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Vogt-Koyanagi-Harada disease

MedGen UID:
22599
Concept ID:
C0042170
Disease or Syndrome
Synonyms: Disease, Vogt-Koyanagi-Harada; Syndrome, Uveomeningoencephalitic; Syndrome, VKH; Syndrome, VKH (Vogt Koyanagi Harada); Syndrome, Vogt Koyanagi Harada; Syndrome, Vogt-Koyanagi-Harada; Uveomeningoencephalitic Syndrome; Uveomeningoencephalitides; Uveomeningoencephalitis; VKH (Vogt Koyanagi Harada) Syndrome; VKH Syndrome; VKH Syndrome (Vogt Koyanagi Harada); Vogt Koyanagi Harada Disease; Vogt Koyanagi Harada Syndrome; Vogt-Koyanagi-Harada Disease; Vogt-Koyanagi-Harada Syndrome
SNOMED CT: Vogt-Koyanagi syndrome (193497004); Vogt-Koyanagi-Harada disease (193497004); VKH - Vogt-Koyanagi-Harada syndrome (193497004); Harada disease (193497004); Vogt's disease (193497004); Vogt-Koyanagi-Harada syndrome (193497004); Harada's disease (193497004)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
 
Monarch Initiative: MONDO:0018092
Orphanet: ORPHA3437

Definition

Vogt-Koyanagi-Harada disease is a bilateral, chronic, diffuse granulomatous panuveitis typically characterized by serous retinal detachment and frequently associated with neurological (meningitis), auditory, and dermatological alterations. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVogt-Koyanagi-Harada disease

Professional guidelines

PubMed

Souto FMS, Lavezzo MM, Oyamada MK, Yamamoto JH
Clin Exp Ophthalmol 2022 Jul;50(5):569-572. Epub 2022 Apr 29 doi: 10.1111/ceo.14081. PMID: 35384212
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:205-211. Epub 2021 Apr 9 doi: 10.1016/j.ajo.2021.03.036. PMID: 33845018Free PMC Article
Du L, Kijlstra A, Yang P
Prog Retin Eye Res 2016 May;52:84-111. Epub 2016 Feb 11 doi: 10.1016/j.preteyeres.2016.02.002. PMID: 26875727

Recent clinical studies

Etiology

Gentile P, Ragusa E, Bolletta E, De Simone L, Gozzi F, Cappella M, Fastiggi M, De Fanti A, Cimino L
Ocul Immunol Inflamm 2023 Dec;31(10):2050-2059. Epub 2023 Dec 14 doi: 10.1080/09273948.2023.2271988. PMID: 37922466
Arriola-Villalobos P, Moll-Udina A, Carrasco-López-Brea M, Sacristan C, Capella MJ, Peiteado D, Garrote-Llordén A, Albert Fort M, Jódar Márquez M, Jacobo Gonzalez Guijarro J, Demetrio-Pablo R, Luis Sánchez Sevilla J, Carreño E, González-López J, Miguel-Escuder L, Cuadros C, Díaz-Valle D, Adan A; Contributors: VKH Spanish Study Group, Benítez Del Castillo JM, Fonollosa A, Cordero M, Martínez Costa L, Blanco-Alonso R
Eur J Ophthalmol 2022 May;32(3):1547-1554. Epub 2021 Jul 16 doi: 10.1177/11206721211033477. PMID: 34269103
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:205-211. Epub 2021 Apr 9 doi: 10.1016/j.ajo.2021.03.036. PMID: 33845018Free PMC Article
Zhong Z, Su G, Kijlstra A, Yang P
Prog Retin Eye Res 2021 Jan;80:100866. Epub 2020 May 16 doi: 10.1016/j.preteyeres.2020.100866. PMID: 32422390
Damico FM, Kiss S, Young LH
Semin Ophthalmol 2005 Jul-Sep;20(3):183-90. doi: 10.1080/08820530500232126. PMID: 16282153

Diagnosis

Tugal-Tutkun I, Smit DP, Abu El-Asrar AM, Herbort CP Jr, Thorne JE
Ocul Immunol Inflamm 2024 May;32(4):363-366. Epub 2024 Apr 24 doi: 10.1080/09273948.2024.2331401. PMID: 38657222
Joye A, Suhler E
Curr Opin Ophthalmol 2021 Nov 1;32(6):574-582. doi: 10.1097/ICU.0000000000000809. PMID: 34545845
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:205-211. Epub 2021 Apr 9 doi: 10.1016/j.ajo.2021.03.036. PMID: 33845018Free PMC Article
O'Keefe GA, Rao NA
Surv Ophthalmol 2017 Jan-Feb;62(1):1-25. Epub 2016 May 27 doi: 10.1016/j.survophthal.2016.05.002. PMID: 27241814
Cunningham ET Jr, Rathinam SR, Tugal-Tutkun I, Muccioli C, Zierhut M
Ocul Immunol Inflamm 2014 Aug;22(4):249-52. doi: 10.3109/09273948.2014.939530. PMID: 25014114

