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Prothrombin time increased

MedGen UID:
56249
•Concept ID:
C0151872
•
Finding
Synonym: Prolonged prothrombin time
SNOMED CT: Prothrombin time increased (409674002)

Professional guidelines

PubMed

Practical Recommendations for Treatment of Dental Patients with Congenital Bleeding Disorders during the Covid-19 Pandemic: A Narrative Review.
Czajkowska S, Rupa-Matysek J, Gil L, Surdacka A
Int J Environ Res Public Health 2020 Oct 3;17(19) doi: 10.3390/ijerph17197245. PMID: 33023050Free PMC Article
A Proposal of the Modification of Japanese Society on Thrombosis and Hemostasis (JSTH) Disseminated Intravascular Coagulation (DIC) Diagnostic Criteria for Sepsis-Associated DIC.
Iba T, Di Nisio M, Thachil J, Wada H, Asakura H, Sato K, Saitoh D
Clin Appl Thromb Hemost 2018 Apr;24(3):439-445. Epub 2017 Jul 27 doi: 10.1177/1076029617720069. PMID: 28747069Free PMC Article
Selection criteria for patients undergoing transjugular intrahepatic portosystemic shunt procedures: current status.
Ferral H, Patel NH
J Vasc Interv Radiol 2005 Apr;16(4):449-55. doi: 10.1097/01.RVI.0000149508.64029.02. PMID: 15802443

Recent clinical studies

Etiology

Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk!
Santoro RC, Molinari AC, Leotta M, Martini T
Medicina (Kaunas) 2023 Jun 17;59(6) doi: 10.3390/medicina59061169. PMID: 37374373Free PMC Article
Prothrombin Time and Coagulation Factor IX as Hemostatic Risk Markers for Legg- Calvé-Perthes Disease.
Hernández-Zamora E, Rodríguez-Olivas AO, Rosales-Cruz E, Galicia-Alvarado MA, Zavala-Hernández C, Reyes-Maldonado E
Clin Appl Thromb Hemost 2023 Jan-Dec;29:10760296221151166. doi: 10.1177/10760296221151166. PMID: 36650707Free PMC Article
Data mining for prothrombin time and international normalized ratio reference intervals in children.
Shaikh MS, Ahmed S
PLoS One 2022;17(10):e0276884. Epub 2022 Oct 27 doi: 10.1371/journal.pone.0276884. PMID: 36302050Free PMC Article
Interactions of sugammadex with various anticoagulants
.
Kruithof AC, Kluft C, de Kam PJ, Laterveer GH, Moerland M, Burggraaf J
Int J Clin Pharmacol Ther 2020 Jul;58(7):395-403. doi: 10.5414/CP203733. PMID: 32383642
International Normalized Ratio Is Significantly Elevated With Rivaroxaban and Apixaban Drug Therapies: A Retrospective Study.
Ofek F, Bar Chaim S, Kronenfeld N, Ziv-Baran T, Berkovitch M
Clin Ther 2017 May;39(5):1003-1010. Epub 2017 May 2 doi: 10.1016/j.clinthera.2017.04.007. PMID: 28476405

Diagnosis

Trauma-induced coagulopathy: What you need to know.
Buzzard L, Schreiber M
J Trauma Acute Care Surg 2024 Feb 1;96(2):179-185. Epub 2023 Oct 13 doi: 10.1097/TA.0000000000004170. PMID: 37828662
Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk!
Santoro RC, Molinari AC, Leotta M, Martini T
Medicina (Kaunas) 2023 Jun 17;59(6) doi: 10.3390/medicina59061169. PMID: 37374373Free PMC Article
Clot Waveform Analysis for Monitoring Hemostasis.
Nogami K
Semin Thromb Hemost 2023 Sep;49(6):592-599. Epub 2022 Sep 29 doi: 10.1055/s-0042-1756706. PMID: 36174610
Thromboelastography for the Orthopaedic Surgeon.
Hagedorn JC 2nd, Bardes JM, Paris CL, Lindsey RW
J Am Acad Orthop Surg 2019 Jul 15;27(14):503-508. doi: 10.5435/JAAOS-D-17-00603. PMID: 30407978
International Normalized Ratio Is Significantly Elevated With Rivaroxaban and Apixaban Drug Therapies: A Retrospective Study.
Ofek F, Bar Chaim S, Kronenfeld N, Ziv-Baran T, Berkovitch M
Clin Ther 2017 May;39(5):1003-1010. Epub 2017 May 2 doi: 10.1016/j.clinthera.2017.04.007. PMID: 28476405

