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Weil disease

MedGen UID:
21912
•Concept ID:
C0043102
•
Disease or Syndrome
Synonym: Weil's disease
SNOMED CT: Weil's disease (398067003); Icteric leptospirosis (398067003); Weil disease (398067003)
 
Monarch Initiative: MONDO:0043004

Definition

A jauncice caused by severe leptospirosis. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWeil disease

Professional guidelines

PubMed

The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study.
Charidimou A, Boulouis G, Frosch MP, Baron JC, Pasi M, Albucher JF, Banerjee G, Barbato C, Bonneville F, Brandner S, Calviere L, Caparros F, Casolla B, Cordonnier C, Delisle MB, Deramecourt V, Dichgans M, Gokcal E, Herms J, Hernandez-Guillamon M, Jäger HR, Jaunmuktane Z, Linn J, Martinez-Ramirez S, Martínez-Sáez E, Mawrin C, Montaner J, Moulin S, Olivot JM, Piazza F, Puy L, Raposo N, Rodrigues MA, Roeber S, Romero JR, Samarasekera N, Schneider JA, Schreiber S, Schreiber F, Schwall C, Smith C, Szalardy L, Varlet P, Viguier A, Wardlaw JM, Warren A, Wollenweber FA, Zedde M, van Buchem MA, Gurol ME, Viswanathan A, Al-Shahi Salman R, Smith EE, Werring DJ, Greenberg SM
Lancet Neurol 2022 Aug;21(8):714-725. doi: 10.1016/S1474-4422(22)00208-3. PMID: 35841910Free PMC Article
Leveraging Antiprogestins in the Treatment of Metastatic Breast Cancer.
Kamaraju S, Fowler AM, Weil E, Wisinski KB, Truong TH, Lehr M, Chaudhary LN, Cheng YC, Chitambar CR, Rui H, Yee D, Lange C
Endocrinology 2021 Aug 1;162(8) doi: 10.1210/endocr/bqab060. PMID: 33735382
Management of latent Mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries.
Getahun H, Matteelli A, Abubakar I, Aziz MA, Baddeley A, Barreira D, Den Boon S, Borroto Gutierrez SM, Bruchfeld J, Burhan E, Cavalcante S, Cedillos R, Chaisson R, Chee CB, Chesire L, Corbett E, Dara M, Denholm J, de Vries G, Falzon D, Ford N, Gale-Rowe M, Gilpin C, Girardi E, Go UY, Govindasamy D, D Grant A, Grzemska M, Harris R, Horsburgh CR Jr, Ismayilov A, Jaramillo E, Kik S, Kranzer K, Lienhardt C, LoBue P, Lönnroth K, Marks G, Menzies D, Migliori GB, Mosca D, Mukadi YD, Mwinga A, Nelson L, Nishikiori N, Oordt-Speets A, Rangaka MX, Reis A, Rotz L, Sandgren A, Sañé Schepisi M, Schünemann HJ, Sharma SK, Sotgiu G, Stagg HR, Sterling TR, Tayeb T, Uplekar M, van der Werf MJ, Vandevelde W, van Kessel F, van't Hoog A, Varma JK, Vezhnina N, Voniatis C, Vonk Noordegraaf-Schouten M, Weil D, Weyer K, Wilkinson RJ, Yoshiyama T, Zellweger JP, Raviglione M
Eur Respir J 2015 Dec;46(6):1563-76. Epub 2015 Sep 24 doi: 10.1183/13993003.01245-2015. PMID: 26405286Free PMC Article

Recent clinical studies

Etiology

Association between age and severity to leptospirosis in children.
Guerrier G, Hie P, Gourinat AC, Huguon E, Polfrit Y, Goarant C, D'Ortenzio E, Missotte I
PLoS Negl Trop Dis 2013;7(9):e2436. Epub 2013 Sep 26 doi: 10.1371/journal.pntd.0002436. PMID: 24086780Free PMC Article
Leptospiral nephropathy.
Andrade L, de Francesco Daher E, Seguro AC
Semin Nephrol 2008 Jul;28(4):383-394. doi: 10.1016/j.semnephrol.2008.04.008. PMID: 18620961
Door-to-dialysis time and daily hemodialysis in patients with leptospirosis: impact on mortality.
Andrade L, Cleto S, Seguro AC
Clin J Am Soc Nephrol 2007 Jul;2(4):739-44. Epub 2007 Jun 20 doi: 10.2215/CJN.00680207. PMID: 17699490
Human leptospirosis--a review of 50 cases.
Lecour H, Miranda M, Magro C, Rocha A, Gonçalves V
Infection 1989 Jan-Feb;17(1):8-12. doi: 10.1007/BF01643489. PMID: 2921094
Human leptospirosis.
Feigin RD, Anderson DC
CRC Crit Rev Clin Lab Sci 1975 Mar;5(4):413-67. doi: 10.3109/10408367509107050. PMID: 237740

