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Ocular tuberculosis

MedGen UID:
52887
•Concept ID:
C0041322
•
Disease or Syndrome
Synonyms: Ocular Tuberculoses; Ocular Tuberculosis; Tuberculoses, Ocular; Tuberculosis, Ocular
SNOMED CT: Ocular tuberculosis (49107007); Tuberculosis of eye (49107007)
 
Monarch Initiative: MONDO:0006876

Definition

Tuberculous infection of the eye, primarily the iris, ciliary body, and choroid. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOcular tuberculosis

Professional guidelines

PubMed

Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis-Report 2: Guidelines for Initiating Antitubercular Therapy in Anterior Uveitis, Intermediate Uveitis, Panuveitis, and Retinal Vasculitis.
Agrawal R, Testi I, Bodaghi B, Barisani-Asenbauer T, McCluskey P, Agarwal A, Kempen JH, Gupta A, Smith JR, de Smet MD, Yuen YS, Mahajan S, Kon OM, Nguyen QD, Pavesio C, Gupta V; Collaborative Ocular Tuberculosis Study Consensus Group
Ophthalmology 2021 Feb;128(2):277-287. Epub 2020 Jun 27 doi: 10.1016/j.ophtha.2020.06.052. PMID: 32603726
Management of Intraocular Infections in HIV.
Testi I, Mahajan S, Agrawal R, Agarwal A, Marchese A, Curi A, Khairallah M, Leo YS, Nguyen QD, Gupta V
Ocul Immunol Inflamm 2020 Oct 2;28(7):1099-1108. Epub 2020 Mar 12 doi: 10.1080/09273948.2020.1727533. PMID: 32162992
Ocular tuberculosis: Position paper on diagnosis and treatment management.
Figueira L, Fonseca S, Ladeira I, Duarte R
Rev Port Pneumol (2006) 2017 Jan-Feb;23(1):31-38. Epub 2016 Dec 14 doi: 10.1016/j.rppnen.2016.10.004. PMID: 27988134

Recent clinical studies

Etiology

Presumed tuberculosis-related scleritis.
Sainz de La Maza M, Hernanz I, Moll-Udina A, Mesquida M, Adan A, Martinez JA, Espinosa G, Llorenç V
Br J Ophthalmol 2023 Apr;107(4):495-499. Epub 2021 Nov 19 doi: 10.1136/bjophthalmol-2021-319799. PMID: 34799367
Tuberculous Scleritis and Multidrug Resistance.
Agarwal M, Patnaik G, Agarwal S, Iyer G, Anand AR, Ar G, Biswas J, Zierhut M
Ocul Immunol Inflamm 2022 May 19;30(4):915-924. Epub 2021 Jan 8 doi: 10.1080/09273948.2020.1853176. PMID: 33416427
Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis-Report 2: Guidelines for Initiating Antitubercular Therapy in Anterior Uveitis, Intermediate Uveitis, Panuveitis, and Retinal Vasculitis.
Agrawal R, Testi I, Bodaghi B, Barisani-Asenbauer T, McCluskey P, Agarwal A, Kempen JH, Gupta A, Smith JR, de Smet MD, Yuen YS, Mahajan S, Kon OM, Nguyen QD, Pavesio C, Gupta V; Collaborative Ocular Tuberculosis Study Consensus Group
Ophthalmology 2021 Feb;128(2):277-287. Epub 2020 Jun 27 doi: 10.1016/j.ophtha.2020.06.052. PMID: 32603726
Ocular tuberculosis: Where are we today?
Testi I, Agrawal R, Mehta S, Basu S, Nguyen Q, Pavesio C, Gupta V
Indian J Ophthalmol 2020 Sep;68(9):1808-1817. doi: 10.4103/ijo.IJO_1451_20. PMID: 32823397Free PMC Article
Tuberculosis.
Bonfioli AA, de Miranda SS, Campos WR, Orefice F
Semin Ophthalmol 2005 Jul-Sep;20(3):169-75. doi: 10.1080/08820530500231912. PMID: 16282151

