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Scleritis

MedGen UID:
48585
Concept ID:
C0036416
Disease or Syndrome
Synonym: Scleritides
SNOMED CT: Scleritis (78370002); Inflammation of white of eye (78370002)
 
HPO: HP:0100532
Monarch Initiative: MONDO:0001718

Definition

Inflammation of the sclera. [from HPO]

Conditions with this feature

Familial antiphospholipid syndrome
MedGen UID:
419641
Concept ID:
C2930802
Disease or Syndrome
The designation 'antiphospholipid syndrome' was proposed for the association of arterial and venous thrombosis, recurrent fetal loss, and immune thrombocytopenia with a spectrum of autoantibodies directed against cellular phospholipid components. Anticardiolipin antibodies may react with cardiolipin and with other negatively charged phospholipids, including beta-2-glycoprotein I (B2GPI, APOH; 138700). The term 'lupus anticoagulant' refers to a heterogeneous group of antibodies, most commonly of the IgG type, that are detected by their inhibitory effect on coagulant-active phospholipid components of in vitro coagulation tests (summary by Matthey et al., 1989). Shoenfeld et al. (2008) noted that antiphospholipid syndrome is characterized by up to 30 different autoantibodies, including those against platelets, glycoproteins, coagulation factors, lamins, mitochondrial antigens, and cell surface markers. Some of these may have an additive effect on the prothrombotic tendency of the syndrome. Ruiz-Irastorza et al. (2010) reviewed pathophysiologic, clinical, diagnostic, and therapeutic advances related to the antiphospholipid syndrome. Various autoimmune disorders that cluster in families, including autoimmune thrombocytopenia (188030), are discussed elsewhere (e.g., 109100, 269200).

Professional guidelines

PubMed

LaMattina KC, Goldstein DA
Expert Rev Clin Immunol 2017 Mar;13(3):181-188. doi: 10.1080/1744666X.2017.1288097. PMID: 28140700
Wilkins T, Jarvis K, Patel J
Am Fam Physician 2011 Dec 15;84(12):1365-75. PMID: 22230271
Cronau H, Kankanala RR, Mauger T
Am Fam Physician 2010 Jan 15;81(2):137-44. PMID: 20082509

Recent clinical studies

Etiology

Ng JY, Zarook E, Nicholson L; Oculi-Cordis group, Khanji MY, Chahal CAA
Heart 2023 Oct 26;109(22):1670-1676. doi: 10.1136/heartjnl-2022-322081. PMID: 37507215Free PMC Article
Junek ML, Zhao L, Garner S, Cuthbertson D, Pagnoux C, Koening CL, Langford CA, McAlear CA, Monach PA, Moreland LW, Rhee RL, Seo P, Specks U, Sreih AG, Warrington K, Wechsler ME, Merkel PA, Khalidi NA
Rheumatology (Oxford) 2023 Jul 5;62(7):2517-2524. doi: 10.1093/rheumatology/keac663. PMID: 36440847Free PMC Article
Dammacco R, Guerriero S, Alessio G, Dammacco F
Int Ophthalmol 2022 Feb;42(2):689-711. Epub 2021 Nov 21 doi: 10.1007/s10792-021-02058-8. PMID: 34802085Free PMC Article
Hankins M, Margo CE
J Clin Pathol 2019 May;72(5):386-390. Epub 2019 Feb 5 doi: 10.1136/jclinpath-2018-205360. PMID: 30723093
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989

Diagnosis

Reddy AK, Kolfenbach JR, Palestine AG
Curr Opin Ophthalmol 2022 Nov 1;33(6):551-556. Epub 2022 Sep 16 doi: 10.1097/ICU.0000000000000890. PMID: 36165413
Murthy SI, Sabhapandit S, Balamurugan S, Subramaniam P, Sainz-de-la-Maza M, Agarwal M, Parvesio C
Indian J Ophthalmol 2020 Sep;68(9):1818-1828. doi: 10.4103/ijo.IJO_2032_20. PMID: 32823398Free PMC Article
Shields RA, Schachar IH
Ophthalmic Surg Lasers Imaging Retina 2019 Oct 1;50(10):660. doi: 10.3928/23258160-20191009-11. PMID: 31671201
Hankins M, Margo CE
J Clin Pathol 2019 May;72(5):386-390. Epub 2019 Feb 5 doi: 10.1136/jclinpath-2018-205360. PMID: 30723093
Dunn JP
Prim Care 2015 Sep;42(3):305-23. Epub 2015 Jul 7 doi: 10.1016/j.pop.2015.05.003. PMID: 26319340

