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Lichen simplex chronicus

MedGen UID:
57449
•Concept ID:
C0149922
•
Disease or Syndrome
Synonyms: Circumscribed Neurodermatitides; Circumscribed Neurodermatitis; Lichen Simplex Chronicus; Localized Neurodermatitides; Localized Neurodermatitis; Neurodermatitides, Circumscribed; Neurodermatitides, Localized; Neurodermatitis, Circumscribed; Neurodermatitis, Localized
SNOMED CT: Lichenoid dermatitis (53891004); Lichen simplex (53891004); LSC - Lichen simplex chronicus (53891004); Circumscribed neurodermatitis (53891004); Lichen simplex chronicus (53891004); Neurodermatitis circumscripta (53891004); Local neurodermatitis (53891004)

Professional guidelines

PubMed

Pruritus in Dermatology: Part 2 - Diseases and Their Treatment.
Navarro-Triviño FJ
Actas Dermosifiliogr 2023 Jul-Aug;114(7):613-626. Epub 2023 Mar 31 doi: 10.1016/j.ad.2023.03.004. PMID: 37003460
Meet the expert: Topical management of vulvar dermatoses.
Jakuboski SH, Noor SJ
J Geriatr Oncol 2022 Apr;13(3):282-286. Epub 2021 Nov 22 doi: 10.1016/j.jgo.2021.10.011. PMID: 34824022
Diagnosis and Management of Vulvar Skin Disorders: ACOG Practice Bulletin, Number 224.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2020 Jul;136(1):e1-e14. doi: 10.1097/AOG.0000000000003944. PMID: 32590724

Recent clinical studies

Etiology

HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva.
Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
DEVIL, VAAD and vLSC constitute a spectrum of HPV-independent, p53-independent intra-epithelial neoplasia of the vulva.
Roy SF, Wong J, Le Page C, Tran-Thanh D, Barkati M, Pina A, Trinh VQ, Rahimi K
Histopathology 2021 Dec;79(6):975-988. Epub 2021 Sep 20 doi: 10.1111/his.14451. PMID: 34265101
Putative precancerous lesions of vulvar squamous cell carcinoma.
Jenkins TM, Mills AM
Semin Diagn Pathol 2021 Jan;38(1):27-36. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.006. PMID: 32948383
The role of capsaicin in dermatology.
Boyd K, Shea SM, Patterson JW
Prog Drug Res 2014;68:293-306. doi: 10.1007/978-3-0348-0828-6_12. PMID: 24941674
Dermacase. Lichen simplex chronicus.
Prajapati V, Barankin B
Can Fam Physician 2008 Oct;54(10):1391-3. PMID: 18854464Free PMC Article

Diagnosis

Lichen Simplex Chronicus Itch: An Update.
Ju T, Vander Does A, Mohsin N, Yosipovitch G
Acta Derm Venereol 2022 Oct 19;102:adv00796. doi: 10.2340/actadv.v102.4367. PMID: 36250769Free PMC Article
HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva.
Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
Diagnosis and Management of Vulvar Skin Disorders: ACOG Practice Bulletin, Number 224.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2020 Jul;136(1):e1-e14. doi: 10.1097/AOG.0000000000003944. PMID: 32590724
Vulvar Pruritus and Lichen Simplex Chronicus.
Chibnall R
Obstet Gynecol Clin North Am 2017 Sep;44(3):379-388. doi: 10.1016/j.ogc.2017.04.003. PMID: 28778638
Vulvar dermatosis.
Moyal-Barracco M, Wendling J
Best Pract Res Clin Obstet Gynaecol 2014 Oct;28(7):946-58. Epub 2014 Jul 18 doi: 10.1016/j.bpobgyn.2014.07.005. PMID: 25132276

