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Osteochondropathy

MedGen UID:
508883
•Concept ID:
C0152091
•
Disease or Syndrome
Synonym: Disease of bone AND cartilage
SNOMED CT: Osteochondropathy (77881008); Disease of bone AND cartilage (77881008)

Recent clinical studies

Etiology

WISP1 Is Involved in the Pathogenesis of Kashin-Beck Disease via the Autophagy Pathway.
Li P, Cheng B, Yao Y, Yu W, Liu L, Cheng S, Zhang L, Ma M, Qi X, Liang C, Chu X, Ye J, Sun S, Jia Y, Guo X, Wen Y, Zhang F
Int J Mol Sci 2023 Nov 7;24(22) doi: 10.3390/ijms242216037. PMID: 38003226Free PMC Article
Relationship of peroxidation indicators and hemograms in children with hip joint pathology.
Teplen'kiy MP, Matveeva EL, Spirkina ES, Gasanova AG
Klin Lab Diagn 2021 Mar 13;66(2):104-109. doi: 10.51620/0869-2084-2021-66-2-104-109. PMID: 33734644
Individual and combined toxicity of T-2 toxin and deoxynivalenol on human C-28/I2 and rat primary chondrocytes.
Lin X, Shao W, Yu F, Xing K, Liu H, Zhang F, Goldring MB, Lammi MJ, Guo X
J Appl Toxicol 2019 Feb;39(2):343-353. Epub 2018 Sep 25 doi: 10.1002/jat.3725. PMID: 30251759
Serum levels of PIICP, PIIANP, and PIIBNP are decreased in patients with an endemic osteochondropathy, Kashin-Beck disease.
Lian W, Liu H, Sun LY, Liu YQ, Cui SL, Wang Y, Song QQ, Deng Q, Wang SP, Cao YH, Zhang XY, Jiang YY, Lv HY, Duan LB, Yu J
J Orthop Surg Res 2018 May 29;13(1):128. doi: 10.1186/s13018-018-0840-z. PMID: 29843748Free PMC Article
Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease.
Guo X, Ma WJ, Zhang F, Ren FL, Qu CJ, Lammi MJ
Osteoarthritis Cartilage 2014 Nov;22(11):1774-83. Epub 2014 Aug 12 doi: 10.1016/j.joca.2014.07.023. PMID: 25106677

Diagnosis

Relationship of peroxidation indicators and hemograms in children with hip joint pathology.
Teplen'kiy MP, Matveeva EL, Spirkina ES, Gasanova AG
Klin Lab Diagn 2021 Mar 13;66(2):104-109. doi: 10.51620/0869-2084-2021-66-2-104-109. PMID: 33734644
Individual and combined toxicity of T-2 toxin and deoxynivalenol on human C-28/I2 and rat primary chondrocytes.
Lin X, Shao W, Yu F, Xing K, Liu H, Zhang F, Goldring MB, Lammi MJ, Guo X
J Appl Toxicol 2019 Feb;39(2):343-353. Epub 2018 Sep 25 doi: 10.1002/jat.3725. PMID: 30251759
Serum levels of PIICP, PIIANP, and PIIBNP are decreased in patients with an endemic osteochondropathy, Kashin-Beck disease.
Lian W, Liu H, Sun LY, Liu YQ, Cui SL, Wang Y, Song QQ, Deng Q, Wang SP, Cao YH, Zhang XY, Jiang YY, Lv HY, Duan LB, Yu J
J Orthop Surg Res 2018 May 29;13(1):128. doi: 10.1186/s13018-018-0840-z. PMID: 29843748Free PMC Article
Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease.
Guo X, Ma WJ, Zhang F, Ren FL, Qu CJ, Lammi MJ
Osteoarthritis Cartilage 2014 Nov;22(11):1774-83. Epub 2014 Aug 12 doi: 10.1016/j.joca.2014.07.023. PMID: 25106677
Pattern of joints involvement in Kashin-Beck disease: a local osteochondropathy in China.
Farooq U, Xiong G, Irshad R, Yaqoob S
J Ayub Med Coll Abbottabad 2010 Jan-Mar;22(1):97-100. PMID: 21409915

