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Pseudogout

MedGen UID:
19539
•Concept ID:
C0033802
•
Disease or Syndrome
Synonym: Chondrocalcinosis

Definition

An acute episode of pain, swelling, and redness, sometimes associated with fever. It is caused by the deposition of calcium pyrophosphate crystals in the joints. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPseudogout

Professional guidelines

PubMed

An Update on the Diagnosis and Management of Calcium Crystal Disease.
Flood R, Stack J, McCarthy G
Curr Rheumatol Rep 2023 Aug;25(8):145-151. Epub 2023 May 30 doi: 10.1007/s11926-023-01106-9. PMID: 37249830Free PMC Article
Management of calcium pyrophosphate crystal deposition disease: A systematic review.
Parperis K, Papachristodoulou E, Kakoullis L, Rosenthal AK
Semin Arthritis Rheum 2021 Feb;51(1):84-94. Epub 2020 Dec 21 doi: 10.1016/j.semarthrit.2020.10.005. PMID: 33360232
Diagnosis and Treatment of Gout and Pseudogout for Everyday Practice.
Sidari A, Hill E
Prim Care 2018 Jun;45(2):213-236. doi: 10.1016/j.pop.2018.02.004. PMID: 29759121

Recent clinical studies

Etiology

An Update on the Diagnosis and Management of Calcium Crystal Disease.
Flood R, Stack J, McCarthy G
Curr Rheumatol Rep 2023 Aug;25(8):145-151. Epub 2023 May 30 doi: 10.1007/s11926-023-01106-9. PMID: 37249830Free PMC Article
Knee Arthrocentesis in Adults.
Tieng A, Franchin G
J Vis Exp 2022 Feb 25;(180) doi: 10.3791/63135. PMID: 35285829
Issues in CPPD Nomenclature and Classification.
Tedeschi SK
Curr Rheumatol Rep 2019 Jul 25;21(9):49. doi: 10.1007/s11926-019-0847-4. PMID: 31346795
Diagnosis and Treatment of Gout and Pseudogout for Everyday Practice.
Sidari A, Hill E
Prim Care 2018 Jun;45(2):213-236. doi: 10.1016/j.pop.2018.02.004. PMID: 29759121
HFE-related hemochromatosis: an update for the rheumatologist.
Husar-Memmer E, Stadlmayr A, Datz C, Zwerina J
Curr Rheumatol Rep 2014 Jan;16(1):393. doi: 10.1007/s11926-013-0393-4. PMID: 24264720

Diagnosis

An Update on the Diagnosis and Management of Calcium Crystal Disease.
Flood R, Stack J, McCarthy G
Curr Rheumatol Rep 2023 Aug;25(8):145-151. Epub 2023 May 30 doi: 10.1007/s11926-023-01106-9. PMID: 37249830Free PMC Article
Hand Infections.
Teo WZW, Chung KC
Clin Plast Surg 2019 Jul;46(3):371-381. doi: 10.1016/j.cps.2019.03.003. PMID: 31103082
Cartilage diseases.
Krishnan Y, Grodzinsky AJ
Matrix Biol 2018 Oct;71-72:51-69. Epub 2018 May 24 doi: 10.1016/j.matbio.2018.05.005. PMID: 29803938Free PMC Article
Diagnosis and Treatment of Gout and Pseudogout for Everyday Practice.
Sidari A, Hill E
Prim Care 2018 Jun;45(2):213-236. doi: 10.1016/j.pop.2018.02.004. PMID: 29759121
Gout and pseudogout.
Higgins PA
JAAPA 2016 Mar;29(3):50-2. doi: 10.1097/01.JAA.0000475472.40251.58. PMID: 26914781

Therapy

Management of calcium pyrophosphate crystal deposition disease: A systematic review.
Parperis K, Papachristodoulou E, Kakoullis L, Rosenthal AK
Semin Arthritis Rheum 2021 Feb;51(1):84-94. Epub 2020 Dec 21 doi: 10.1016/j.semarthrit.2020.10.005. PMID: 33360232
Hand Infections.
Teo WZW, Chung KC
Clin Plast Surg 2019 Jul;46(3):371-381. doi: 10.1016/j.cps.2019.03.003. PMID: 31103082
Emergent nanotherapies in microcrystal-induced arthritis.
Zamudio-Cuevas Y, Fernández-Torres J, Martínez-Nava GA, Martínez-Flores K, López-Reyes A
Int Immunopharmacol 2018 Aug;61:197-203. Epub 2018 Jun 8 doi: 10.1016/j.intimp.2018.06.007. PMID: 29890413
Diagnosis and Treatment of Gout and Pseudogout for Everyday Practice.
Sidari A, Hill E
Prim Care 2018 Jun;45(2):213-236. doi: 10.1016/j.pop.2018.02.004. PMID: 29759121
Gout and pseudogout.
Higgins PA
JAAPA 2016 Mar;29(3):50-2. doi: 10.1097/01.JAA.0000475472.40251.58. PMID: 26914781

