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Sicca syndrome

MedGen UID:
39529
•Concept ID:
C0086981
•
Disease or Syndrome
Synonyms: Sicca Syndrome; Syndrome, Sicca
SNOMED CT: Sicca syndrome (83901003)
 
OMIM®: 270150

Definition

A constellation of symptoms that include abnormal dryness of the mouth, eyes and other mucous membranes. The condition is seen in patients with Sjogren syndrome, sarcoidosis, amyloidosis, and deficiencies of vitamins A and C. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSicca syndrome

Professional guidelines

PubMed

Treatment of Primary Biliary Cholangitis including Transplantation.
Muzahim Y, Wakil A, Bassi M, Pyrsopoulos N
Clin Liver Dis 2024 Feb;28(1):103-114. Epub 2023 Aug 26 doi: 10.1016/j.cld.2023.07.003. PMID: 37945152
Treatment of rheumatic adverse events of cancer immunotherapy.
Reid P, Cappelli LC
Best Pract Res Clin Rheumatol 2022 Dec;36(4):101805. Epub 2022 Dec 18 doi: 10.1016/j.berh.2022.101805. PMID: 36539321Free PMC Article
A Clinical Review of Primary Biliary Cholangitis.
Pullen R
Gastroenterol Nurs 2020 Mar/Apr;43(2):E48-E55. doi: 10.1097/SGA.0000000000000480. PMID: 32251226

Recent clinical studies

Etiology

Causal association between common rheumatic diseases and glaucoma: a Mendelian randomization study.
Meng Y, Tan Z, Su Y, Li L, Chen C
Front Immunol 2023;14:1227138. Epub 2023 Sep 19 doi: 10.3389/fimmu.2023.1227138. PMID: 37799717Free PMC Article
The Involvement of Alarmins in the Pathogenesis of Sjögren's Syndrome.
Sarrand J, Baglione L, Parisis D, Soyfoo M
Int J Mol Sci 2022 May 18;23(10) doi: 10.3390/ijms23105671. PMID: 35628481Free PMC Article
Management of rheumatic complications of immune checkpoint inhibitor therapy - an oncological perspective.
Steven NM, Fisher BA
Rheumatology (Oxford) 2019 Dec 1;58(Suppl 7):vii29-vii39. doi: 10.1093/rheumatology/kez536. PMID: 31816079Free PMC Article
HCV-Related Rheumatic Manifestations and Therapeutic Strategies.
Sebastiani M, Giuggioli D, Colaci M, Fallahi P, Gragnani L, Antonelli A, Zignego AL, Ferri C
Curr Drug Targets 2017;18(7):803-810. doi: 10.2174/1389450116666150907103622. PMID: 26343108
Primary Sjögren's syndrome.
Rischmueller M, Tieu J, Lester S
Best Pract Res Clin Rheumatol 2016 Feb;30(1):189-220. Epub 2016 May 13 doi: 10.1016/j.berh.2016.04.003. PMID: 27421224

Diagnosis

Immune Checkpoint Inhibitor-induced Sicca Syndrome.
Bitoun S, Rousseau A, Gosset M, Belkhir R, Lazure T, Mariette X, Nocturne G
Rheum Dis Clin North Am 2024 May;50(2):291-300. doi: 10.1016/j.rdc.2024.02.004. PMID: 38670727
Non-primary Sjogren's Syndrome: Secondary or associated?
Felten R, Meyer A, Gottenberg JE
Joint Bone Spine 2023 Mar;90(2):105502. Epub 2022 Dec 1 doi: 10.1016/j.jbspin.2022.105502. PMID: 36464213
Pulmonary involvement in Sjögren's syndrome.
Mestre-Torres J, Solans-Laque R
Med Clin (Barc) 2022 Feb 25;158(4):181-185. Epub 2021 Aug 13 doi: 10.1016/j.medcli.2021.06.016. PMID: 34392987
HCV-Related Rheumatic Manifestations and Therapeutic Strategies.
Sebastiani M, Giuggioli D, Colaci M, Fallahi P, Gragnani L, Antonelli A, Zignego AL, Ferri C
Curr Drug Targets 2017;18(7):803-810. doi: 10.2174/1389450116666150907103622. PMID: 26343108
Primary Sjögren's syndrome.
Rischmueller M, Tieu J, Lester S
Best Pract Res Clin Rheumatol 2016 Feb;30(1):189-220. Epub 2016 May 13 doi: 10.1016/j.berh.2016.04.003. PMID: 27421224

Therapy

Immune Checkpoint Inhibitor-induced Sicca Syndrome.
Bitoun S, Rousseau A, Gosset M, Belkhir R, Lazure T, Mariette X, Nocturne G
Rheum Dis Clin North Am 2024 May;50(2):291-300. doi: 10.1016/j.rdc.2024.02.004. PMID: 38670727
New Therapies on the Horizon for Primary Biliary Cholangitis.
Tanaka A
Drugs 2024 Jan;84(1):1-15. Epub 2023 Dec 12 doi: 10.1007/s40265-023-01979-1. PMID: 38082142
Treatment of Primary Biliary Cholangitis including Transplantation.
Muzahim Y, Wakil A, Bassi M, Pyrsopoulos N
Clin Liver Dis 2024 Feb;28(1):103-114. Epub 2023 Aug 26 doi: 10.1016/j.cld.2023.07.003. PMID: 37945152
Sicca syndrome associated with immune checkpoint inhibitor therapy.
Harris JA, Huang K, Miloslavsky E, Hanna GJ
Oral Dis 2022 Nov;28(8):2083-2092. Epub 2021 Aug 17 doi: 10.1111/odi.14000. PMID: 34379884
HCV-Related Rheumatic Manifestations and Therapeutic Strategies.
Sebastiani M, Giuggioli D, Colaci M, Fallahi P, Gragnani L, Antonelli A, Zignego AL, Ferri C
Curr Drug Targets 2017;18(7):803-810. doi: 10.2174/1389450116666150907103622. PMID: 26343108

