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Sarcoma, Experimental

MedGen UID:
20652
•Concept ID:
C0036216
•
Experimental Model of Disease; Neoplastic Process
Synonyms: Experimental Sarcoma; Experimental Sarcomas; Sarcomas, Experimental

Definition

Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSarcoma, Experimental

Professional guidelines

PubMed

4-amino-2-phenyl-6-(p-fluorophenyl)-5-carbonitrile-pyrimidine-bis-substituted-loaded liposomes as promising system for cancer treatment.
Oliveira JV, Almeida GC, Nogueira MCBL, Aguiar Júnior FCA, Melo AO, Silva TDS, Santos NPS, Magalhães NSS, Melo SJ, Falcão EPS
An Acad Bras Cienc 2023;95(suppl 1):e20211078. Epub 2023 Jul 10 doi: 10.1590/0001-3765202320211078. PMID: 37436228
Survival impact of centralization and clinical guidelines for soft tissue sarcoma (A prospective and exhaustive population-based cohort).
Derbel O, Heudel PE, Cropet C, Meeus P, Vaz G, Biron P, Cassier P, Decouvelaere AV, Ranchere-Vince D, Collard O, De Laroche E, Thiesse P, Farsi F, Cellier D, Gilly FN, Blay JY, Ray-Coquard I
PLoS One 2017;12(2):e0158406. Epub 2017 Feb 3 doi: 10.1371/journal.pone.0158406. PMID: 28158190Free PMC Article

Recent clinical studies

Etiology

The anticancer peptide RT53 induces immunogenic cell death.
Pasquereau-Kotula E, Habault J, Kroemer G, Poyet JL
PLoS One 2018;13(8):e0201220. Epub 2018 Aug 6 doi: 10.1371/journal.pone.0201220. PMID: 30080874Free PMC Article
Present at the beginning: a personal reminiscence on the history of teriparatide.
Marcus R
Osteoporos Int 2011 Aug;22(8):2241-8. Epub 2011 Mar 31 doi: 10.1007/s00198-011-1598-x. PMID: 21452026
The high mobility group protein, HMGI-C.
Goodwin G
Int J Biochem Cell Biol 1998 Jul;30(7):761-6. doi: 10.1016/s1357-2725(98)00016-8. PMID: 9722980
Biology of the human malignant lymphomas. IV. Functional characterization of ten diffuse histiocytic lymphoma cell lines.
Epstein AL, Levy R, Kim H, Henle W, Henle G, Kaplan HS
Cancer 1978 Nov;42(5):2379-91. doi: 10.1002/1097-0142(197811)42:5<2379::aid-cncr2820420539>3.0.co;2-4. PMID: 214220
Microwave absorption by normal and tumor cells.
Webb SJ, Booth AD
Science 1971 Oct 1;174(4004):72-4. doi: 10.1126/science.174.4004.72. PMID: 5120873

Diagnosis

Type 1 Innate Lymphoid Cells Limit the Antitumoral Immune Response.
Vienne M, Etiennot M, Escalière B, Galluso J, Spinelli L, Guia S, Fenis A, Vivier E, Kerdiles YM
Front Immunol 2021;12:768989. Epub 2021 Nov 16 doi: 10.3389/fimmu.2021.768989. PMID: 34868026Free PMC Article
A "protective umbrella" nanoplatform for loading ICG and multi-modal imaging-guided phototherapy.
Zhou J, Meng L, Sun C, Ye W, Chen C, Du B
Nanomedicine 2018 Feb;14(2):289-301. Epub 2017 Oct 7 doi: 10.1016/j.nano.2017.09.009. PMID: 28993266
Cytogenetic and experimental models.
Fletcher J
Curr Opin Oncol 1992 Aug;4(4):659-66. doi: 10.1097/00001622-199208000-00010. PMID: 1511022
Cell cycle analysis using flow cytometry.
Gray JW, Dolbeare F, Pallavicini MG, Beisker W, Waldman F
Int J Radiat Biol Relat Stud Phys Chem Med 1986 Feb;49(2):237-55. doi: 10.1080/09553008514552531. PMID: 3510993
Biology of the human malignant lymphomas. IV. Functional characterization of ten diffuse histiocytic lymphoma cell lines.
Epstein AL, Levy R, Kim H, Henle W, Henle G, Kaplan HS
Cancer 1978 Nov;42(5):2379-91. doi: 10.1002/1097-0142(197811)42:5<2379::aid-cncr2820420539>3.0.co;2-4. PMID: 214220

