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Central nervous system depression

MedGen UID:
508773
•Concept ID:
C0151559
•
Disease or Syndrome
SNOMED CT: Central nervous system depression (418072004)

Professional guidelines

PubMed

Acute pain management in the Emergency Department: Use of multimodal and non-opioid analgesic treatment strategies.
Rech MA, Griggs C, Lovett S, Motov S
Am J Emerg Med 2022 Aug;58:57-65. Epub 2022 May 22 doi: 10.1016/j.ajem.2022.05.022. PMID: 35636044
Screening for and Management of Opioid Use Disorder in Older Adults in Primary Care.
Duggirala R, Khushalani S, Palmer T, Brandt N, Desai A
Clin Geriatr Med 2022 Feb;38(1):23-38. doi: 10.1016/j.cger.2021.07.001. PMID: 34794701
Brimonidine tartrate for the treatment of glaucoma.
Oh DJ, Chen JL, Vajaranant TS, Dikopf MS
Expert Opin Pharmacother 2019 Jan;20(1):115-122. Epub 2018 Nov 8 doi: 10.1080/14656566.2018.1544241. PMID: 30407890

Recent clinical studies

Etiology

Drug Prescribing: Drug-Drug Interactions.
McQuade BM, Campbell A
FP Essent 2021 Sep;508:25-32. PMID: 34491709
Brimonidine tartrate for the treatment of glaucoma.
Oh DJ, Chen JL, Vajaranant TS, Dikopf MS
Expert Opin Pharmacother 2019 Jan;20(1):115-122. Epub 2018 Nov 8 doi: 10.1080/14656566.2018.1544241. PMID: 30407890
Replacing GHB with GBL in Recreational Settings: A New Trend in Chemsex.
Busardò FP, Gottardi M, Tini A, Minutillo A, Sirignano A, Marinelli E, Zaami S
Curr Drug Metab 2018;19(13):1080-1085. doi: 10.2174/1389200219666180925090834. PMID: 30251602
The effects of opioids on the lung.
Radke JB, Owen KP, Sutter ME, Ford JB, Albertson TE
Clin Rev Allergy Immunol 2014 Feb;46(1):54-64. doi: 10.1007/s12016-013-8373-z. PMID: 23636734
Respiratory failure.
Roussos C, Koutsoukou A
Eur Respir J Suppl 2003 Nov;47:3s-14s. doi: 10.1183/09031936.03.00038503. PMID: 14621112

Diagnosis

Toxin-Induced Coma and Central Nervous System Depression.
Krause M, Hocker S
Neurol Clin 2020 Nov;38(4):825-841. Epub 2020 Sep 12 doi: 10.1016/j.ncl.2020.07.002. PMID: 33040863
The effects of opioids on the lung.
Radke JB, Owen KP, Sutter ME, Ford JB, Albertson TE
Clin Rev Allergy Immunol 2014 Feb;46(1):54-64. doi: 10.1007/s12016-013-8373-z. PMID: 23636734
Ethylene glycol poisoning.
Leth PM, Gregersen M
Forensic Sci Int 2005 Dec 20;155(2-3):179-84. Epub 2005 Jan 21 doi: 10.1016/j.forsciint.2004.11.012. PMID: 16226155
Organophosphate and carbamate poisoning.
Bardin PG, van Eeden SF, Moolman JA, Foden AP, Joubert JR
Arch Intern Med 1994 Jul 11;154(13):1433-41. PMID: 8017998
Acute suppurative cholangitis.
Chock E, Wolfe BM, Matolo NM
Surg Clin North Am 1981 Aug;61(4):885-92. doi: 10.1016/s0039-6109(16)42486-2. PMID: 7025298

