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Sclerosis

MedGen UID:
48587
Concept ID:
C0036429
Pathologic Function
Synonym: Scleroses
SNOMED CT: Sclerosis (43846000); Fibrosclerosis (43846000)

Definition

A pathological hardening or thickening of tissue, especially that of the interstitial substance. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSclerosis

Professional guidelines

PubMed

Banwell B, Bennett JL, Marignier R, Kim HJ, Brilot F, Flanagan EP, Ramanathan S, Waters P, Tenembaum S, Graves JS, Chitnis T, Brandt AU, Hemingway C, Neuteboom R, Pandit L, Reindl M, Saiz A, Sato DK, Rostasy K, Paul F, Pittock SJ, Fujihara K, Palace J
Lancet Neurol 2023 Mar;22(3):268-282. Epub 2023 Jan 24 doi: 10.1016/S1474-4422(22)00431-8. PMID: 36706773
Northrup H, Aronow ME, Bebin EM, Bissler J, Darling TN, de Vries PJ, Frost MD, Fuchs Z, Gosnell ES, Gupta N, Jansen AC, Jóźwiak S, Kingswood JC, Knilans TK, McCormack FX, Pounders A, Roberds SL, Rodriguez-Buritica DF, Roth J, Sampson JR, Sparagana S, Thiele EA, Weiner HL, Wheless JW, Towbin AJ, Krueger DA; International Tuberous Sclerosis Complex Consensus Group
Pediatr Neurol 2021 Oct;123:50-66. Epub 2021 Jul 24 doi: 10.1016/j.pediatrneurol.2021.07.011. PMID: 34399110
Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA
Lancet Neurol 2018 Feb;17(2):162-173. Epub 2017 Dec 21 doi: 10.1016/S1474-4422(17)30470-2. PMID: 29275977

Recent clinical studies

Etiology

Graves JS, Krysko KM, Hua LH, Absinta M, Franklin RJM, Segal BM
Lancet Neurol 2023 Jan;22(1):66-77. Epub 2022 Oct 7 doi: 10.1016/S1474-4422(22)00184-3. PMID: 36216015
Dobson R, Giovannoni G
Eur J Neurol 2019 Jan;26(1):27-40. Epub 2018 Nov 18 doi: 10.1111/ene.13819. PMID: 30300457
Kalincik T
Neuroepidemiology 2015;44(4):199-214. Epub 2015 May 20 doi: 10.1159/000382130. PMID: 25997994
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774
Compston A, Coles A
Lancet 2008 Oct 25;372(9648):1502-17. doi: 10.1016/S0140-6736(08)61620-7. PMID: 18970977

Diagnosis

Marcus R
JAMA 2022 Nov 22;328(20):2078. doi: 10.1001/jama.2022.14236. PMID: 36413229
Oh J, Vidal-Jordana A, Montalban X
Curr Opin Neurol 2018 Dec;31(6):752-759. doi: 10.1097/WCO.0000000000000622. PMID: 30300239
Doshi A, Chataway J
Clin Med (Lond) 2016 Dec;16(Suppl 6):s53-s59. doi: 10.7861/clinmedicine.16-6-s53. PMID: 27956442Free PMC Article
Howard J, Trevick S, Younger DS
Neurol Clin 2016 Nov;34(4):919-939. Epub 2016 Aug 18 doi: 10.1016/j.ncl.2016.06.016. PMID: 27720001
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774

Therapy

Paganoni S, Berry JD, Quintana M, Macklin E, Saville BR, Detry MA, Chase M, Sherman AV, Yu H, Drake K, Andrews J, Shefner J, Chibnik LB, Vestrucci M, Cudkowicz ME; Healey ALS Platform Trial Study Group
Ann Neurol 2022 Feb;91(2):165-175. Epub 2022 Jan 10 doi: 10.1002/ana.26285. PMID: 34935174
Alessandrini M, Preynat-Seauve O, De Bruin K, Pepper MS
S Afr Med J 2019 Sep 10;109(8b):70-77. doi: 10.7196/SAMJ.2019.v109i8b.14009. PMID: 31662153
McDermott CJ
Curr Opin Neurol 2019 Oct;32(5):758-763. doi: 10.1097/WCO.0000000000000731. PMID: 31335338
Amatya B, Khan F, Galea M
Cochrane Database Syst Rev 2019 Jan 14;1(1):CD012732. doi: 10.1002/14651858.CD012732.pub2. PMID: 30637728Free PMC Article
Lasky J
IDrugs 2004 Feb;7(2):166-72. PMID: 15057662