Therapy

Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact.
Hattinger CM, Patrizio MP, Luppi S, Serra M
Int J Mol Sci 2020 Jun 30;21(13) doi: 10.3390/ijms21134659. PMID: 32629971Free PMC Article
Cell cycle analysis using flow cytometry.
Gray JW, Dolbeare F, Pallavicini MG, Beisker W, Waldman F
Int J Radiat Biol Relat Stud Phys Chem Med 1986 Feb;49(2):237-55. doi: 10.1080/09553008514552531. PMID: 3510993
A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes.
Rosenberg SA, Spiess P, Lafreniere R
Science 1986 Sep 19;233(4770):1318-21. doi: 10.1126/science.3489291. PMID: 3489291
Carcinogenesis and aging.
Anisimov VN
Adv Cancer Res 1983;40:365-424. doi: 10.1016/s0065-230x(08)60684-3. PMID: 6419551
Radiation sensitizers.
Cancer 1976 Apr;37(4 Suppl):2062-70. PMID: 130967

Prognosis

Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact.
Hattinger CM, Patrizio MP, Luppi S, Serra M
Int J Mol Sci 2020 Jun 30;21(13) doi: 10.3390/ijms21134659. PMID: 32629971Free PMC Article
Hiwi mediated tumorigenesis is associated with DNA hypermethylation.
Siddiqi S, Terry M, Matushansky I
PLoS One 2012;7(3):e33711. Epub 2012 Mar 16 doi: 10.1371/journal.pone.0033711. PMID: 22438986Free PMC Article
Osteosarcoma and other tumors of bone.
Mertens WC, Bramwell V
Curr Opin Oncol 1994 Jul;6(4):384-90. doi: 10.1097/00001622-199407000-00010. PMID: 7803539
Perioperative blood transfusions and survival in osteosarcoma.
Chesi R, Borghi B, Lari S
Cancer Treat Res 1993;62:25-8. doi: 10.1007/978-1-4615-3518-8_4. PMID: 8096741
Cytogenetic and experimental models.
Fletcher J
Curr Opin Oncol 1992 Aug;4(4):659-66. doi: 10.1097/00001622-199208000-00010. PMID: 1511022

Clinical prediction guides

Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact.
Hattinger CM, Patrizio MP, Luppi S, Serra M
Int J Mol Sci 2020 Jun 30;21(13) doi: 10.3390/ijms21134659. PMID: 32629971Free PMC Article
Oncopig Soft-Tissue Sarcomas Recapitulate Key Transcriptional Features of Human Sarcomas.
Schachtschneider KM, Liu Y, Mäkeläinen S, Madsen O, Rund LA, Groenen MAM, Schook LB
Sci Rep 2017 Jun 1;7(1):2624. doi: 10.1038/s41598-017-02912-9. PMID: 28572589Free PMC Article
p53: functions, mutations and sarcomas.
Hung J, Anderson R
Acta Orthop Scand Suppl 1997 Feb;273:68-73. doi: 10.1080/17453674.1997.11744705. PMID: 9057590
Antitumor 2-(aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)- hydrazines.
Shyam K, Penketh PG, Loomis RH, Rose WC, Sartorelli AC
J Med Chem 1996 Feb 2;39(3):796-801. doi: 10.1021/jm9505021. PMID: 8576923
Reverse transformation of multidrug-resistant cells.
Biedler JL, Spengler BA
Cancer Metastasis Rev 1994 Jun;13(2):191-207. doi: 10.1007/BF00689636. PMID: 7923550

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