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Epididymo-orchitis

MedGen UID:
508448
•Concept ID:
C0149881
•
Disease or Syndrome
Synonyms: epididymo-orchitis; Inflammation of testis and epididymis; Orchitis and epididymitis
SNOMED CT: Epididymo-orchitis (197983000); Orchitis and epididymitis (197983000); Inflammation of testis and epididymis (197983000)
 
Monarch Initiative: MONDO:0004778

Definition

A disorder involving inflammation of the epididymis and testes. [from MONDO]

Professional guidelines

PubMed

Clinical spectrum and management options for prostatic utricle in children.
Gupta A, Khosa J, Barker A, Samnakay N
J Pediatr Surg 2022 Nov;57(11):690-695. Epub 2022 Jan 19 doi: 10.1016/j.jpedsurg.2022.01.013. PMID: 35101262
The 2016 European guideline on the management of epididymo-orchitis.
Street EJ, Justice ED, Kopa Z, Portman MD, Ross JD, Skerlev M, Wilson JD, Patel R
Int J STD AIDS 2017 Jul;28(8):744-749. Epub 2017 Mar 22 doi: 10.1177/0956462417699356. PMID: 28632112
The aetiology and current management of prepubertal epididymitis.
Gkentzis A, Lee L
Ann R Coll Surg Engl 2014 Apr;96(3):181-3. doi: 10.1308/003588414X13814021679311. PMID: 24780779Free PMC Article

Recent clinical studies

Etiology

Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): an open-label, parallel-group, randomised controlled trial.
Taheri S, Zaghloul H, Chagoury O, Elhadad S, Ahmed SH, El Khatib N, Amona RA, El Nahas K, Suleiman N, Alnaama A, Al-Hamaq A, Charlson M, Wells MT, Al-Abdulla S, Abou-Samra AB
Lancet Diabetes Endocrinol 2020 Jun;8(6):477-489. doi: 10.1016/S2213-8587(20)30117-0. PMID: 32445735
Candida urinary tract infections in adults.
Odabasi Z, Mert A
World J Urol 2020 Nov;38(11):2699-2707. Epub 2019 Oct 25 doi: 10.1007/s00345-019-02991-5. PMID: 31654220
Brucellar epididymo-orchitis: a retrospective multicenter study of 28 cases and review of the literature.
Savasci U, Zor M, Karakas A, Aydin E, Kocaaslan R, Oren NC, Coskun O, Turhan V, Gul HC, Cicek AF, Aydur E, Eyigun CP
Travel Med Infect Dis 2014 Nov-Dec;12(6 Pt A):667-72. Epub 2014 Oct 25 doi: 10.1016/j.tmaid.2014.10.005. PMID: 25457303
Ultrasound of the scrotum.
Akin EA, Khati NJ, Hill MC
Ultrasound Q 2004 Dec;20(4):181-200. doi: 10.1097/00013644-200412000-00004. PMID: 15602220
Acute painful scrotum.
Dogra V, Bhatt S
Radiol Clin North Am 2004 Mar;42(2):349-63. doi: 10.1016/j.rcl.2003.12.002. PMID: 15136021

Diagnosis

Brucella epididymo-orchitis: A single-center experience with a review of the literature.
Bapir R, Abdalqadir AM, Aghaways E, Bayz HH, Abdullah HO, Ahmed SF, Abdalla BA, Hama JI, Muhammed BO, Hamahussein KF, Faraj FM, Kakamad FH
Arch Ital Urol Androl 2023 Dec 28;95(4):11978. doi: 10.4081/aiua.2023.11978. PMID: 38193225
Functional Imaging of Testicular Torsion.
Siraj QH
Semin Nucl Med 2023 Nov;53(6):797-808. Epub 2023 May 18 doi: 10.1053/j.semnuclmed.2023.04.005. PMID: 37210316
Candida urinary tract infections in adults.
Odabasi Z, Mert A
World J Urol 2020 Nov;38(11):2699-2707. Epub 2019 Oct 25 doi: 10.1007/s00345-019-02991-5. PMID: 31654220
Mycoplasma genitalium Infection in Men.
Horner PJ, Martin DH
J Infect Dis 2017 Jul 15;216(suppl_2):S396-S405. doi: 10.1093/infdis/jix145. PMID: 28838074Free PMC Article
Inferno sign in epididymo-orchitis.
Fonseca EKUN, Tomazoni D, Enge Júnior DJ, do Amaral E Castro A
Abdom Radiol (NY) 2017 Dec;42(12):2955-2956. doi: 10.1007/s00261-017-1222-4. PMID: 28647767

Therapy

Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): an open-label, parallel-group, randomised controlled trial.
Taheri S, Zaghloul H, Chagoury O, Elhadad S, Ahmed SH, El Khatib N, Amona RA, El Nahas K, Suleiman N, Alnaama A, Al-Hamaq A, Charlson M, Wells MT, Al-Abdulla S, Abou-Samra AB
Lancet Diabetes Endocrinol 2020 Jun;8(6):477-489. doi: 10.1016/S2213-8587(20)30117-0. PMID: 32445735
Candida urinary tract infections in adults.
Odabasi Z, Mert A
World J Urol 2020 Nov;38(11):2699-2707. Epub 2019 Oct 25 doi: 10.1007/s00345-019-02991-5. PMID: 31654220
Atypical testicular pain.
Bedi N, Rahimi MNC, Menzies S, Kalsi J
BMJ Case Rep 2019 Feb 19;12(2) doi: 10.1136/bcr-2018-226697. PMID: 30787023Free PMC Article
Multiparametric US for scrotal diseases.
Bertolotto M, Muça M, Currò F, Bucci S, Rocher L, Cova MA
Abdom Radiol (NY) 2018 Apr;43(4):899-917. doi: 10.1007/s00261-018-1510-7. PMID: 29460046
Mycoplasma genitalium Infection in Men.
Horner PJ, Martin DH
J Infect Dis 2017 Jul 15;216(suppl_2):S396-S405. doi: 10.1093/infdis/jix145. PMID: 28838074Free PMC Article

