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Trigeminal neuralgia

MedGen UID:
21683
•Concept ID:
C0040997
•
Disease or Syndrome
Synonyms: Disease, Fothergill; Epileptiform Neuralgia; Epileptiform Neuralgias; Fothergill Disease; Neuralgia, Epileptiform; Neuralgia, Trifacial; Neuralgia, Trigeminal; Tic Doloureux; Tic Douloureux; Trifacial Neuralgia; Trifacial Neuralgias; Trigeminal Neuralgia; Trigeminal Neuralgias
SNOMED CT: TN - Trigeminal neuralgia (31681005); Trigeminal neuralgia (31681005); Tic douloureux (31681005); Trifacial neuralgia (31681005); Fothergill's neuralgia (31681005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0100661
Monarch Initiative: MONDO:0008599
OMIM®: 190400
Orphanet: ORPHA221091

Definition

A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected. [from HPO]

Clinical features

From HPO
Trigeminal neuralgia
MedGen UID:
21683
•Concept ID:
C0040997
•
Disease or Syndrome
A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected.
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrigeminal neuralgia
Follow this link to review classifications for Trigeminal neuralgia in Orphanet.

Conditions with this feature

Facial hemiatrophy
MedGen UID:
8761
•Concept ID:
C0015458
•
Disease or Syndrome
Unilateral atrophy of facial tissues, including muscles, bones and skin.
See: Condition Record
Trigeminal neuralgia
MedGen UID:
21683
•Concept ID:
C0040997
•
Disease or Syndrome
A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected.
See: Condition Record
Facial hemiatrophy
Trigeminal neuralgia

Professional guidelines

PubMed

Trigeminal Neuralgia: Diagnosis and Treatment.
Allam AK, Sharma H, Larkin MB, Viswanathan A
Neurol Clin 2023 Feb;41(1):107-121. doi: 10.1016/j.ncl.2022.09.001. PMID: 36400550
Neuropathic Pain: From Mechanisms to Treatment.
Finnerup NB, Kuner R, Jensen TS
Physiol Rev 2021 Jan 1;101(1):259-301. Epub 2020 Jun 25 doi: 10.1152/physrev.00045.2019. PMID: 32584191
Advances in diagnosis, classification, pathophysiology, and management of trigeminal neuralgia.
Bendtsen L, Zakrzewska JM, Heinskou TB, Hodaie M, Leal PRL, Nurmikko T, Obermann M, Cruccu G, Maarbjerg S
Lancet Neurol 2020 Sep;19(9):784-796. doi: 10.1016/S1474-4422(20)30233-7. PMID: 32822636

Curated

UK NICE Clinical Guideline CG173, Neuropathic pain in adults: pharmacological management in non-specialist settings, 2020

Recent clinical studies

Etiology

Microvascular Decompression and Trigeminal Neuralgia: Patient Sentiment Analysis Using Natural Language Processing.
Niazi F, Elkaim LM, Zadeh Khomami NM, Levett JJ, Weil AG, Hodaie M, Alotaibi NM
World Neurosurg 2023 Dec;180:e528-e536. Epub 2023 Sep 30 doi: 10.1016/j.wneu.2023.09.107. PMID: 37778624
Acupuncture for the treatment of trigeminal neuralgia: A systematic review and meta-analysis.
Ang L, Kim HJ, Heo JW, Choi TY, Lee HW, Kim JI, Lee MS
Complement Ther Clin Pract 2023 Aug;52:101763. Epub 2023 May 2 doi: 10.1016/j.ctcp.2023.101763. PMID: 37159979
Trigeminal Neuralgia.
Khawaja SN, Scrivani SJ
Dent Clin North Am 2023 Jan;67(1):99-115. Epub 2022 Oct 27 doi: 10.1016/j.cden.2022.07.008. PMID: 36404084
Trigeminal neuralgia: a practical guide.
Lambru G, Zakrzewska J, Matharu M
Pract Neurol 2021 Oct;21(5):392-402. Epub 2021 Jun 9 doi: 10.1136/practneurol-2020-002782. PMID: 34108244Free PMC Article
Trigeminal neuralgia secondary to multiple sclerosis: from the clinical picture to the treatment options.
Di Stefano G, Maarbjerg S, Truini A
J Headache Pain 2019 Feb 19;20(1):20. doi: 10.1186/s10194-019-0969-0. PMID: 30782116Free PMC Article

