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Radiation Syndromes

MedGen UID:
11097
•Concept ID:
C0034535
•
Disease or Syndrome
Synonyms: Radiation Syndrome; Syndrome, Radiation; Syndromes, Radiation

Professional guidelines

PubMed

Acute radiation risk assessment and mitigation strategies in near future exploration spaceflights.
Hu S, Barzilla JE, Semones E
Life Sci Space Res (Amst) 2020 Feb;24:25-33. Epub 2019 Oct 31 doi: 10.1016/j.lssr.2019.10.006. PMID: 31987477
Linking the human response to unplanned radiation and treatment to the nonhuman primate response to controlled radiation and treatment.
Dörr H, Lamkowski A, Graessle DH, Bennett A, Shapiro A, Farese AM, Garofalo M, MacVittie TJ, Meineke V
Health Phys 2014 Jan;106(1):129-34. doi: 10.1097/HP.0b013e3182a12de0. PMID: 24276556Free PMC Article

Recent clinical studies

Etiology

Acute radiation risk assessment and mitigation strategies in near future exploration spaceflights.
Hu S, Barzilla JE, Semones E
Life Sci Space Res (Amst) 2020 Feb;24:25-33. Epub 2019 Oct 31 doi: 10.1016/j.lssr.2019.10.006. PMID: 31987477
Transplantation of Endothelial Cells to Mitigate Acute and Chronic Radiation Injury to Vital Organs.
Rafii S, Ginsberg M, Scandura J, Butler JM, Ding BS
Radiat Res 2016 Aug;186(2):196-202. Epub 2016 Jul 26 doi: 10.1667/RR14461.1. PMID: 27459700Free PMC Article
Radiation accident preparedness: a European approach to train physicians to manage mass radiation casualties.
Hotz ME, Fliedner TM, Meineke V
Health Phys 2010 Jun;98(6):894-7. doi: 10.1097/HP.0b013e3181ab3e71. PMID: 20445401
Response of normal stem cells to ionizing radiation: a balance between homeostasis and genomic stability.
Harfouche G, Martin MT
Mutat Res 2010 Apr-Jun;704(1-3):167-74. Epub 2010 Feb 1 doi: 10.1016/j.mrrev.2010.01.007. PMID: 20117235
Radiation accidents in a developing country: the Nigerian experience.
Ketiku KK, Ogunleye OT
West Afr J Med 1994 Jan-Mar;13(1):63-5. PMID: 8080836

Diagnosis

Gastrointestinal Acute Radiation Syndrome: Mechanisms, Models, Markers, and Medical Countermeasures.
Winters TA, Marzella L, Molinar-Inglis O, Price PW, Han NC, Cohen JE, Wang SJ, Fotenos AF, Sullivan JM, Esker JI, Lapinskas PJ, DiCarlo AL
Radiat Res 2024 Jun 1;201(6):628-646. doi: 10.1667/RADE-23-00196.1. PMID: 38616048
Guidance in Managing Patients Following Radiation Events.
Veenema TG, Thornton CP
Adv Emerg Nurs J 2015 Jul-Sep;37(3):197-208. doi: 10.1097/TME.0000000000000058. PMID: 26218486
Linking the human response to unplanned radiation and treatment to the nonhuman primate response to controlled radiation and treatment.
Dörr H, Lamkowski A, Graessle DH, Bennett A, Shapiro A, Farese AM, Garofalo M, MacVittie TJ, Meineke V
Health Phys 2014 Jan;106(1):129-34. doi: 10.1097/HP.0b013e3182a12de0. PMID: 24276556Free PMC Article
Identification of sensitive serum microRNA biomarkers for radiation biodosimetry.
Jacob NK, Cooley JV, Yee TN, Jacob J, Alder H, Wickramasinghe P, Maclean KH, Chakravarti A
PLoS One 2013;8(2):e57603. Epub 2013 Feb 25 doi: 10.1371/journal.pone.0057603. PMID: 23451251Free PMC Article
Radiation accident preparedness: a European approach to train physicians to manage mass radiation casualties.
Hotz ME, Fliedner TM, Meineke V
Health Phys 2010 Jun;98(6):894-7. doi: 10.1097/HP.0b013e3181ab3e71. PMID: 20445401