Prognosis

Hand Infections.
Teo WZW, Chung KC
Clin Plast Surg 2019 Jul;46(3):371-381. doi: 10.1016/j.cps.2019.03.003. PMID: 31103082
Calcium pyrophosphate deposition disease: a review of epidemiologic findings.
Abhishek A
Curr Opin Rheumatol 2016 Mar;28(2):133-9. doi: 10.1097/BOR.0000000000000246. PMID: 26626724
Arthroscopic intervention in early hip disease.
McCarthy JC, Lee JA
Clin Orthop Relat Res 2004 Dec;(429):157-62. doi: 10.1097/01.blo.0000150118.42360.1d. PMID: 15577481
Crystal-associated arthritis.
Agudelo CA, Wise CM
Clin Geriatr Med 1998 Aug;14(3):495-513. PMID: 9664104
Pyrophosphate arthropathy.
Bjelle A
Scand J Rheumatol 1979;8(3):145-53. doi: 10.3109/03009747909114447. PMID: 227047

Clinical prediction guides

Non-loading versus loading low-dose colchicine in acute crystal-associated arthritis: A double-blinded randomized controlled study.
Laosuksri P, Phrintrakul N, Gumtorntip W, Na-Nan K, Wongthanee A, Kasitanon N, Louthrenoo W
Int J Rheum Dis 2023 Dec;26(12):2478-2488. Epub 2023 Oct 20 doi: 10.1111/1756-185X.14943. PMID: 37860923
Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages.
Renaudin F, Orliaguet L, Castelli F, Fenaille F, Prignon A, Alzaid F, Combes C, Delvaux A, Adimy Y, Cohen-Solal M, Richette P, Bardin T, Riveline JP, Venteclef N, Lioté F, Campillo-Gimenez L, Ea HK
Ann Rheum Dis 2020 Nov;79(11):1506-1514. Epub 2020 Jul 22 doi: 10.1136/annrheumdis-2020-217342. PMID: 32699039
Neutrophil Extracellular Traps and Microcrystals.
Rada B
J Immunol Res 2017;2017:2896380. Epub 2017 Mar 7 doi: 10.1155/2017/2896380. PMID: 28373994Free PMC Article
Arthroscopic intervention in early hip disease.
McCarthy JC, Lee JA
Clin Orthop Relat Res 2004 Dec;(429):157-62. doi: 10.1097/01.blo.0000150118.42360.1d. PMID: 15577481
Antibodies against crystals.
Kam M, Perl-Treves D, Caspi D, Addadi L
FASEB J 1992 May;6(8):2608-13. doi: 10.1096/fasebj.6.8.1592211. PMID: 1592211

Recent systematic reviews

Distinguishing Periprosthetic Crystalline Arthropathy from Infection in Total Knee Arthroplasty: A Systematic Review.
Bradley AT, King CA, Lin Y, Sculco P, Balach T, Landy DC
J Knee Surg 2022 May;35(6):668-675. Epub 2020 Sep 17 doi: 10.1055/s-0040-1716507. PMID: 32942331
Management of calcium pyrophosphate crystal deposition disease: A systematic review.
Parperis K, Papachristodoulou E, Kakoullis L, Rosenthal AK
Semin Arthritis Rheum 2021 Feb;51(1):84-94. Epub 2020 Dec 21 doi: 10.1016/j.semarthrit.2020.10.005. PMID: 33360232
Systematic Overview of Solid Particles and Their Host Responses.
Shu F, Shi Y
Front Immunol 2018;9:1157. Epub 2018 May 28 doi: 10.3389/fimmu.2018.01157. PMID: 29892295Free PMC Article
Rheumatic diseases presenting as sports-related injuries.
Jennings F, Lambert E, Fredericson M
Sports Med 2008;38(11):917-30. doi: 10.2165/00007256-200838110-00003. PMID: 18937522

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