Prognosis

Zhang GX, Carrillo-Vico A, Zhang WT, Gao SS, Izquierdo Ayuso G
Neurologia (Engl Ed) 2023 Apr;38(3):159-172. doi: 10.1016/j.nrleng.2020.07.022. PMID: 37059571
Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, Robertson N, La Rocca N, Uitdehaag B, van der Mei I, Wallin M, Helme A, Angood Napier C, Rijke N, Baneke P
Mult Scler 2020 Dec;26(14):1816-1821. Epub 2020 Nov 11 doi: 10.1177/1352458520970841. PMID: 33174475Free PMC Article
Longinetti E, Fang F
Curr Opin Neurol 2019 Oct;32(5):771-776. doi: 10.1097/WCO.0000000000000730. PMID: 31361627Free PMC Article
GBD 2016 Neurology Collaborators
Lancet Neurol 2019 May;18(5):459-480. Epub 2019 Mar 14 doi: 10.1016/S1474-4422(18)30499-X. PMID: 30879893Free PMC Article
Ten Berge JC, Schreurs MWJ, van Daele PLA, Rothova A
Acta Ophthalmol 2018 Aug;96(5):481-485. Epub 2018 Jan 25 doi: 10.1111/aos.13652. PMID: 29369534

Clinical prediction guides

Pullen WM, Carreira DS, Wong I, Aoki SK, Lynch TS, Mather RC 3rd, Ayeni OR, Byrd JWT, Safran MR
Am J Sports Med 2023 Feb;51(2):476-480. Epub 2023 Jan 16 doi: 10.1177/03635465221147055. PMID: 36645041
Mateos-Pérez JM, Dadar M, Lacalle-Aurioles M, Iturria-Medina Y, Zeighami Y, Evans AC
Neuroimage Clin 2018;20:506-522. Epub 2018 Aug 10 doi: 10.1016/j.nicl.2018.08.019. PMID: 30167371Free PMC Article
Louapre C, Bodini B, Lubetzki C, Freeman L, Stankoff B
Curr Opin Neurol 2017 Jun;30(3):231-236. doi: 10.1097/WCO.0000000000000456. PMID: 28362719
Uher T, Vaneckova M, Sobisek L, Tyblova M, Seidl Z, Krasensky J, Ramasamy D, Zivadinov R, Havrdova E, Kalincik T, Horakova D
Mult Scler 2017 Jan;23(1):51-61. Epub 2016 Jul 11 doi: 10.1177/1352458516642314. PMID: 27053635
Lublin FD
Curr Opin Neurol 2002 Jun;15(3):253-6. doi: 10.1097/00019052-200206000-00005. PMID: 12045721

Recent systematic reviews

Samjoo IA, Drudge C, Walsh S, Tiwari S, Brennan R, Boer I, Häring DA, Klotz L, Adlard N, Banhazi J
J Comp Eff Res 2023 Jul;12(7):e230016. Epub 2023 Jun 2 doi: 10.57264/cer-2023-0016. PMID: 37265062Free PMC Article
Morales-Suarez-Varela M, Collado Sánchez E, Peraita-Costa I, Llopis-Morales A, Soriano JM
Nutrients 2021 Sep 13;13(9) doi: 10.3390/nu13093179. PMID: 34579056Free PMC Article
Ortega-Hombrados L, Molina-Torres G, Galán-Mercant A, Sánchez-Guerrero E, González-Sánchez M, Ruiz-Muñoz M
Int J Environ Res Public Health 2021 Jan 26;18(3) doi: 10.3390/ijerph18031074. PMID: 33530383Free PMC Article
Corvillo I, Varela E, Armijo F, Alvarez-Badillo A, Armijo O, Maraver F
Eur J Phys Rehabil Med 2017 Dec;53(6):944-952. Epub 2017 Feb 17 doi: 10.23736/S1973-9087.17.04570-1. PMID: 28215060
Kalincik T
Neuroepidemiology 2015;44(4):199-214. Epub 2015 May 20 doi: 10.1159/000382130. PMID: 25997994

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