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Trypanosomiasis

MedGen UID:
52872
•Concept ID:
C0041227
•
Disease or Syndrome
Synonym: Trypanosomiases
SNOMED CT: Trypanosomiasis (78940002); Trypanosomosis (78940002)
 
Monarch Initiative: MONDO:0000940

Definition

Infection with protozoa of the genus trypanosoma. [from MONDO]

Professional guidelines

PubMed

Future treatment options for human African trypanosomiasis.
Jones AJ, Avery VM
Expert Rev Anti Infect Ther 2015;13(12):1429-32. Epub 2015 Sep 28 doi: 10.1586/14787210.2015.1094374. PMID: 26414688
Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects.
Patterson S, Wyllie S
Trends Parasitol 2014 Jun;30(6):289-98. Epub 2014 Apr 26 doi: 10.1016/j.pt.2014.04.003. PMID: 24776300Free PMC Article
Eflornithine. A new drug in the treatment of sleeping sickness.
Van Bogaert I, Haemers A
Pharm Weekbl Sci 1989 Jun 23;11(3):69-75. doi: 10.1007/BF02110252. PMID: 2505225

Recent clinical studies

Etiology

APOL1-Mediated Kidney Disease.
Hopper T, Olabisi OA
JAMA 2024 May 21;331(19):1668-1669. doi: 10.1001/jama.2024.2667. PMID: 38662391Free PMC Article
Trypanocidal Essential Oils: A Review.
Morais MC, Souza JV, da Silva Maia Bezerra Filho C, Dolabella SS, Sousa DP
Molecules 2020 Oct 6;25(19) doi: 10.3390/molecules25194568. PMID: 33036315Free PMC Article
Gene of the month: APOL1.
Raghubeer S, Pillay TS, Matsha TE
J Clin Pathol 2020 Aug;73(8):441-443. Epub 2020 May 13 doi: 10.1136/jclinpath-2020-206517. PMID: 32404472
Melarsoprol Resistance in African Trypanosomiasis.
Fairlamb AH, Horn D
Trends Parasitol 2018 Jun;34(6):481-492. Epub 2018 Apr 25 doi: 10.1016/j.pt.2018.04.002. PMID: 29705579
The trypanosomiases.
Barrett MP, Burchmore RJ, Stich A, Lazzari JO, Frasch AC, Cazzulo JJ, Krishna S
Lancet 2003 Nov 1;362(9394):1469-80. doi: 10.1016/S0140-6736(03)14694-6. PMID: 14602444

Diagnosis

Human African Trypanosomiasis: Progress and Stagnation.
Bottieau E, Clerinx J
Infect Dis Clin North Am 2019 Mar;33(1):61-77. doi: 10.1016/j.idc.2018.10.003. PMID: 30712768
Sleeping Sickness in the 'Omics Era.
Tiberti N, Sanchez JC
Proteomics Clin Appl 2018 Jul;12(4):e1700041. Epub 2018 Apr 3 doi: 10.1002/prca.201700041. PMID: 29517161
Historical aspects.
Skoog L, Tani E
Monogr Clin Cytol 2009;18:1-4. Epub 2008 Dec 18 doi: 10.1159/000188789. PMID: 19092258
The trypanosomiases.
Barrett MP, Burchmore RJ, Stich A, Lazzari JO, Frasch AC, Cazzulo JJ, Krishna S
Lancet 2003 Nov 1;362(9394):1469-80. doi: 10.1016/S0140-6736(03)14694-6. PMID: 14602444
Trypanosomiasis.
Lumsden WH
Br Med Bull 1972 Jan;28(1):34-8. doi: 10.1093/oxfordjournals.bmb.a070890. PMID: 4628062

Therapy

Trypanocidal Essential Oils: A Review.
Morais MC, Souza JV, da Silva Maia Bezerra Filho C, Dolabella SS, Sousa DP
Molecules 2020 Oct 6;25(19) doi: 10.3390/molecules25194568. PMID: 33036315Free PMC Article
100 Years of Suramin.
Wiedemar N, Hauser DA, Mäser P
Antimicrob Agents Chemother 2020 Feb 21;64(3) doi: 10.1128/AAC.01168-19. PMID: 31844000Free PMC Article
Human African Trypanosomiasis: Progress and Stagnation.
Bottieau E, Clerinx J
Infect Dis Clin North Am 2019 Mar;33(1):61-77. doi: 10.1016/j.idc.2018.10.003. PMID: 30712768
Melarsoprol Resistance in African Trypanosomiasis.
Fairlamb AH, Horn D
Trends Parasitol 2018 Jun;34(6):481-492. Epub 2018 Apr 25 doi: 10.1016/j.pt.2018.04.002. PMID: 29705579
African trypanosomiasis.
Morrison LJ, MacLeod A
Parasite Immunol 2011 Aug;33(8):421-2. doi: 10.1111/j.1365-3024.2011.01302.x. PMID: 21609334Free PMC Article