Therapy

Association of prothrombin time, thrombin time and activated partial thromboplastin time levels with preeclampsia: a systematic review and meta-analysis.
Alemayehu E, Mohammed O, Belete MA, Mulatie Z, Debash H, Gedefie A, Weldehanna DG, Eshetu B, Shibabaw A, Tekele SG, Tilahun M, Ebrahim H
BMC Pregnancy Childbirth 2024 May 13;24(1):354. doi: 10.1186/s12884-024-06543-7. PMID: 38741046Free PMC Article
A next generation FVIII mimetic bispecific antibody, Mim8, the impact on non-factor VIII related haemostasis assays.
Bowyer AE, Hickey K, Kitchen S, Ezban M
Haemophilia 2023 Nov;29(6):1633-1637. Epub 2023 Oct 12 doi: 10.1111/hae.14884. PMID: 37824563
Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk!
Santoro RC, Molinari AC, Leotta M, Martini T
Medicina (Kaunas) 2023 Jun 17;59(6) doi: 10.3390/medicina59061169. PMID: 37374373Free PMC Article
International Normalized Ratio Is Significantly Elevated With Rivaroxaban and Apixaban Drug Therapies: A Retrospective Study.
Ofek F, Bar Chaim S, Kronenfeld N, Ziv-Baran T, Berkovitch M
Clin Ther 2017 May;39(5):1003-1010. Epub 2017 May 2 doi: 10.1016/j.clinthera.2017.04.007. PMID: 28476405
Neonatal thrombosis.
Barnard DR, Hathaway WE
Am J Pediatr Hematol Oncol 1979 Fall;1(3):235-44. doi: 10.1097/00043426-197923000-00007. PMID: 396799

Prognosis

Glycemia and Coagulation in Patients with Glioblastomas.
Orešković D, Madero Pohlen A, Cvitković I, Alen JF, Álvarez-Sala de la Cuadra A, Bazarra Castro GJ, Bušić Ž, Kaštelančić A, Konstantinović I, Rotim A, Lakić M, Ledenko V, Martínez Macho C, Raguž M, Žarak M, Chudy D, Marinović T
World Neurosurg 2024 Sep;189:e999-e1005. Epub 2024 Jul 14 doi: 10.1016/j.wneu.2024.07.060. PMID: 39004176
A next generation FVIII mimetic bispecific antibody, Mim8, the impact on non-factor VIII related haemostasis assays.
Bowyer AE, Hickey K, Kitchen S, Ezban M
Haemophilia 2023 Nov;29(6):1633-1637. Epub 2023 Oct 12 doi: 10.1111/hae.14884. PMID: 37824563
Association between admission prothrombin time activity and hospital readmission in heart failure: A retrospective study.
Xu M, Li Y, Zhao W, Song X, Gan G, Li B, Zhou X
Clin Chim Acta 2023 Aug 1;548:117463. Epub 2023 Jun 29 doi: 10.1016/j.cca.2023.117463. PMID: 37392864
Association between prothrombin time-international normalized ratio and prognosis of post-cardiac arrest patients: A retrospective cohort study.
Tang Y, Sun J, Yu Z, Liang B, Peng B, Ma J, Zeng X, Feng Y, Chen Q, Zha L
Front Public Health 2023;11:1112623. Epub 2023 Jan 20 doi: 10.3389/fpubh.2023.1112623. PMID: 36741950Free PMC Article
Acute Cerebrovascular Events With COVID-19 Infection.
Dhamoon MS, Thaler A, Gururangan K, Kohli A, Sisniega D, Wheelwright D, Mensching C, Fifi JT, Fara MG, Jette N, Cohen E, Dave P, DiRisio AC, Goldstein J, Loebel EM, Mayman NA, Sharma A, Thomas DS, Vega Perez RD, Weingarten MR, Wen HH, Tuhrim S, Stein LK; Mount Sinai Stroke Investigators*
Stroke 2021 Jan;52(1):48-56. Epub 2020 Dec 7 doi: 10.1161/STROKEAHA.120.031668. PMID: 33280551

