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respiratory syncytial virus infection

MedGen UID:
48424
•Concept ID:
C0035235
•
Disease or Syndrome
Synonyms: Infection, RSV; Infections, Respiratory Syncytial Virus; Respiratory Syncytial Virus Infection; Respiratory Syncytial Virus Infections; RSV Infection; RSV Infections
SNOMED CT: RSV - Respiratory syncytial virus infection (55735004); Respiratory syncytial virus infection (55735004)
 
Monarch Initiative: MONDO:0001577

Definition

Infection with the respiratory syncytial virus, an RNA virus of the genus Pneumovirus, in the family Paramyxoviridae, which is characterized by the formation of syncytia in tissue culture. It causes minor respiratory infection with rhinitis and cough in adults, but is capable of causing severe bronchitis and bronchopneumonia in young children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVrespiratory syncytial virus infection

Professional guidelines

PubMed

Ribavirin treatment for respiratory syncytial virus infection in patients with haematologic malignancy and haematopoietic stem cell transplant recipients: a systematic review and meta-analysis.
Manothummetha K, Mongkolkaew T, Tovichayathamrong P, Boonyawairote R, Meejun T, Srisurapanont K, Phongkhun K, Sanguankeo A, Torvorapanit P, Moonla C, Plongla R, Kates OS, Avery RK, Nematollahi S, Permpalung N
Clin Microbiol Infect 2023 Oct;29(10):1272-1279. Epub 2023 Apr 26 doi: 10.1016/j.cmi.2023.04.021. PMID: 37116860
Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment.
Griffiths C, Drews SJ, Marchant DJ
Clin Microbiol Rev 2017 Jan;30(1):277-319. doi: 10.1128/CMR.00010-16. PMID: 27903593Free PMC Article
Diagnosis and management of bronchiolitis.
American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis
Pediatrics 2006 Oct;118(4):1774-93. doi: 10.1542/peds.2006-2223. PMID: 17015575

Recent clinical studies

Etiology

Respiratory Syncytial Virus Infection in Older Adults: An Update.
Alfano F, Bigoni T, Caggiano FP, Papi A
Drugs Aging 2024 Jun;41(6):487-505. Epub 2024 May 7 doi: 10.1007/s40266-024-01118-9. PMID: 38713299Free PMC Article
Epidemiology of Respiratory Infections during the COVID-19 Pandemic.
Principi N, Autore G, Ramundo G, Esposito S
Viruses 2023 May 13;15(5) doi: 10.3390/v15051160. PMID: 37243246Free PMC Article
Respiratory syncytial virus infection in the modern era.
Ludlow M
Curr Opin Infect Dis 2023 Jun 1;36(3):155-163. Epub 2023 Mar 20 doi: 10.1097/QCO.0000000000000917. PMID: 36939556
Respiratory Syncytial Virus is the Most Common Causative Agent of Viral Bronchiolitis in Young Children: An Updated Review.
Hon KL, Leung AKC, Wong AHC, Dudi A, Leung KKY
Curr Pediatr Rev 2023;19(2):139-149. doi: 10.2174/1573396318666220810161945. PMID: 35950255
Incidence of Respiratory Syncytial Virus Infection Among Hospitalized Adults, 2017-2020.
Branche AR, Saiman L, Walsh EE, Falsey AR, Sieling WD, Greendyke W, Peterson DR, Vargas CY, Phillips M, Finelli L
Clin Infect Dis 2022 Mar 23;74(6):1004-1011. doi: 10.1093/cid/ciab595. PMID: 34244735

Diagnosis

Respiratory Syncytial Virus is the Most Common Causative Agent of Viral Bronchiolitis in Young Children: An Updated Review.
Hon KL, Leung AKC, Wong AHC, Dudi A, Leung KKY
Curr Pediatr Rev 2023;19(2):139-149. doi: 10.2174/1573396318666220810161945. PMID: 35950255
Burden of respiratory syncytial virus infection in older and high-risk adults: a systematic review and meta-analysis of the evidence from developed countries.
Nguyen-Van-Tam JS, O'Leary M, Martin ET, Heijnen E, Callendret B, Fleischhackl R, Comeaux C, Tran TMP, Weber K
Eur Respir Rev 2022 Dec 31;31(166) Epub 2022 Nov 15 doi: 10.1183/16000617.0105-2022. PMID: 36384703Free PMC Article
Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment.
Griffiths C, Drews SJ, Marchant DJ
Clin Microbiol Rev 2017 Jan;30(1):277-319. doi: 10.1128/CMR.00010-16. PMID: 27903593Free PMC Article
Respiratory syncytial virus infection and bronchiolitis.
Piedimonte G, Perez MK
Pediatr Rev 2014 Dec;35(12):519-30. doi: 10.1542/pir.35-12-519. PMID: 25452661Free PMC Article
Respiratory syncytial virus infection in elderly and high-risk adults.
Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE
N Engl J Med 2005 Apr 28;352(17):1749-59. doi: 10.1056/NEJMoa043951. PMID: 15858184

