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Hypochloremic alkalosis

MedGen UID:
508763
•Concept ID:
C0151476
•
Disease or Syndrome
SNOMED CT: Hypochloremic alkalosis (70134007)

Professional guidelines

PubMed

Diagnosis and management of Bartter syndrome: executive summary of the consensus and recommendations from the European Rare Kidney Disease Reference Network Working Group for Tubular Disorders.
Konrad M, Nijenhuis T, Ariceta G, Bertholet-Thomas A, Calo LA, Capasso G, Emma F, Schlingmann KP, Singh M, Trepiccione F, Walsh SB, Whitton K, Vargas-Poussou R, Bockenhauer D
Kidney Int 2021 Feb;99(2):324-335. doi: 10.1016/j.kint.2020.10.035. PMID: 33509356
Pathophysiology of Diuretic Resistance and Its Implications for the Management of Chronic Heart Failure.
Wilcox CS, Testani JM, Pitt B
Hypertension 2020 Oct;76(4):1045-1054. Epub 2020 Aug 24 doi: 10.1161/HYPERTENSIONAHA.120.15205. PMID: 32829662Free PMC Article
Treatment of nausea and vomiting in pregnancy. When should it be treated and what can be safely taken?
Nelson-Piercy C
Drug Saf 1998 Aug;19(2):155-64. doi: 10.2165/00002018-199819020-00006. PMID: 9704251

Recent clinical studies

Etiology

Monogenic mutations in four cases of neonatal-onset watery diarrhea and a mutation review in East Asia.
Yan W, Xiao Y, Zhang Y, Tao Y, Cao Y, Liu K, Cai W, Wang Y
Orphanet J Rare Dis 2021 Sep 9;16(1):383. doi: 10.1186/s13023-021-01995-y. PMID: 34503561Free PMC Article
Insulin infusion responses in diabetic ketoacidosis alone and with a mixed hypochloremic alkalosis.
Gupta D, Prasad A, Siddiqui F, Sitaula S, Albert SG
Diabetes Metab Syndr 2019 Jan-Feb;13(1):216-221. Epub 2018 Aug 22 doi: 10.1016/j.dsx.2018.08.015. PMID: 30641700
Acidosis-Induced Hypochloremic Alkalosis in Diabetic Ketoacidosis Confirmed by The Modified Base Excess Method.
Yasuda K, Hayashi M, Murayama M, Yamakita N
J Clin Endocrinol Metab 2016 Jun;101(6):2390-5. Epub 2016 Apr 6 doi: 10.1210/jc.2016-1324. PMID: 27050945
Defining metabolic acidosis in patients with septic shock using Stewart approach.
Mallat J, Michel D, Salaun P, Thevenin D, Tronchon L
Am J Emerg Med 2012 Mar;30(3):391-8. Epub 2011 Jan 28 doi: 10.1016/j.ajem.2010.11.039. PMID: 21277142
Cerebral dysfunction following infantile dietary chloride deficiency.
Chutorian AM, LaScala CP, Ores CN, Nass R
Pediatr Neurol 1985 Nov-Dec;1(6):335-41. doi: 10.1016/0887-8994(85)90067-0. PMID: 3880419

Diagnosis

Gitelman syndrome with normocalciuria - a case report.
Flisiński M, Skalska E, Mączyńska B, Butt-Hussaim N, Sobczyńska-Tomaszewska A, Haus O, Manitius J
BMC Nephrol 2022 May 4;23(1):170. doi: 10.1186/s12882-022-02782-y. PMID: 35509038Free PMC Article
Acidosis-Induced Hypochloremic Alkalosis in Diabetic Ketoacidosis Confirmed by The Modified Base Excess Method.
Yasuda K, Hayashi M, Murayama M, Yamakita N
J Clin Endocrinol Metab 2016 Jun;101(6):2390-5. Epub 2016 Apr 6 doi: 10.1210/jc.2016-1324. PMID: 27050945
Atypical CF and CF related diseases.
Kerem E
Paediatr Respir Rev 2006;7 Suppl 1:S144-6. Epub 2006 Jun 5 doi: 10.1016/j.prrv.2006.04.219. PMID: 16798544
Neonatal Bartter syndrome.
Muranjan MN, Kantharia VC, Bavdekar SB, Kabde U, Parmar RC
Indian J Pediatr 2002 Jan;69(1):105-7. doi: 10.1007/BF02723788. PMID: 11876110
Bartter's syndrome.
Bartter FC
Urol Clin North Am 1977 Jun;4(2):253-61. PMID: 331616

