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Thyroglossal cyst

MedGen UID:
11810
•Concept ID:
C0040124
•
Congenital Abnormality
Synonym: Thyroglossal duct cyst
SNOMED CT: Thyroglossal duct cyst (39462005); Thyroglossal cyst (39462005)
 
HPO: HP:0010518
Monarch Initiative: MONDO:0006460
Orphanet: ORPHA489

Definition

An abnormality of the thyroid gland owing to the presence of a fibrous cyst resulting from the persistence of the thyroglossal duct. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroglossal cyst

Professional guidelines

PubMed

Ethanol ablation for the treatment of thyroglossal duct cysts: follow-up results for longer than 2 years.
Park SI, Baek JH, Chung SR, Choi YJ, Lee JH, Kim TY, Lee YM, Baek SM
Eur Radiol 2022 May;32(5):3525-3531. Epub 2022 Jan 7 doi: 10.1007/s00330-021-08402-x. PMID: 34993573
Simple bone cyst of the hyoid: A radiological diagnosis and follow-up.
Koç N, Parlak Ş
Dent Med Probl 2020 Jul-Sep;57(3):333-337. doi: 10.17219/dmp/120079. PMID: 33113293
Management of well-differentiated thyroid carcinoma presenting within a thyroglossal duct cyst.
Patel SG, Escrig M, Shaha AR, Singh B, Shah JP
J Surg Oncol 2002 Mar;79(3):134-9; discussion 140-1. doi: 10.1002/jso.10059. PMID: 11870661

Recent clinical studies

Etiology

Preoperative investigations in thyroglossal duct cyst surgery: a 9-year experience and proposed practice guide.
Mettias B, Cole S, Valsamakis T
Ann R Coll Surg Engl 2023 Jul;105(6):554-560. doi: 10.1308/rcsann.2022.0060. PMID: 37390846Free PMC Article
¿Who was Sistrunk?
Girón Vallejo O
Cir Pediatr 2022 Apr 1;35(2):55-56. doi: 10.54847/cp.2022.02.11. PMID: 35485751
Congenital Neck Masses.
Pupić-Bakrač J, Pupić-Bakrač A, Novaković J, Skitarelić N
J Craniofac Surg 2021 Jun 1;32(4):1417-1420. doi: 10.1097/SCS.0000000000007122. PMID: 33170821
Congenital Neck Masses.
Quintanilla-Dieck L, Penn EB Jr
Clin Perinatol 2018 Dec;45(4):769-785. Epub 2018 Sep 18 doi: 10.1016/j.clp.2018.07.012. PMID: 30396417
Thyroglossal duct cyst and ectopic thyroid: surgical management.
Oomen KP, Modi VK, Maddalozzo J
Otolaryngol Clin North Am 2015 Feb;48(1):15-27. doi: 10.1016/j.otc.2014.09.003. PMID: 25439547

Diagnosis

Congenital Neck Masses.
Ryu J, Igawa T, Mohole J, Coward M
Neoreviews 2023 Oct 1;24(10):e642-e649. doi: 10.1542/neo.24-10-e642. PMID: 37777610
Congenital Neck Masses.
Quintanilla-Dieck L, Penn EB Jr
Clin Perinatol 2018 Dec;45(4):769-785. Epub 2018 Sep 18 doi: 10.1016/j.clp.2018.07.012. PMID: 30396417
Thyroglossal duct cyst.
Thompson LD
Ear Nose Throat J 2017 Feb;96(2):54-55. doi: 10.1177/014556131709600204. PMID: 28231361
Pediatric neck masses.
Curtis WJ, Edwards SP
Atlas Oral Maxillofac Surg Clin North Am 2015 Mar;23(1):15-20. Epub 2014 Nov 26 doi: 10.1016/j.cxom.2014.10.002. PMID: 25707561
Pediatric neck masses.
Goins MR, Beasley MS
Oral Maxillofac Surg Clin North Am 2012 Aug;24(3):457-68. doi: 10.1016/j.coms.2012.05.006. PMID: 22857718

Therapy

Ultrasound-Guided Ethanol Ablation as a Primary Treatment for Thyroglossal Duct Cyst: Feasibility, Characteristics, and Outcomes.
Ahn D, Kwak JH, Lee GJ, Sohn JH
Otolaryngol Head Neck Surg 2023 Jun;168(6):1381-1388. Epub 2023 Jan 25 doi: 10.1002/ohn.231. PMID: 36939631
Treatment Efficacy and Safety of Ethanol Ablation for Thyroglossal Duct Cysts: A Comparison with Surgery.
Chung MS, Baek JH, Lee JH, Choi YJ, Yoon JH, Nam SY, Kim SC, Sung JY, Baek SM, Na DG
Eur Radiol 2017 Jul;27(7):2708-2716. Epub 2016 Dec 12 doi: 10.1007/s00330-016-4659-x. PMID: 27957639
Curiositas.
Ulster Med J 2015 Oct;84(3):215-6. PMID: 26668426Free PMC Article
Surgical management outcomes of recurrent thyroglossal duct cyst in children--A systematic review.
Ibrahim FF, Alnoury MK, Varma N, Daniel SJ
Int J Pediatr Otorhinolaryngol 2015 Jun;79(6):863-867. Epub 2015 Mar 28 doi: 10.1016/j.ijporl.2015.03.019. PMID: 25890397
Congenital lesions of epithelial origin.
Hills SE, Maddalozzo J
Otolaryngol Clin North Am 2015 Feb;48(1):209-23. doi: 10.1016/j.otc.2014.09.014. PMID: 25439555