Therapy

Nguyen M, Doan T, Seitzman GD
Curr Opin Ophthalmol 2024 Sep 1;35(5):423-429. Epub 2024 Jun 6 doi: 10.1097/ICU.0000000000001066. PMID: 38847744Free PMC Article
Dutta Majumder P, Agarwal S, Shah M, Srinivasan B, K P, Iyer G, Sharma N, Biswas J, McCluskey P
Ocul Immunol Inflamm 2024 Sep;32(7):1405-1419. Epub 2023 Jun 6 doi: 10.1080/09273948.2023.2206898. PMID: 37279404
Sainz de La Maza M, Hernanz I, Moll-Udina A, Mesquida M, Adan A, Martinez JA, Espinosa G, Llorenç V
Br J Ophthalmol 2023 Apr;107(4):495-499. Epub 2021 Nov 19 doi: 10.1136/bjophthalmol-2021-319799. PMID: 34799367
Cunningham ET Jr, McCluskey P, Pavesio C, Wakefield D, Zierhut M
Ocul Immunol Inflamm 2016;24(1):2-5. doi: 10.3109/09273948.2016.1136190. PMID: 26872551
Sainz de la Maza M, Molina N, Gonzalez-Gonzalez LA, Doctor PP, Tauber J, Foster CS
Ophthalmology 2012 Jan;119(1):51-8. Epub 2011 Oct 19 doi: 10.1016/j.ophtha.2011.07.043. PMID: 22015381

Prognosis

Ng JY, Zarook E, Nicholson L; Oculi-Cordis group, Khanji MY, Chahal CAA
Heart 2023 Oct 26;109(22):1670-1676. doi: 10.1136/heartjnl-2022-322081. PMID: 37507215Free PMC Article
Junek ML, Zhao L, Garner S, Cuthbertson D, Pagnoux C, Koening CL, Langford CA, McAlear CA, Monach PA, Moreland LW, Rhee RL, Seo P, Specks U, Sreih AG, Warrington K, Wechsler ME, Merkel PA, Khalidi NA
Rheumatology (Oxford) 2023 Jul 5;62(7):2517-2524. doi: 10.1093/rheumatology/keac663. PMID: 36440847Free PMC Article
Marzoli SB, Criscuoli A
Neurol Sci 2018 Jun;39(Suppl 1):25-31. doi: 10.1007/s10072-018-3334-1. PMID: 29904831
Ten Berge JC, Schreurs MWJ, van Daele PLA, Rothova A
Acta Ophthalmol 2018 Aug;96(5):481-485. Epub 2018 Jan 25 doi: 10.1111/aos.13652. PMID: 29369534
Illingworth CD, Cook SD
Surv Ophthalmol 1998 May-Jun;42(6):493-508. doi: 10.1016/s0039-6257(98)00004-6. PMID: 9635900

Clinical prediction guides

Tarsia M, Gaggiano C, Gessaroli E, Grosso S, Tosi GM, Frediani B, Cantarini L, Fabiani C
Ocul Immunol Inflamm 2023 Jan;31(1):175-184. Epub 2022 Feb 28 doi: 10.1080/09273948.2021.2023582. PMID: 35226583
Dammacco R, Guerriero S, Alessio G, Dammacco F
Int Ophthalmol 2022 Feb;42(2):689-711. Epub 2021 Nov 21 doi: 10.1007/s10792-021-02058-8. PMID: 34802085Free PMC Article
Ten Berge JC, Schreurs MWJ, van Daele PLA, Rothova A
Acta Ophthalmol 2018 Aug;96(5):481-485. Epub 2018 Jan 25 doi: 10.1111/aos.13652. PMID: 29369534
Moorthy RS, London NJ, Garg SJ, Cunningham ET Jr
Curr Opin Ophthalmol 2013 Nov;24(6):589-97. doi: 10.1097/01.icu.0000434534.32063.5c. PMID: 24100371
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989

Recent systematic reviews

Moin KA, Yeakle MM, Parrill AM, Garofalo VA, Tsiyer AR, Bishev D, Gala D, Fogel J, Hatsis AJ, Wickas TD, Anand P, Morcos M
Rom J Ophthalmol 2023 Jul-Sep;67(3):214-221. doi: 10.22336/rjo.2023.38. PMID: 37876507Free PMC Article
Khaslavsky S, Starkey SY, Avraham S, Kashetsky N, Mukovozov I
Ann Dermatol Venereol 2023 Sep;150(3):199-201. Epub 2023 Aug 16 doi: 10.1016/j.annder.2023.05.004. PMID: 37596128
Damian L, Pamfil C, Bucșa C, Nicula C, Mouthon L, Amoura Z, Cutolo M, Burmester GR, Fonseca JE, Grapini L, Arnaud L, Rednic S
Clin Exp Rheumatol 2022 May;40 Suppl 134(5):86-92. Epub 2022 Feb 24 doi: 10.55563/clinexprheumatol/27n7im. PMID: 35238768
Dammacco R, Guerriero S, Alessio G, Dammacco F
Int Ophthalmol 2022 Feb;42(2):689-711. Epub 2021 Nov 21 doi: 10.1007/s10792-021-02058-8. PMID: 34802085Free PMC Article
Turk MA, Hayworth JL, Nevskaya T, Pope JE
J Rheumatol 2021 Jan 1;48(1):25-34. Epub 2020 May 1 doi: 10.3899/jrheum.190768. PMID: 32358156

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