Therapy

Respiratory syncytial virus infection and novel interventions.
Langedijk AC, Bont LJ
Nat Rev Microbiol 2023 Nov;21(11):734-749. Epub 2023 Jul 12 doi: 10.1038/s41579-023-00919-w. PMID: 37438492
Respiratory Syncytial Virus is the Most Common Causative Agent of Viral Bronchiolitis in Young Children: An Updated Review.
Hon KL, Leung AKC, Wong AHC, Dudi A, Leung KKY
Curr Pediatr Rev 2023;19(2):139-149. doi: 10.2174/1573396318666220810161945. PMID: 35950255
Burden of respiratory syncytial virus infection in older and high-risk adults: a systematic review and meta-analysis of the evidence from developed countries.
Nguyen-Van-Tam JS, O'Leary M, Martin ET, Heijnen E, Callendret B, Fleischhackl R, Comeaux C, Tran TMP, Weber K
Eur Respir Rev 2022 Dec 31;31(166) Epub 2022 Nov 15 doi: 10.1183/16000617.0105-2022. PMID: 36384703Free PMC Article
Respiratory syncytial virus infection in adults.
Nam HH, Ison MG
BMJ 2019 Sep 10;366:l5021. doi: 10.1136/bmj.l5021. PMID: 31506273
Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment.
Griffiths C, Drews SJ, Marchant DJ
Clin Microbiol Rev 2017 Jan;30(1):277-319. doi: 10.1128/CMR.00010-16. PMID: 27903593Free PMC Article

Prognosis

Risk factors for severe respiratory syncytial virus infection during the first year of life: development and validation of a clinical prediction model.
Vartiainen P, Jukarainen S, Rhedin SA, Prinz A, Hartonen T, Vabalas A, Viippola E, Rodosthenous RS, Koskelainen S, Liu A, Lundholm C, Smew AI, Osvald EC, Helle E, Perola M, Almqvist C, Heinonen S, Ganna A
Lancet Digit Health 2023 Nov;5(11):e821-e830. doi: 10.1016/S2589-7500(23)00175-9. PMID: 37890904
Change in functional status associated with respiratory syncytial virus infection in hospitalized older adults.
Branche AR, Saiman L, Walsh EE, Falsey AR, Jia H, Barrett A, Alba L, Phillips M, Finelli L
Influenza Other Respir Viruses 2022 Nov;16(6):1151-1160. Epub 2022 Sep 7 doi: 10.1111/irv.13043. PMID: 36069297Free PMC Article
Incidence of Respiratory Syncytial Virus Infection Among Hospitalized Adults, 2017-2020.
Branche AR, Saiman L, Walsh EE, Falsey AR, Sieling WD, Greendyke W, Peterson DR, Vargas CY, Phillips M, Finelli L
Clin Infect Dis 2022 Mar 23;74(6):1004-1011. doi: 10.1093/cid/ciab595. PMID: 34244735
Burden of respiratory syncytial virus infection in community-dwelling older adults in Europe (RESCEU): an international prospective cohort study.
Korsten K, Adriaenssens N, Coenen S, Butler C, Ravanfar B, Rutter H, Allen J, Falsey A, Pirçon JY, Gruselle O, Pavot V, Vernhes C, Balla-Jhagjhoorsingh S, Öner D, Ispas G, Aerssens J, Shinde V, Verheij T, Bont L, Wildenbeest J; RESCEU investigators
Eur Respir J 2021 Apr;57(4) Epub 2021 Apr 1 doi: 10.1183/13993003.02688-2020. PMID: 33060153
Severe Morbidity and Short- and Mid- to Long-term Mortality in Older Adults Hospitalized with Respiratory Syncytial Virus Infection.
Tseng HF, Sy LS, Ackerson B, Solano Z, Slezak J, Luo Y, Fischetti CA, Shinde V
J Infect Dis 2020 Sep 14;222(8):1298-1310. doi: 10.1093/infdis/jiaa361. PMID: 32591787