Diagnosis

Leptospirosis and Weil's disease in the UK.
Forbes AE, Zochowski WJ, Dubrey SW, Sivaprakasam V
QJM 2012 Dec;105(12):1151-62. Epub 2012 Jul 27 doi: 10.1093/qjmed/hcs145. PMID: 22843698
Feverish, jaundiced.
Leung J, Schiffer J
Am J Med 2009 Feb;122(2):129-31. doi: 10.1016/j.amjmed.2008.10.009. PMID: 19185086
Weil's syndrome.
dos Santos VM, dos Santos JA, Sugai TA, dos Santos LA
Rev Cubana Med Trop 2003 Jan-Apr;55(1):44-6. PMID: 15849953
Clinical observation and treatment of leptospirosis.
Kobayashi Y
J Infect Chemother 2001 Jun;7(2):59-68. doi: 10.1007/s101560100011. PMID: 11455495
Leptospirosis in Latin America.
Lomar AV, Diament D, Torres JR
Infect Dis Clin North Am 2000 Mar;14(1):23-39, vii-viii. doi: 10.1016/s0891-5520(05)70216-6. PMID: 10738671

Therapy

Weil syndrome causing autoimmune haemolytic anaemia.
Gangula RS, Prabhu MM, Stanley W
Natl Med J India 2019 Mar-Apr;32(2):88-89. doi: 10.4103/0970-258X.275913. PMID: 31939404
Rhabdomyolysis-associated acute kidney injury: Answers.
Aksoy GK, Gemici A, Koyun M, Çomak E, Akman S
Pediatr Nephrol 2018 Sep;33(9):1503-1504. Epub 2017 Nov 9 doi: 10.1007/s00467-017-3837-7. PMID: 29124428
Clinical observation and treatment of leptospirosis.
Kobayashi Y
J Infect Chemother 2001 Jun;7(2):59-68. doi: 10.1007/s101560100011. PMID: 11455495
Human leptospirosis--a review of 50 cases.
Lecour H, Miranda M, Magro C, Rocha A, Gonçalves V
Infection 1989 Jan-Feb;17(1):8-12. doi: 10.1007/BF01643489. PMID: 2921094
Spirochetal infections.
Taber LH, Feigin RD
Pediatr Clin North Am 1979 May;26(2):377-413. doi: 10.1016/s0031-3955(16)33713-0. PMID: 379781

Prognosis

Weil's Disease-Immunopathogenesis, Multiple Organ Failure, and Potential Role of Gut Microbiota.
Petakh P, Isevych V, Kamyshnyi A, Oksenych V
Biomolecules 2022 Dec 7;12(12) doi: 10.3390/biom12121830. PMID: 36551258Free PMC Article
Clinical and imaging manifestations of hemorrhagic pulmonary leptospirosis: a state-of-the-art review.
Marchiori E, Lourenço S, Setúbal S, Zanetti G, Gasparetto TD, Hochhegger B
Lung 2011 Feb;189(1):1-9. Epub 2010 Dec 9 doi: 10.1007/s00408-010-9273-0. PMID: 21152929
Door-to-dialysis time and daily hemodialysis in patients with leptospirosis: impact on mortality.
Andrade L, Cleto S, Seguro AC
Clin J Am Soc Nephrol 2007 Jul;2(4):739-44. Epub 2007 Jun 20 doi: 10.2215/CJN.00680207. PMID: 17699490
Leptospirosis--3 cases and a review.
Gerke P, Rump LC
Clin Nephrol 2003 Jul;60(1):42-8. doi: 10.5414/cnp60042. PMID: 12872857
Clinical observation and treatment of leptospirosis.
Kobayashi Y
J Infect Chemother 2001 Jun;7(2):59-68. doi: 10.1007/s101560100011. PMID: 11455495

Clinical prediction guides

Transposable Prophages in Leptospira: An Ancient, Now Diverse, Group Predominant in Causative Agents of Weil's Disease.
Olo Ndela E, Enault F, Toussaint A
Int J Mol Sci 2021 Dec 14;22(24) doi: 10.3390/ijms222413434. PMID: 34948244Free PMC Article
Leptospirosis in South-western Spain.
Rodríguez-Vidigal FF, Vera-Tomé A, Nogales-Muñoz N, Muñoz-García-Borruel M, Muñoz-Sanz A
Rev Clin Esp (Barc) 2014 Jun-Jul;214(5):247-52. Epub 2014 Apr 1 doi: 10.1016/j.rce.2014.02.009. PMID: 24703813
Clinical and imaging manifestations of hemorrhagic pulmonary leptospirosis: a state-of-the-art review.
Marchiori E, Lourenço S, Setúbal S, Zanetti G, Gasparetto TD, Hochhegger B
Lung 2011 Feb;189(1):1-9. Epub 2010 Dec 9 doi: 10.1007/s00408-010-9273-0. PMID: 21152929
Door-to-dialysis time and daily hemodialysis in patients with leptospirosis: impact on mortality.
Andrade L, Cleto S, Seguro AC
Clin J Am Soc Nephrol 2007 Jul;2(4):739-44. Epub 2007 Jun 20 doi: 10.2215/CJN.00680207. PMID: 17699490
Clinical observation and treatment of leptospirosis.
Kobayashi Y
J Infect Chemother 2001 Jun;7(2):59-68. doi: 10.1007/s101560100011. PMID: 11455495

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