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Hypermobility syndrome

MedGen UID:
508885
•Concept ID:
C0152093
•
Disease or Syndrome
Synonyms: benign joint hypermobility; Familial ligamentous laxity; hypermobility syndrome
SNOMED CT: Familial ligamentous laxity (85551004); Hypermobility syndrome (85551004)
 
Monarch Initiative: MONDO:0001798

Professional guidelines

PubMed

Practical management strategies for benign hypermobility syndromes.
Minhas D
Curr Opin Rheumatol 2021 May 1;33(3):249-254. doi: 10.1097/BOR.0000000000000798. PMID: 33741806
The evidence-based rationale for physical therapy treatment of children, adolescents, and adults diagnosed with joint hypermobility syndrome/hypermobile Ehlers Danlos syndrome.
Engelbert RH, Juul-Kristensen B, Pacey V, de Wandele I, Smeenk S, Woinarosky N, Sabo S, Scheper MC, Russek L, Simmonds JV
Am J Med Genet C Semin Med Genet 2017 Mar;175(1):158-167. doi: 10.1002/ajmg.c.31545. PMID: 28306230
Differential diagnosis and diagnostic flow chart of joint hypermobility syndrome/ehlers-danlos syndrome hypermobility type compared to other heritable connective tissue disorders.
Colombi M, Dordoni C, Chiarelli N, Ritelli M
Am J Med Genet C Semin Med Genet 2015 Mar;169C(1):6-22. doi: 10.1002/ajmg.c.31429. PMID: 25821090

Recent clinical studies

Etiology

Joint Hypermobility Syndrome and Membrane Proteins: A Comprehensive Review.
Pliego-Arreaga R, Cervantes-Montelongo JA, Silva-Martínez GA, Tristán-Flores FE, Pantoja-Hernández MA, Maldonado-Coronado JR
Biomolecules 2024 Apr 12;14(4) doi: 10.3390/biom14040472. PMID: 38672488Free PMC Article
Hypermobility, the Ehlers-Danlos syndromes and chronic pain.
Syx D, De Wandele I, Rombaut L, Malfait F
Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 107(5):116-122. Epub 2017 Sep 28 PMID: 28967365
The evidence-based rationale for physical therapy treatment of children, adolescents, and adults diagnosed with joint hypermobility syndrome/hypermobile Ehlers Danlos syndrome.
Engelbert RH, Juul-Kristensen B, Pacey V, de Wandele I, Smeenk S, Woinarosky N, Sabo S, Scheper MC, Russek L, Simmonds JV
Am J Med Genet C Semin Med Genet 2017 Mar;175(1):158-167. doi: 10.1002/ajmg.c.31545. PMID: 28306230
A framework for the classification of joint hypermobility and related conditions.
Castori M, Tinkle B, Levy H, Grahame R, Malfait F, Hakim A
Am J Med Genet C Semin Med Genet 2017 Mar;175(1):148-157. Epub 2017 Feb 1 doi: 10.1002/ajmg.c.31539. PMID: 28145606
Generalized joint hypermobility, joint hypermobility syndrome and Ehlers-Danlos syndrome, hypermobility type.
Castori M, Colombi M
Am J Med Genet C Semin Med Genet 2015 Mar;169C(1):1-5. doi: 10.1002/ajmg.c.31432. PMID: 25821089

