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Alkaline phosphatase above reference range

MedGen UID:
57737
Concept ID:
C0151849
Finding
Synonyms: Elevated alkaline phosphatase; Elevated alkaline phosphatase level; Hyperphosphatasia; Increased alkaline phosphatase
SNOMED CT: Alkaline phosphatase raised (274770006); Alkaline phosphatase above reference range (274770006)

Professional guidelines

PubMed

Kishnani PS, Martos-Moreno GÁ, Linglart A, Petryk A, Messali A, Fang S, Rockman-Greenberg C, Ozono K, Högler W, Seefried L, Dahir KM
Orphanet J Rare Dis 2024 Mar 8;19(1):109. doi: 10.1186/s13023-024-03048-6. PMID: 38459585Free PMC Article
Bacchetta J
Pediatr Nephrol 2020 Mar;35(3):493-500. Epub 2019 Nov 6 doi: 10.1007/s00467-019-04400-w. PMID: 31696357
Kovar I, Mayne P, Barltrop D
Lancet 1982 Feb 6;1(8267):308-10. doi: 10.1016/s0140-6736(82)91569-0. PMID: 6120314

Recent clinical studies

Etiology

Kishnani PS, Martos-Moreno GÁ, Linglart A, Petryk A, Messali A, Fang S, Rockman-Greenberg C, Ozono K, Högler W, Seefried L, Dahir KM
Orphanet J Rare Dis 2024 Mar 8;19(1):109. doi: 10.1186/s13023-024-03048-6. PMID: 38459585Free PMC Article
Corpechot C, Lemoinne S, Soret PA, Hansen B, Hirschfield G, Gulamhusein A, Montano-Loza AJ, Lytvyak E, Pares A, Olivas I, Eaton JE, Osman KT, Schramm C, Sebode M, Lohse AW, Dalekos G, Gatselis N, Nevens F, Cazzagon N, Zago A, Russo FP, Floreani A, Abbas N, Trivedi P, Thorburn D, Saffioti F, Barkai L, Roccarina D, Calvaruso V, Fichera A, Delamarre A, Sobenko N, Villamil AM, Medina-Morales E, Bonder A, Patwardhan V, Rigamonti C, Carbone M, Invernizzi P, Cristoferi L, van der Meer A, de Veer R, Zigmond E, Yehezkel E, Kremer AE, Deibel A, Bruns T, Große K, Wetten A, Dyson JK, Jones D, Dumortier J, Pageaux GP, de Lédinghen V, Chazouillères O, Carrat F; Global & ERN Rare-Liver PBC Study Groups
Hepatology 2024 Jan 1;79(1):39-48. Epub 2023 Jul 3 doi: 10.1097/HEP.0000000000000529. PMID: 37399238
Bacchetta J, Ginhoux T, Bernoux D, Dubourg L, Ranchin B, Roger C
Acta Paediatr 2019 Dec;108(12):2253-2260. Epub 2019 Jul 15 doi: 10.1111/apa.14907. PMID: 31215071
Gauss A, Sauer P, Stiehl A, Rupp C, Krisam J, Leopold Y, Kloeters-Plachky P, Stremmel W, Gotthardt D
Medicine (Baltimore) 2016 Apr;95(17):e3510. doi: 10.1097/MD.0000000000003510. PMID: 27124059Free PMC Article
D'Andrea MA, Reddy GK
Am J Med 2014 Sep;127(9):886.e9 -13. Epub 2014 May 21 doi: 10.1016/j.amjmed.2014.04.035. PMID: 24859637

Diagnosis

Bacchetta J
Pediatr Nephrol 2020 Mar;35(3):493-500. Epub 2019 Nov 6 doi: 10.1007/s00467-019-04400-w. PMID: 31696357
Corbetta F, Tremolizzo L, Conti E, Ferrarese C, Neri F, Bomba M, Nacinovich R
Int J Eat Disord 2015 Apr;48(3):317-22. Epub 2014 Nov 29 doi: 10.1002/eat.22371. PMID: 25446249
Azemi M, Berisha M, Kolgeci S, Ismaili-Jaha V, Hoxha R, Hoxha-Kamberi T
Med Arch 2013;67(3):219-22. doi: 10.5455/medarh.2013.67.219-222. PMID: 23848049
Kelso T
Emerg Med Clin North Am 1990 May;8(2):241-54. PMID: 2187680
Aabo K, Pedersen H, Kjaer M
Eur J Cancer Clin Oncol 1986 Feb;22(2):211-7. doi: 10.1016/0277-5379(86)90033-7. PMID: 3699082