Prognosis

Neuropsychiatric Aspects of Parasitic Infections-A Review.
Goyal G, Kaur U, Sharma M, Sehgal R
Neurol India 2023 Mar-Apr;71(2):228-232. doi: 10.4103/0028-3886.375424. PMID: 37148042
Transporters of Trypanosoma brucei-phylogeny, physiology, pharmacology.
Schmidt RS, Macêdo JP, Steinmann ME, Salgado AG, Bütikofer P, Sigel E, Rentsch D, Mäser P
FEBS J 2018 Mar;285(6):1012-1023. Epub 2017 Nov 13 doi: 10.1111/febs.14302. PMID: 29063677
Nodding syndrome.
Dowell SF, Sejvar JJ, Riek L, Vandemaele KA, Lamunu M, Kuesel AC, Schmutzhard E, Matuja W, Bunga S, Foltz J, Nutman TB, Winkler AS, Mbonye AK
Emerg Infect Dis 2013;19(9):1374-84. doi: 10.3201/eid1909.130401. PMID: 23965548Free PMC Article
Transfusion-transmitted infectious diseases.
Allain JP, Stramer SL, Carneiro-Proietti AB, Martins ML, Lopes da Silva SN, Ribeiro M, Proietti FA, Reesink HW
Biologicals 2009 Apr;37(2):71-7. Epub 2009 Feb 20 doi: 10.1016/j.biologicals.2009.01.002. PMID: 19231236
Congenital trypanosomiasis.
Ngoma MS, Nalubamba M, Kowa S, Minyoi D, Mubanga J, Mwansa J, Musuku J, Chintu C, Bhat G, Kapakala T, Mumba P, Nyalungwe K
J Trop Pediatr 2004 Dec;50(6):377-8. doi: 10.1093/tropej/50.6.377. PMID: 15537729

Clinical prediction guides

Vanadium compounds as antiparasitic agents: An approach to their mechanisms of action.
Brenda CT, Norma RF, Marcela RL, Nelly LV, Teresa F 1st
J Trace Elem Med Biol 2023 Jul;78:127201. Epub 2023 May 15 doi: 10.1016/j.jtemb.2023.127201. PMID: 37210920
Nuclear localization signals in trypanosomal proteins.
Canela-Pérez I, López-Villaseñor I, Mendoza L, Cevallos AM, Hernández R
Mol Biochem Parasitol 2019 Apr;229:15-23. Epub 2019 Feb 14 doi: 10.1016/j.molbiopara.2019.02.003. PMID: 30772422
Transporters of Trypanosoma brucei-phylogeny, physiology, pharmacology.
Schmidt RS, Macêdo JP, Steinmann ME, Salgado AG, Bütikofer P, Sigel E, Rentsch D, Mäser P
FEBS J 2018 Mar;285(6):1012-1023. Epub 2017 Nov 13 doi: 10.1111/febs.14302. PMID: 29063677
Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story.
Baker N, de Koning HP, Mäser P, Horn D
Trends Parasitol 2013 Mar;29(3):110-8. Epub 2013 Jan 30 doi: 10.1016/j.pt.2012.12.005. PMID: 23375541Free PMC Article
Boron-based drugs as antiprotozoals.
Jacobs RT, Plattner JJ, Keenan M
Curr Opin Infect Dis 2011 Dec;24(6):586-92. doi: 10.1097/QCO.0b013e32834c630e. PMID: 22001943

Recent systematic reviews

A systematic review and meta-analysis of small ruminant and porcine trypanosomiasis prevalence in sub-Saharan Africa (1986 to 2018).
Ebhodaghe F, Ohiolei JA, Isaac C
Acta Trop 2018 Dec;188:118-131. Epub 2018 Sep 1 doi: 10.1016/j.actatropica.2018.08.034. PMID: 30179607
Is metformin poised for a second career as an antimicrobial?
Malik F, Mehdi SF, Ali H, Patel P, Basharat A, Kumar A, Ashok F, Stein J, Brima W, Malhotra P, Roth J
Diabetes Metab Res Rev 2018 May;34(4):e2975. Epub 2018 Feb 20 doi: 10.1002/dmrr.2975. PMID: 29271563
A systematic review of pentacyclic triterpenes and their derivatives as chemotherapeutic agents against tropical parasitic diseases.
Isah MB, Ibrahim MA, Mohammed A, Aliyu AB, Masola B, Coetzer TH
Parasitology 2016 Sep;143(10):1219-31. Epub 2016 May 31 doi: 10.1017/S0031182016000718. PMID: 27240847
Human African trypanosomiasis prevention, treatment and control costs: a systematic review.
Keating J, Yukich JO, Sutherland CS, Woods G, Tediosi F
Acta Trop 2015 Oct;150:4-13. Epub 2015 Jun 6 doi: 10.1016/j.actatropica.2015.06.003. PMID: 26056739
Human african trypanosomiasis diagnosis in first-line health services of endemic countries, a systematic review.
Mitashi P, Hasker E, Lejon V, Kande V, Muyembe JJ, Lutumba P, Boelaert M
PLoS Negl Trop Dis 2012;6(11):e1919. Epub 2012 Nov 29 doi: 10.1371/journal.pntd.0001919. PMID: 23209860Free PMC Article

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