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Orbital pseudotumor

MedGen UID:
43140
Concept ID:
C0085270
Disease or Syndrome
Synonyms: Inflammatory pseudotumor of orbit; Orbital plasma cell granuloma
SNOMED CT: Inflammatory pseudotumor of orbit (72789009); Inflammatory pseudotumor of orbit proper (72789009); Idiopathic orbital inflammation (72789009); Chronic pseudotumor (72789009); Orbital pseudotumor (72789009)
 
Monarch Initiative: MONDO:0004769

Definition

A nonspecific tumor-like inflammatory lesion in the orbit of the eye. It is usually composed of mature lymphocytes; plasma cells; macrophages; leukocytes with varying degrees of fibrosis. Orbital pseudotumors are often associated with inflammation of the extraocular muscles (orbital myositis) or inflammation of the lacrimal glands (dacryoadenitis). [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrbital pseudotumor

Professional guidelines

PubMed

Montagnese F, Wenninger S, Schoser B
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Recent clinical studies

Etiology

Huang YM, Lin PH
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Diagnosis

Lanzillotta M, Culver E, Sharma A, Zen Y, Zhang W, Stone JH, Della-Torre E
Lancet Rheumatol 2024 Jul;6(7):e469-e480. Epub 2024 Apr 1 doi: 10.1016/S2665-9913(23)00299-0. PMID: 38574746
Fang Y, Shen B, Dai Q, Xie Q, Wu W, Wang M
Eur J Med Res 2023 Oct 4;28(1):395. doi: 10.1186/s40001-023-01330-0. PMID: 37794419Free PMC Article
Rachwani-Anil R, Zamorano-Martín F, Rocha-de-Lossada C, García-Lorente M, Pérez-Casaseca C, Hernando-Ayala C, Ortiz-Pérez S
Arch Soc Esp Oftalmol (Engl Ed) 2022 Feb;97(2):89-99. Epub 2022 Feb 3 doi: 10.1016/j.oftale.2021.05.001. PMID: 35152954
Yeşiltaş YS, Gündüz AK
Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):71-80. doi: 10.4103/meajo.MEAJO_44_18. PMID: 30122852Free PMC Article
Geyer JT, Deshpande V
Curr Opin Rheumatol 2011 Jan;23(1):95-101. doi: 10.1097/BOR.0b013e3283413011. PMID: 21124091

Therapy

Lanzillotta M, Culver E, Sharma A, Zen Y, Zhang W, Stone JH, Della-Torre E
Lancet Rheumatol 2024 Jul;6(7):e469-e480. Epub 2024 Apr 1 doi: 10.1016/S2665-9913(23)00299-0. PMID: 38574746
Rachwani-Anil R, Zamorano-Martín F, Rocha-de-Lossada C, García-Lorente M, Pérez-Casaseca C, Hernando-Ayala C, Ortiz-Pérez S
Arch Soc Esp Oftalmol (Engl Ed) 2022 Feb;97(2):89-99. Epub 2022 Feb 3 doi: 10.1016/j.oftale.2021.05.001. PMID: 35152954
Dagi Glass LR, Freitag SK
Surv Ophthalmol 2016 Sep-Oct;61(5):670-3. Epub 2016 Mar 10 doi: 10.1016/j.survophthal.2016.01.005. PMID: 26973286
Mendenhall WM, Lessner AM
Am J Clin Oncol 2010 Jun;33(3):304-6. doi: 10.1097/COC.0b013e3181a07567. PMID: 19738455
Snebold NG
Curr Opin Ophthalmol 1997 Dec;8(6):41-4. doi: 10.1097/00055735-199712000-00007. PMID: 10176102

Prognosis

Rachwani-Anil R, Zamorano-Martín F, Rocha-de-Lossada C, García-Lorente M, Pérez-Casaseca C, Hernando-Ayala C, Ortiz-Pérez S
Arch Soc Esp Oftalmol (Engl Ed) 2022 Feb;97(2):89-99. Epub 2022 Feb 3 doi: 10.1016/j.oftale.2021.05.001. PMID: 35152954
McNab AA, McKelvie P
Ophthalmic Plast Reconstr Surg 2015 May-Jun;31(3):167-78. doi: 10.1097/IOP.0000000000000364. PMID: 25564258
Jacobs D, Galetta S
Curr Opin Ophthalmol 2002 Dec;13(6):347-51. doi: 10.1097/00055735-200212000-00001. PMID: 12441835
Mombaerts I, Goldschmeding R, Schlingemann RO, Koornneef L
Surv Ophthalmol 1996 Jul-Aug;41(1):66-78. doi: 10.1016/s0039-6257(97)81996-0. PMID: 8827931
Moorman CM, Elston JS
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Clinical prediction guides

Son KY, Woo KI, Kim YD
Ophthalmic Plast Reconstr Surg 2022 Jan-Feb 01;38(1):34-39. doi: 10.1097/IOP.0000000000001975. PMID: 33782329
Goto H, Yamakawa N, Komatsu H, Asakage M, Tsubota K, Ueda SI, Nemoto R, Umazume K, Usui Y, Mori H
Jpn J Ophthalmol 2021 Sep;65(5):704-723. Epub 2021 Jul 27 doi: 10.1007/s10384-021-00857-1. PMID: 34313901
Jakobiec FA, Syed ZA, Stagner AM, Harris GJ, Rootman J, Yoon MK, Mombaerts I
Am J Ophthalmol 2016 Jun;166:91-102. Epub 2016 Mar 31 doi: 10.1016/j.ajo.2016.03.029. PMID: 27038895
Mombaerts I, Rose GE, Garrity JA
Surv Ophthalmol 2016 Sep-Oct;61(5):664-9. Epub 2016 Mar 17 doi: 10.1016/j.survophthal.2016.03.002. PMID: 26994870
Bhatti MT
Semin Neurol 2007 Jul;27(3):269-87. doi: 10.1055/s-2007-979685. PMID: 17577868

Recent systematic reviews

Baca V, Barragán-García AA, García-Vega D, Vázquez-Lara Y, Siordia-Reyes G, Yañez-Gutierrez L
Rheumatol Int 2024 Nov;44(11):2679-2690. Epub 2023 Jun 15 doi: 10.1007/s00296-023-05366-7. PMID: 37322355
Fionda B, Pagliara MM, Lancellotta V, Sammarco MG, Casà C, Savino G, Deodato F, Morganti AG, Gambacorta MA, Tagliaferri L, Blasi MA
Ocul Immunol Inflamm 2022 Jul;30(5):1162-1167. Epub 2021 Feb 9 doi: 10.1080/09273948.2020.1871493. PMID: 33561371

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