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Reactive arthritis triad

MedGen UID:
11170
•Concept ID:
C0035012
•
Disease or Syndrome
Synonyms: Reiter Disease; Reiter Syndrome; Reiter's Disease; Reiter's Syndrome; Reiters Disease; Reiters Syndrome
SNOMED CT: Reiter's disease (67224007); Urethrooculoarticular syndrome (67224007); Reiter's syndrome (67224007); Reiter disease (67224007); Reactive arthritis triad (67224007)

Definition

A rare, reactive inflammatory disorder seen following bacterial infection. It predominantly affects males aged 20-40. Individuals with HLA-B27 antigen are estimated to have a 50 % increased risk. The disorder is characterized by arthritis, conjunctivitis, uveitis, iritis and ulceration of the oral cavity, genitals and volar surfaces of the hands and feet. The clinical course is self-limited with resolution of clinical disease usually within six months of onset. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReactive arthritis triad

Professional guidelines

PubMed

ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update.
Ramiro S, Nikiphorou E, Sepriano A, Ortolan A, Webers C, Baraliakos X, Landewé RBM, Van den Bosch FE, Boteva B, Bremander A, Carron P, Ciurea A, van Gaalen FA, Géher P, Gensler L, Hermann J, de Hooge M, Husakova M, Kiltz U, López-Medina C, Machado PM, Marzo-Ortega H, Molto A, Navarro-Compán V, Nissen MJ, Pimentel-Santos FM, Poddubnyy D, Proft F, Rudwaleit M, Telkman M, Zhao SS, Ziade N, van der Heijde D
Ann Rheum Dis 2023 Jan;82(1):19-34. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223296. PMID: 36270658
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Diagnosis and management of rheumatoid arthritis.
Wasserman AM
Am Fam Physician 2011 Dec 1;84(11):1245-52. PMID: 22150658

Recent clinical studies

Etiology

Spondyloarthritides.
Taitt HA, Balakrishnan R
Immunol Allergy Clin North Am 2023 Aug;43(3):593-612. doi: 10.1016/j.iac.2022.10.001. PMID: 37394262
Reactive Arthritis Update: Spotlight on New and Rare Infectious Agents Implicated as Pathogens.
Zeidler H, Hudson AP
Curr Rheumatol Rep 2021 Jul 1;23(7):53. doi: 10.1007/s11926-021-01018-6. PMID: 34196842Free PMC Article
Understanding the Pathogenesis of Spondyloarthritis.
Sharip A, Kunz J
Biomolecules 2020 Oct 20;10(10) doi: 10.3390/biom10101461. PMID: 33092023Free PMC Article
Post-Streptococcal Reactive Arthritis.
Bawazir Y, Towheed T, Anastassiades T
Curr Rheumatol Rev 2020;16(1):2-8. doi: 10.2174/1573397115666190808110337. PMID: 31393253
Traveler's Diarrhea.
Giddings SL, Stevens AM, Leung DT
Med Clin North Am 2016 Mar;100(2):317-30. doi: 10.1016/j.mcna.2015.08.017. PMID: 26900116Free PMC Article

Diagnosis

Reactive Arthritis.
Vičić M, Prpić Massari L
N Engl J Med 2022 May 26;386(21):2035. doi: 10.1056/NEJMicm2117883. PMID: 35613024
Reactive Arthritis Update: Spotlight on New and Rare Infectious Agents Implicated as Pathogens.
Zeidler H, Hudson AP
Curr Rheumatol Rep 2021 Jul 1;23(7):53. doi: 10.1007/s11926-021-01018-6. PMID: 34196842Free PMC Article
Post-Streptococcal Reactive Arthritis.
Bawazir Y, Towheed T, Anastassiades T
Curr Rheumatol Rev 2020;16(1):2-8. doi: 10.2174/1573397115666190808110337. PMID: 31393253
Reactive arthritis: update 2018.
García-Kutzbach A, Chacón-Súchite J, García-Ferrer H, Iraheta I
Clin Rheumatol 2018 Apr;37(4):869-874. Epub 2018 Feb 17 doi: 10.1007/s10067-018-4022-5. PMID: 29455267
Reactive Arthritis.
Schmitt SK
Infect Dis Clin North Am 2017 Jun;31(2):265-277. Epub 2017 Mar 11 doi: 10.1016/j.idc.2017.01.002. PMID: 28292540