Prognosis

Congenital Neck Masses.
Ryu J, Igawa T, Mohole J, Coward M
Neoreviews 2023 Oct 1;24(10):e642-e649. doi: 10.1542/neo.24-10-e642. PMID: 37777610
Congenital Neck Masses.
Quintanilla-Dieck L, Penn EB Jr
Clin Perinatol 2018 Dec;45(4):769-785. Epub 2018 Sep 18 doi: 10.1016/j.clp.2018.07.012. PMID: 30396417
Congenital lesions of epithelial origin.
Hills SE, Maddalozzo J
Otolaryngol Clin North Am 2015 Feb;48(1):209-23. doi: 10.1016/j.otc.2014.09.014. PMID: 25439555
Thyroglossal duct cyst and ectopic thyroid: surgical management.
Oomen KP, Modi VK, Maddalozzo J
Otolaryngol Clin North Am 2015 Feb;48(1):15-27. doi: 10.1016/j.otc.2014.09.003. PMID: 25439547
Thyroglossal duct carcinoma.
Motamed M, McGlashan JA
Curr Opin Otolaryngol Head Neck Surg 2004 Apr;12(2):106-9. doi: 10.1097/00020840-200404000-00009. PMID: 15167046

Clinical prediction guides

Diagnosis and Treatment of Double Thyroglossal Duct Cyst.
Li B, Wang Y, Fu Y, Liu D, She C
J Craniofac Surg 2023 Nov-Dec 01;34(8):e763-e767. Epub 2023 Aug 18 doi: 10.1097/SCS.0000000000009633. PMID: 37594049Free PMC Article
Removal of Thyroglossal Duct Cyst by a Submental Approach.
Roh JL
World J Surg 2022 Jun;46(6):1431-1437. Epub 2022 Feb 23 doi: 10.1007/s00268-022-06493-1. PMID: 35195754
Cancer in thyroglossal duct cysts.
Wong J, Lee JC, Grodski S, Yeung M, Serpell J
ANZ J Surg 2022 Mar;92(3):443-447. Epub 2021 Nov 18 doi: 10.1111/ans.17369. PMID: 34791748
Thyroglossal duct cyst: Factors affecting cosmetic outcome and recurrence.
Batazzi A, Leng S, Ghionzoli M, Lo Piccolo R, Martin A, Facchini F, Messineo A
Pediatr Int 2019 Oct;61(10):1020-1024. doi: 10.1111/ped.13955. PMID: 31282046
No-Scar Transoral Thyroglossal Duct Cyst Excision in Children.
Kim JP, Park JJ, Woo SH
Thyroid 2018 Jun;28(6):755-761. Epub 2018 May 30 doi: 10.1089/thy.2017.0529. PMID: 29742987Free PMC Article

Recent systematic reviews

Endoscopic management of intralingual thyroglossal duct cysts: Case series and systematic review.
Pereira NM, Drusin MA, Modi VK
Auris Nasus Larynx 2023 Feb;50(1):119-125. Epub 2022 Jun 2 doi: 10.1016/j.anl.2022.05.014. PMID: 35659788
Chemical ablation using ethanol or OK-432 for the treatment of thyroglossal duct cysts: a systematic review and meta-analysis.
Park SI, Baek JH, Suh CH, Chung SR, Choi YJ, Kim TY, Lee YM, Lee JH
Eur Radiol 2021 Dec;31(12):9048-9056. Epub 2021 May 18 doi: 10.1007/s00330-021-08033-2. PMID: 34003346
Thyroglossal Duct Cyst Carcinoma: A Systematic Review of Clinical Features and Outcomes.
Rayess HM, Monk I, Svider PF, Gupta A, Raza SN, Lin HS
Otolaryngol Head Neck Surg 2017 May;156(5):794-802. Epub 2017 Mar 21 doi: 10.1177/0194599817696504. PMID: 28322121
Surgical management outcomes of recurrent thyroglossal duct cyst in children--A systematic review.
Ibrahim FF, Alnoury MK, Varma N, Daniel SJ
Int J Pediatr Otorhinolaryngol 2015 Jun;79(6):863-867. Epub 2015 Mar 28 doi: 10.1016/j.ijporl.2015.03.019. PMID: 25890397
Clinical presentation and treatment outcomes of thyroglossal duct cysts: a systematic review.
Gioacchini FM, Alicandri-Ciufelli M, Kaleci S, Magliulo G, Presutti L, Re M
Int J Oral Maxillofac Surg 2015 Jan;44(1):119-26. Epub 2014 Aug 15 doi: 10.1016/j.ijom.2014.07.007. PMID: 25132570

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