Prognosis

Is there any association of COVID-19 with testicular pain and epididymo-orchitis?
Ediz C, Tavukcu HH, Akan S, Kizilkan YE, Alcin A, Oz K, Yilmaz O
Int J Clin Pract 2021 Mar;75(3):e13753. Epub 2020 Nov 9 doi: 10.1111/ijcp.13753. PMID: 33063899Free PMC Article
Salmonella epididymo-orchitis presenting as acute scrotum in a 2-week-old infant.
Ngoo A, Rodriguez-Acevedo O, Carroll D, Stalewski H, Mariyappa Rathnamma B
J Paediatr Child Health 2019 Apr;55(4):468-471. Epub 2018 Nov 8 doi: 10.1111/jpc.14295. PMID: 30407675
Epididymo-Orchitis in Bechet's Disease: A Review of the Wide Spectrum of the Disease.
Kanakis MA, Vaiopoulos AG, Vaiopoulos GA, Kaklamanis PG
Acta Med Iran 2017 Aug;55(8):482-485. PMID: 29034643
Antegrade scrotal sclerotherapy and varicocele.
Ficarra V, Sarti A, Novara G, Artibani W
Asian J Androl 2002 Sep;4(3):221-4. PMID: 12364980
Tuberculous epididymo-orchitis.
Koyama Y, Iigaya T, Saito S
Urology 1988 May;31(5):419-21. doi: 10.1016/0090-4295(88)90739-x. PMID: 3284153

Clinical prediction guides

Is there any association of COVID-19 with testicular pain and epididymo-orchitis?
Ediz C, Tavukcu HH, Akan S, Kizilkan YE, Alcin A, Oz K, Yilmaz O
Int J Clin Pract 2021 Mar;75(3):e13753. Epub 2020 Nov 9 doi: 10.1111/ijcp.13753. PMID: 33063899Free PMC Article
Infectious, inflammatory and 'autoimmune' male factor infertility: how do rodent models inform clinical practice?
Fijak M, Pilatz A, Hedger MP, Nicolas N, Bhushan S, Michel V, Tung KSK, Schuppe HC, Meinhardt A
Hum Reprod Update 2018 Jul 1;24(4):416-441. doi: 10.1093/humupd/dmy009. PMID: 29648649Free PMC Article
Ultrasound of the male genital tract in relation to male reproductive health.
Lotti F, Maggi M
Hum Reprod Update 2015 Jan-Feb;21(1):56-83. Epub 2014 Jul 19 doi: 10.1093/humupd/dmu042. PMID: 25038770
Chronic orchitis: a neglected cause of male infertility?
Schuppe HC, Meinhardt A, Allam JP, Bergmann M, Weidner W, Haidl G
Andrologia 2008 Apr;40(2):84-91. doi: 10.1111/j.1439-0272.2008.00837.x. PMID: 18336456
Antegrade scrotal sclerotherapy and varicocele.
Ficarra V, Sarti A, Novara G, Artibani W
Asian J Androl 2002 Sep;4(3):221-4. PMID: 12364980

Recent systematic reviews

Robotic-assisted pull-through procedures for anorectal malformation: a systematic review.
Sharma S, Geetha V
Pediatr Surg Int 2024 Jul 16;40(1):194. doi: 10.1007/s00383-024-05782-1. PMID: 39014174
Impact of Sexual Activity on the Risk of Male Genital Tumors: A Systematic Review of the Literature.
Crocetto F, Arcaniolo D, Napolitano L, Barone B, La Rocca R, Capece M, Caputo VF, Imbimbo C, De Sio M, Calace FP, Manfredi C
Int J Environ Res Public Health 2021 Aug 11;18(16) doi: 10.3390/ijerph18168500. PMID: 34444249Free PMC Article
Predictive value of haematologic parameters in diagnosis of testicular torsion: Evidence from a systematic review and meta-analysis.
Zhu J, Song Y, Chen G, Hu R, Ou N, Zhang W, Liang Z, Liu X
Andrologia 2020 Mar;52(2):e13490. Epub 2019 Nov 28 doi: 10.1111/and.13490. PMID: 31782182
Ultrasound of the male genital tract in relation to male reproductive health.
Lotti F, Maggi M
Hum Reprod Update 2015 Jan-Feb;21(1):56-83. Epub 2014 Jul 19 doi: 10.1093/humupd/dmu042. PMID: 25038770
Clinical manifestations of human brucellosis: a systematic review and meta-analysis.
Dean AS, Crump L, Greter H, Hattendorf J, Schelling E, Zinsstag J
PLoS Negl Trop Dis 2012;6(12):e1929. Epub 2012 Dec 6 doi: 10.1371/journal.pntd.0001929. PMID: 23236528Free PMC Article

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