Therapy

Post-Streptococcal Reactive Arthritis.
Bawazir Y, Towheed T, Anastassiades T
Curr Rheumatol Rev 2020;16(1):2-8. doi: 10.2174/1573397115666190808110337. PMID: 31393253
Reactive Arthritis.
Schmitt SK
Infect Dis Clin North Am 2017 Jun;31(2):265-277. Epub 2017 Mar 11 doi: 10.1016/j.idc.2017.01.002. PMID: 28292540
Traveler's Diarrhea.
Giddings SL, Stevens AM, Leung DT
Med Clin North Am 2016 Mar;100(2):317-30. doi: 10.1016/j.mcna.2015.08.017. PMID: 26900116Free PMC Article
Reactive arthritis.
Kwiatkowska B, Filipowicz-Sosnowska A
Pol Arch Med Wewn 2009 Jan-Feb;119(1-2):60-5. PMID: 19341180
Reactive arthritis.
Leirisalo-Repo M
Scand J Rheumatol 2005 Jul-Aug;34(4):251-9. doi: 10.1080/03009740500202540. PMID: 16195157

Prognosis

Reactive Arthritis.
Schmitt SK
Infect Dis Clin North Am 2017 Jun;31(2):265-277. Epub 2017 Mar 11 doi: 10.1016/j.idc.2017.01.002. PMID: 28292540
Reactive arthritis.
Hannu T
Best Pract Res Clin Rheumatol 2011 Jun;25(3):347-57. doi: 10.1016/j.berh.2011.01.018. PMID: 22100285
Reactive arthritis.
Kwiatkowska B, Filipowicz-Sosnowska A
Pol Arch Med Wewn 2009 Jan-Feb;119(1-2):60-5. PMID: 19341180
Reactive arthritis.
Leirisalo-Repo M
Scand J Rheumatol 2005 Jul-Aug;34(4):251-9. doi: 10.1080/03009740500202540. PMID: 16195157
Reactive arthritis.
Toivanen A, Toivanen P
Isr Med Assoc J 2001 Sep;3(9):681-5. PMID: 11574987

Clinical prediction guides

Reactive arthritis: images.
Aitken-Saavedra J, Maturana-Ramirez A, Fernández Moraga J, Doro Dias V, Galdino-Santos L, Pineda Flores D
Dermatol Online J 2021 Jul 15;27(7) doi: 10.5070/D327754373. PMID: 34391335
EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors.
Kostine M, Finckh A, Bingham CO, Visser K, Leipe J, Schulze-Koops H, Choy EH, Benesova K, Radstake TRDJ, Cope AP, Lambotte O, Gottenberg JE, Allenbach Y, Visser M, Rusthoven C, Thomasen L, Jamal S, Marabelle A, Larkin J, Haanen JBAG, Calabrese LH, Mariette X, Schaeverbeke T
Ann Rheum Dis 2021 Jan;80(1):36-48. Epub 2020 Apr 23 doi: 10.1136/annrheumdis-2020-217139. PMID: 32327425Free PMC Article
Synovitis score: discrimination between chronic low-grade and high-grade synovitis.
Krenn V, Morawietz L, Burmester GR, Kinne RW, Mueller-Ladner U, Muller B, Haupl T
Histopathology 2006 Oct;49(4):358-64. doi: 10.1111/j.1365-2559.2006.02508.x. PMID: 16978198
Reactive arthritis.
Toivanen A, Toivanen P
Best Pract Res Clin Rheumatol 2004 Oct;18(5):689-703. doi: 10.1016/j.berh.2004.05.008. PMID: 15454127
Grading of chronic synovitis--a histopathological grading system for molecular and diagnostic pathology.
Krenn V, Morawietz L, Häupl T, Neidel J, Petersen I, König A
Pathol Res Pract 2002;198(5):317-25. doi: 10.1078/0344-0338-5710261. PMID: 12092767

Recent systematic reviews

Biomarkers for the diagnosis and treatment of rheumatoid arthritis - a systematic review.
Abdelhafiz D, Baker T, Glascow DA, Abdelhafiz A
Postgrad Med 2023 Apr;135(3):214-223. Epub 2022 Mar 16 doi: 10.1080/00325481.2022.2052626. PMID: 35275765
Effect of Anti-Inflammatory Diets on Pain in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.
Schönenberger KA, Schüpfer AC, Gloy VL, Hasler P, Stanga Z, Kaegi-Braun N, Reber E
Nutrients 2021 Nov 24;13(12) doi: 10.3390/nu13124221. PMID: 34959772Free PMC Article
Rheumatoid meningitis: A systematic review and meta-analysis.
Villa E, Sarquis T, de Grazia J, Núñez R, Alarcón P, Villegas R, Guevara C
Eur J Neurol 2021 Sep;28(9):3201-3210. Epub 2021 Jun 29 doi: 10.1111/ene.14904. PMID: 33966315
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Evidence-based diagnostics: adult septic arthritis.
Carpenter CR, Schuur JD, Everett WW, Pines JM
Acad Emerg Med 2011 Aug;18(8):781-96. doi: 10.1111/j.1553-2712.2011.01121.x. PMID: 21843213Free PMC Article

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