Clinical prediction guides

A next generation FVIII mimetic bispecific antibody, Mim8, the impact on non-factor VIII related haemostasis assays.
Bowyer AE, Hickey K, Kitchen S, Ezban M
Haemophilia 2023 Nov;29(6):1633-1637. Epub 2023 Oct 12 doi: 10.1111/hae.14884. PMID: 37824563
Association between admission prothrombin time activity and hospital readmission in heart failure: A retrospective study.
Xu M, Li Y, Zhao W, Song X, Gan G, Li B, Zhou X
Clin Chim Acta 2023 Aug 1;548:117463. Epub 2023 Jun 29 doi: 10.1016/j.cca.2023.117463. PMID: 37392864
Association between prothrombin time-international normalized ratio and prognosis of post-cardiac arrest patients: A retrospective cohort study.
Tang Y, Sun J, Yu Z, Liang B, Peng B, Ma J, Zeng X, Feng Y, Chen Q, Zha L
Front Public Health 2023;11:1112623. Epub 2023 Jan 20 doi: 10.3389/fpubh.2023.1112623. PMID: 36741950Free PMC Article
Clot Waveform Analysis for Monitoring Hemostasis.
Nogami K
Semin Thromb Hemost 2023 Sep;49(6):592-599. Epub 2022 Sep 29 doi: 10.1055/s-0042-1756706. PMID: 36174610
Hematologic effects and complications of snake envenoming.
Berling I, Isbister GK
Transfus Med Rev 2015 Apr;29(2):82-9. Epub 2014 Dec 18 doi: 10.1016/j.tmrv.2014.09.005. PMID: 25556574

Recent systematic reviews

Association of prothrombin time, thrombin time and activated partial thromboplastin time levels with preeclampsia: a systematic review and meta-analysis.
Alemayehu E, Mohammed O, Belete MA, Mulatie Z, Debash H, Gedefie A, Weldehanna DG, Eshetu B, Shibabaw A, Tekele SG, Tilahun M, Ebrahim H
BMC Pregnancy Childbirth 2024 May 13;24(1):354. doi: 10.1186/s12884-024-06543-7. PMID: 38741046Free PMC Article
Alteration of prothrombin time in Plasmodium falciparum and Plasmodium vivax infections with different levels of severity: a systematic review and meta-analysis.
Sukati S, Wannatung T, Duangchan T, Kotepui KU, Masangkay FR, Tseng CP, Kotepui M
Sci Rep 2024 May 2;14(1):9816. doi: 10.1038/s41598-024-60170-y. PMID: 38698102Free PMC Article
Prothrombin complex concentrate (PCC) for treatment of trauma-induced coagulopathy: systematic review and meta-analyses.
Hannadjas I, James A, Davenport R, Lindsay C, Brohi K, Cole E
Crit Care 2023 Nov 2;27(1):422. doi: 10.1186/s13054-023-04688-z. PMID: 37919775Free PMC Article
COVID-19 and coagulation dysfunction in adults: A systematic review and meta-analysis.
Lin J, Yan H, Chen H, He C, Lin C, He H, Zhang S, Shi S, Lin K
J Med Virol 2021 Feb;93(2):934-944. Epub 2020 Aug 2 doi: 10.1002/jmv.26346. PMID: 32706426Free PMC Article
Methotrexate for primary biliary cirrhosis.
Giljaca V, Poropat G, Stimac D, Gluud C
Cochrane Database Syst Rev 2010 May 12;(5):CD004385. doi: 10.1002/14651858.CD004385.pub3. PMID: 20464729

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