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Alveolar echinococcosis

MedGen UID:
508867
•Concept ID:
C0152069
•
Disease or Syndrome
Synonyms: Alveolar hydatid disease; Alveolococcosis; Echinococcus Multilocularis Infection; Multilocular echinococcosis
SNOMED CT: Echinococcus multilocularis infection (21009004); Alveolar hydatid disease (21009004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0017282
Orphanet: ORPHA284

Definition

A rare parasitic disorder that occurs after ingestion of eggs of <i>Echinococcus multilocularis</i> and characterized by an initial asymptomatic incubation period of many years followed by a chronic course where the clinical manifestations include epigastric pain and jaundice. [from ORDO]

Professional guidelines

PubMed

Multimodality imaging in diagnosis and management of alveolar echinococcosis: an update.
Bulakçı M, Kartal MG, Yılmaz S, Yılmaz E, Yılmaz R, Şahin D, Aşık M, Erol OB
Diagn Interv Radiol 2016 May-Jun;22(3):247-56. doi: 10.5152/dir.2015.15456. PMID: 27082120Free PMC Article
Treatment of echinococcosis: albendazole and mebendazole--what else?
Hemphill A, Stadelmann B, Rufener R, Spiliotis M, Boubaker G, Müller J, Müller N, Gorgas D, Gottstein B
Parasite 2014;21:70. Epub 2014 Dec 22 doi: 10.1051/parasite/2014073. PMID: 25526545Free PMC Article
Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans.
Brunetti E, Kern P, Vuitton DA; Writing Panel for the WHO-IWGE
Acta Trop 2010 Apr;114(1):1-16. Epub 2009 Nov 30 doi: 10.1016/j.actatropica.2009.11.001. PMID: 19931502

Recent clinical studies

Etiology

Ultrasound identification of hepatic echinococcosis using a deep convolutional neural network model in China: a retrospective, large-scale, multicentre, diagnostic accuracy study.
Yang Y, Cairang Y, Jiang T, Zhou J, Zhang L, Qi B, Ma S, Tang L, Xu D, Bu L, Bu R, Jing X, Wang H, Zhou Z, Zhao C, Luo B, Liu L, Guo J, Nima Y, Hua G, Wa Z, Zhang Y, Zhou G, Jiang W, Wang C, De Y, Yu X, Cheng Z, Han Z, Liu F, Dou J, Feng H, Wu C, Wang R, Hu J, Yang Q, Luo Y, Wu J, Fan H, Liang P, Yu J
Lancet Digit Health 2023 Aug;5(8):e503-e514. doi: 10.1016/S2589-7500(23)00091-2. PMID: 37507196
Alveolar echinococcosis in immunocompromised hosts.
Autier B, Gottstein B, Millon L, Ramharter M, Gruener B, Bresson-Hadni S, Dion S, Robert-Gangneux F
Clin Microbiol Infect 2023 May;29(5):593-599. Epub 2022 Dec 15 doi: 10.1016/j.cmi.2022.12.010. PMID: 36528295
Global Distribution of Alveolar and Cystic Echinococcosis.
Deplazes P, Rinaldi L, Alvarez Rojas CA, Torgerson PR, Harandi MF, Romig T, Antolova D, Schurer JM, Lahmar S, Cringoli G, Magambo J, Thompson RC, Jenkins EJ
Adv Parasitol 2017;95:315-493. Epub 2017 Jan 20 doi: 10.1016/bs.apar.2016.11.001. PMID: 28131365
Historical Aspects of Echinococcosis.
Eckert J, Thompson RC
Adv Parasitol 2017;95:1-64. Epub 2016 Sep 29 doi: 10.1016/bs.apar.2016.07.003. PMID: 28131361
Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans.
Brunetti E, Kern P, Vuitton DA; Writing Panel for the WHO-IWGE
Acta Trop 2010 Apr;114(1):1-16. Epub 2009 Nov 30 doi: 10.1016/j.actatropica.2009.11.001. PMID: 19931502

