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Hypogammaglobulinemia

MedGen UID:
88568
•Concept ID:
C0086438
•
Disease or Syndrome
Synonym: Hypogammaglobulinemias
SNOMED CT: Hypogammaglobulinemia (119250001)

Definition

Decreased concentration of the gamma fraction of serum globulin [from SNOMEDCT_US]

Professional guidelines

PubMed

Monitoring, prophylaxis, and treatment of infections in patients with MM receiving bispecific antibody therapy: consensus recommendations from an expert panel.
Raje N, Anderson K, Einsele H, Efebera Y, Gay F, Hammond SP, Lesokhin AM, Lonial S, Ludwig H, Moreau P, Patel K, Ramasamy K, Mateos MV
Blood Cancer J 2023 Aug 1;13(1):116. doi: 10.1038/s41408-023-00879-7. PMID: 37528088Free PMC Article
Practical guidance for the diagnosis and management of secondary hypogammaglobulinemia: A Work Group Report of the AAAAI Primary Immunodeficiency and Altered Immune Response Committees.
Otani IM, Lehman HK, Jongco AM, Tsao LR, Azar AE, Tarrant TK, Engel E, Walter JE, Truong TQ, Khan DA, Ballow M, Cunningham-Rundles C, Lu H, Kwan M, Barmettler S
J Allergy Clin Immunol 2022 May;149(5):1525-1560. Epub 2022 Feb 14 doi: 10.1016/j.jaci.2022.01.025. PMID: 35176351
Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical Manifestations, Diagnosis, Classification, and Management.
Yazdani R, Habibi S, Sharifi L, Azizi G, Abolhassani H, Olbrich P, Aghamohammadi A
J Investig Allergol Clin Immunol 2020;30(1):14-34. Epub 2019 Feb 11 doi: 10.18176/jiaci.0388. PMID: 30741636

Recent clinical studies

Etiology

Nephrotic syndrome: pathophysiology and consequences.
Claudio P, Gabriella M
J Nephrol 2023 Nov;36(8):2179-2190. Epub 2023 Jul 19 doi: 10.1007/s40620-023-01697-7. PMID: 37466816
Hypogammaglobulinemia, late-onset neutropenia, and infections following rituximab.
Athni TS, Barmettler S
Ann Allergy Asthma Immunol 2023 Jun;130(6):699-712. Epub 2023 Jan 24 doi: 10.1016/j.anai.2023.01.018. PMID: 36706910Free PMC Article
Use of Rituximab in Childhood Idiopathic Nephrotic Syndrome.
Chan EY, Yap DY, Colucci M, Ma AL, Parekh RS, Tullus K
Clin J Am Soc Nephrol 2023 Apr 1;18(4):533-548. Epub 2023 Feb 22 doi: 10.2215/CJN.08570722. PMID: 36456193Free PMC Article
Toxicities following CAR-T therapy for hematological malignancies.
Hernani R, Benzaquén A, Solano C
Cancer Treat Rev 2022 Dec;111:102479. Epub 2022 Oct 22 doi: 10.1016/j.ctrv.2022.102479. PMID: 36308910
Practical guidance for the diagnosis and management of secondary hypogammaglobulinemia: A Work Group Report of the AAAAI Primary Immunodeficiency and Altered Immune Response Committees.
Otani IM, Lehman HK, Jongco AM, Tsao LR, Azar AE, Tarrant TK, Engel E, Walter JE, Truong TQ, Khan DA, Ballow M, Cunningham-Rundles C, Lu H, Kwan M, Barmettler S
J Allergy Clin Immunol 2022 May;149(5):1525-1560. Epub 2022 Feb 14 doi: 10.1016/j.jaci.2022.01.025. PMID: 35176351