Diagnosis

The Beighton Score as a measure of generalised joint hypermobility.
Malek S, Reinhold EJ, Pearce GS
Rheumatol Int 2021 Oct;41(10):1707-1716. Epub 2021 Mar 18 doi: 10.1007/s00296-021-04832-4. PMID: 33738549Free PMC Article
Hypermobility, the Ehlers-Danlos syndromes and chronic pain.
Syx D, De Wandele I, Rombaut L, Malfait F
Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 107(5):116-122. Epub 2017 Sep 28 PMID: 28967365
The evidence-based rationale for physical therapy treatment of children, adolescents, and adults diagnosed with joint hypermobility syndrome/hypermobile Ehlers Danlos syndrome.
Engelbert RH, Juul-Kristensen B, Pacey V, de Wandele I, Smeenk S, Woinarosky N, Sabo S, Scheper MC, Russek L, Simmonds JV
Am J Med Genet C Semin Med Genet 2017 Mar;175(1):158-167. doi: 10.1002/ajmg.c.31545. PMID: 28306230
Hypermobile Ehlers-Danlos syndrome (a.k.a. Ehlers-Danlos syndrome Type III and Ehlers-Danlos syndrome hypermobility type): Clinical description and natural history.
Tinkle B, Castori M, Berglund B, Cohen H, Grahame R, Kazkaz H, Levy H
Am J Med Genet C Semin Med Genet 2017 Mar;175(1):48-69. Epub 2017 Feb 1 doi: 10.1002/ajmg.c.31538. PMID: 28145611
Differential diagnosis and diagnostic flow chart of joint hypermobility syndrome/ehlers-danlos syndrome hypermobility type compared to other heritable connective tissue disorders.
Colombi M, Dordoni C, Chiarelli N, Ritelli M
Am J Med Genet C Semin Med Genet 2015 Mar;169C(1):6-22. doi: 10.1002/ajmg.c.31429. PMID: 25821090

Therapy

Hypermobility of joints in dancers.
Skwiot M, Śliwiński G, Milanese S, Śliwiński Z
PLoS One 2019;14(2):e0212188. Epub 2019 Feb 22 doi: 10.1371/journal.pone.0212188. PMID: 30794600Free PMC Article
Pediatric Pain Syndromes and Noninflammatory Musculoskeletal Pain.
Weiss JE, Stinson JN
Pediatr Clin North Am 2018 Aug;65(4):801-826. doi: 10.1016/j.pcl.2018.04.004. PMID: 30031499
The evidence-based rationale for physical therapy treatment of children, adolescents, and adults diagnosed with joint hypermobility syndrome/hypermobile Ehlers Danlos syndrome.
Engelbert RH, Juul-Kristensen B, Pacey V, de Wandele I, Smeenk S, Woinarosky N, Sabo S, Scheper MC, Russek L, Simmonds JV
Am J Med Genet C Semin Med Genet 2017 Mar;175(1):158-167. doi: 10.1002/ajmg.c.31545. PMID: 28306230
Disability in Adolescents and Adults Diagnosed With Hypermobility-Related Disorders: A Meta-Analysis.
Scheper MC, Juul-Kristensen B, Rombaut L, Rameckers EA, Verbunt J, Engelbert RH
Arch Phys Med Rehabil 2016 Dec;97(12):2174-2187. Epub 2016 Mar 11 doi: 10.1016/j.apmr.2016.02.015. PMID: 26976801
Physiotherapy and occupational therapy interventions for people with benign joint hypermobility syndrome: a systematic review of clinical trials.
Smith TO, Bacon H, Jerman E, Easton V, Armon K, Poland F, Macgregor AJ
Disabil Rehabil 2014;36(10):797-803. Epub 2013 Jul 26 doi: 10.3109/09638288.2013.819388. PMID: 23889528

Prognosis

Iron deficiency and fatigue among adolescents with bleeding disorders.
Zia A, Stanek J, Christian-Rancy M, Savelli S, O'Brien SH
Am J Hematol 2022 Jan 1;97(1):60-67. Epub 2021 Nov 8 doi: 10.1002/ajh.26389. PMID: 34710246
Recognizing and Effectively Managing Hypermobility-Related Conditions.
Russek LN, Stott P, Simmonds J
Phys Ther 2019 Sep 1;99(9):1189-1200. doi: 10.1093/ptj/pzz078. PMID: 31158283
Joint Hypermobility Syndrome: Recognizing a Commonly Overlooked Cause of Chronic Pain.
Kumar B, Lenert P
Am J Med 2017 Jun;130(6):640-647. Epub 2017 Mar 10 doi: 10.1016/j.amjmed.2017.02.013. PMID: 28286166
Joint hypermobility and the heritable disorders of connective tissue: clinical and empirical evidence of links with psychiatry.
Baeza-Velasco C, Pailhez G, Bulbena A, Baghdadli A
Gen Hosp Psychiatry 2015 Jan-Feb;37(1):24-30. Epub 2014 Oct 16 doi: 10.1016/j.genhosppsych.2014.10.002. PMID: 25459977
Benign joint hypermobility syndrome: evaluation, diagnosis, and management.
Simpson MR
J Am Osteopath Assoc 2006 Sep;106(9):531-6. PMID: 17079522

