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Chromosomal translocation

MedGen UID:
21243
•Concept ID:
C0040715
•
Cell or Molecular Dysfunction
Synonyms: Chromosomal Translocation; Chromosomal Translocations; Genetic Translocation; Genetic Translocations; Translocation, Chromosomal; Translocation, Genetic; Translocations, Chromosomal; Translocations, Genetic
SNOMED CT: Chromosomal translocation (15897004)

Definition

A genetic exchange where a piece of one chromosome is transferred to another chromosome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChromosomal translocation

Professional guidelines

PubMed

Exploration of treatment-free remission in CML, based on molecular monitoring.
Zhang Z, Zhou X, Zhou X, Cheng Z, Hu Y
Cancer Med 2024 Jan;13(1):e6849. Epub 2023 Dec 22 doi: 10.1002/cam4.6849. PMID: 38133525Free PMC Article
Advances in treatment of alveolar soft part sarcoma: an updated review.
Fujiwara T, Kunisada T, Nakata E, Nishida K, Yanai H, Nakamura T, Tanaka K, Ozaki T
Jpn J Clin Oncol 2023 Nov 5;53(11):1009-1018. doi: 10.1093/jjco/hyad102. PMID: 37626447Free PMC Article
Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management.
Vose JM
Am J Hematol 2017 Aug;92(8):806-813. doi: 10.1002/ajh.24797. PMID: 28699667

Recent clinical studies

Etiology

Polycomb complexes in MLL-AF9-related leukemias.
Sparavier A, Di Croce L
Curr Opin Genet Dev 2022 Aug;75:101920. Epub 2022 May 21 doi: 10.1016/j.gde.2022.101920. PMID: 35609423
Imaging characteristics of infantile fibrosarcoma.
Eleti S, Meshaka R, McHugh K, Sebire N, Tahir N
Clin Radiol 2022 Jul;77(7):e532-e539. Epub 2022 Apr 30 doi: 10.1016/j.crad.2022.03.023. PMID: 35504757
Role of Oncogenes and Tumor-suppressor Genes in Carcinogenesis: A Review.
Kontomanolis EN, Koutras A, Syllaios A, Schizas D, Mastoraki A, Garmpis N, Diakosavvas M, Angelou K, Tsatsaris G, Pagkalos A, Ntounis T, Fasoulakis Z
Anticancer Res 2020 Nov;40(11):6009-6015. doi: 10.21873/anticanres.14622. PMID: 33109539
Follicular lymphoma.
Carbone A, Roulland S, Gloghini A, Younes A, von Keudell G, López-Guillermo A, Fitzgibbon J
Nat Rev Dis Primers 2019 Dec 12;5(1):83. doi: 10.1038/s41572-019-0132-x. PMID: 31831752
Burkitt's lymphoma.
Molyneux EM, Rochford R, Griffin B, Newton R, Jackson G, Menon G, Harrison CJ, Israels T, Bailey S
Lancet 2012 Mar 31;379(9822):1234-44. Epub 2012 Feb 13 doi: 10.1016/S0140-6736(11)61177-X. PMID: 22333947

Diagnosis

Synovial Sarcoma: A Clinical Review.
Gazendam AM, Popovic S, Munir S, Parasu N, Wilson D, Ghert M
Curr Oncol 2021 May 19;28(3):1909-1920. doi: 10.3390/curroncol28030177. PMID: 34069748Free PMC Article
Follicular lymphoma.
Carbone A, Roulland S, Gloghini A, Younes A, von Keudell G, López-Guillermo A, Fitzgibbon J
Nat Rev Dis Primers 2019 Dec 12;5(1):83. doi: 10.1038/s41572-019-0132-x. PMID: 31831752
Translocation-Related Sarcomas.
Nakano K, Takahashi S
Int J Mol Sci 2018 Nov 28;19(12) doi: 10.3390/ijms19123784. PMID: 30487384Free PMC Article
Clinical and Molecular Spectrum of Liposarcoma.
Lee ATJ, Thway K, Huang PH, Jones RL
J Clin Oncol 2018 Jan 10;36(2):151-159. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.74.9598. PMID: 29220294Free PMC Article
FGF receptors: cancer biology and therapeutics.
Katoh M, Nakagama H
Med Res Rev 2014 Mar;34(2):280-300. Epub 2013 May 21 doi: 10.1002/med.21288. PMID: 23696246

