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Q fever

MedGen UID:
48290
•Concept ID:
C0034362
•
Disease or Syndrome
Synonyms: Coxiella Burnetii fever; Q fever pneumonia; Query fever
SNOMED CT: Infection due to Coxiella burnetii (186788009); Q fever (186788009); Abattoir fever (186788009); Balkan influenza (186788009); Balkan grippe (186788009); Query fever (186788009)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019186
Orphanet: ORPHA781

Definition

Q fever, caused by <i>Coxiella burnetii</i>, is a bacterial zoonosis with a wide clinical spectrum that can be life-threatening and, in some cases, can become chronic. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVQ fever
Follow this link to review classifications for Q fever in Orphanet.

Professional guidelines

PubMed

Diagnosis and management of Q fever--United States, 2013: recommendations from CDC and the Q Fever Working Group.
Anderson A, Bijlmer H, Fournier PE, Graves S, Hartzell J, Kersh GJ, Limonard G, Marrie TJ, Massung RF, McQuiston JH, Nicholson WL, Paddock CD, Sexton DJ
MMWR Recomm Rep 2013 Mar 29;62(RR-03):1-30. PMID: 23535757
Q fever: clinical manifestations and treatment.
Gikas A, Kokkini S, Tsioutis C
Expert Rev Anti Infect Ther 2010 May;8(5):529-39. doi: 10.1586/eri.10.29. PMID: 20455682
Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis.
Li JS, Sexton DJ, Mick N, Nettles R, Fowler VG Jr, Ryan T, Bashore T, Corey GR
Clin Infect Dis 2000 Apr;30(4):633-8. Epub 2000 Apr 3 doi: 10.1086/313753. PMID: 10770721

Recent clinical studies

Etiology

Q fever and prevention.
Škultéty L
Epidemiol Mikrobiol Imunol 2020 Spring;69(2):87-94. PMID: 32819108
From Q Fever to Coxiella burnetii Infection: a Paradigm Change.
Eldin C, Mélenotte C, Mediannikov O, Ghigo E, Million M, Edouard S, Mege JL, Maurin M, Raoult D
Clin Microbiol Rev 2017 Jan;30(1):115-190. doi: 10.1128/CMR.00045-16. PMID: 27856520Free PMC Article
Q Fever.
Shishido AA, Letizia AG, Hartzell JD
US Army Med Dep J 2016 Jan-Mar;2016 Jan-Mar:68-70. PMID: 26874100
Diagnosis and management of Q fever--United States, 2013: recommendations from CDC and the Q Fever Working Group.
Anderson A, Bijlmer H, Fournier PE, Graves S, Hartzell J, Kersh GJ, Limonard G, Marrie TJ, Massung RF, McQuiston JH, Nicholson WL, Paddock CD, Sexton DJ
MMWR Recomm Rep 2013 Mar 29;62(RR-03):1-30. PMID: 23535757
Q fever.
Cutler SJ, Bouzid M, Cutler RR
J Infect 2007 Apr;54(4):313-8. Epub 2006 Dec 4 doi: 10.1016/j.jinf.2006.10.048. PMID: 17147957

Diagnosis

Q fever and prevention.
Škultéty L
Epidemiol Mikrobiol Imunol 2020 Spring;69(2):87-94. PMID: 32819108
From Q Fever to Coxiella burnetii Infection: a Paradigm Change.
Eldin C, Mélenotte C, Mediannikov O, Ghigo E, Million M, Edouard S, Mege JL, Maurin M, Raoult D
Clin Microbiol Rev 2017 Jan;30(1):115-190. doi: 10.1128/CMR.00045-16. PMID: 27856520Free PMC Article
Q Fever.
Burnett MW
J Spec Oper Med 2015 Summer;15(2):109-111. doi: 10.55460/Z76J-ESMB. PMID: 26125173
Diagnosis and management of Q fever--United States, 2013: recommendations from CDC and the Q Fever Working Group.
Anderson A, Bijlmer H, Fournier PE, Graves S, Hartzell J, Kersh GJ, Limonard G, Marrie TJ, Massung RF, McQuiston JH, Nicholson WL, Paddock CD, Sexton DJ
MMWR Recomm Rep 2013 Mar 29;62(RR-03):1-30. PMID: 23535757
Q fever.
Geddes AM
Br Med J (Clin Res Ed) 1983 Oct 1;287(6397):927-8. doi: 10.1136/bmj.287.6397.927. PMID: 6412891Free PMC Article

Therapy

Q Fever (Coxiella Burnetii).
España PP, Uranga A, Cillóniz C, Torres A
Semin Respir Crit Care Med 2020 Aug;41(4):509-521. Epub 2020 Jul 6 doi: 10.1055/s-0040-1710594. PMID: 32629489
Atypical pneumonia.
Basarab M, Macrae MB, Curtis CM
Curr Opin Pulm Med 2014 May;20(3):247-51. doi: 10.1097/MCP.0000000000000048. PMID: 24626238
Diagnosis and management of Q fever--United States, 2013: recommendations from CDC and the Q Fever Working Group.
Anderson A, Bijlmer H, Fournier PE, Graves S, Hartzell J, Kersh GJ, Limonard G, Marrie TJ, Massung RF, McQuiston JH, Nicholson WL, Paddock CD, Sexton DJ
MMWR Recomm Rep 2013 Mar 29;62(RR-03):1-30. PMID: 23535757
Q Fever.
Angelakis E, Raoult D
Vet Microbiol 2010 Jan 27;140(3-4):297-309. Epub 2009 Aug 8 doi: 10.1016/j.vetmic.2009.07.016. PMID: 19875249
The tetracyclines.
Smilack JD
Mayo Clin Proc 1999 Jul;74(7):727-9. doi: 10.4065/74.7.727. PMID: 10405705

