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Tick-borne relapsing fever

MedGen UID:
20515
•Concept ID:
C0035022
•
Disease or Syndrome
Synonyms: Relapsing fever, tick-borne; Tick-Borne Relapsing Fever; tick-borne relapsing fever
SNOMED CT: Tick-borne relapsing fever (10301003)
 
Monarch Initiative: MONDO:0001621

Definition

An infection that is caused by certain species of Rickettsia or Borrelia, which are transmitted to humans from infected ticks; it is characterized by sudden fever, chills, headaches, myalgia, arthralgia, nausea, and possibly a rash. Symptoms usually persist for two to nine days, then disappear, with recurrence after several weeks if the patient remains untreated. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTick-borne relapsing fever

Professional guidelines

PubMed

Recombinant protein immunoblots for differential diagnosis of tick-borne relapsing fever and Lyme disease.
Shah JS, Burrascano JJ, Ramasamy R
J Vector Borne Dis 2023 Oct-Dec;60(4):353-364. doi: 10.4103/0972-9062.383641. PMID: 38174512
Tick-borne infections in children: epidemiology, clinical manifestations, and optimal management strategies.
Buckingham SC
Paediatr Drugs 2005;7(3):163-76. doi: 10.2165/00148581-200507030-00003. PMID: 15977962
Neuroborreliosis during relapsing fever: review of the clinical manifestations, pathology, and treatment of infections in humans and experimental animals.
Cadavid D, Barbour AG
Clin Infect Dis 1998 Jan;26(1):151-64. doi: 10.1086/516276. PMID: 9455525

Recent clinical studies

Etiology

Recombinant protein immunoblots for differential diagnosis of tick-borne relapsing fever and Lyme disease.
Shah JS, Burrascano JJ, Ramasamy R
J Vector Borne Dis 2023 Oct-Dec;60(4):353-364. doi: 10.4103/0972-9062.383641. PMID: 38174512
Doxycycline for Prevention of Spirochetal Infections: Status Report.
Wormser GP
Clin Infect Dis 2020 Nov 5;71(8):2014-2017. doi: 10.1093/cid/ciaa240. PMID: 32157268
Louse-borne relapsing fever (Borrelia recurrentis infection).
Warrell DA
Epidemiol Infect 2019 Jan;147:e106. doi: 10.1017/S0950268819000116. PMID: 30869050Free PMC Article
Dermatoses from ticks.
McGinley-Smith DE, Tsao SS
J Am Acad Dermatol 2003 Sep;49(3):363-92; quiz 393-6. doi: 10.1067/s0190-9622(03)01868-1. PMID: 12963900
Relapsing fever in pregnancy: analysis of high-risk factors.
Melkert PW
Br J Obstet Gynaecol 1988 Oct;95(10):1070-2. doi: 10.1111/j.1471-0528.1988.tb06516.x. PMID: 3191046

Diagnosis

Detection of Borrelia crocidurae in a vaginal swab after miscarriage, rural Senegal, Western Africa.
Fall NS, Diagne N, Mediannikov O, Fenollar F, Parola P, Sokhna C, Raoult D, Lagier JC
Int J Infect Dis 2020 Feb;91:261-263. Epub 2019 Dec 19 doi: 10.1016/j.ijid.2019.12.020. PMID: 31863877
Tick-Borne Illnesses.
Choi E, Pyzocha NJ, Maurer DM
Curr Sports Med Rep 2016 Mar-Apr;15(2):98-104. doi: 10.1249/JSR.0000000000000238. PMID: 26963018
Relapsing Fever Borreliae: A Global Review.
Cutler SJ
Clin Lab Med 2015 Dec;35(4):847-65. Epub 2015 Aug 22 doi: 10.1016/j.cll.2015.07.001. PMID: 26593261
Borrelia hispanica relapsing fever, Morocco.
Sarih M, Garnier M, Boudebouch N, Bouattour A, Rihani A, Hassar M, Gern L, Postic D, Cornet M
Emerg Infect Dis 2009 Oct;15(10):1626-9. doi: 10.3201/eid1510.090403. PMID: 19861058Free PMC Article
Relapsing fever in pregnancy: analysis of high-risk factors.
Melkert PW
Br J Obstet Gynaecol 1988 Oct;95(10):1070-2. doi: 10.1111/j.1471-0528.1988.tb06516.x. PMID: 3191046