Therapy

Tugal-Tutkun I, Smit DP, Abu El-Asrar AM, Herbort CP Jr, Thorne JE
Ocul Immunol Inflamm 2024 May;32(4):363-366. Epub 2024 Apr 24 doi: 10.1080/09273948.2024.2331401. PMID: 38657222
Habot-Wilner Z, Neri P, Okada AA, Agrawal R, Xin Le N, Cohen S, Fischer N, Kilmartin F, Coman A, Kilmartin D
Ocul Immunol Inflamm 2023 Aug;31(6):1198-1205. Epub 2023 May 5 doi: 10.1080/09273948.2023.2200858. PMID: 37145198
Street D, Sivaguru A, Sreekantam S, Mollan SP
Pract Neurol 2019 Aug;19(4):364-367. Epub 2019 Mar 19 doi: 10.1136/practneurol-2018-002152. PMID: 30890584
O'Keefe GA, Rao NA
Surv Ophthalmol 2017 Jan-Feb;62(1):1-25. Epub 2016 May 27 doi: 10.1016/j.survophthal.2016.05.002. PMID: 27241814
Damico FM, Kiss S, Young LH
Semin Ophthalmol 2005 Jul-Sep;20(3):183-90. doi: 10.1080/08820530500232126. PMID: 16282153

Prognosis

Habot-Wilner Z, Neri P, Okada AA, Agrawal R, Xin Le N, Cohen S, Fischer N, Kilmartin F, Coman A, Kilmartin D
Ocul Immunol Inflamm 2023 Aug;31(6):1198-1205. Epub 2023 May 5 doi: 10.1080/09273948.2023.2200858. PMID: 37145198
Arriola-Villalobos P, Moll-Udina A, Carrasco-López-Brea M, Sacristan C, Capella MJ, Peiteado D, Garrote-Llordén A, Albert Fort M, Jódar Márquez M, Jacobo Gonzalez Guijarro J, Demetrio-Pablo R, Luis Sánchez Sevilla J, Carreño E, González-López J, Miguel-Escuder L, Cuadros C, Díaz-Valle D, Adan A; Contributors: VKH Spanish Study Group, Benítez Del Castillo JM, Fonollosa A, Cordero M, Martínez Costa L, Blanco-Alonso R
Eur J Ophthalmol 2022 May;32(3):1547-1554. Epub 2021 Jul 16 doi: 10.1177/11206721211033477. PMID: 34269103
Burkholder BM
Curr Opin Ophthalmol 2015 Nov;26(6):506-11. doi: 10.1097/ICU.0000000000000206. PMID: 26448042
Damico FM, Kiss S, Young LH
Semin Ophthalmol 2005 Jul-Sep;20(3):183-90. doi: 10.1080/08820530500232126. PMID: 16282153
Read RW, Rao NA, Cunningham ET
Curr Opin Ophthalmol 2000 Dec;11(6):437-42. doi: 10.1097/00055735-200012000-00009. PMID: 11141638

Clinical prediction guides

Noh H, Nam SW, Yoon JM, Ham DI
Eye (Lond) 2024 Oct;38(15):2960-2967. Epub 2024 Jun 29 doi: 10.1038/s41433-024-03198-8. PMID: 38951674Free PMC Article
Liu X, Meng J, Liao X, Liu Y, Zhou Q, Xu Z, Yin S, Cao Q, Su G, He S, Li W, Wang X, Wang G, Li D, Yang P, Hou S
Cell Mol Immunol 2023 Nov;20(11):1379-1392. Epub 2023 Oct 12 doi: 10.1038/s41423-023-01088-9. PMID: 37828081Free PMC Article
Wang Q, Wu S, Ye X, Tan S, Huang F, Su G, Kijlstra A, Yang P
J Autoimmun 2023 May;137:103055. Epub 2023 May 18 doi: 10.1016/j.jaut.2023.103055. PMID: 37208257
Ataş F, Kaya M, Saatci AO
Turk J Ophthalmol 2022 Dec 28;52(6):400-404. doi: 10.4274/tjo.galenos.2021.86821. PMID: 36578215Free PMC Article
Huang G, Peng J, Ye Z, Kijlstra A, Zhang D, Yang P
Acta Ophthalmol 2018 Jun;96(4):411-419. Epub 2017 Dec 8 doi: 10.1111/aos.13606. PMID: 29220112

Recent systematic reviews

Edwards Mayhew RG, Li T, McCann P, Leslie L, Strong Caldwell A, Palestine AG
Cochrane Database Syst Rev 2022 Oct 31;10(10):CD014831. doi: 10.1002/14651858.CD014831.pub2. PMID: 36315029Free PMC Article
Toudou-Daouda M, Ibrahim-Mamadou AK
BMC Neurol 2022 Feb 4;22(1):44. doi: 10.1186/s12883-022-02569-6. PMID: 35120474Free PMC Article
Liu B, Deng T, Zhu L, Zhong J
Medicine (Baltimore) 2018 Feb;97(7):e9914. doi: 10.1097/MD.0000000000009914. PMID: 29443768Free PMC Article
Shi T, Lv W, Zhang L, Chen J, Chen H
Sci Rep 2014 Nov 10;4:6887. doi: 10.1038/srep06887. PMID: 25382027Free PMC Article
Mehta S, Linton MM, Kempen JH
Am J Ophthalmol 2014 Oct;158(4):676-692.e7. Epub 2014 Jun 28 doi: 10.1016/j.ajo.2014.06.018. PMID: 24983790

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