Therapy

Celebrating 60 Years of Accomplishments of the Armed Forces Radiobiology Research Institute1.
Bene BJ, Blakely WF, Burmeister DM, Cary L, Chhetri SJ, Davis CM, Ghosh SP, Holmes-Hampton GP, Iordanskiy S, Kalinich JF, Kiang JG, Kumar VP, Lowy RJ, Miller A, Naeem M, Schauer DA, Senchak L, Singh VK, Stewart AJ, Velazquez EM, Xiao M
Radiat Res 2021 Aug 1;196(2):129-146. doi: 10.1667/21-00064.1. PMID: 33979439
Drug discovery strategies for acute radiation syndrome.
Singh VK, Seed TM, Olabisi AO
Expert Opin Drug Discov 2019 Jul;14(7):701-715. Epub 2019 Apr 22 doi: 10.1080/17460441.2019.1604674. PMID: 31008662
Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist.
Patil R, Szabó E, Fells JI, Balogh A, Lim KG, Fujiwara Y, Norman DD, Lee SC, Balazs L, Thomas F, Patil S, Emmons-Thompson K, Boler A, Strobos J, McCool SW, Yates CR, Stabenow J, Byrne GI, Miller DD, Tigyi GJ
Chem Biol 2015 Feb 19;22(2):206-16. Epub 2015 Jan 22 doi: 10.1016/j.chembiol.2014.12.009. PMID: 25619933Free PMC Article
Acute gastrointestinal syndrome in high-dose irradiated mice.
Booth C, Tudor G, Tudor J, Katz BP, MacVittie TJ
Health Phys 2012 Oct;103(4):383-99. doi: 10.1097/hp.0b013e318266ee13. PMID: 23091876Free PMC Article
Current status of hematopoietic stem cell transplantation for acute radiation syndromes.
Asano S
Int J Hematol 2012 Mar;95(3):227-31. Epub 2012 Mar 3 doi: 10.1007/s12185-012-1027-8. PMID: 22382644

Prognosis

Impact of GADD45A on Radiation Biodosimetry Using Mouse Peripheral Blood.
Broustas CG, Mukherjee S, Shuryak I, Taraboletti A, Angdisen J, Ake P, Fornace AJ, Amundson SA
Radiat Res 2023 Sep 1;200(3):296-306. doi: 10.1667/RADE-23-00052.1. PMID: 37421415Free PMC Article
Acute radiation risk assessment and mitigation strategies in near future exploration spaceflights.
Hu S, Barzilla JE, Semones E
Life Sci Space Res (Amst) 2020 Feb;24:25-33. Epub 2019 Oct 31 doi: 10.1016/j.lssr.2019.10.006. PMID: 31987477
Acute gastrointestinal syndrome in high-dose irradiated mice.
Booth C, Tudor G, Tudor J, Katz BP, MacVittie TJ
Health Phys 2012 Oct;103(4):383-99. doi: 10.1097/hp.0b013e318266ee13. PMID: 23091876Free PMC Article
Radiation rescue: mesenchymal stromal cells protect from lethal irradiation.
Lange C, Brunswig-Spickenheier B, Cappallo-Obermann H, Eggert K, Gehling UM, Rudolph C, Schlegelberger B, Cornils K, Zustin J, Spiess AN, Zander AR
PLoS One 2011 Jan 5;6(1):e14486. doi: 10.1371/journal.pone.0014486. PMID: 21245929Free PMC Article
Radioprotective agents in medicine.
Duraković A
Arh Hig Rada Toksikol 1993 Dec;44(4):331-54. PMID: 8192608

Clinical prediction guides

Impact of GADD45A on Radiation Biodosimetry Using Mouse Peripheral Blood.
Broustas CG, Mukherjee S, Shuryak I, Taraboletti A, Angdisen J, Ake P, Fornace AJ, Amundson SA
Radiat Res 2023 Sep 1;200(3):296-306. doi: 10.1667/RADE-23-00052.1. PMID: 37421415Free PMC Article
Acute radiation risk assessment and mitigation strategies in near future exploration spaceflights.
Hu S, Barzilla JE, Semones E
Life Sci Space Res (Amst) 2020 Feb;24:25-33. Epub 2019 Oct 31 doi: 10.1016/j.lssr.2019.10.006. PMID: 31987477
Nuclear Countermeasure Activity of TP508 Linked to Restoration of Endothelial Function and Acceleration of DNA Repair.
Olszewska-Pazdrak B, McVicar SD, Rayavara K, Moya SM, Kantara C, Gammarano C, Olszewska P, Fuller GM, Sower LE, Carney DH
Radiat Res 2016 Aug;186(2):162-74. Epub 2016 Jul 7 doi: 10.1667/RR14409.1. PMID: 27388041Free PMC Article
Current status of hematopoietic stem cell transplantation for acute radiation syndromes.
Asano S
Int J Hematol 2012 Mar;95(3):227-31. Epub 2012 Mar 3 doi: 10.1007/s12185-012-1027-8. PMID: 22382644
Radioprotective agents in medicine.
Duraković A
Arh Hig Rada Toksikol 1993 Dec;44(4):331-54. PMID: 8192608

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