Therapy

Individual and combined toxicity of T-2 toxin and deoxynivalenol on human C-28/I2 and rat primary chondrocytes.
Lin X, Shao W, Yu F, Xing K, Liu H, Zhang F, Goldring MB, Lammi MJ, Guo X
J Appl Toxicol 2019 Feb;39(2):343-353. Epub 2018 Sep 25 doi: 10.1002/jat.3725. PMID: 30251759
Chondrocytes damage induced by T-2 toxin via Wnt/β-catenin signaling pathway is involved in the pathogenesis of an endemic osteochondropathy, Kashin-Beck disease.
Wang X, Ning Y, Zhang P, Yang L, Wang Y, Guo X
Exp Cell Res 2017 Dec 1;361(1):141-148. Epub 2017 Oct 16 doi: 10.1016/j.yexcr.2017.10.012. PMID: 29042209
Genome-wide gene expression analysis suggests an important role of hypoxia in the pathogenesis of endemic osteochondropathy Kashin-Beck disease.
Zhang F, Guo X, Wang W, Yan H, Li C
PLoS One 2011;6(7):e22983. Epub 2011 Jul 29 doi: 10.1371/journal.pone.0022983. PMID: 21829570Free PMC Article

Prognosis

Long noncoding RNA expression profile reveals lncRNAs signature associated with extracellular matrix degradation in kashin-beck disease.
Wu C, Liu H, Zhang F, Shao W, Yang L, Ning Y, Wang S, Zhao G, Lee BJ, Lammi M, Guo X
Sci Rep 2017 Dec 14;7(1):17553. doi: 10.1038/s41598-017-17875-0. PMID: 29242531Free PMC Article
Comparison of microRNA expression profiles of Kashin-Beck disease, osteoarthritis and rheumatoid arthritis.
Wu W, He A, Wen Y, Xiao X, Hao J, Zhang F, Guo X
Sci Rep 2017 Apr 3;7(1):540. doi: 10.1038/s41598-017-00522-z. PMID: 28373711Free PMC Article
Investigation of MMP-1 genetic polymorphisms and protein expression and their effects on the risk of Kashin-Beck disease in the northwest Chinese Han population.
Shi X, Lv A, Ma J, Zhang F, Wen Y, Zhang Z, Guo X
J Orthop Surg Res 2016 May 31;11(1):64. doi: 10.1186/s13018-016-0398-6. PMID: 27245218Free PMC Article
Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease.
Guo X, Ma WJ, Zhang F, Ren FL, Qu CJ, Lammi MJ
Osteoarthritis Cartilage 2014 Nov;22(11):1774-83. Epub 2014 Aug 12 doi: 10.1016/j.joca.2014.07.023. PMID: 25106677
Epidemiology of hospitalised osteochondritis dissecans in young people: incidence, geographical variation and trends over time in England from 2002 to 2010.
Keenan OJ, Turner PG, Yeates D, Goldacre MJ
Knee 2014 Mar;21(2):497-500. Epub 2013 Nov 26 doi: 10.1016/j.knee.2013.11.010. PMID: 24369808

Clinical prediction guides

WISP1 Is Involved in the Pathogenesis of Kashin-Beck Disease via the Autophagy Pathway.
Li P, Cheng B, Yao Y, Yu W, Liu L, Cheng S, Zhang L, Ma M, Qi X, Liang C, Chu X, Ye J, Sun S, Jia Y, Guo X, Wen Y, Zhang F
Int J Mol Sci 2023 Nov 7;24(22) doi: 10.3390/ijms242216037. PMID: 38003226Free PMC Article
CLINICAL FEATURES OF CONNECTIVE TISSUE DYSPLASIA, OSGOOD-SCHLATTER DISEASE AND MULTIPLE CORTICAL DISORDERS IN A CHILD.
Protsailo MD, Fedortsiv OY, Dzhyvak VG, Krycky IO, Hoshchynskyi PV, Horishnyi IM, Chornomydz IB, Rohalska YV, Synytska VO, Prodan AM, Nikitina IM
Wiad Lek 2023;76(8):1854-1860. doi: 10.36740/WLek202308120. PMID: 37740981
Long noncoding RNA expression profile reveals lncRNAs signature associated with extracellular matrix degradation in kashin-beck disease.
Wu C, Liu H, Zhang F, Shao W, Yang L, Ning Y, Wang S, Zhao G, Lee BJ, Lammi M, Guo X
Sci Rep 2017 Dec 14;7(1):17553. doi: 10.1038/s41598-017-17875-0. PMID: 29242531Free PMC Article
The expression of ERK and JNK in patients with an endemic osteochondropathy, Kashin-Beck disease.
Dai X, Song R, Xiong Y
Exp Cell Res 2017 Oct 15;359(2):337-341. Epub 2017 Aug 12 doi: 10.1016/j.yexcr.2017.08.015. PMID: 28807789
Heritability estimates and linkage analysis of 23 short tandem repeat loci on chromosomes 2, 11, and 12 in an endemic osteochondropathy in China.
Shi XW, Guo X, Lv AL, Kang L, Zhou YL, Zhang YZ, Wu XM, Bai YD
Scand J Rheumatol 2010 May;39(3):259-65. doi: 10.3109/03009740903270599. PMID: 20166850

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