U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Latent syphilis

MedGen UID:
21056
•Concept ID:
C0039133
•
Disease or Syndrome
Synonyms: Latent Stage Syphilis; Syphilis, Latent; Syphilis, Latent Stage
SNOMED CT: Latent syphilis (444150000)
 
Monarch Initiative: MONDO:0005822

Definition

A stage of syphilis characterized by the serologic evidence of infection by Treponema pallidum without evidence of accompanying signs or symptoms related to the disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLatent syphilis

Professional guidelines

PubMed

AEDV Expert Consensus for the Management of Syphilis.
Fuertes de Vega L, de la Torre García JM, Suarez Farfante JM, Ceballos Rodríguez MC
Actas Dermosifiliogr 2024 Oct;115(9):896-905. Epub 2024 Apr 23 doi: 10.1016/j.ad.2024.03.033. PMID: 38663730
Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Treatment of syphilis: a systematic review.
Clement ME, Okeke NL, Hicks CB
JAMA 2014 Nov 12;312(18):1905-17. doi: 10.1001/jama.2014.13259. PMID: 25387188Free PMC Article

Recent clinical studies

Etiology

Syphilis.
Peeling RW, Mabey D, Chen XS, Garcia PJ
Lancet 2023 Jul 22;402(10398):336-346. doi: 10.1016/S0140-6736(22)02348-0. PMID: 37481272
Investigating latent syphilis in HIV treatment-experienced Ethiopians and response to therapy.
Girma S, Amogne W
PLoS One 2022;17(7):e0270878. Epub 2022 Jul 12 doi: 10.1371/journal.pone.0270878. PMID: 35819944Free PMC Article
Prevalence Estimates of Complicated Syphilis.
Dombrowski JC, Pedersen R, Marra CM, Kerani RP, Golden MR
Sex Transm Dis 2015 Dec;42(12):702-4. doi: 10.1097/OLQ.0000000000000368. PMID: 26562700
Syphilis in the United States.
Shockman S, Buescher LS, Stone SP
Clin Dermatol 2014 Mar-Apr;32(2):213-8. doi: 10.1016/j.clindermatol.2013.08.005. PMID: 24559556
Syphilis: a reemerging infection.
Mattei PL, Beachkofsky TM, Gilson RT, Wisco OJ
Am Fam Physician 2012 Sep 1;86(5):433-40. PMID: 22963062

Diagnosis

Syphilis.
Peeling RW, Mabey D, Chen XS, Garcia PJ
Lancet 2023 Jul 22;402(10398):336-346. doi: 10.1016/S0140-6736(22)02348-0. PMID: 37481272
Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Syphilis.
Arando Lasagabaster M, Otero Guerra L
Enferm Infecc Microbiol Clin (Engl Ed) 2019 Jun-Jul;37(6):398-404. Epub 2019 Feb 7 doi: 10.1016/j.eimc.2018.12.009. PMID: 30738716
Syphilis.
Crissey JT, Denenholz DA
Clin Dermatol 1984 Jan-Mar;2(1):1-166. doi: 10.1016/0738-081x(84)90003-8. PMID: 6400314
Syphilis--diagnosis and treatment.
Rudolph AH, Duncan WC
Clin Obstet Gynecol 1975 Mar;18(1):163-82. doi: 10.1097/00003081-197503000-00015. PMID: 1091382

Therapy

Investigating latent syphilis in HIV treatment-experienced Ethiopians and response to therapy.
Girma S, Amogne W
PLoS One 2022;17(7):e0270878. Epub 2022 Jul 12 doi: 10.1371/journal.pone.0270878. PMID: 35819944Free PMC Article
Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Treatment of syphilis: a systematic review.
Clement ME, Okeke NL, Hicks CB
JAMA 2014 Nov 12;312(18):1905-17. doi: 10.1001/jama.2014.13259. PMID: 25387188Free PMC Article
Syphilis: a reemerging infection.
Mattei PL, Beachkofsky TM, Gilson RT, Wisco OJ
Am Fam Physician 2012 Sep 1;86(5):433-40. PMID: 22963062
Syphilis.
Crissey JT, Denenholz DA
Clin Dermatol 1984 Jan-Mar;2(1):1-166. doi: 10.1016/0738-081x(84)90003-8. PMID: 6400314

