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Reactive arthritis

MedGen UID:
39047
•Concept ID:
C0085435
•
Disease or Syndrome
Synonyms: Reiter syndrome; Reiter's syndrome
SNOMED CT: Post-bacterial arthropathy (129133005); Reactive arthritis (201736002); Post-infective arthritis (239783001); Post-infective arthropathy (239783001); Arthritis occurring after infection (239783001)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Non-Mendelian inheritance (Orphanet)
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0017376
Orphanet: ORPHA29207

Definition

A rare spondyloarthritis characterized by acute or chronic sterile synovitis with or without extra-articular manifestations, becoming manifest after an infection. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReactive arthritis

Professional guidelines

PubMed

Reactive Arthritis: Treatment Challenges and Future Perspectives.
Wendling D, Prati C, Chouk M, Verhoeven F
Curr Rheumatol Rep 2020 May 26;22(7):29. doi: 10.1007/s11926-020-00904-9. PMID: 32458153
Evaluation and Management of Septic Arthritis and its Mimics in the Emergency Department.
Long B, Koyfman A, Gottlieb M
West J Emerg Med 2019 Mar;20(2):331-341. Epub 2018 Dec 6 doi: 10.5811/westjem.2018.10.40974. PMID: 30881554Free PMC Article
Hepatitis A: clinical manifestations and management.
Jeong SH, Lee HS
Intervirology 2010;53(1):15-9. Epub 2010 Jan 5 doi: 10.1159/000252779. PMID: 20068336

Recent clinical studies

Etiology

Reactive Arthritis Update: Spotlight on New and Rare Infectious Agents Implicated as Pathogens.
Zeidler H, Hudson AP
Curr Rheumatol Rep 2021 Jul 1;23(7):53. doi: 10.1007/s11926-021-01018-6. PMID: 34196842Free PMC Article
Understanding the Pathogenesis of Spondyloarthritis.
Sharip A, Kunz J
Biomolecules 2020 Oct 20;10(10) doi: 10.3390/biom10101461. PMID: 33092023Free PMC Article
Post-Streptococcal Reactive Arthritis.
Bawazir Y, Towheed T, Anastassiades T
Curr Rheumatol Rev 2020;16(1):2-8. doi: 10.2174/1573397115666190808110337. PMID: 31393253
Traveler's Diarrhea.
Giddings SL, Stevens AM, Leung DT
Med Clin North Am 2016 Mar;100(2):317-30. doi: 10.1016/j.mcna.2015.08.017. PMID: 26900116Free PMC Article
Spondyloarthritis.
Dougados M, Baeten D
Lancet 2011 Jun 18;377(9783):2127-37. doi: 10.1016/S0140-6736(11)60071-8. PMID: 21684383

Diagnosis

Spondyloarthritides.
Taitt HA, Balakrishnan R
Emerg Med Clin North Am 2022 Feb;40(1):159-178. Epub 2021 Oct 29 doi: 10.1016/j.emc.2021.08.005. PMID: 34782086
Reactive Arthritis Update: Spotlight on New and Rare Infectious Agents Implicated as Pathogens.
Zeidler H, Hudson AP
Curr Rheumatol Rep 2021 Jul 1;23(7):53. doi: 10.1007/s11926-021-01018-6. PMID: 34196842Free PMC Article
Post-Streptococcal Reactive Arthritis.
Bawazir Y, Towheed T, Anastassiades T
Curr Rheumatol Rev 2020;16(1):2-8. doi: 10.2174/1573397115666190808110337. PMID: 31393253
Reactive arthritis: update 2018.
García-Kutzbach A, Chacón-Súchite J, García-Ferrer H, Iraheta I
Clin Rheumatol 2018 Apr;37(4):869-874. Epub 2018 Feb 17 doi: 10.1007/s10067-018-4022-5. PMID: 29455267
Reactive Arthritis.
Schmitt SK
Infect Dis Clin North Am 2017 Jun;31(2):265-277. Epub 2017 Mar 11 doi: 10.1016/j.idc.2017.01.002. PMID: 28292540

Therapy

Post-Streptococcal Reactive Arthritis.
Bawazir Y, Towheed T, Anastassiades T
Curr Rheumatol Rev 2020;16(1):2-8. doi: 10.2174/1573397115666190808110337. PMID: 31393253
Evaluation and Management of Septic Arthritis and its Mimics in the Emergency Department.
Long B, Koyfman A, Gottlieb M
West J Emerg Med 2019 Mar;20(2):331-341. Epub 2018 Dec 6 doi: 10.5811/westjem.2018.10.40974. PMID: 30881554Free PMC Article
Reactive Arthritis.
Schmitt SK
Infect Dis Clin North Am 2017 Jun;31(2):265-277. Epub 2017 Mar 11 doi: 10.1016/j.idc.2017.01.002. PMID: 28292540
Traveler's Diarrhea.
Giddings SL, Stevens AM, Leung DT
Med Clin North Am 2016 Mar;100(2):317-30. doi: 10.1016/j.mcna.2015.08.017. PMID: 26900116Free PMC Article
Reactive arthritis.
Kwiatkowska B, Filipowicz-Sosnowska A
Pol Arch Med Wewn 2009 Jan-Feb;119(1-2):60-5. PMID: 19341180