Diagnosis

Diffuse alveolar echinococcosis.
Aydin Y, Ogul H, Eren S
Med Clin (Barc) 2023 Jun 9;160(11):e7. Epub 2023 Jan 14 doi: 10.1016/j.medcli.2022.12.004. PMID: 36646551
Hepatic Alveolar Echinococcosis.
Bresson-Hadni S, Spahr L, Chappuis F
Semin Liver Dis 2021 Aug;41(3):393-408. Epub 2021 Jun 23 doi: 10.1055/s-0041-1730925. PMID: 34161992
Echinococcus granulosus sensu lato and Echinococcus multilocularis: A review.
Woolsey ID, Miller AL
Res Vet Sci 2021 Mar;135:517-522. Epub 2020 Nov 19 doi: 10.1016/j.rvsc.2020.11.010. PMID: 33246571
Echinococcosis: Advances in the 21st Century.
Wen H, Vuitton L, Tuxun T, Li J, Vuitton DA, Zhang W, McManus DP
Clin Microbiol Rev 2019 Mar 20;32(2) Epub 2019 Feb 13 doi: 10.1128/CMR.00075-18. PMID: 30760475Free PMC Article
Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans.
Brunetti E, Kern P, Vuitton DA; Writing Panel for the WHO-IWGE
Acta Trop 2010 Apr;114(1):1-16. Epub 2009 Nov 30 doi: 10.1016/j.actatropica.2009.11.001. PMID: 19931502

Therapy

Ultrasound identification of hepatic echinococcosis using a deep convolutional neural network model in China: a retrospective, large-scale, multicentre, diagnostic accuracy study.
Yang Y, Cairang Y, Jiang T, Zhou J, Zhang L, Qi B, Ma S, Tang L, Xu D, Bu L, Bu R, Jing X, Wang H, Zhou Z, Zhao C, Luo B, Liu L, Guo J, Nima Y, Hua G, Wa Z, Zhang Y, Zhou G, Jiang W, Wang C, De Y, Yu X, Cheng Z, Han Z, Liu F, Dou J, Feng H, Wu C, Wang R, Hu J, Yang Q, Luo Y, Wu J, Fan H, Liang P, Yu J
Lancet Digit Health 2023 Aug;5(8):e503-e514. doi: 10.1016/S2589-7500(23)00091-2. PMID: 37507196
Echinococcosis: Advances in the 21st Century.
Wen H, Vuitton L, Tuxun T, Li J, Vuitton DA, Zhang W, McManus DP
Clin Microbiol Rev 2019 Mar 20;32(2) Epub 2019 Feb 13 doi: 10.1128/CMR.00075-18. PMID: 30760475Free PMC Article
Hepatic alveolar echinococcosis.
Detry O, Meurisse N, Delwaide J, Giot JB, Leonard P, Losson B, Hayette MP, Bletard N, Meunier P, Honoré P
Acta Chir Belg 2018 Dec;118(6):402-403. Epub 2018 Apr 13 doi: 10.1080/00015458.2018.1427838. PMID: 29653501
Historical Aspects of Echinococcosis.
Eckert J, Thompson RC
Adv Parasitol 2017;95:1-64. Epub 2016 Sep 29 doi: 10.1016/bs.apar.2016.07.003. PMID: 28131361
Echinococcus multilocularis.
Craig P
Curr Opin Infect Dis 2003 Oct;16(5):437-44. doi: 10.1097/00001432-200310000-00010. PMID: 14501996

Prognosis

Hepatic Alveolar Echinococcosis.
Bresson-Hadni S, Spahr L, Chappuis F
Semin Liver Dis 2021 Aug;41(3):393-408. Epub 2021 Jun 23 doi: 10.1055/s-0041-1730925. PMID: 34161992
Global Distribution of Alveolar and Cystic Echinococcosis.
Deplazes P, Rinaldi L, Alvarez Rojas CA, Torgerson PR, Harandi MF, Romig T, Antolova D, Schurer JM, Lahmar S, Cringoli G, Magambo J, Thompson RC, Jenkins EJ
Adv Parasitol 2017;95:315-493. Epub 2017 Jan 20 doi: 10.1016/bs.apar.2016.11.001. PMID: 28131365
Cystic and alveolar echinococcosis.
Stojkovic M, Junghanss T
Handb Clin Neurol 2013;114:327-34. doi: 10.1016/B978-0-444-53490-3.00026-1. PMID: 23829922
Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans.
Brunetti E, Kern P, Vuitton DA; Writing Panel for the WHO-IWGE
Acta Trop 2010 Apr;114(1):1-16. Epub 2009 Nov 30 doi: 10.1016/j.actatropica.2009.11.001. PMID: 19931502
Echinococcosis.
McManus DP, Zhang W, Li J, Bartley PB
Lancet 2003 Oct 18;362(9392):1295-304. doi: 10.1016/S0140-6736(03)14573-4. PMID: 14575976