Prognosis

Syphilis.
Peeling RW, Mabey D, Chen XS, Garcia PJ
Lancet 2023 Jul 22;402(10398):336-346. doi: 10.1016/S0140-6736(22)02348-0. PMID: 37481272
Investigating latent syphilis in HIV treatment-experienced Ethiopians and response to therapy.
Girma S, Amogne W
PLoS One 2022;17(7):e0270878. Epub 2022 Jul 12 doi: 10.1371/journal.pone.0270878. PMID: 35819944Free PMC Article
Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Syphilis in the United States.
Shockman S, Buescher LS, Stone SP
Clin Dermatol 2014 Mar-Apr;32(2):213-8. doi: 10.1016/j.clindermatol.2013.08.005. PMID: 24559556
Testing for syphilis.
Johnson PC, Farnie MA
Dermatol Clin 1994 Jan;12(1):9-17. PMID: 8143388

Clinical prediction guides

A masquerade of recurrent anaphylaxis.
Gabreski LN, Schuldt MM, Adams KE
Allergy Asthma Proc 2023 Sep 1;44(5):374-376. doi: 10.2500/aap.2023.44.230048. PMID: 37641215
Clinical and laboratory features in patients with positive syphilis serology presenting with acute ischemic stroke or transient ischemic attack: a prospective cohort study.
Jitpratoom P, Boonyasiri A
BMC Infect Dis 2022 Aug 30;22(1):717. doi: 10.1186/s12879-022-07700-z. PMID: 36042411Free PMC Article
Clinical features associated with neurosyphilis in people living with HIV and late latent syphilis.
Martínez-Ayala P, Quiñonez-Flores A, González-Hernández LA, Ruíz-Herrera VV, Zúñiga-Quiñones S, Alanis-Sánchez GA, Cabrera-Silva RI, Amador-Lara F, Sánchez-Reyes K, Álvarez-Zavala M, Vázquez-Limón JC, Sánchez-Navarro JP, Andrade-Villanueva JF
Int J STD AIDS 2022 Mar;33(4):330-336. Epub 2022 Jan 3 doi: 10.1177/09564624211063091. PMID: 34978502Free PMC Article
Syphilis infection and epidemiological characteristics in Haidian District, Beijing, China, 2013-2018.
Peng X, Yu S, Wu F, Yang J, Wang Y, Li Y, Zhang G, Lai C, Wei Z, Zhang W
Public Health 2021 Jan;190:62-66. Epub 2020 Dec 21 doi: 10.1016/j.puhe.2020.11.009. PMID: 33360028
Testing for syphilis.
Johnson PC, Farnie MA
Dermatol Clin 1994 Jan;12(1):9-17. PMID: 8143388

Recent systematic reviews

Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Treatment of syphilis: a systematic review.
Clement ME, Okeke NL, Hicks CB
JAMA 2014 Nov 12;312(18):1905-17. doi: 10.1001/jama.2014.13259. PMID: 25387188Free PMC Article
Azithromycin versus penicillin G benzathine for early syphilis.
Bai ZG, Wang B, Yang K, Tian JH, Ma B, Liu Y, Jiang L, Gai QY, He X, Li Y
Cochrane Database Syst Rev 2012 Jun 13;2012(6):CD007270. doi: 10.1002/14651858.CD007270.pub2. PMID: 22696367Free PMC Article
Treatment of syphilis in HIV-infected subjects: a systematic review of the literature.
Blank LJ, Rompalo AM, Erbelding EJ, Zenilman JM, Ghanem KG
Sex Transm Infect 2011 Feb;87(1):9-16. Epub 2010 Oct 5 doi: 10.1136/sti.2010.043893. PMID: 20924048

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...