Therapy

TK216 targets microtubules in Ewing sarcoma cells.
Povedano JM, Li V, Lake KE, Bai X, Rallabandi R, Kim J, Xie Y, De Brabander JK, McFadden DG
Cell Chem Biol 2022 Aug 18;29(8):1325-1332.e4. Epub 2022 Jul 7 doi: 10.1016/j.chembiol.2022.06.002. PMID: 35803262Free PMC Article
CRISPR/Cas9-Engineered Universal CD19/CD22 Dual-Targeted CAR-T Cell Therapy for Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia.
Hu Y, Zhou Y, Zhang M, Ge W, Li Y, Yang L, Wei G, Han L, Wang H, Yu S, Chen Y, Wang Y, He X, Zhang X, Gao M, Yang J, Li X, Ren J, Huang H
Clin Cancer Res 2021 May 15;27(10):2764-2772. Epub 2021 Feb 24 doi: 10.1158/1078-0432.CCR-20-3863. PMID: 33627493
Follicular lymphoma.
Carbone A, Roulland S, Gloghini A, Younes A, von Keudell G, López-Guillermo A, Fitzgibbon J
Nat Rev Dis Primers 2019 Dec 12;5(1):83. doi: 10.1038/s41572-019-0132-x. PMID: 31831752
FGF receptors: cancer biology and therapeutics.
Katoh M, Nakagama H
Med Res Rev 2014 Mar;34(2):280-300. Epub 2013 May 21 doi: 10.1002/med.21288. PMID: 23696246
Burkitt's lymphoma.
Molyneux EM, Rochford R, Griffin B, Newton R, Jackson G, Menon G, Harrison CJ, Israels T, Bailey S
Lancet 2012 Mar 31;379(9822):1234-44. Epub 2012 Feb 13 doi: 10.1016/S0140-6736(11)61177-X. PMID: 22333947

Prognosis

Synovial Sarcoma: A Clinical Review.
Gazendam AM, Popovic S, Munir S, Parasu N, Wilson D, Ghert M
Curr Oncol 2021 May 19;28(3):1909-1920. doi: 10.3390/curroncol28030177. PMID: 34069748Free PMC Article
B Cell Lymphoma.
Meng X, Min Q, Wang JY
Adv Exp Med Biol 2020;1254:161-181. doi: 10.1007/978-981-15-3532-1_12. PMID: 32323276
Translocation-Related Sarcomas.
Nakano K, Takahashi S
Int J Mol Sci 2018 Nov 28;19(12) doi: 10.3390/ijms19123784. PMID: 30487384Free PMC Article
Clinical and Molecular Spectrum of Liposarcoma.
Lee ATJ, Thway K, Huang PH, Jones RL
J Clin Oncol 2018 Jan 10;36(2):151-159. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.74.9598. PMID: 29220294Free PMC Article
Burkitt's lymphoma.
Molyneux EM, Rochford R, Griffin B, Newton R, Jackson G, Menon G, Harrison CJ, Israels T, Bailey S
Lancet 2012 Mar 31;379(9822):1234-44. Epub 2012 Feb 13 doi: 10.1016/S0140-6736(11)61177-X. PMID: 22333947

Clinical prediction guides

TK216 targets microtubules in Ewing sarcoma cells.
Povedano JM, Li V, Lake KE, Bai X, Rallabandi R, Kim J, Xie Y, De Brabander JK, McFadden DG
Cell Chem Biol 2022 Aug 18;29(8):1325-1332.e4. Epub 2022 Jul 7 doi: 10.1016/j.chembiol.2022.06.002. PMID: 35803262Free PMC Article
Synovial Sarcoma: A Clinical Review.
Gazendam AM, Popovic S, Munir S, Parasu N, Wilson D, Ghert M
Curr Oncol 2021 May 19;28(3):1909-1920. doi: 10.3390/curroncol28030177. PMID: 34069748Free PMC Article
Translocation-Related Sarcomas.
Nakano K, Takahashi S
Int J Mol Sci 2018 Nov 28;19(12) doi: 10.3390/ijms19123784. PMID: 30487384Free PMC Article
Mechanisms of NF-κB deregulation in lymphoid malignancies.
Krappmann D, Vincendeau M
Semin Cancer Biol 2016 Aug;39:3-14. Epub 2016 Jun 2 doi: 10.1016/j.semcancer.2016.05.002. PMID: 27262792
Ewing sarcoma: a chronicle of molecular pathogenesis.
Kim SK, Park YK
Hum Pathol 2016 Sep;55:91-100. Epub 2016 May 28 doi: 10.1016/j.humpath.2016.05.008. PMID: 27246176

Recent systematic reviews

Predictive performance of population pharmacokinetic models of imatinib in chronic myeloid leukemia patients.
Dilli Batcha JS, Gota V, Matcha S, Raju AP, Rao M, Udupa KS, Mallayasamy S
Cancer Chemother Pharmacol 2024 Jul;94(1):35-44. Epub 2024 Mar 5 doi: 10.1007/s00280-024-04644-w. PMID: 38441626Free PMC Article
Reciprocal translocation and Robertsonian translocation in relation to semen parameters: A retrospective study and systematic review.
Chen X, Zhou C
Andrologia 2022 Feb;54(1):e14262. Epub 2021 Oct 2 doi: 10.1111/and.14262. PMID: 34599520

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