Prognosis

Reactive Arthritis.
Schmitt SK
Infect Dis Clin North Am 2017 Jun;31(2):265-277. Epub 2017 Mar 11 doi: 10.1016/j.idc.2017.01.002. PMID: 28292540
Reactive arthritis.
Hannu T
Best Pract Res Clin Rheumatol 2011 Jun;25(3):347-57. doi: 10.1016/j.berh.2011.01.018. PMID: 22100285
Seronegative spondyloarthritis.
Zochling J, Smith EU
Best Pract Res Clin Rheumatol 2010 Dec;24(6):747-56. doi: 10.1016/j.berh.2011.02.002. PMID: 21665123
Hepatitis A: clinical manifestations and management.
Jeong SH, Lee HS
Intervirology 2010;53(1):15-9. Epub 2010 Jan 5 doi: 10.1159/000252779. PMID: 20068336
Reactive arthritis.
Kwiatkowska B, Filipowicz-Sosnowska A
Pol Arch Med Wewn 2009 Jan-Feb;119(1-2):60-5. PMID: 19341180

Clinical prediction guides

Reactive arthritis: images.
Aitken-Saavedra J, Maturana-Ramirez A, Fernández Moraga J, Doro Dias V, Galdino-Santos L, Pineda Flores D
Dermatol Online J 2021 Jul 15;27(7) doi: 10.5070/D327754373. PMID: 34391335
EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors.
Kostine M, Finckh A, Bingham CO, Visser K, Leipe J, Schulze-Koops H, Choy EH, Benesova K, Radstake TRDJ, Cope AP, Lambotte O, Gottenberg JE, Allenbach Y, Visser M, Rusthoven C, Thomasen L, Jamal S, Marabelle A, Larkin J, Haanen JBAG, Calabrese LH, Mariette X, Schaeverbeke T
Ann Rheum Dis 2021 Jan;80(1):36-48. Epub 2020 Apr 23 doi: 10.1136/annrheumdis-2020-217139. PMID: 32327425Free PMC Article
Bacillus Calmette-Guérin (BCG) infection following intravesical BCG administration as adjunctive therapy for bladder cancer: incidence, risk factors, and outcome in a single-institution series and review of the literature.
Pérez-Jacoiste Asín MA, Fernández-Ruiz M, López-Medrano F, Lumbreras C, Tejido Á, San Juan R, Arrebola-Pajares A, Lizasoain M, Prieto S, Aguado JM
Medicine (Baltimore) 2014 Oct;93(17):236-254. doi: 10.1097/MD.0000000000000119. PMID: 25398060Free PMC Article
Hepatitis A: clinical manifestations and management.
Jeong SH, Lee HS
Intervirology 2010;53(1):15-9. Epub 2010 Jan 5 doi: 10.1159/000252779. PMID: 20068336
Synovitis score: discrimination between chronic low-grade and high-grade synovitis.
Krenn V, Morawietz L, Burmester GR, Kinne RW, Mueller-Ladner U, Muller B, Haupl T
Histopathology 2006 Oct;49(4):358-64. doi: 10.1111/j.1365-2559.2006.02508.x. PMID: 16978198

Recent systematic reviews

COVID-associated arthritis after severe and non-severe COVID-19: A systematic review.
Zarpoosh M, Amirian P
Immun Inflamm Dis 2023 Oct;11(10):e1035. doi: 10.1002/iid3.1035. PMID: 37904701Free PMC Article
Reactive arthritis following COVID-19 current evidence, diagnosis, and management strategies.
Migliorini F, Bell A, Vaishya R, Eschweiler J, Hildebrand F, Maffulli N
J Orthop Surg Res 2023 Mar 15;18(1):205. doi: 10.1186/s13018-023-03651-6. PMID: 36922870Free PMC Article
Reactive Arthritis following Bacillus Calmette-Guerin Therapy for Bladder Cancer: a Systematic Literature Review.
Abdelghani KB, Nacef L, Miladi S, Sellami M, Ouenniche K, Souabni L, Kassab S, Chekili S, Fazaa A, Laatar A
Curr Rheumatol Rep 2021 Apr 28;23(6):39. doi: 10.1007/s11926-021-01004-y. PMID: 33913026
The incidence of sexually acquired reactive arthritis: a systematic literature review.
Denison HJ, Curtis EM, Clynes MA, Bromhead C, Dennison EM, Grainger R
Clin Rheumatol 2016 Nov;35(11):2639-2648. Epub 2016 Aug 1 doi: 10.1007/s10067-016-3364-0. PMID: 27480977Free PMC Article
Global Prevalence of Spondyloarthritis: A Systematic Review and Meta-Regression Analysis.
Stolwijk C, van Onna M, Boonen A, van Tubergen A
Arthritis Care Res (Hoboken) 2016 Sep;68(9):1320-31. Epub 2016 Jul 27 doi: 10.1002/acr.22831. PMID: 26713432

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