;6(4):1119-1130. doi: 10.1016/j.jaip.2018.03.007. PMID: 30033913
Exercise-induced anaphylaxis.
Feldweg AM
Immunol Allergy Clin North Am 2015 May;35(2):261-75. Epub 2015 Feb 28 doi: 10.1016/j.iac.2015.01.005. PMID: 25841550

Therapy

An open-label, proof-of-concept study of lirentelimab for antihistamine-resistant chronic spontaneous and inducible urticaria.
Altrichter S, Staubach P, Pasha M, Singh B, Chang AT, Bernstein JA, Rasmussen HS, Siebenhaar F, Maurer M
J Allergy Clin Immunol 2022 May;149(5):1683-1690.e7. Epub 2021 Dec 23 doi: 10.1016/j.jaci.2021.12.772. PMID: 34954198
Exercise-induced anaphylaxis.
Feldweg AM
Immunol Allergy Clin North Am 2015 May;35(2):261-75. Epub 2015 Feb 28 doi: 10.1016/j.iac.2015.01.005. PMID: 25841550
Physical urticaria.
Dice JP
Immunol Allergy Clin North Am 2004 May;24(2):225-46, vi. doi: 10.1016/j.iac.2004.01.005. PMID: 15120149
Unusual urticarias.
Black AK
J Dermatol 2001 Nov;28(11):632-4. doi: 10.1111/j.1346-8138.2001.tb00050.x. PMID: 11770721
Chronic urticaria.
Burrall BA, Halpern GM, Huntley AC
West J Med 1990 Mar;152(3):268-76. PMID: 1970697Free PMC Article

Prognosis

Chronic inducible urticaria subtypes in children: Clinical features and prognosis.
Bal F, Kahveci M, Soyer O, Sekerel BE, Sahiner UM
Pediatr Allergy Immunol 2021 Jan;32(1):146-152. Epub 2020 Aug 24 doi: 10.1111/pai.13324. PMID: 32741017
Cholinergic Urticaria: Clinical Presentation and Natural History in a Tropical Country.
Rujitharanawong C, Tuchinda P, Chularojanamontri L, Chanchaemsri N, Kulthanan K
Biomed Res Int 2020;2020:7301652. Epub 2020 May 24 doi: 10.1155/2020/7301652. PMID: 32596363Free PMC Article
Exercise-induced anaphylaxis.
Feldweg AM
Immunol Allergy Clin North Am 2015 May;35(2):261-75. Epub 2015 Feb 28 doi: 10.1016/j.iac.2015.01.005. PMID: 25841550
Cholinergic urticaria and exercise-induced anaphylaxis.
Montgomery SL
Curr Sports Med Rep 2015 Jan;14(1):61-3. doi: 10.1249/JSR.0000000000000111. PMID: 25574887
Unusual urticarias.
Black AK
J Dermatol 2001 Nov;28(11):632-4. doi: 10.1111/j.1346-8138.2001.tb00050.x. PMID: 11770721

Clinical prediction guides

An open-label, proof-of-concept study of lirentelimab for antihistamine-resistant chronic spontaneous and inducible urticaria.
Altrichter S, Staubach P, Pasha M, Singh B, Chang AT, Bernstein JA, Rasmussen HS, Siebenhaar F, Maurer M
J Allergy Clin Immunol 2022 May;149(5):1683-1690.e7. Epub 2021 Dec 23 doi: 10.1016/j.jaci.2021.12.772. PMID: 34954198
Chronic inducible urticaria subtypes in children: Clinical features and prognosis.
Bal F, Kahveci M, Soyer O, Sekerel BE, Sahiner UM
Pediatr Allergy Immunol 2021 Jan;32(1):146-152. Epub 2020 Aug 24 doi: 10.1111/pai.13324. PMID: 32741017
Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020.
Maurer M, Eyerich K, Eyerich S, Ferrer M, Gutermuth J, Hartmann K, Jakob T, Kapp A, Kolkhir P, Larenas-Linnemann D, Park HS, Pejler G, Sánchez-Borges M, Schäkel K, Simon D, Simon HU, Weller K, Zuberbier T, Metz M
Int Arch Allergy Immunol 2020;181(5):321-333. Epub 2020 Mar 30 doi: 10.1159/000507218. PMID: 32224621Free PMC Article
Sweat allergy.
Takahagi S, Tanaka A, Hide M
Allergol Int 2018 Oct;67(4):435-441. Epub 2018 Jul 31 doi: 10.1016/j.alit.2018.07.002. PMID: 30075993
Cholinergic Urticaria with Anaphylaxis: An Underrecognized Clinical Entity.
Vadas P, Sinilaite A, Chaim M
J Allergy Clin Immunol Pract 2016 Mar-Apr;4(2):284-91. Epub 2015 Nov 24 doi: 10.1016/j.jaip.2015.09.021. PMID: 26619922

Recent systematic reviews

Evidence for histamine release in chronic inducible urticaria - A systematic review.
Kulthanan K, Church MK, Grekowitz EM, Hawro T, Kiefer LA, Munprom K, Nanchaipruek Y, Rujitharanawong C, Terhorst-Molawi D, Maurer M
Front Immunol 2022;13:901851. Epub 2022 Jul 28 doi: 10.3389/fimmu.2022.901851. PMID: 35967442Free PMC Article
Dupilumab use in dermatologic conditions beyond atopic dermatitis - a systematic review.
Hendricks AJ, Yosipovitch G, Shi VY
J Dermatolog Treat 2021 Feb;32(1):19-28. Epub 2019 Nov 12 doi: 10.1080/09546634.2019.1689227. PMID: 31693426
Omalizumab for cholinergic urticaria: 6 months prospective study and systematic review of the literature.
Ghazanfar MN, Holm JG, Thomsen SF
Dermatol Ther 2020 Nov;33(6):e14010. Epub 2020 Aug 11 doi: 10.1111/dth.14010. PMID: 32654349
Chronic inducible urticaria: A systematic review of treatment options.
Dressler C, Werner RN, Eisert L, Zuberbier T, Nast A, Maurer M
J Allergy Clin Immunol 2018 May;141(5):1726-1734. Epub 2018 Feb 10 doi: 10.1016/j.jaci.2018.01.031. PMID: 29438771
Diagnostic utility of challenge procedures for physical urticaria/angioedema syndromes: a systematic review.
Cuervo-Pardo L, Gonzalez-Estrada A, Lang DM
Curr Opin Allergy Clin Immunol 2016 Oct;16(5):511-5. doi: 10.1097/ACI.0000000000000298. PMID: 27585061

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