Clinical prediction guides

Host Responses to Respiratory Syncytial Virus Infection.
Agac A, Kolbe SM, Ludlow M, Osterhaus ADME, Meineke R, Rimmelzwaan GF
Viruses 2023 Sep 26;15(10) doi: 10.3390/v15101999. PMID: 37896776Free PMC Article
Risk factors for severe respiratory syncytial virus infection during the first year of life: development and validation of a clinical prediction model.
Vartiainen P, Jukarainen S, Rhedin SA, Prinz A, Hartonen T, Vabalas A, Viippola E, Rodosthenous RS, Koskelainen S, Liu A, Lundholm C, Smew AI, Osvald EC, Helle E, Perola M, Almqvist C, Heinonen S, Ganna A
Lancet Digit Health 2023 Nov;5(11):e821-e830. doi: 10.1016/S2589-7500(23)00175-9. PMID: 37890904
Ribavirin treatment for respiratory syncytial virus infection in patients with haematologic malignancy and haematopoietic stem cell transplant recipients: a systematic review and meta-analysis.
Manothummetha K, Mongkolkaew T, Tovichayathamrong P, Boonyawairote R, Meejun T, Srisurapanont K, Phongkhun K, Sanguankeo A, Torvorapanit P, Moonla C, Plongla R, Kates OS, Avery RK, Nematollahi S, Permpalung N
Clin Microbiol Infect 2023 Oct;29(10):1272-1279. Epub 2023 Apr 26 doi: 10.1016/j.cmi.2023.04.021. PMID: 37116860
Respiratory Syncytial Virus is the Most Common Causative Agent of Viral Bronchiolitis in Young Children: An Updated Review.
Hon KL, Leung AKC, Wong AHC, Dudi A, Leung KKY
Curr Pediatr Rev 2023;19(2):139-149. doi: 10.2174/1573396318666220810161945. PMID: 35950255
Change in functional status associated with respiratory syncytial virus infection in hospitalized older adults.
Branche AR, Saiman L, Walsh EE, Falsey AR, Jia H, Barrett A, Alba L, Phillips M, Finelli L
Influenza Other Respir Viruses 2022 Nov;16(6):1151-1160. Epub 2022 Sep 7 doi: 10.1111/irv.13043. PMID: 36069297Free PMC Article

Recent systematic reviews

Economic burden of respiratory syncytial virus infection in adults: a systematic literature review.
Grace M, Colosia A, Wolowacz S, Panozzo C, Ghaswalla P
J Med Econ 2023 Jan-Dec;26(1):742-759. doi: 10.1080/13696998.2023.2213125. PMID: 37167068
Ribavirin treatment for respiratory syncytial virus infection in patients with haematologic malignancy and haematopoietic stem cell transplant recipients: a systematic review and meta-analysis.
Manothummetha K, Mongkolkaew T, Tovichayathamrong P, Boonyawairote R, Meejun T, Srisurapanont K, Phongkhun K, Sanguankeo A, Torvorapanit P, Moonla C, Plongla R, Kates OS, Avery RK, Nematollahi S, Permpalung N
Clin Microbiol Infect 2023 Oct;29(10):1272-1279. Epub 2023 Apr 26 doi: 10.1016/j.cmi.2023.04.021. PMID: 37116860
Underascertainment of Respiratory Syncytial Virus Infection in Adults Due to Diagnostic Testing Limitations: A Systematic Literature Review and Meta-analysis.
Onwuchekwa C, Moreo LM, Menon S, Machado B, Curcio D, Kalina W, Atwell JE, Gessner BD, Siapka M, Agarwal N, Rubbrecht M, Nair H, Rozenbaum M, Aponte-Torres Z, Vroling H, Begier E
J Infect Dis 2023 Jul 14;228(2):173-184. doi: 10.1093/infdis/jiad012. PMID: 36661222Free PMC Article
Burden of respiratory syncytial virus infection in older and high-risk adults: a systematic review and meta-analysis of the evidence from developed countries.
Nguyen-Van-Tam JS, O'Leary M, Martin ET, Heijnen E, Callendret B, Fleischhackl R, Comeaux C, Tran TMP, Weber K
Eur Respir Rev 2022 Dec 31;31(166) Epub 2022 Nov 15 doi: 10.1183/16000617.0105-2022. PMID: 36384703Free PMC Article
The Human Immune Response to Respiratory Syncytial Virus Infection.
Russell CD, Unger SA, Walton M, Schwarze J
Clin Microbiol Rev 2017 Apr;30(2):481-502. doi: 10.1128/CMR.00090-16. PMID: 28179378Free PMC Article

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