Prognosis

Q fever - immune responses and novel vaccine strategies.
Redden P, Parker K, Henderson S, Fourie P, Agnew L, Stenos J, Graves S, Govan B, Norton R, Ketheesan N
Future Microbiol 2023 Nov;18:1185-1196. Epub 2023 Oct 18 doi: 10.2217/fmb-2023-0117. PMID: 37850346
Better Epitope Discovery, Precision Immune Engineering, and Accelerated Vaccine Design Using Immunoinformatics Tools.
De Groot AS, Moise L, Terry F, Gutierrez AH, Hindocha P, Richard G, Hoft DF, Ross TM, Noe AR, Takahashi Y, Kotraiah V, Silk SE, Nielsen CM, Minassian AM, Ashfield R, Ardito M, Draper SJ, Martin WD
Front Immunol 2020;11:442. Epub 2020 Apr 7 doi: 10.3389/fimmu.2020.00442. PMID: 32318055Free PMC Article
Q fever endocarditis.
Mazokopakis EE, Karefilakis CM, Starakis IK
Infect Disord Drug Targets 2010 Feb;10(1):27-31. doi: 10.2174/187152610790410918. PMID: 20218950
Q fever.
Cutler SJ, Bouzid M, Cutler RR
J Infect 2007 Apr;54(4):313-8. Epub 2006 Dec 4 doi: 10.1016/j.jinf.2006.10.048. PMID: 17147957
Q fever.
Maurin M, Raoult D
Clin Microbiol Rev 1999 Oct;12(4):518-53. doi: 10.1128/CMR.12.4.518. PMID: 10515901Free PMC Article

Clinical prediction guides

Q fever - immune responses and novel vaccine strategies.
Redden P, Parker K, Henderson S, Fourie P, Agnew L, Stenos J, Graves S, Govan B, Norton R, Ketheesan N
Future Microbiol 2023 Nov;18:1185-1196. Epub 2023 Oct 18 doi: 10.2217/fmb-2023-0117. PMID: 37850346
Q fever vertebral osteomyelitis among adults: a case series and literature review.
Ghanem-Zoubi N, Karram T, Kagna O, Merhav G, Keidar Z, Paul M
Infect Dis (Lond) 2021 Apr;53(4):231-240. Epub 2021 Jan 21 doi: 10.1080/23744235.2020.1871508. PMID: 33475036
Better Epitope Discovery, Precision Immune Engineering, and Accelerated Vaccine Design Using Immunoinformatics Tools.
De Groot AS, Moise L, Terry F, Gutierrez AH, Hindocha P, Richard G, Hoft DF, Ross TM, Noe AR, Takahashi Y, Kotraiah V, Silk SE, Nielsen CM, Minassian AM, Ashfield R, Ardito M, Draper SJ, Martin WD
Front Immunol 2020;11:442. Epub 2020 Apr 7 doi: 10.3389/fimmu.2020.00442. PMID: 32318055Free PMC Article
Human Tick-Borne Diseases in Australia.
Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ
Front Cell Infect Microbiol 2019;9:3. Epub 2019 Jan 28 doi: 10.3389/fcimb.2019.00003. PMID: 30746341Free PMC Article
The atypical pneumonias: clinical diagnosis and importance.
Cunha BA
Clin Microbiol Infect 2006 May;12 Suppl 3:12-24. doi: 10.1111/j.1469-0691.2006.01393.x. PMID: 16669925Free PMC Article

Recent systematic reviews

Q fever in Spain: Description of a new series, and systematic review.
Alende-Castro V, Macía-Rodríguez C, Novo-Veleiro I, García-Fernández X, Treviño-Castellano M, Rodríguez-Fernández S, González-Quintela A
PLoS Negl Trop Dis 2018 Mar;12(3):e0006338. Epub 2018 Mar 15 doi: 10.1371/journal.pntd.0006338. PMID: 29543806Free PMC Article
Seroprevalence of Q fever among human and animal in Iran; A systematic review and meta-analysis.
Mohabbati Mobarez A, Bagheri Amiri F, Esmaeili S
PLoS Negl Trop Dis 2017 Apr;11(4):e0005521. Epub 2017 Apr 10 doi: 10.1371/journal.pntd.0005521. PMID: 28394889Free PMC Article
Fatigue following Acute Q-Fever: A Systematic Literature Review.
Morroy G, Keijmel SP, Delsing CE, Bleijenberg G, Langendam M, Timen A, Bleeker-Rovers CP
PLoS One 2016;11(5):e0155884. Epub 2016 May 25 doi: 10.1371/journal.pone.0155884. PMID: 27223465Free PMC Article
Q fever is an old and neglected zoonotic disease in Kenya: a systematic review.
Njeru J, Henning K, Pletz MW, Heller R, Neubauer H
BMC Public Health 2016 Apr 5;16:297. doi: 10.1186/s12889-016-2929-9. PMID: 27048480Free PMC Article
Q fever in China: a systematic review, 1989-2013.
El-Mahallawy HS, Lu G, Kelly P, Xu D, Li Y, Fan W, Wang C
Epidemiol Infect 2015 Mar;143(4):673-81. Epub 2014 Oct 2 doi: 10.1017/S0950268814002593. PMID: 25274488Free PMC Article

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