Clinical prediction guides

Nutritional Implications of Patients with Dysautonomia and Hypermobility Syndromes.
Do T, Diamond S, Green C, Warren M
Curr Nutr Rep 2021 Dec;10(4):324-333. Epub 2021 Sep 12 doi: 10.1007/s13668-021-00373-1. PMID: 34510391Free PMC Article
The Beighton Score as a measure of generalised joint hypermobility.
Malek S, Reinhold EJ, Pearce GS
Rheumatol Int 2021 Oct;41(10):1707-1716. Epub 2021 Mar 18 doi: 10.1007/s00296-021-04832-4. PMID: 33738549Free PMC Article
Hypermobility of joints in dancers.
Skwiot M, Śliwiński G, Milanese S, Śliwiński Z
PLoS One 2019;14(2):e0212188. Epub 2019 Feb 22 doi: 10.1371/journal.pone.0212188. PMID: 30794600Free PMC Article
Gastrointestinal disorders in joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type: A review for the gastroenterologist.
Beckers AB, Keszthelyi D, Fikree A, Vork L, Masclee A, Farmer AD, Aziz Q
Neurogastroenterol Motil 2017 Aug;29(8) Epub 2017 Jan 13 doi: 10.1111/nmo.13013. PMID: 28086259
Pregnancy outcome in joint hypermobility syndrome and Ehlers-Danlos syndrome.
Sundelin HE, Stephansson O, Johansson K, Ludvigsson JF
Acta Obstet Gynecol Scand 2017 Jan;96(1):114-119. Epub 2016 Nov 22 doi: 10.1111/aogs.13043. PMID: 27743500

Recent systematic reviews

Physical therapy interventions in generalized hypermobility spectrum disorder and hypermobile Ehlers-Danlos syndrome: a scoping review.
Garreth Brittain M, Flanagan S, Foreman L, Teran-Wodzinski P
Disabil Rehabil 2024 May;46(10):1936-1953. Epub 2023 May 25 doi: 10.1080/09638288.2023.2216028. PMID: 37231592
Prevalence of Obstructive Sleep Apnea in Joint Hypermobility Syndrome: A Systematic Review and Meta-Analysis.
Sedky K, Gaisl T, Bennett DS
J Clin Sleep Med 2019 Feb 15;15(2):293-299. doi: 10.5664/jcsm.7636. PMID: 30736885Free PMC Article
Kinematics and kinetics of people who are hypermobile. A systematic review.
Bates AV, Alexander CM
Gait Posture 2015 Feb;41(2):361-9. Epub 2015 Jan 20 doi: 10.1016/j.gaitpost.2015.01.009. PMID: 25684143
The effectiveness of therapeutic exercise for joint hypermobility syndrome: a systematic review.
Palmer S, Bailey S, Barker L, Barney L, Elliott A
Physiotherapy 2014 Sep;100(3):220-7. Epub 2013 Oct 5 doi: 10.1016/j.physio.2013.09.002. PMID: 24238699
The relationship between benign joint hypermobility syndrome and psychological distress: a systematic review and meta-analysis.
Smith TO, Easton V, Bacon H, Jerman E, Armon K, Poland F, Macgregor AJ
Rheumatology (Oxford) 2014 Jan;53(1):114-22. Epub 2013 Sep 29 doi: 10.1093/rheumatology/ket317. PMID: 24080253

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