U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kimura disease

MedGen UID:
46183
Concept ID:
C0033838
Disease or Syndrome
Synonyms: Angiolymphoid hyperplasia with eosinophilia; Eosinophilic granuloma of soft tissue; Eosinophilic hyperplastic lymphogranuloma; Eosinophilic lymphofollicular granuloma; Eosinophilic lymphofolliculosis; Kimura's disease
SNOMED CT: Kimura's disease (399894006); Kimura disease (399894006)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
Concept ID:
CN307042
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
 
Monarch Initiative: MONDO:0018830
Orphanet: ORPHA482

Definition

Kimura disease is a benign and chronic inflammatory disorder of unknown etiology, occurring mainly in Asian countries (very rarely in Western countries) and predominantly affecting young men, that usually presents with solitary or multiple non-tender subcutaneous masses in the head and neck region (in particular the preauricular and submandibular area) and/or generalized painless lymphadenopathy, often with salivary gland involvement. Characteristic laboratory findings include blood eosinophilia and markedly elevated serum immunoglobulin E (IgE) levels. It is often associated with autoinflammatory disorders (i.e. ulcerative colitis, bronchial asthma) and a co-existing renal disease. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKimura disease
Follow this link to review classifications for Kimura disease in Orphanet.

Professional guidelines

PubMed

Szeto VG, Chin-Yee B, Dehghani M, Rizkalla K, Licskai C, Hsia CC
Ann Hematol 2022 Sep;101(9):2099-2100. Epub 2022 May 27 doi: 10.1007/s00277-022-04873-0. PMID: 35622096
Teraki Y, Terao A
JAMA Dermatol 2022 Mar 1;158(3):329-330. doi: 10.1001/jamadermatol.2021.5885. PMID: 35138349
Ye P, Wei T, Yu GY, Wu LL, Peng X
J Craniofac Surg 2016 Jan;27(1):170-4. doi: 10.1097/SCS.0000000000002337. PMID: 26674917

Recent clinical studies

Therapy

Liu YL, Ran YT, Zhang YF, Peng XT, Xia YM, Yan HL
QJM 2024 Aug 1;117(8):575-580. doi: 10.1093/qjmed/hcae048. PMID: 38492561
Battesti G, Jachiet M, Lepelletier C, Petit A, Vignon-Pennamen MD, Cassius C, de Masson A, Battistella M, Bagot M, Bouaziz JD, Mahévas T
Clin Exp Dermatol 2024 Apr 23;49(5):502-506. doi: 10.1093/ced/llad455. PMID: 38149974
Ao S, Huang G, Tang X, Zhu Z, Han J, Wang F, Zhai W
J Dermatol 2024 Apr;51(4):602-606. Epub 2023 Nov 10 doi: 10.1111/1346-8138.17021. PMID: 37950550
Teraki Y, Terao A
JAMA Dermatol 2022 Mar 1;158(3):329-330. doi: 10.1001/jamadermatol.2021.5885. PMID: 35138349
Kinoshita M, Ogawa Y, Onaka M, Shimada S, Kawamura T
J Allergy Clin Immunol Pract 2021 Jul;9(7):2928-2930. Epub 2021 Mar 5 doi: 10.1016/j.jaip.2021.02.049. PMID: 33684634

Prognosis

Sangwan A, Goyal A, Bhalla AS, Kumar A, Sharma R, Arava S, Dawar R
Curr Probl Diagn Radiol 2022 Jan-Feb;51(1):130-142. Epub 2020 Nov 17 doi: 10.1067/j.cpradiol.2020.10.003. PMID: 33250297
Thakral B, Zhou J, Medeiros LJ
Hum Pathol 2015 Aug;46(8):1079-100. Epub 2015 Jun 1 doi: 10.1016/j.humpath.2015.05.007. PMID: 26118762
Sun QF, Xu DZ, Pan SH, Ding JG, Xue ZQ, Miao CS, Cao GJ, Jin DJ
Intern Med J 2008 Aug;38(8):668-72. doi: 10.1111/j.1445-5994.2008.01711.x. PMID: 18808562
Abuel-Haija M, Hurford MT
Arch Pathol Lab Med 2007 Apr;131(4):650-1. doi: 10.5858/2007-131-650-KD. PMID: 17425383
Clauser L, Mandrioli S, Polito J, Marchetti E
J Craniofac Surg 2006 Jul;17(4):812-4. doi: 10.1097/00001665-200607000-00040. PMID: 16877941

Clinical prediction guides

Shang BS, Hsiao CH, Tsao TF, Liao YY, Lin WL, Lee WI, Lue KH
Immun Inflamm Dis 2023 Nov;11(11):e1084. doi: 10.1002/iid3.1084. PMID: 38018601Free PMC Article
Munemura R, Maehara T, Murakami Y, Koga R, Aoyagi R, Kaneko N, Doi A, Perugino CA, Della-Torre E, Saeki T, Sato Y, Yamamoto H, Kiyoshima T, Stone JH, Pillai S, Nakamura S
J Allergy Clin Immunol 2022 Aug;150(2):440-455.e17. Epub 2022 May 11 doi: 10.1016/j.jaci.2022.03.034. PMID: 35568079Free PMC Article
Yang B, Liao H, Wang M, Long Q, Zhong H, Luo L, Liu Z, Cheng X
BMC Ophthalmol 2022 Apr 2;22(1):154. doi: 10.1186/s12886-022-02378-y. PMID: 35366827Free PMC Article
Lee CC, Feng IJ, Chen YT, Weng SF, Chan LP, Lai CS, Lin SD, Kuo YR
Int J Surg 2022 Apr;100:106591. Epub 2022 Mar 5 doi: 10.1016/j.ijsu.2022.106591. PMID: 35259522
Sato R, Bandoh N, Goto T, Ichikawa H, Uemura A, Suzuki S, Yamaguchi T, Aimono E, Nishihara H, Katada A, Harabuchi Y
Head Neck Pathol 2021 Jun;15(2):657-662. Epub 2020 Jul 25 doi: 10.1007/s12105-020-01206-3. PMID: 32712881Free PMC Article

Recent systematic reviews

Lee CC, Feng IJ, Chen YT, Weng SF, Chan LP, Lai CS, Lin SD, Kuo YR
Int J Surg 2022 Apr;100:106591. Epub 2022 Mar 5 doi: 10.1016/j.ijsu.2022.106591. PMID: 35259522
Sangwan A, Goyal A, Bhalla AS, Kumar A, Sharma R, Arava S, Dawar R
Curr Probl Diagn Radiol 2022 Jan-Feb;51(1):130-142. Epub 2020 Nov 17 doi: 10.1067/j.cpradiol.2020.10.003. PMID: 33250297
Fionda B, Loperfido A, Bussu F, Lancellotta V, Casà C, Vavassori A, Vicenzi L, Re A, Deodato F, Morganti AG, Gambacorta MA, Tagliaferri L
Eur Rev Med Pharmacol Sci 2021 Jun;25(12):4205-4210. doi: 10.26355/eurrev_202106_26124. PMID: 34227087

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...