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Tear film insufficiency

MedGen UID:
12182
•Concept ID:
C0043349
•
Disease or Syndrome
Synonyms: Xerophthalmia; Xerophthalmias
SNOMED CT: Xerophthalmia (363677007); Tear film insufficiency (46152009)

Definition

Dryness of the eye due to inadequate production of tears. Causes include vitamin A deficiency, Sjogren syndrome, rheumatoid arthritis, systemic lupus erythematosus, and scleroderma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTear film insufficiency

Professional guidelines

PubMed

Superior limbic keratoconjunctivitis: Update on pathophysiology and management.
Lee DH, Margolis MS, Iovieno A, Ling J, Ng T, Djalilian AR, Yeung SN
Ocul Surf 2023 Apr;28:144-152. Epub 2023 Apr 1 doi: 10.1016/j.jtos.2023.03.004. PMID: 37011726

Recent clinical studies

Etiology

Prediction of Sjögren's disease diagnosis using matched electronic dental-health record data.
Mao J, Gomez GGF, Wang M, Xu H, Thyvalikakath TP
BMC Med Inform Decis Mak 2024 Feb 9;24(1):43. doi: 10.1186/s12911-024-02448-9. PMID: 38336735Free PMC Article
Prevalence and incidence of dry eye in the USA: a systematic review protocol.
McCann P, Abraham AG, Gregory DG, Hauswirth S, Ifantides C, Liu SH, Saldanha IJ, Li T
BMJ Open 2021 Nov 23;11(11):e056203. doi: 10.1136/bmjopen-2021-056203. PMID: 34815292Free PMC Article
The assessment of the impact of glistening on visual performance in relation to tear film quality.
Argay A, Vamosi P
PLoS One 2020;15(10):e0240440. Epub 2020 Oct 12 doi: 10.1371/journal.pone.0240440. PMID: 33044979Free PMC Article
Update in Current Diagnostics and Therapeutics of Dry Eye Disease.
Thulasi P, Djalilian AR
Ophthalmology 2017 Nov;124(11S):S27-S33. doi: 10.1016/j.ophtha.2017.07.022. PMID: 29055359Free PMC Article
Tear meniscus measurement in the diagnosis of dry eye.
Mainstone JC, Bruce AS, Golding TR
Curr Eye Res 1996 Jun;15(6):653-61. doi: 10.3109/02713689609008906. PMID: 8670769

Diagnosis

Prediction of Sjögren's disease diagnosis using matched electronic dental-health record data.
Mao J, Gomez GGF, Wang M, Xu H, Thyvalikakath TP
BMC Med Inform Decis Mak 2024 Feb 9;24(1):43. doi: 10.1186/s12911-024-02448-9. PMID: 38336735Free PMC Article
Common ocular findings in patients with acne rosacea.
Ozturk T, Kayabasi M, Ozbagcivan O, Ayhan Z, Utine CA
Int Ophthalmol 2022 Apr;42(4):1077-1084. Epub 2021 Nov 2 doi: 10.1007/s10792-021-02093-5. PMID: 34727263
The assessment of the impact of glistening on visual performance in relation to tear film quality.
Argay A, Vamosi P
PLoS One 2020;15(10):e0240440. Epub 2020 Oct 12 doi: 10.1371/journal.pone.0240440. PMID: 33044979Free PMC Article
Update in Current Diagnostics and Therapeutics of Dry Eye Disease.
Thulasi P, Djalilian AR
Ophthalmology 2017 Nov;124(11S):S27-S33. doi: 10.1016/j.ophtha.2017.07.022. PMID: 29055359Free PMC Article
Tear meniscus measurement in the diagnosis of dry eye.
Mainstone JC, Bruce AS, Golding TR
Curr Eye Res 1996 Jun;15(6):653-61. doi: 10.3109/02713689609008906. PMID: 8670769

Therapy

Post-refractive surgery complications and eye disease, active component, U.S. Armed Forces, 2005-2014.
Blitz JB, Hunt DJ, Cost AA
MSMR 2016 May;23(5):2-11. PMID: 27255946

Prognosis

Prediction of Sjögren's disease diagnosis using matched electronic dental-health record data.
Mao J, Gomez GGF, Wang M, Xu H, Thyvalikakath TP
BMC Med Inform Decis Mak 2024 Feb 9;24(1):43. doi: 10.1186/s12911-024-02448-9. PMID: 38336735Free PMC Article
Common ocular findings in patients with acne rosacea.
Ozturk T, Kayabasi M, Ozbagcivan O, Ayhan Z, Utine CA
Int Ophthalmol 2022 Apr;42(4):1077-1084. Epub 2021 Nov 2 doi: 10.1007/s10792-021-02093-5. PMID: 34727263
Prevalence and incidence of dry eye in the USA: a systematic review protocol.
McCann P, Abraham AG, Gregory DG, Hauswirth S, Ifantides C, Liu SH, Saldanha IJ, Li T
BMJ Open 2021 Nov 23;11(11):e056203. doi: 10.1136/bmjopen-2021-056203. PMID: 34815292Free PMC Article
The assessment of the impact of glistening on visual performance in relation to tear film quality.
Argay A, Vamosi P
PLoS One 2020;15(10):e0240440. Epub 2020 Oct 12 doi: 10.1371/journal.pone.0240440. PMID: 33044979Free PMC Article
Tear meniscus measurement in the diagnosis of dry eye.
Mainstone JC, Bruce AS, Golding TR
Curr Eye Res 1996 Jun;15(6):653-61. doi: 10.3109/02713689609008906. PMID: 8670769

Clinical prediction guides

Unveiling senescence-associated ocular pathogenesis via lacrimal gland organoid magnetic bioassembly platform and HMGB1-Box A gene therapy.
Ferreira JN, Bhummaphan N, Chaisuparat R, Van Phan T, Oo Y, Jaru-Ampornpan P, Matangkasombut O, Mutirangura A
Sci Rep 2024 Sep 18;14(1):21784. doi: 10.1038/s41598-024-73101-8. PMID: 39294273Free PMC Article
Prediction of Sjögren's disease diagnosis using matched electronic dental-health record data.
Mao J, Gomez GGF, Wang M, Xu H, Thyvalikakath TP
BMC Med Inform Decis Mak 2024 Feb 9;24(1):43. doi: 10.1186/s12911-024-02448-9. PMID: 38336735Free PMC Article
Common ocular findings in patients with acne rosacea.
Ozturk T, Kayabasi M, Ozbagcivan O, Ayhan Z, Utine CA
Int Ophthalmol 2022 Apr;42(4):1077-1084. Epub 2021 Nov 2 doi: 10.1007/s10792-021-02093-5. PMID: 34727263
The assessment of the impact of glistening on visual performance in relation to tear film quality.
Argay A, Vamosi P
PLoS One 2020;15(10):e0240440. Epub 2020 Oct 12 doi: 10.1371/journal.pone.0240440. PMID: 33044979Free PMC Article
Tear meniscus measurement in the diagnosis of dry eye.
Mainstone JC, Bruce AS, Golding TR
Curr Eye Res 1996 Jun;15(6):653-61. doi: 10.3109/02713689609008906. PMID: 8670769

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