Diagnosis

Choroidal tubercles.
Banerjee M, Kaur I, Venkatesh P
Natl Med J India 2023 Sep-Oct;36(5):338. doi: 10.25259/NMJI_763_2022. PMID: 38759991
Diagnosis and biomarkers for ocular tuberculosis: From the present into the future.
Ludi Z, Sule AA, Samy RP, Putera I, Schrijver B, Hutchinson PE, Gunaratne J, Verma I, Singhal A, Nora RD, van Hagen PM, Dik WA, Gupta V, Agrawal R
Theranostics 2023;13(7):2088-2113. Epub 2023 Apr 1 doi: 10.7150/thno.81488. PMID: 37153734Free PMC Article
Presumed tuberculosis-related scleritis.
Sainz de La Maza M, Hernanz I, Moll-Udina A, Mesquida M, Adan A, Martinez JA, Espinosa G, Llorenç V
Br J Ophthalmol 2023 Apr;107(4):495-499. Epub 2021 Nov 19 doi: 10.1136/bjophthalmol-2021-319799. PMID: 34799367
Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis-Report 2: Guidelines for Initiating Antitubercular Therapy in Anterior Uveitis, Intermediate Uveitis, Panuveitis, and Retinal Vasculitis.
Agrawal R, Testi I, Bodaghi B, Barisani-Asenbauer T, McCluskey P, Agarwal A, Kempen JH, Gupta A, Smith JR, de Smet MD, Yuen YS, Mahajan S, Kon OM, Nguyen QD, Pavesio C, Gupta V; Collaborative Ocular Tuberculosis Study Consensus Group
Ophthalmology 2021 Feb;128(2):277-287. Epub 2020 Jun 27 doi: 10.1016/j.ophtha.2020.06.052. PMID: 32603726
Ocular tuberculosis: Where are we today?
Testi I, Agrawal R, Mehta S, Basu S, Nguyen Q, Pavesio C, Gupta V
Indian J Ophthalmol 2020 Sep;68(9):1808-1817. doi: 10.4103/ijo.IJO_1451_20. PMID: 32823397Free PMC Article

Therapy

Choroidal tubercles.
Banerjee M, Kaur I, Venkatesh P
Natl Med J India 2023 Sep-Oct;36(5):338. doi: 10.25259/NMJI_763_2022. PMID: 38759991
Presumed tuberculosis-related scleritis.
Sainz de La Maza M, Hernanz I, Moll-Udina A, Mesquida M, Adan A, Martinez JA, Espinosa G, Llorenç V
Br J Ophthalmol 2023 Apr;107(4):495-499. Epub 2021 Nov 19 doi: 10.1136/bjophthalmol-2021-319799. PMID: 34799367
Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis-Report 2: Guidelines for Initiating Antitubercular Therapy in Anterior Uveitis, Intermediate Uveitis, Panuveitis, and Retinal Vasculitis.
Agrawal R, Testi I, Bodaghi B, Barisani-Asenbauer T, McCluskey P, Agarwal A, Kempen JH, Gupta A, Smith JR, de Smet MD, Yuen YS, Mahajan S, Kon OM, Nguyen QD, Pavesio C, Gupta V; Collaborative Ocular Tuberculosis Study Consensus Group
Ophthalmology 2021 Feb;128(2):277-287. Epub 2020 Jun 27 doi: 10.1016/j.ophtha.2020.06.052. PMID: 32603726
Ocular tuberculosis: Where are we today?
Testi I, Agrawal R, Mehta S, Basu S, Nguyen Q, Pavesio C, Gupta V
Indian J Ophthalmol 2020 Sep;68(9):1808-1817. doi: 10.4103/ijo.IJO_1451_20. PMID: 32823397Free PMC Article
Tuberculosis.
Bonfioli AA, de Miranda SS, Campos WR, Orefice F
Semin Ophthalmol 2005 Jul-Sep;20(3):169-75. doi: 10.1080/08820530500231912. PMID: 16282151