Therapy

Acute pain management in the Emergency Department: Use of multimodal and non-opioid analgesic treatment strategies.
Rech MA, Griggs C, Lovett S, Motov S
Am J Emerg Med 2022 Aug;58:57-65. Epub 2022 May 22 doi: 10.1016/j.ajem.2022.05.022. PMID: 35636044
Hypothermia-rewarming: A Double-edged sword?
Hou Y, Qiao Y, Xiong M, Zhang D, Rao W, Shi C
Med Hypotheses 2019 Dec;133:109387. Epub 2019 Aug 30 doi: 10.1016/j.mehy.2019.109387. PMID: 31541781
Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review.
Armenian P, Vo KT, Barr-Walker J, Lynch KL
Neuropharmacology 2018 May 15;134(Pt A):121-132. Epub 2017 Oct 14 doi: 10.1016/j.neuropharm.2017.10.016. PMID: 29042317
Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: A comprehensive review of the literature.
Ruiz-Colón K, Chavez-Arias C, Díaz-Alcalá JE, Martínez MA
Forensic Sci Int 2014 Jul;240:1-8. Epub 2014 Mar 26 doi: 10.1016/j.forsciint.2014.03.015. PMID: 24769343
The effects of opioids on the lung.
Radke JB, Owen KP, Sutter ME, Ford JB, Albertson TE
Clin Rev Allergy Immunol 2014 Feb;46(1):54-64. doi: 10.1007/s12016-013-8373-z. PMID: 23636734

Prognosis

Safety assessment and adverse drug reaction reporting of tea tree oil (Melaleuca aetheroleum).
Bekhof AMW, van Hunsel FPAM, van de Koppel S, Woerdenbag HJ
Phytother Res 2023 Apr;37(4):1309-1318. Epub 2022 Nov 23 doi: 10.1002/ptr.7687. PMID: 36420525
Categorization of Abuse Potential-Related Adverse Events.
Sellers EM, Romach MK
Clin Pharmacol Drug Dev 2018 Aug;7(6):569-574. Epub 2017 Oct 11 doi: 10.1002/cpdd.394. PMID: 29024490
Respiratory failure.
Roussos C, Koutsoukou A
Eur Respir J Suppl 2003 Nov;47:3s-14s. doi: 10.1183/09031936.03.00038503. PMID: 14621112
Problems and pitfalls in the use of benzodiazepines in the elderly.
Kruse WH
Drug Saf 1990 Sep-Oct;5(5):328-44. doi: 10.2165/00002018-199005050-00003. PMID: 2222867
Acute suppurative cholangitis.
Chock E, Wolfe BM, Matolo NM
Surg Clin North Am 1981 Aug;61(4):885-92. doi: 10.1016/s0039-6109(16)42486-2. PMID: 7025298

Clinical prediction guides

1,1,1,3,3,3-Hexamethyldisilazane (2018).
Toxicol Ind Health 2019 Mar;35(3):189-195. Epub 2019 Feb 13 doi: 10.1177/0748233719825531. PMID: 30760128
Categorization of Abuse Potential-Related Adverse Events.
Sellers EM, Romach MK
Clin Pharmacol Drug Dev 2018 Aug;7(6):569-574. Epub 2017 Oct 11 doi: 10.1002/cpdd.394. PMID: 29024490
Hydrocarbon toxicity: A review.
Tormoehlen LM, Tekulve KJ, Nañagas KA
Clin Toxicol (Phila) 2014 Jun;52(5):479-89. doi: 10.3109/15563650.2014.923904. PMID: 24911841
Phenazepam and its effects on driving.
Stephenson JB, Golz DE, Brasher MJ
J Anal Toxicol 2013 Jan-Feb;37(1):25-9. Epub 2012 Oct 16 doi: 10.1093/jat/bks080. PMID: 23074215
Depression, cytokines, and glial function.
Miller DB, O'Callaghan JP
Metabolism 2005 May;54(5 Suppl 1):33-8. doi: 10.1016/j.metabol.2005.01.011. PMID: 15877311

Recent systematic reviews

A review on four different paths to respiratory arrest from brain injury in children; implications for child abuse.
Paek D, Kwon DI
J Forensic Leg Med 2020 Apr;71:101938. Epub 2020 Mar 10 doi: 10.1016/j.jflm.2020.101938. PMID: 32342908
Quality of Evidence Supporting Major Psychotropic Drug-Drug Interaction Warnings: A Systematic Literature Review.
Nguyen T, Liu X, Abuhashem W, Bussing R, Winterstein AG
Pharmacotherapy 2020 May;40(5):455-468. Epub 2020 Mar 23 doi: 10.1002/phar.2382. PMID: 32107798
Intravenous lipid emulsion as antidote: a summary of published human experience.
Cave G, Harvey M, Graudins A
Emerg Med Australas 2011 Apr;23(2):123-41. Epub 2011 Apr 7 doi: 10.1111/j.1742-6723.2011.01398.x. PMID: 21489160

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