Diagnosis

Trigeminal Neuralgia.
Khawaja SN, Scrivani SJ
Dent Clin North Am 2023 Jan;67(1):99-115. Epub 2022 Oct 27 doi: 10.1016/j.cden.2022.07.008. PMID: 36404084
Trigeminal Neuralgia: Diagnosis and Treatment.
Allam AK, Sharma H, Larkin MB, Viswanathan A
Neurol Clin 2023 Feb;41(1):107-121. doi: 10.1016/j.ncl.2022.09.001. PMID: 36400550
TREATMENT OPTIONS FOR TRIGEMINAL NEURALGIA.
Radoš I
Acta Clin Croat 2022 Sep;61(Suppl 2):96-102. doi: 10.20471/acc.2022.61.s2.12. PMID: 36824641Free PMC Article
Advances in diagnosis, classification, pathophysiology, and management of trigeminal neuralgia.
Bendtsen L, Zakrzewska JM, Heinskou TB, Hodaie M, Leal PRL, Nurmikko T, Obermann M, Cruccu G, Maarbjerg S
Lancet Neurol 2020 Sep;19(9):784-796. doi: 10.1016/S1474-4422(20)30233-7. PMID: 32822636
Trigeminal neuralgia - diagnosis and treatment.
Maarbjerg S, Di Stefano G, Bendtsen L, Cruccu G
Cephalalgia 2017 Jun;37(7):648-657. Epub 2017 Jan 11 doi: 10.1177/0333102416687280. PMID: 28076964

Therapy

Acupuncture for the treatment of trigeminal neuralgia: A systematic review and meta-analysis.
Ang L, Kim HJ, Heo JW, Choi TY, Lee HW, Kim JI, Lee MS
Complement Ther Clin Pract 2023 Aug;52:101763. Epub 2023 May 2 doi: 10.1016/j.ctcp.2023.101763. PMID: 37159979
TREATMENT OPTIONS FOR TRIGEMINAL NEURALGIA.
Radoš I
Acta Clin Croat 2022 Sep;61(Suppl 2):96-102. doi: 10.20471/acc.2022.61.s2.12. PMID: 36824641Free PMC Article
Trigeminal Neuralgia.
Cruccu G, Di Stefano G, Truini A
N Engl J Med 2020 Aug 20;383(8):754-762. doi: 10.1056/NEJMra1914484. PMID: 32813951
Use of Botulinum Toxin in Orofacial Clinical Practice.
Serrera-Figallo MA, Ruiz-de-León-Hernández G, Torres-Lagares D, Castro-Araya A, Torres-Ferrerosa O, Hernández-Pacheco E, Gutierrez-Perez JL
Toxins (Basel) 2020 Feb 11;12(2) doi: 10.3390/toxins12020112. PMID: 32053883Free PMC Article
Interventional management of neuropathic pain: NeuPSIG recommendations.
Dworkin RH, O'Connor AB, Kent J, Mackey SC, Raja SN, Stacey BR, Levy RM, Backonja M, Baron R, Harke H, Loeser JD, Treede RD, Turk DC, Wells CD
Pain 2013 Nov;154(11):2249-2261. Epub 2013 Jun 6 doi: 10.1016/j.pain.2013.06.004. PMID: 23748119Free PMC Article

Prognosis

Secondary Trigeminal Neuralgia- Surgery vs. Radiosurgery: Which is better?
Chandra PS
Neurol India 2022 May-Jun;70(3):843-844. doi: 10.4103/0028-3886.349723. PMID: 35864606
Glossopharyngeal neuralgia and radiosurgery.
Martínez-Álvarez R, Martínez-Moreno N, Kusak ME, Rey-Portolés G
J Neurosurg 2014 Dec;121 Suppl:222-5. doi: 10.3171/2014.8.GKS141273. PMID: 25434956
Neuropathic pain in the general population: a systematic review of epidemiological studies.
van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N
Pain 2014 Apr;155(4):654-662. Epub 2013 Nov 26 doi: 10.1016/j.pain.2013.11.013. PMID: 24291734
Trigeminal neuralgia.
Hayashi M
Prog Neurol Surg 2009;22:182-190. doi: 10.1159/000163431. PMID: 18948729
The facial tics.
Harrison MS
J Laryngol Otol 1976 Jun;90(6):561-70. doi: 10.1017/s0022215100082451. PMID: 778316

