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Struma ovarii

MedGen UID:
20977
•Concept ID:
C0038478
•
Neoplastic Process
Synonym: Struma Ovarii
SNOMED CT: Struma ovarii (24327009)
 
Monarch Initiative: MONDO:0006980

Definition

An ovarian mature teratoma characterized by the presence of aberrant thyroid tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStruma ovarii

Professional guidelines

PubMed

It Does Exist! Diagnosis and Management of Thyroid Carcinomas Originating in Struma Ovarii.
Smith LP, Brubaker LW, Wolsky RJ
Surg Pathol Clin 2023 Mar;16(1):75-86. Epub 2022 Dec 13 doi: 10.1016/j.path.2022.09.008. PMID: 36739168
Malignant struma ovarii: surgical, histopathological and survival outcomes for thyroid-type carcinoma of struma ovarii with recommendations for standardising multi-modal management. A retrospective case series sharing the experience of a single institution over 10 years.
Addley S, Mihai R, Alazzam M, Dhar S, Soleymani Majd H
Arch Gynecol Obstet 2021 Apr;303(4):863-870. Epub 2021 Jan 29 doi: 10.1007/s00404-021-05969-0. PMID: 33512594
Thyroid tissue outside the thyroid gland: Differential diagnosis and associated diagnostic challenges.
Barbieri A, Prasad ML, Gilani SM
Ann Diagn Pathol 2020 Oct;48:151584. Epub 2020 Aug 15 doi: 10.1016/j.anndiagpath.2020.151584. PMID: 32871503

Recent clinical studies

Etiology

Incidence, clinical characteristics, and survival outcomes of ovarian strumal diseases: a retrospective cohort study.
Li S, Hong R, Yin M, Zhang T, Zhang X, Yang J
BMC Womens Health 2023 Sep 19;23(1):497. doi: 10.1186/s12905-023-02624-5. PMID: 37726744Free PMC Article
It Does Exist! Diagnosis and Management of Thyroid Carcinomas Originating in Struma Ovarii.
Smith LP, Brubaker LW, Wolsky RJ
Surg Pathol Clin 2023 Mar;16(1):75-86. Epub 2022 Dec 13 doi: 10.1016/j.path.2022.09.008. PMID: 36739168
Metastatic malignant struma ovarii: a case report and review of the literature on the management of malignant struma ovarii.
Taelman V, Boer M, Taelman P
Acta Clin Belg 2022 Jun;77(3):721-725. Epub 2021 Jun 30 doi: 10.1080/17843286.2021.1944583. PMID: 34191687
Malignant struma ovarii: surgical, histopathological and survival outcomes for thyroid-type carcinoma of struma ovarii with recommendations for standardising multi-modal management. A retrospective case series sharing the experience of a single institution over 10 years.
Addley S, Mihai R, Alazzam M, Dhar S, Soleymani Majd H
Arch Gynecol Obstet 2021 Apr;303(4):863-870. Epub 2021 Jan 29 doi: 10.1007/s00404-021-05969-0. PMID: 33512594
Struma ovarii.
Ayhan A, Yanik F, Tuncer R, Tuncer ZS, Ruacan S
Int J Gynaecol Obstet 1993 Aug;42(2):143-6. doi: 10.1016/0020-7292(93)90628-a. PMID: 7901063

Diagnosis

Neoplasms in Struma Ovarii: A Review.
Tondi Resta I, Sande CM, LiVolsi VA
Endocr Pathol 2023 Dec;34(4):455-460. Epub 2023 Oct 21 doi: 10.1007/s12022-023-09789-7. PMID: 37864665
It Does Exist! Diagnosis and Management of Thyroid Carcinomas Originating in Struma Ovarii.
Smith LP, Brubaker LW, Wolsky RJ
Surg Pathol Clin 2023 Mar;16(1):75-86. Epub 2022 Dec 13 doi: 10.1016/j.path.2022.09.008. PMID: 36739168
Malignant struma ovarii: surgical, histopathological and survival outcomes for thyroid-type carcinoma of struma ovarii with recommendations for standardising multi-modal management. A retrospective case series sharing the experience of a single institution over 10 years.
Addley S, Mihai R, Alazzam M, Dhar S, Soleymani Majd H
Arch Gynecol Obstet 2021 Apr;303(4):863-870. Epub 2021 Jan 29 doi: 10.1007/s00404-021-05969-0. PMID: 33512594
Thyroid-type carcinoma of struma ovarii.
Zhang X, Axiotis C
Arch Pathol Lab Med 2010 May;134(5):786-91. doi: 10.5858/134.5.786. PMID: 20441513
Hyperthyroidism.
Cooper DS
Lancet 2003 Aug 9;362(9382):459-68. doi: 10.1016/S0140-6736(03)14073-1. PMID: 12927435

