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Diffuse Mixed Cell Lymphoma

MedGen UID:
42542
•Concept ID:
C0079757
•
Neoplastic Process
Synonyms: Diffuse Mixed Small and Large Cell Lymphoma; Diffuse Mixed-Cell Lymphoma; Diffuse Mixed-Cell Lymphomas; Lymphoma, Diffuse Mixed-Cell; Lymphoma, Diffuse, Mixed Lymphocytic-Histiocytic; Lymphoma, Mixed Cell, Diffuse; Lymphoma, Mixed Small and Large Cell, Diffuse; Lymphoma, Mixed-Cell, Diffuse; Lymphoma, Small and Large Cleaved-Cell, Diffuse; Mixed Cell Lymphoma, Diffuse; Mixed Small and Large Cell Lymphoma, Diffuse; Mixed-Cell Lymphoma, Diffuse

Definition

An antiquated term referring to non-Hodgkin lymphomas with a mixed cellular composition. This term applies to both B- and T- cell non-Hodgkin lymphomas. [from NCI]

Professional guidelines

PubMed

The non-Hodgkin's lymphomas: pathology, staging, treatment.
Hoppe RT
Curr Probl Cancer 1987 Nov-Dec;11(6):363-447. doi: 10.1016/s0147-0272(87)80006-5. PMID: 3125008

Recent clinical studies

Etiology

Detection of Epstein-Barr viral RNA in malignant lymphomas of the upper aerodigestive tract.
Chan JK, Yip TT, Tsang WY, Ng CS, Lau WH, Poon YF, Wong CC, Ma VW
Am J Surg Pathol 1994 Sep;18(9):938-46. doi: 10.1097/00000478-199409000-00009. PMID: 8067515
The non-Hodgkin's lymphomas: pathology, staging, treatment.
Hoppe RT
Curr Probl Cancer 1987 Nov-Dec;11(6):363-447. doi: 10.1016/s0147-0272(87)80006-5. PMID: 3125008
Peripheral T-cell lymphoma. A case report demonstrating morphologic heterogeneity and progression, and atypical immune reactions.
Winberg CD, Krance R, Sheibani K, Rappaport H
Cancer 1986 Jun 15;57(12):2329-42. doi: 10.1002/1097-0142(19860615)57:12<2329::aid-cncr2820571216>3.0.co;2-3. PMID: 3516376
Peripheral T cell lymphoma: immunologic and cell-kinetic observations associated with morphological progression.
Winberg CD, Sheibani K, Krance R, Rappaport H
Blood 1985 Oct;66(4):980-9. PMID: 3876128
Malignant lymphoma, mixed cell type, diffuse.
Nathwani BN, Metter GE, Gams RA, Bartolucci AA, Hartsock RJ, Neiman RS, Byrne GE Jr, Barcos M, Kim H, Rappaport H
Blood 1983 Jul;62(1):200-8. PMID: 6602632

Diagnosis

Primary central nervous system non-Hodgkin's lymphoma (PCNSL): does age and histology at presentation affect outcome?
Schaller C, Kelly PJ
Zentralbl Neurochir 1996;57(3):156-62. PMID: 8794548
Detection of Epstein-Barr viral RNA in malignant lymphomas of the upper aerodigestive tract.
Chan JK, Yip TT, Tsang WY, Ng CS, Lau WH, Poon YF, Wong CC, Ma VW
Am J Surg Pathol 1994 Sep;18(9):938-46. doi: 10.1097/00000478-199409000-00009. PMID: 8067515
Bone marrow involvement by non-Hodgkin's lymphom.
Lee WI, Lee JH, Kim IS, Lee KN, Kim SH
J Korean Med Sci 1994 Oct;9(5):402-8. doi: 10.3346/jkms.1994.9.5.402. PMID: 7702789Free PMC Article
The value of immunophenotyping on paraffin sections in the identification of T-cell rich B-cell large-cell lymphomas: lineage confirmed by JH rearrangement.
Osborne BM, Butler JJ, Pugh WC
Am J Surg Pathol 1990 Oct;14(10):933-8. doi: 10.1097/00000478-199010000-00006. PMID: 2169708
The non-Hodgkin's lymphomas: pathology, staging, treatment.
Hoppe RT
Curr Probl Cancer 1987 Nov-Dec;11(6):363-447. doi: 10.1016/s0147-0272(87)80006-5. PMID: 3125008

Therapy

A randomized British National Lymphoma Investigation trial of CHOP vs. a weekly multi-agent regimen (PACEBOM) in patients with histologically aggressive non-Hodgkin's lymphoma.
Linch DC, Smith P, Hancock BW, Hoskin PJ, Cunningham DC, Newland AC, Milligan D, Stevenson PA, Wood JK, Maclennan KA, Vaughan B, Vaughan G, Gregory WM
Ann Oncol 2000;11 Suppl 1:87-90. PMID: 10707786
The non-Hodgkin's lymphomas: pathology, staging, treatment.
Hoppe RT
Curr Probl Cancer 1987 Nov-Dec;11(6):363-447. doi: 10.1016/s0147-0272(87)80006-5. PMID: 3125008
The significance of bone marrow involvement in non-Hodgkin's lymphoma: the Eastern Cooperative Oncology Group experience.
Bennett JM, Cain KC, Glick JH, Johnson GJ, Ezdinli E, O'Connell MJ
J Clin Oncol 1986 Oct;4(10):1462-9. doi: 10.1200/JCO.1986.4.10.1462. PMID: 3531421

Prognosis

Primary central nervous system non-Hodgkin's lymphoma (PCNSL): does age and histology at presentation affect outcome?
Schaller C, Kelly PJ
Zentralbl Neurochir 1996;57(3):156-62. PMID: 8794548
The non-Hodgkin's lymphomas: pathology, staging, treatment.
Hoppe RT
Curr Probl Cancer 1987 Nov-Dec;11(6):363-447. doi: 10.1016/s0147-0272(87)80006-5. PMID: 3125008
The significance of bone marrow involvement in non-Hodgkin's lymphoma: the Eastern Cooperative Oncology Group experience.
Bennett JM, Cain KC, Glick JH, Johnson GJ, Ezdinli E, O'Connell MJ
J Clin Oncol 1986 Oct;4(10):1462-9. doi: 10.1200/JCO.1986.4.10.1462. PMID: 3531421
Peripheral T-cell lymphoma. A case report demonstrating morphologic heterogeneity and progression, and atypical immune reactions.
Winberg CD, Krance R, Sheibani K, Rappaport H
Cancer 1986 Jun 15;57(12):2329-42. doi: 10.1002/1097-0142(19860615)57:12<2329::aid-cncr2820571216>3.0.co;2-3. PMID: 3516376
Malignant lymphoma, mixed cell type, diffuse.
Nathwani BN, Metter GE, Gams RA, Bartolucci AA, Hartsock RJ, Neiman RS, Byrne GE Jr, Barcos M, Kim H, Rappaport H
Blood 1983 Jul;62(1):200-8. PMID: 6602632

Clinical prediction guides

Peripheral T-cell lymphoma. A case report demonstrating morphologic heterogeneity and progression, and atypical immune reactions.
Winberg CD, Krance R, Sheibani K, Rappaport H
Cancer 1986 Jun 15;57(12):2329-42. doi: 10.1002/1097-0142(19860615)57:12<2329::aid-cncr2820571216>3.0.co;2-3. PMID: 3516376
Peripheral T cell lymphoma: immunologic and cell-kinetic observations associated with morphological progression.
Winberg CD, Sheibani K, Krance R, Rappaport H
Blood 1985 Oct;66(4):980-9. PMID: 3876128

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