Clinical prediction guides

Trigeminal neuralgia caused by venous compression: a comprehensive literature review.
Alzeeralhouseini A, Moisak G, Labzina E, Rzaev J
J Med Life 2024 May;17(5):462-470. doi: 10.25122/jml-2024-0040. PMID: 39144685Free PMC Article
Trigeminal Neuralgia as a Primary Demyelinating Disease: Potential Multimodal Evidence and Remaining Controversies.
Mousavi SH, Lindsey JW, Westlund KN, Alles SRA
J Pain 2024 Feb;25(2):302-311. Epub 2023 Aug 27 doi: 10.1016/j.jpain.2023.08.012. PMID: 37643657
Open and Percutaneous Trigeminal Nucleotractotomy: A Case Series and Literature Review.
Anisimov ED, Rzaev JA, Moysak GI, Dmitriev AB, Duff IE, Slavin KV
Stereotact Funct Neurosurg 2023;101(6):387-394. Epub 2023 Nov 6 doi: 10.1159/000534488. PMID: 37931603
Acupuncture for the treatment of trigeminal neuralgia: A systematic review and meta-analysis.
Ang L, Kim HJ, Heo JW, Choi TY, Lee HW, Kim JI, Lee MS
Complement Ther Clin Pract 2023 Aug;52:101763. Epub 2023 May 2 doi: 10.1016/j.ctcp.2023.101763. PMID: 37159979
Retrospective Analysis of Clinical Feature in Trigeminal Neuralgia.
Hong JH, Lee JY, Kim SJ, Seo KH
Pain Physician 2023 Jan;26(1):39-44. PMID: 36791292

Recent systematic reviews

Repeat Surgery for Recurrent or Refractory Trigeminal Neuralgia: A Systematic Review and Meta-Analysis.
Rheaume AR, Pietrosanu M, Ostertag C, Sankar T
World Neurosurg 2024 May;185:370-380.e2. Epub 2024 Feb 24 doi: 10.1016/j.wneu.2024.02.097. PMID: 38403014
Joint European Academy of Neurology-European Pain Federation-Neuropathic Pain Special Interest Group of the International Association for the Study of Pain guidelines on neuropathic pain assessment.
Truini A, Aleksovska K, Anderson CC, Attal N, Baron R, Bennett DL, Bouhassira D, Cruccu G, Eisenberg E, Enax-Krumova E, Davis KD, Di Stefano G, Finnerup NB, Garcia-Larrea L, Hanafi I, Haroutounian S, Karlsson P, Rakusa M, Rice ASC, Sachau J, Smith BH, Sommer C, Tölle T, Valls-Solé J, Veluchamy A
Eur J Neurol 2023 Aug;30(8):2177-2196. Epub 2023 May 30 doi: 10.1111/ene.15831. PMID: 37253688
Acupuncture for the treatment of trigeminal neuralgia: A systematic review and meta-analysis.
Ang L, Kim HJ, Heo JW, Choi TY, Lee HW, Kim JI, Lee MS
Complement Ther Clin Pract 2023 Aug;52:101763. Epub 2023 May 2 doi: 10.1016/j.ctcp.2023.101763. PMID: 37159979
Trigeminal neuralgia.
Zakrzewska JM, Linskey ME
BMJ Clin Evid 2014 Oct 6;2014 PMID: 25299564Free PMC Article
Neuropathic pain in the general population: a systematic review of epidemiological studies.
van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N
Pain 2014 Apr;155(4):654-662. Epub 2013 Nov 26 doi: 10.1016/j.pain.2013.11.013. PMID: 24291734

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2020
      UK NICE Clinical Guideline CG173, Neuropathic pain in adults: pharmacological management in non-specialist settings, 2020

    Reviews

    Related information

    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

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