Therapy

Proposed Risk Stratification and Patterns of Radioactive Iodine Therapy in Malignant Struma Ovarii.
Egan C, Stefanova D, Thiesmeyer JW, Lee YJ, Greenberg J, Beninato T, Zarnegar R, Christos PJ, Klein IL, Fahey TJ 3rd, Finnerty BM
Thyroid 2022 Sep;32(9):1101-1108. Epub 2022 Aug 11 doi: 10.1089/thy.2022.0145. PMID: 35765923
Metastatic malignant struma ovarii: a case report and review of the literature on the management of malignant struma ovarii.
Taelman V, Boer M, Taelman P
Acta Clin Belg 2022 Jun;77(3):721-725. Epub 2021 Jun 30 doi: 10.1080/17843286.2021.1944583. PMID: 34191687
Struma Ovarii With Hyperthyroidism.
Ang LP, Avram AM, Lieberman RW, Esfandiari NH
Clin Nucl Med 2017 Jun;42(6):475-477. doi: 10.1097/RLU.0000000000001667. PMID: 28394842
Struma ovarii maligna.
Matysiak-Grzes M, Fischbach J, Gut P, Klimowicz A, Gryczynska M, Wasko R, Ruchala M
Neuro Endocrinol Lett 2013;34(2):97-101. PMID: 23645304
Hyperthyroidism.
Cooper DS
Lancet 2003 Aug 9;362(9382):459-68. doi: 10.1016/S0140-6736(03)14073-1. PMID: 12927435

Prognosis

Incidence, clinical characteristics, and survival outcomes of ovarian strumal diseases: a retrospective cohort study.
Li S, Hong R, Yin M, Zhang T, Zhang X, Yang J
BMC Womens Health 2023 Sep 19;23(1):497. doi: 10.1186/s12905-023-02624-5. PMID: 37726744Free PMC Article
It Does Exist! Diagnosis and Management of Thyroid Carcinomas Originating in Struma Ovarii.
Smith LP, Brubaker LW, Wolsky RJ
Surg Pathol Clin 2023 Mar;16(1):75-86. Epub 2022 Dec 13 doi: 10.1016/j.path.2022.09.008. PMID: 36739168
Malignant struma ovarii: surgical, histopathological and survival outcomes for thyroid-type carcinoma of struma ovarii with recommendations for standardising multi-modal management. A retrospective case series sharing the experience of a single institution over 10 years.
Addley S, Mihai R, Alazzam M, Dhar S, Soleymani Majd H
Arch Gynecol Obstet 2021 Apr;303(4):863-870. Epub 2021 Jan 29 doi: 10.1007/s00404-021-05969-0. PMID: 33512594
Struma ovarii complicating pregnancy. Case report and literature review.
Pepe F, Valenti O, Insalaco G, Zigarelli MMG, Pepe L, Piana M
G Chir 2019 May-Jun;40(3):199-207. PMID: 31484009
Thyroid-type carcinoma of struma ovarii.
Zhang X, Axiotis C
Arch Pathol Lab Med 2010 May;134(5):786-91. doi: 10.5858/134.5.786. PMID: 20441513

Clinical prediction guides

Struma ovarii with synchronous ascites and elevated CA125 level: a retrospective cohort study.
Li S, Hong R, Yin M, Zhang X, Zhang T, Yang J
Acta Oncol 2023 Aug;62(8):889-896. Epub 2023 Jun 30 doi: 10.1080/0284186X.2023.2226798. PMID: 37391865
Current state of management of struma ovarii and preoperative imaging features: A retrospective case series study of 18 patients at a single institution.
Tamura N, Murakami K, Ozaki R, Takeuchi S, Ochiai A, Kawasaki Y, Okada Y, Kitade M, Itakura A
J Obstet Gynaecol Res 2023 Mar;49(3):1007-1011. Epub 2023 Jan 11 doi: 10.1111/jog.15545. PMID: 36631946
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Late Manifestation of Struma Peritonei and Widespread Functioning Lesions in the Setting of Struma Ovarii Simulating Highly Differentiated Follicular Carcinoma.
Ranade R, Rachh S, Basu S
J Nucl Med Technol 2015 Sep;43(3):231-3. Epub 2014 Dec 23 doi: 10.2967/jnmt.114.149294. PMID: 25537757
Monodermal teratomas (struma ovarii). Clinicopathological characteristics of 11 cases and literature review.
Kondi-Pafiti A, Mavrigiannaki P, Grigoriadis Ch, Kontogianni-Katsarou K, Mellou A, Kleanthis CK, Liapis A
Eur J Gynaecol Oncol 2011;32(6):657-9. PMID: 22335029

Recent systematic reviews

Highly Differentiated Follicular Carcinoma of Ovarian Origin: A Systematic Review of the Literature.
Giovannopoulou E, Saliaris K, Kavoura E, Pavlakis K, Lathouras K
Curr Oncol 2022 Nov 23;29(12):9105-9116. doi: 10.3390/curroncol29120712. PMID: 36547126Free PMC Article
Ovarian Strumal Carcinoid: Case Report, Systematic Literature Review and Pooled Analysis.
Turla A, Zamparini M, Milione M, Grisanti S, Amoroso V, Pedersini R, Cosentini D, Berruti A
Front Endocrinol (Lausanne) 2022;13:871210. Epub 2022 Apr 21 doi: 10.3389/fendo.2022.871210. PMID: 35528006Free PMC Article
Malignant struma ovarii: From case to analysis.
Ayhan S, Kilic F, Ersak B, Aytekin O, Akar S, Turkmen O, Akgul G, Toyran A, Turan T, Kimyon Comert G
J Obstet Gynaecol Res 2021 Sep;47(9):3339-3351. Epub 2021 Jul 4 doi: 10.1111/jog.14902. PMID: 34219334

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