Therapy

Vulvovaginal Issues in Mature Women.
Marnach ML, Torgerson RR
Mayo Clin Proc 2017 Mar;92(3):449-454. doi: 10.1016/j.mayocp.2016.10.031. PMID: 28259230
Inflammatory Vulvar Dermatoses.
Guerrero A, Venkatesan A
Clin Obstet Gynecol 2015 Sep;58(3):464-75. doi: 10.1097/GRF.0000000000000125. PMID: 26125955
The role of capsaicin in dermatology.
Boyd K, Shea SM, Patterson JW
Prog Drug Res 2014;68:293-306. doi: 10.1007/978-3-0348-0828-6_12. PMID: 24941674
Dermacase. Lichen simplex chronicus.
Prajapati V, Barankin B
Can Fam Physician 2008 Oct;54(10):1391-3. PMID: 18854464Free PMC Article
The skin and the mind.
Chuh A, Wong W, Zawar V
Aust Fam Physician 2006 Sep;35(9):723-5. PMID: 16969446

Prognosis

Putative precancerous lesions of vulvar squamous cell carcinoma.
Jenkins TM, Mills AM
Semin Diagn Pathol 2021 Jan;38(1):27-36. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.006. PMID: 32948383
Common and critical inflammatory dermatoses every pathologist should know.
Billings SD
Mod Pathol 2020 Jan;33(Suppl 1):107-117. Epub 2019 Nov 1 doi: 10.1038/s41379-019-0400-z. PMID: 31676787
Skin diseases of the vulva: eczematous diseases and contact urticaria.
Sand FL, Thomsen SF
J Obstet Gynaecol 2018 Apr;38(3):295-300. Epub 2017 Aug 7 doi: 10.1080/01443615.2017.1329283. PMID: 28780897
Vulvar dermatosis.
Moyal-Barracco M, Wendling J
Best Pract Res Clin Obstet Gynaecol 2014 Oct;28(7):946-58. Epub 2014 Jul 18 doi: 10.1016/j.bpobgyn.2014.07.005. PMID: 25132276
An approach to the treatment of anogenital pruritus.
Weichert GE
Dermatol Ther 2004;17(1):129-33. doi: 10.1111/j.1396-0296.2004.04013.x. PMID: 14756897

Clinical prediction guides

The Effect of the COVID-19 Pandemic on Stress-related Dermatologic Diseases.
Ustaoglu E
Acta Dermatovenerol Croat 2022 Nov;30(3):157-162. PMID: 36812273
Non-venereal genital dermatoses and their impact on quality of life-A cross-sectional study.
Vinay N, Ranugha PSS, Betkerur JB, Shastry V, Ashwini PK
Indian J Dermatol Venereol Leprol 2022 May-Jun;88(3):354-359. doi: 10.25259/IJDVL_329_18. PMID: 33871197
More than a skin disease: stress, depression, anxiety levels, and serum neurotrophins in lichen simplex chronicus.
Altunay İK, Özkur E, Uğurer E, Baltan E, Aydın Ç, Serin E
An Bras Dermatol 2021 Nov-Dec;96(6):700-705. Epub 2021 Oct 4 doi: 10.1016/j.abd.2021.04.011. PMID: 34620525Free PMC Article
DEVIL, VAAD and vLSC constitute a spectrum of HPV-independent, p53-independent intra-epithelial neoplasia of the vulva.
Roy SF, Wong J, Le Page C, Tran-Thanh D, Barkati M, Pina A, Trinh VQ, Rahimi K
Histopathology 2021 Dec;79(6):975-988. Epub 2021 Sep 20 doi: 10.1111/his.14451. PMID: 34265101
Common and critical inflammatory dermatoses every pathologist should know.
Billings SD
Mod Pathol 2020 Jan;33(Suppl 1):107-117. Epub 2019 Nov 1 doi: 10.1038/s41379-019-0400-z. PMID: 31676787

Recent systematic reviews

Psychopathology Associated with Chronic Pruritus: A Systematic Review.
Ferreira BR, Misery L
Acta Derm Venereol 2023 Aug 22;103:adv8488. doi: 10.2340/actadv.v103.8488. PMID: 37606153Free PMC Article
A systematic review of evidence based treatments for lichen simplex chronicus.
Juarez MC, Kwatra SG
J Dermatolog Treat 2021 Nov;32(7):684-692. Epub 2020 Mar 6 doi: 10.1080/09546634.2019.1708856. PMID: 31884840

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