Prognosis

Pulmonary involvement in Sjögren's syndrome.
Mestre-Torres J, Solans-Laque R
Med Clin (Barc) 2022 Feb 25;158(4):181-185. Epub 2021 Aug 13 doi: 10.1016/j.medcli.2021.06.016. PMID: 34392987
Minor salivary gland biopsy: Its role in the classification and prognosis of Sjögren's syndrome.
Bautista-Vargas M, Vivas AJ, Tobón GJ
Autoimmun Rev 2020 Dec;19(12):102690. Epub 2020 Oct 22 doi: 10.1016/j.autrev.2020.102690. PMID: 33099041
Corneal and scleral involvement in inflammatory rheumatic disease: Rheumatologists and ophthalmologists exchanging views.
Clavel G, Gabison E, Semerano L
Joint Bone Spine 2019 Nov;86(6):699-705. Epub 2019 Feb 1 doi: 10.1016/j.jbspin.2019.01.014. PMID: 30711694
Hepatitis C cure with antiviral therapy--benefits beyond the liver.
Soriano V, Labarga P, Fernandez-Montero JV, de Mendoza C, Esposito I, Benítez-Gutiérrez L, Barreiro P
Antivir Ther 2016;21(1):1-8. Epub 2015 Jun 25 doi: 10.3851/IMP2975. PMID: 26110692
Sjogren's syndrome is associated with and not secondary to systemic sclerosis.
Salliot C, Mouthon L, Ardizzone M, Sibilia J, Guillevin L, Gottenberg JE, Mariette X
Rheumatology (Oxford) 2007 Feb;46(2):321-6. Epub 2006 Jul 28 doi: 10.1093/rheumatology/kel252. PMID: 16877466

Clinical prediction guides

Causal association between common rheumatic diseases and glaucoma: a Mendelian randomization study.
Meng Y, Tan Z, Su Y, Li L, Chen C
Front Immunol 2023;14:1227138. Epub 2023 Sep 19 doi: 10.3389/fimmu.2023.1227138. PMID: 37799717Free PMC Article
Not all autoantibodies are clinically relevant. Classic and novel autoantibodies in Sjögren's syndrome: A critical review.
Vílchez-Oya F, Balastegui Martin H, García-Martínez E, Corominas H
Front Immunol 2022;13:1003054. Epub 2022 Oct 17 doi: 10.3389/fimmu.2022.1003054. PMID: 36325321Free PMC Article
Clinical characteristics of rheumatic syndromes associated with checkpoint inhibitors therapy.
Kostine M, Truchetet ME, Schaeverbeke T
Rheumatology (Oxford) 2019 Dec 1;58(Suppl 7):vii68-vii74. doi: 10.1093/rheumatology/kez295. PMID: 31816082Free PMC Article
The diffuse infiltrative lymphocytosis syndrome (DILS). A comprehensive review.
Ghrenassia E, Martis N, Boyer J, Burel-Vandenbos F, Mekinian A, Coppo P
J Autoimmun 2015 May;59:19-25. Epub 2015 Feb 7 doi: 10.1016/j.jaut.2015.01.010. PMID: 25660200
The pathogenesis of systemic sclerosis revisited.
Geyer M, Müller-Ladner U
Clin Rev Allergy Immunol 2011 Apr;40(2):92-103. doi: 10.1007/s12016-009-8193-3. PMID: 20087791

Recent systematic reviews

The association between primary Sjogren's syndrome and non-Hodgkin's lymphoma: a systematic review and meta-analysis of cohort studies.
Ansari N, Salesi M
Clin Rheumatol 2024 Jul;43(7):2177-2186. Epub 2024 May 9 doi: 10.1007/s10067-024-06993-6. PMID: 38722505
Systematic review to estimate the prevalence of inflammatory rheumatic diseases in Germany.
Albrecht K, Binder S, Minden K, Poddubnyy D, Regierer AC, Strangfeld A, Callhoff J
Z Rheumatol 2024 Feb;83(Suppl 1):20-30. Epub 2023 Feb 7 doi: 10.1007/s00393-022-01302-5. PMID: 36749363Free PMC Article
TAFRO syndrome: A severe manifestation of Sjogren's syndrome? A systematic review.
Grange L, Chalayer E, Boutboul D, Paul S, Galicier L, Gramont B, Killian M
Autoimmun Rev 2022 Aug;21(8):103137. Epub 2022 Jul 6 doi: 10.1016/j.autrev.2022.103137. PMID: 35803499
Diagnostic performance of serology against histologic assessment to diagnose Sjogren's syndrome: a systematic review.
Viegas-Costa LC, Friesen R, Flores-Mir C, McGaw T
Clin Rheumatol 2021 Dec;40(12):4817-4828. Epub 2021 Jun 17 doi: 10.1007/s10067-021-05813-5. PMID: 34142295
Unstimulated whole salivary flow in Sjögren's Syndrome: systematic literature review and meta-analysis.
Martínez-Ceballos MA, Aguilera N, Garzón-González KC, Cajamarca-Baron J, Alzate-Granados JP, Rojas-Villarraga A
Adv Rheumatol 2021 Feb 3;61(1):8. doi: 10.1186/s42358-020-00158-0. PMID: 33536075

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