Prognosis

Opportunistic ocular infections in the setting of HIV.
Laovirojjanakul W, Thanathanee O
Curr Opin Ophthalmol 2018 Nov;29(6):558-565. doi: 10.1097/ICU.0000000000000531. PMID: 30169465
Orbital tuberculosis: perspectives from Victoria, Australia.
Yao A, Aboltins C, McNab AA, Rosa CS, Denholm J, Khong JJ
Graefes Arch Clin Exp Ophthalmol 2018 Dec;256(12):2443-2448. Epub 2018 Aug 18 doi: 10.1007/s00417-018-4099-1. PMID: 30121712
Tuberculous uveitis.
Abu El-Asrar AM, Abouammoh M, Al-Mezaine HS
Int Ophthalmol Clin 2010 Spring;50(2):19-39. doi: 10.1097/IIO.0b013e3181d2ccb9. PMID: 20375860
Tuberculosis.
Tabbara KF
Curr Opin Ophthalmol 2007 Nov;18(6):493-501. doi: 10.1097/ICU.0b013e3282f06d2e. PMID: 18163002
HIV/AIDS and blindness.
Kestelyn PG, Cunningham ET Jr
Bull World Health Organ 2001;79(3):208-13. PMID: 11285664Free PMC Article

Clinical prediction guides

Ocular Tuberculosis in Pediatrics: A Case Report.
Vieira PM, Zilhão C, Miranda V
Acta Med Port 2023 Oct 2;36(10):683-686. Epub 2023 Apr 19 doi: 10.20344/amp.19245. PMID: 37080196
Detection of viable Mycobacterium tuberculosis in ocular fluids using mRNA-based multiplex polymerase chain reaction.
Sharma K, Gupta A, Sharma M, Singh S, Sharma A, Singh R, Gupta V
Indian J Med Microbiol 2022 Apr-Jun;40(2):254-257. Epub 2022 Jan 17 doi: 10.1016/j.ijmmb.2021.12.019. PMID: 35058073
Tuberculosis Exposure With Risk of Behçet Disease Among Patients With Uveitis.
Zhong Z, Su G, Zhou Q, Meguro A, Takeuchi M, Mizuki N, Ohno S, Liao W, Feng X, Ding J, Gao Y, Chi W, Zhang M, Zuo X, Yang P
JAMA Ophthalmol 2021 Apr 1;139(4):415-422. doi: 10.1001/jamaophthalmol.2020.6985. PMID: 33599689Free PMC Article
Periorbital tuberculosis.
Kaur A, Kant S, Bhasker SK
Orbit 2007 Mar;26(1):39-42. doi: 10.1080/01676830600671482. PMID: 17510870
Intraocular tuberculosis.
Rosen PH, Spalton DJ, Graham EM
Eye (Lond) 1990;4 ( Pt 3):486-92. doi: 10.1038/eye.1990.63. PMID: 2209914

Recent systematic reviews

Anti-tubercular therapy in the treatment of tubercular uveitis: A systematic review and meta-analysis.
Betzler BK, Putera I, Testi I, La Distia Nora R, Kempen J, Kon OM, Pavesio C, Gupta V, Agrawal R
Surv Ophthalmol 2023 Mar-Apr;68(2):241-256. Epub 2022 Oct 19 doi: 10.1016/j.survophthal.2022.10.001. PMID: 36272559
Global prevalence and clinical outcomes of tubercular uveitis: a systematic review and meta-analysis.
Alli HD, Ally N, Mayet I, Dangor Z, Madhi SA
Surv Ophthalmol 2022 May-Jun;67(3):770-792. Epub 2021 Oct 7 doi: 10.1016/j.survophthal.2021.10.001. PMID: 34626620
Tuberculous Uveitis Presenting with a Bullous Exudative Retinal Detachment: A Case Report and Systematic Literature Review.
Song JH, Koreishi AF, Goldstein DA
Ocul Immunol Inflamm 2019;27(6):998-1009. Epub 2018 Jul 3 doi: 10.1080/09273948.2018.1485958. PMID: 29969330
Anti-tubercular therapy for intraocular tuberculosis: A systematic review and meta-analysis.
Kee AR, Gonzalez-Lopez JJ, Al-Hity A, Gupta B, Lee CS, Gunasekeran DV, Jayabalan N, Grant R, Kon OM, Gupta V, Westcott M, Pavesio C, Agrawal R
Surv Ophthalmol 2016 Sep-Oct;61(5):628-53. Epub 2016 Mar 10 doi: 10.1016/j.survophthal.2016.03.001. PMID: 26970263Free PMC Article
Orbital tuberculosis: a review of the literature.
Madge SN, Prabhakaran VC, Shome D, Kim U, Honavar S, Selva D
Orbit 2008;27(4):267-77. doi: 10.1080/01676830802225152. PMID: 18716964

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