Therapy

Insulin infusion responses in diabetic ketoacidosis alone and with a mixed hypochloremic alkalosis.
Gupta D, Prasad A, Siddiqui F, Sitaula S, Albert SG
Diabetes Metab Syndr 2019 Jan-Feb;13(1):216-221. Epub 2018 Aug 22 doi: 10.1016/j.dsx.2018.08.015. PMID: 30641700
Defining metabolic acidosis in patients with septic shock using Stewart approach.
Mallat J, Michel D, Salaun P, Thevenin D, Tronchon L
Am J Emerg Med 2012 Mar;30(3):391-8. Epub 2011 Jan 28 doi: 10.1016/j.ajem.2010.11.039. PMID: 21277142
Neonatal Bartter syndrome.
Muranjan MN, Kantharia VC, Bavdekar SB, Kabde U, Parmar RC
Indian J Pediatr 2002 Jan;69(1):105-7. doi: 10.1007/BF02723788. PMID: 11876110
Loop diuretic therapy in liver cirrhosis with ascites.
Laffi G, La Villa G, Carloni V, Foschi M, Bartoletti L, Quartini M, Gentilini P
J Cardiovasc Pharmacol 1993;22 Suppl 3:S51-8. doi: 10.1097/00005344-199322003-00007. PMID: 7506337
Bartter's syndrome.
Bartter FC
Urol Clin North Am 1977 Jun;4(2):253-61. PMID: 331616

Prognosis

Gitelman syndrome with normocalciuria - a case report.
Flisiński M, Skalska E, Mączyńska B, Butt-Hussaim N, Sobczyńska-Tomaszewska A, Haus O, Manitius J
BMC Nephrol 2022 May 4;23(1):170. doi: 10.1186/s12882-022-02782-y. PMID: 35509038Free PMC Article
Insulin infusion responses in diabetic ketoacidosis alone and with a mixed hypochloremic alkalosis.
Gupta D, Prasad A, Siddiqui F, Sitaula S, Albert SG
Diabetes Metab Syndr 2019 Jan-Feb;13(1):216-221. Epub 2018 Aug 22 doi: 10.1016/j.dsx.2018.08.015. PMID: 30641700
Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3.
McCormick JA, Yang CL, Zhang C, Davidge B, Blankenstein KI, Terker AS, Yarbrough B, Meermeier NP, Park HJ, McCully B, West M, Borschewski A, Himmerkus N, Bleich M, Bachmann S, Mutig K, Argaiz ER, Gamba G, Singer JD, Ellison DH
J Clin Invest 2014 Nov;124(11):4723-36. Epub 2014 Sep 24 doi: 10.1172/JCI76126. PMID: 25250572Free PMC Article
Defining metabolic acidosis in patients with septic shock using Stewart approach.
Mallat J, Michel D, Salaun P, Thevenin D, Tronchon L
Am J Emerg Med 2012 Mar;30(3):391-8. Epub 2011 Jan 28 doi: 10.1016/j.ajem.2010.11.039. PMID: 21277142
Neonatal Bartter syndrome.
Muranjan MN, Kantharia VC, Bavdekar SB, Kabde U, Parmar RC
Indian J Pediatr 2002 Jan;69(1):105-7. doi: 10.1007/BF02723788. PMID: 11876110

Clinical prediction guides

Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3.
McCormick JA, Yang CL, Zhang C, Davidge B, Blankenstein KI, Terker AS, Yarbrough B, Meermeier NP, Park HJ, McCully B, West M, Borschewski A, Himmerkus N, Bleich M, Bachmann S, Mutig K, Argaiz ER, Gamba G, Singer JD, Ellison DH
J Clin Invest 2014 Nov;124(11):4723-36. Epub 2014 Sep 24 doi: 10.1172/JCI76126. PMID: 25250572Free PMC Article
Defining metabolic acidosis in patients with septic shock using Stewart approach.
Mallat J, Michel D, Salaun P, Thevenin D, Tronchon L
Am J Emerg Med 2012 Mar;30(3):391-8. Epub 2011 Jan 28 doi: 10.1016/j.ajem.2010.11.039. PMID: 21277142
Clinical use of diuretics in congestive heart failure.
Hutcheon D, Vincent ME, Sandhu RS
J Clin Pharmacol 1981 Nov-Dec;21(11):668-72. doi: 10.1002/j.1552-4604.1981.tb05681.x. PMID: 7338577
Hypokaliemic, hypochloremic alkalosis in cushing's syndrome. Observations on the effects of treatment with potassium chloride and testosterone.
TEABEAUT R, ENGEL FL, TAYLOR H
J Clin Endocrinol Metab 1950 Apr;10(4):399-409. doi: 10.1210/jcem-10-4-399. PMID: 15415430

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