Therapy

Tick-borne relapsing fever.
Aviles ES, Oakes M, Algranati M, Mansoor AM
BMJ Case Rep 2020 Jul 16;13(7) doi: 10.1136/bcr-2020-237296. PMID: 32675137Free PMC Article
Doxycycline for Prevention of Spirochetal Infections: Status Report.
Wormser GP
Clin Infect Dis 2020 Nov 5;71(8):2014-2017. doi: 10.1093/cid/ciaa240. PMID: 32157268
Louse-borne relapsing fever (Borrelia recurrentis infection).
Warrell DA
Epidemiol Infect 2019 Jan;147:e106. doi: 10.1017/S0950268819000116. PMID: 30869050Free PMC Article
Diagnosis and Management of Borrelia turicatae Infection in Febrile Soldier, Texas, USA.
Christensen AM, Pietralczyk E, Lopez JE, Brooks C, Schriefer ME, Wozniak E, Stermole B
Emerg Infect Dis 2017 May;23(5):883-884. doi: 10.3201/eid2305.162069. PMID: 28418310Free PMC Article
Tick-borne relapsing fever.
Dworkin MS, Schwan TG, Anderson DE Jr, Borchardt SM
Infect Dis Clin North Am 2008 Sep;22(3):449-68, viii. doi: 10.1016/j.idc.2008.03.006. PMID: 18755384Free PMC Article

Prognosis

Relapsing Fever Borreliae: A Global Review.
Cutler SJ
Clin Lab Med 2015 Dec;35(4):847-65. Epub 2015 Aug 22 doi: 10.1016/j.cll.2015.07.001. PMID: 26593261
Relapsing fever borreliosis in Eurasia--forgotten, but certainly not gone!
Assous MV, Wilamowski A
Clin Microbiol Infect 2009 May;15(5):407-14. doi: 10.1111/j.1469-0691.2009.02767.x. PMID: 19489923
Dermatoses from ticks.
McGinley-Smith DE, Tsao SS
J Am Acad Dermatol 2003 Sep;49(3):363-92; quiz 393-6. doi: 10.1067/s0190-9622(03)01868-1. PMID: 12963900
Tick-borne relapsing fever and pregnancy outcome in rural Tanzania.
Jongen VH, van Roosmalen J, Tiems J, Van Holten J, Wetsteyn JC
Acta Obstet Gynecol Scand 1997 Oct;76(9):834-8. doi: 10.3109/00016349709024361. PMID: 9351408
An overview of tick-borne relapsing fever with emphasis on outbreaks in Texas.
Rawlings JA
Tex Med 1995 May;91(5):56-9. PMID: 7778052

Clinical prediction guides

Borrelia miyamotoi a neglected tick-borne relapsing fever spirochete in Thailand.
Takhampunya R, Longkunan A, Somchaimongkol S, Youngdech N, Chanarat N, Sakolvaree J, Tippayachai B, Promsathaporn S, Phanpheuch B, Poole-Smith BK, McCardle PW, Lindroth EJ
PLoS Negl Trop Dis 2023 Feb;17(2):e0011159. Epub 2023 Feb 21 doi: 10.1371/journal.pntd.0011159. PMID: 36809255Free PMC Article
Comparative genomics of the Western Hemisphere soft tick-borne relapsing fever borreliae highlights extensive plasmid diversity.
Kneubehl AR, Krishnavajhala A, Leal SM, Replogle AJ, Kingry LC, Bermúdez SE, Labruna MB, Lopez JE
BMC Genomics 2022 May 31;23(1):410. doi: 10.1186/s12864-022-08523-7. PMID: 35641918Free PMC Article
Tick-borne relapsing fever Borreliosis, a major public health problem overlooked in Senegal.
Ndiaye EHI, Diouf FS, Ndiaye M, Bassene H, Raoult D, Sokhna C, Parola P, Diatta G
PLoS Negl Trop Dis 2021 Apr;15(4):e0009184. Epub 2021 Apr 22 doi: 10.1371/journal.pntd.0009184. PMID: 33886571Free PMC Article
Molecular prevalence and ecoregion distribution of select tick-borne pathogens in Texas dogs.
Modarelli JJ, Tomeček JM, Piccione J, Ferro PJ, Esteve-Gasent MD
Transbound Emerg Dis 2019 May;66(3):1291-1300. Epub 2019 Mar 6 doi: 10.1111/tbed.13145. PMID: 30739394
Relapsing fever--a forgotten disease revealed.
Cutler SJ
J Appl Microbiol 2010 Apr;108(4):1115-22. Epub 2009 Oct 20 doi: 10.1111/j.1365-2672.2009.04598.x. PMID: 19886891

Recent systematic reviews

Tick borne relapsing fever - a systematic review and analysis of the literature.
Jakab Á, Kahlig P, Kuenzli E, Neumayr A
PLoS Negl Trop Dis 2022 Feb;16(2):e0010212. Epub 2022 Feb 16 doi: 10.1371/journal.pntd.0010212. PMID: 35171908Free PMC Article

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