Diagnosis

Common Variable Immunodeficiency.
Remiker A, Bolling K, Verbsky J
Med Clin North Am 2024 Jan;108(1):107-121. Epub 2023 Jul 21 doi: 10.1016/j.mcna.2023.06.012. PMID: 37951645
Practical guidance for the diagnosis and management of secondary hypogammaglobulinemia: A Work Group Report of the AAAAI Primary Immunodeficiency and Altered Immune Response Committees.
Otani IM, Lehman HK, Jongco AM, Tsao LR, Azar AE, Tarrant TK, Engel E, Walter JE, Truong TQ, Khan DA, Ballow M, Cunningham-Rundles C, Lu H, Kwan M, Barmettler S
J Allergy Clin Immunol 2022 May;149(5):1525-1560. Epub 2022 Feb 14 doi: 10.1016/j.jaci.2022.01.025. PMID: 35176351
Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical Manifestations, Diagnosis, Classification, and Management.
Yazdani R, Habibi S, Sharifi L, Azizi G, Abolhassani H, Olbrich P, Aghamohammadi A
J Investig Allergol Clin Immunol 2020;30(1):14-34. Epub 2019 Feb 11 doi: 10.18176/jiaci.0388. PMID: 30741636
Association of Immunoglobulin Levels, Infectious Risk, and Mortality With Rituximab and Hypogammaglobulinemia.
Barmettler S, Ong MS, Farmer JR, Choi H, Walter J
JAMA Netw Open 2018 Nov 2;1(7):e184169. doi: 10.1001/jamanetworkopen.2018.4169. PMID: 30646343Free PMC Article
X-linked Agammaglobulinemia.
Suri D, Rawat A, Singh S
Indian J Pediatr 2016 Apr;83(4):331-7. Epub 2016 Feb 24 doi: 10.1007/s12098-015-2024-8. PMID: 26909497

Therapy

Bispecific antibody therapies.
de Assis LH, Fassi DE, Hutchings M
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):216-222. doi: 10.1182/hematology.2023000508. PMID: 38066890Free PMC Article
Hypogammaglobulinemia, late-onset neutropenia, and infections following rituximab.
Athni TS, Barmettler S
Ann Allergy Asthma Immunol 2023 Jun;130(6):699-712. Epub 2023 Jan 24 doi: 10.1016/j.anai.2023.01.018. PMID: 36706910Free PMC Article
Use of Rituximab in Childhood Idiopathic Nephrotic Syndrome.
Chan EY, Yap DY, Colucci M, Ma AL, Parekh RS, Tullus K
Clin J Am Soc Nephrol 2023 Apr 1;18(4):533-548. Epub 2023 Feb 22 doi: 10.2215/CJN.08570722. PMID: 36456193Free PMC Article
Toxicities following CAR-T therapy for hematological malignancies.
Hernani R, Benzaquén A, Solano C
Cancer Treat Rev 2022 Dec;111:102479. Epub 2022 Oct 22 doi: 10.1016/j.ctrv.2022.102479. PMID: 36308910
Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical Manifestations, Diagnosis, Classification, and Management.
Yazdani R, Habibi S, Sharifi L, Azizi G, Abolhassani H, Olbrich P, Aghamohammadi A
J Investig Allergol Clin Immunol 2020;30(1):14-34. Epub 2019 Feb 11 doi: 10.18176/jiaci.0388. PMID: 30741636

Prognosis

Incidence, timing, and management of infections in patients receiving teclistamab for the treatment of relapsed/refractory multiple myeloma in the MajesTEC-1 study.
Nooka AK, Rodriguez C, Mateos MV, Manier S, Chastain K, Banerjee A, Kobos R, Qi K, Verona R, Doyle M, Martin TG, van de Donk NWCJ
Cancer 2024 Mar 15;130(6):886-900. Epub 2023 Nov 14 doi: 10.1002/cncr.35107. PMID: 37960969
Use of Rituximab in Childhood Idiopathic Nephrotic Syndrome.
Chan EY, Yap DY, Colucci M, Ma AL, Parekh RS, Tullus K
Clin J Am Soc Nephrol 2023 Apr 1;18(4):533-548. Epub 2023 Feb 22 doi: 10.2215/CJN.08570722. PMID: 36456193Free PMC Article
Long-Term Follow-Up of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy.
Cappell KM, Sherry RM, Yang JC, Goff SL, Vanasse DA, McIntyre L, Rosenberg SA, Kochenderfer JN
J Clin Oncol 2020 Nov 10;38(32):3805-3815. Epub 2020 Oct 6 doi: 10.1200/JCO.20.01467. PMID: 33021872Free PMC Article
Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children.
Minard-Colin V, Aupérin A, Pillon M, Burke GAA, Barkauskas DA, Wheatley K, Delgado RF, Alexander S, Uyttebroeck A, Bollard CM, Zsiros J, Csoka M, Kazanowska B, Chiang AK, Miles RR, Wotherspoon A, Adamson PC, Vassal G, Patte C, Gross TG; European Intergroup for Childhood Non-Hodgkin Lymphoma; Children’s Oncology Group
N Engl J Med 2020 Jun 4;382(23):2207-2219. doi: 10.1056/NEJMoa1915315. PMID: 32492302Free PMC Article
Association of Immunoglobulin Levels, Infectious Risk, and Mortality With Rituximab and Hypogammaglobulinemia.
Barmettler S, Ong MS, Farmer JR, Choi H, Walter J
JAMA Netw Open 2018 Nov 2;1(7):e184169. doi: 10.1001/jamanetworkopen.2018.4169. PMID: 30646343Free PMC Article