Clinical prediction guides

Detection and subtyping of hepatic echinococcosis from plain CT images with deep learning: a retrospective, multicentre study.
Wang Z, Bian H, Li J, Xu J, Fan H, Wu X, Cao Y, Guo B, Xu X, Wang H, Zhang L, Zhou H, Fan J, Ren Y, Geng Y, Feng X, Li L, Wei L, Zhang X
Lancet Digit Health 2023 Nov;5(11):e754-e762. Epub 2023 Sep 26 doi: 10.1016/S2589-7500(23)00136-X. PMID: 37770335
Echinococcoses - A Primer for Radiologists.
Weber TF, Mokry T, Stojkovic M
Rofo 2023 Dec;195(12):1106-1121. Epub 2023 Jul 19 doi: 10.1055/a-2114-1980. PMID: 37467780
Echinococcus infections in the Baltic region.
Marcinkutė A, Šarkūnas M, Moks E, Saarma U, Jokelainen P, Bagrade G, Laivacuma S, Strupas K, Sokolovas V, Deplazes P
Vet Parasitol 2015 Oct 30;213(3-4):121-31. Epub 2015 Jul 31 doi: 10.1016/j.vetpar.2015.07.032. PMID: 26324242
Clinical features and treatment of alveolar echinococcosis.
Kern P
Curr Opin Infect Dis 2010 Oct;23(5):505-12. doi: 10.1097/QCO.0b013e32833d7516. PMID: 20683265
Echinococcosis and allergy.
Vuitton DA
Clin Rev Allergy Immunol 2004 Apr;26(2):93-104. doi: 10.1007/s12016-004-0004-2. PMID: 15146106

Recent systematic reviews

Past and present of diagnosis of echinococcosis: A review (1999-2021).
Alvi MA, Ali RMA, Khan S, Saqib M, Qamar W, Li L, Fu BQ, Yan HB, Jia WZ
Acta Trop 2023 Jul;243:106925. Epub 2023 Apr 18 doi: 10.1016/j.actatropica.2023.106925. PMID: 37080264
Echinococcosis in immunocompromised patients: A systematic review.
Ghasemirad H, Bazargan N, Shahesmaeili A, Harandi MF
Acta Trop 2022 Aug;232:106490. Epub 2022 Apr 28 doi: 10.1016/j.actatropica.2022.106490. PMID: 35490729
Prevalence of human alveolar echinococcosis in China: a systematic review and meta-analysis.
Wang X, Dai G, Li M, Jia W, Guo Z, Lu J
BMC Public Health 2020 Jul 14;20(1):1105. doi: 10.1186/s12889-020-08989-8. PMID: 32664905Free PMC Article
Epidemiology of echinococcosis in Iran: a systematic review and meta-analysis.
Mahmoudi S, Mamishi S, Banar M, Pourakbari B, Keshavarz H
BMC Infect Dis 2019 Nov 4;19(1):929. doi: 10.1186/s12879-019-4458-5. PMID: 31684882Free PMC Article
Potential risk factors associated with human alveolar echinococcosis: Systematic review and meta-analysis.
Conraths FJ, Probst C, Possenti A, Boufana B, Saulle R, La Torre G, Busani L, Casulli A
PLoS Negl Trop Dis 2017 Jul;11(7):e0005801. Epub 2017 Jul 17 doi: 10.1371/journal.pntd.0005801. PMID: 28715408Free PMC Article

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