Therapy

Kishnani PS, Martos-Moreno GÁ, Linglart A, Petryk A, Messali A, Fang S, Rockman-Greenberg C, Ozono K, Högler W, Seefried L, Dahir KM
Orphanet J Rare Dis 2024 Mar 8;19(1):109. doi: 10.1186/s13023-024-03048-6. PMID: 38459585Free PMC Article
Corpechot C, Lemoinne S, Soret PA, Hansen B, Hirschfield G, Gulamhusein A, Montano-Loza AJ, Lytvyak E, Pares A, Olivas I, Eaton JE, Osman KT, Schramm C, Sebode M, Lohse AW, Dalekos G, Gatselis N, Nevens F, Cazzagon N, Zago A, Russo FP, Floreani A, Abbas N, Trivedi P, Thorburn D, Saffioti F, Barkai L, Roccarina D, Calvaruso V, Fichera A, Delamarre A, Sobenko N, Villamil AM, Medina-Morales E, Bonder A, Patwardhan V, Rigamonti C, Carbone M, Invernizzi P, Cristoferi L, van der Meer A, de Veer R, Zigmond E, Yehezkel E, Kremer AE, Deibel A, Bruns T, Große K, Wetten A, Dyson JK, Jones D, Dumortier J, Pageaux GP, de Lédinghen V, Chazouillères O, Carrat F; Global & ERN Rare-Liver PBC Study Groups
Hepatology 2024 Jan 1;79(1):39-48. Epub 2023 Jul 3 doi: 10.1097/HEP.0000000000000529. PMID: 37399238
Bacchetta J
Pediatr Nephrol 2020 Mar;35(3):493-500. Epub 2019 Nov 6 doi: 10.1007/s00467-019-04400-w. PMID: 31696357
D'Andrea MA, Reddy GK
Am J Med 2014 Sep;127(9):886.e9 -13. Epub 2014 May 21 doi: 10.1016/j.amjmed.2014.04.035. PMID: 24859637
Azemi M, Berisha M, Kolgeci S, Ismaili-Jaha V, Hoxha R, Hoxha-Kamberi T
Med Arch 2013;67(3):219-22. doi: 10.5455/medarh.2013.67.219-222. PMID: 23848049

Prognosis

Bacchetta J
Pediatr Nephrol 2020 Mar;35(3):493-500. Epub 2019 Nov 6 doi: 10.1007/s00467-019-04400-w. PMID: 31696357
Bacchetta J, Ginhoux T, Bernoux D, Dubourg L, Ranchin B, Roger C
Acta Paediatr 2019 Dec;108(12):2253-2260. Epub 2019 Jul 15 doi: 10.1111/apa.14907. PMID: 31215071
Riancho-Zarrabeitia L, García-Unzueta M, Tenorio JA, Gómez-Gerique JA, Ruiz Pérez VL, Heath KE, Lapunzina P, Riancho JA
Eur J Intern Med 2016 Apr;29:40-5. Epub 2016 Jan 11 doi: 10.1016/j.ejim.2015.12.019. PMID: 26783040
Salem GI, Abdulrahman AA
Rheumatol Int 2012 Aug;32(8):2371-5. Epub 2011 Jun 5 doi: 10.1007/s00296-011-1963-2. PMID: 21644046
Aabo K, Pedersen H, Kjaer M
Eur J Cancer Clin Oncol 1986 Feb;22(2):211-7. doi: 10.1016/0277-5379(86)90033-7. PMID: 3699082

Clinical prediction guides

Matejek T, Zapletalova B, Stranik J, Zaloudkova L, Palicka V
Ann Clin Biochem 2024 Sep;61(5):372-385. Epub 2024 Apr 6 doi: 10.1177/00045632241245942. PMID: 38520177
Kishnani PS, Martos-Moreno GÁ, Linglart A, Petryk A, Messali A, Fang S, Rockman-Greenberg C, Ozono K, Högler W, Seefried L, Dahir KM
Orphanet J Rare Dis 2024 Mar 8;19(1):109. doi: 10.1186/s13023-024-03048-6. PMID: 38459585Free PMC Article
Bacchetta J
Pediatr Nephrol 2020 Mar;35(3):493-500. Epub 2019 Nov 6 doi: 10.1007/s00467-019-04400-w. PMID: 31696357
Riancho-Zarrabeitia L, García-Unzueta M, Tenorio JA, Gómez-Gerique JA, Ruiz Pérez VL, Heath KE, Lapunzina P, Riancho JA
Eur J Intern Med 2016 Apr;29:40-5. Epub 2016 Jan 11 doi: 10.1016/j.ejim.2015.12.019. PMID: 26783040
Wichary H, Gasińska T
Thyroid 2012 Jan;22(1):64-9. Epub 2011 Oct 26 doi: 10.1089/thy.2010.0158. PMID: 22029719

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