Clinical prediction guides

IVIg Use Associated with Ten-Fold Reduction of Serious Infections in Multiple Myeloma Patients Treated with Anti-BCMA Bispecific Antibodies.
Lancman G, Parsa K, Kotlarz K, Avery L, Lurie A, Lieberman-Cribbin A, Cho HJ, Parekh SS, Richard S, Richter J, Rodriguez C, Rossi A, Sanchez LJ, Thibaud S, Jagannath S, Chari A
Blood Cancer Discov 2023 Nov 1;4(6):440-451. doi: 10.1158/2643-3230.BCD-23-0049. PMID: 37769148Free PMC Article
Use of Rituximab in Childhood Idiopathic Nephrotic Syndrome.
Chan EY, Yap DY, Colucci M, Ma AL, Parekh RS, Tullus K
Clin J Am Soc Nephrol 2023 Apr 1;18(4):533-548. Epub 2023 Feb 22 doi: 10.2215/CJN.08570722. PMID: 36456193Free PMC Article
Hypogammaglobulinemia After Chimeric Antigen Receptor (CAR) T-Cell Therapy: Characteristics, Management, and Future Directions.
Wat J, Barmettler S
J Allergy Clin Immunol Pract 2022 Feb;10(2):460-466. Epub 2021 Oct 28 doi: 10.1016/j.jaip.2021.10.037. PMID: 34757064Free PMC Article
Late Events after Treatment with CD19-Targeted Chimeric Antigen Receptor Modified T Cells.
Cordeiro A, Bezerra ED, Hirayama AV, Hill JA, Wu QV, Voutsinas J, Sorror ML, Turtle CJ, Maloney DG, Bar M
Biol Blood Marrow Transplant 2020 Jan;26(1):26-33. Epub 2019 Aug 13 doi: 10.1016/j.bbmt.2019.08.003. PMID: 31419568Free PMC Article
Anaphylaxis to IVIG.
Williams SJ, Gupta S
Arch Immunol Ther Exp (Warsz) 2017 Feb;65(1):11-19. Epub 2016 Jul 13 doi: 10.1007/s00005-016-0410-1. PMID: 27412077

Recent systematic reviews

Clinical Courses of IKAROS and CTLA4 Deficiencies: A Systematic Literature Review and Retrospective Longitudinal Study.
Hoshino A, Toyofuku E, Mitsuiki N, Yamashita M, Okamoto K, Yamamoto M, Kanda K, Yamato G, Keino D, Yoshimoto-Suzuki Y, Kamizono J, Onoe Y, Ichimura T, Nagao M, Yoshimura M, Tsugawa K, Igarashi T, Mitsui-Sekinaka K, Sekinaka Y, Doi T, Yasumi T, Nakazawa Y, Takagi M, Imai K, Nonoyama S, Morio T, Latour S, Kanegane H
Front Immunol 2021;12:784901. Epub 2022 Jan 11 doi: 10.3389/fimmu.2021.784901. PMID: 35087518Free PMC Article
Systematic review of childhood-onset polyarteritis nodosa and DADA2.
Kasap Cuceoglu M, Sener S, Batu ED, Kaya Akca U, Demir S, Sag E, Atalay E, Balık Z, Basaran O, Bilginer Y, Ozen S
Semin Arthritis Rheum 2021 Jun;51(3):559-564. Epub 2021 Apr 19 doi: 10.1016/j.semarthrit.2021.04.009. PMID: 33901990
Autoimmunity in common variable immunodeficiency: a systematic review and meta-analysis.
Rizvi FS, Zainaldain H, Rafiemanesh H, Jamee M, Hossein-Khannazer N, Hamedifar H, Sabzevari A, Yazdani R, Abolhassani H, Aghamohammadi A, Azizi G
Expert Rev Clin Immunol 2020 Dec;16(12):1227-1235. Epub 2020 Dec 7 doi: 10.1080/1744666X.2021.1850272. PMID: 33203275
Characteristics of Good's Syndrome in China: A Systematic Review.
Dong JP, Gao W, Teng GG, Tian Y, Wang HH
Chin Med J (Engl) 2017 Jul 5;130(13):1604-1609. doi: 10.4103/0366-6999.208234. PMID: 28639577Free PMC Article
Impact of rare diseases in oral health.
Molina-García A, Castellanos-Cosano L, Machuca-Portillo G, Posada-de la Paz M
Med Oral Patol Oral Cir Bucal 2016 Sep 1;21(5):e587-94. doi: 10.4317/medoral.20972. PMID: 27475682Free PMC Article

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