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Premature ejaculation

MedGen UID:
452112
Concept ID:
C0033038
Mental or Behavioral Dysfunction
Synonym: Premature ejaculation (disease)
SNOMED CT: Premature orgasm - male (44001008); Ejaculates too soon (44001008); Premature ejaculation (44001008); Ejaculatio praecox (44001008)
 
HPO: HP:0012876
Monarch Initiative: MONDO:0001780

Definition

The emission of semen and seminal fluid during the act of preparation for sexual intercourse, i.e. before there is penetration, or shortly after penetration. [from HPO]

Professional guidelines

PubMed

Gul M, Bocu K, Serefoglu EC
Nat Rev Urol 2022 Nov;19(11):659-680. Epub 2022 Aug 25 doi: 10.1038/s41585-022-00639-5. PMID: 36008555
Martin-Tuite P, Shindel AW
Sex Med Rev 2020 Jul;8(3):473-485. Epub 2019 Oct 23 doi: 10.1016/j.sxmr.2019.09.002. PMID: 31668585
Waldinger MD
Expert Opin Pharmacother 2018 Jul;19(10):1077-1085. Epub 2018 Jul 20 doi: 10.1080/14656566.2018.1494725. PMID: 30028639

Recent clinical studies

Etiology

Jannini TB, Lorenzo GD, Bianciardi E, Niolu C, Toscano M, Ciocca G, Jannini EA, Siracusano A
Curr Neuropharmacol 2022;20(4):693-712. doi: 10.2174/1570159X19666210517150418. PMID: 33998993Free PMC Article
Bearelly P, Avellino GJ
Fertil Steril 2021 Sep;116(3):611-617. doi: 10.1016/j.fertnstert.2021.07.1199. PMID: 34462095
Salonia A, Bettocchi C, Boeri L, Capogrosso P, Carvalho J, Cilesiz NC, Cocci A, Corona G, Dimitropoulos K, Gül M, Hatzichristodoulou G, Jones TH, Kadioglu A, Martínez Salamanca JI, Milenkovic U, Modgil V, Russo GI, Serefoglu EC, Tharakan T, Verze P, Minhas S; EAU Working Group on Male Sexual and Reproductive Health
Eur Urol 2021 Sep;80(3):333-357. Epub 2021 Jun 26 doi: 10.1016/j.eururo.2021.06.007. PMID: 34183196
Fiala L, Lenz J, Konecna P, Zajicova M, Cerna J, Sajdlova R
Andrologia 2021 Aug;53(7):e14093. Epub 2021 May 1 doi: 10.1111/and.14093. PMID: 33932044
El-Hamd MA, Saleh R, Majzoub A
Asian J Androl 2019 Sep-Oct;21(5):425-432. doi: 10.4103/aja.aja_122_18. PMID: 30860082Free PMC Article

Diagnosis

Gul M, Bocu K, Serefoglu EC
Nat Rev Urol 2022 Nov;19(11):659-680. Epub 2022 Aug 25 doi: 10.1038/s41585-022-00639-5. PMID: 36008555
Salonia A, Bettocchi C, Boeri L, Capogrosso P, Carvalho J, Cilesiz NC, Cocci A, Corona G, Dimitropoulos K, Gül M, Hatzichristodoulou G, Jones TH, Kadioglu A, Martínez Salamanca JI, Milenkovic U, Modgil V, Russo GI, Serefoglu EC, Tharakan T, Verze P, Minhas S; EAU Working Group on Male Sexual and Reproductive Health
Eur Urol 2021 Sep;80(3):333-357. Epub 2021 Jun 26 doi: 10.1016/j.eururo.2021.06.007. PMID: 34183196
Ma GC, Zou ZJ, Lai YF, Zhang X, Zhang Y
Asian J Androl 2019 Nov-Dec;21(6):631-634. doi: 10.4103/aja.aja_34_19. PMID: 31115366Free PMC Article
El-Hamd MA, Saleh R, Majzoub A
Asian J Androl 2019 Sep-Oct;21(5):425-432. doi: 10.4103/aja.aja_122_18. PMID: 30860082Free PMC Article
Chung E, Gilbert B, Perera M, Roberts MJ
Aust Fam Physician 2015 Oct;44(10):737-43. PMID: 26484490

Therapy

Vieiralves RR, Favorito LA
Int Braz J Urol 2023 Jul-Aug;49(4):511-514. doi: 10.1590/S1677-5538.IBJU.2023.9908. PMID: 37267615Free PMC Article
Gul M, Bocu K, Serefoglu EC
Nat Rev Urol 2022 Nov;19(11):659-680. Epub 2022 Aug 25 doi: 10.1038/s41585-022-00639-5. PMID: 36008555
Jannini TB, Lorenzo GD, Bianciardi E, Niolu C, Toscano M, Ciocca G, Jannini EA, Siracusano A
Curr Neuropharmacol 2022;20(4):693-712. doi: 10.2174/1570159X19666210517150418. PMID: 33998993Free PMC Article
Martin-Tuite P, Shindel AW
Sex Med Rev 2020 Jul;8(3):473-485. Epub 2019 Oct 23 doi: 10.1016/j.sxmr.2019.09.002. PMID: 31668585
Ma GC, Zou ZJ, Lai YF, Zhang X, Zhang Y
Asian J Androl 2019 Nov-Dec;21(6):631-634. doi: 10.4103/aja.aja_34_19. PMID: 31115366Free PMC Article

Prognosis

Sertkaya Z, Ertaş K, Tokuç E
Andrologia 2020 Jul;52(6):e13571. Epub 2020 Mar 23 doi: 10.1111/and.13571. PMID: 32201974
Jern P, Ventus D
Mol Cell Endocrinol 2018 May 15;467:60-65. Epub 2017 Nov 8 doi: 10.1016/j.mce.2017.10.017. PMID: 29104138
Waldinger MD
Expert Opin Pharmacother 2015;16(17):2615-24. Epub 2015 Nov 18 doi: 10.1517/14656566.2015.1096928. PMID: 26579971
Waldinger MD
Curr Opin Psychiatry 2014 Nov;27(6):400-5. doi: 10.1097/YCO.0000000000000096. PMID: 25203721
Perelman MA, Rowland DL
World J Urol 2006 Dec;24(6):645-52. doi: 10.1007/s00345-006-0127-6. PMID: 17082938

Clinical prediction guides

Memik O, Voyvoda B, Ustuner M, Karsli O, Halat AO, Ozcan L
Prog Urol 2023 Dec;33(15-16):1008-1013. Epub 2023 Sep 26 doi: 10.1016/j.purol.2023.09.010. PMID: 37758608
Mohseni Rad H, Zahirian Moghadam T, Hosseinkhani A, Nima Soluki N, Amani F
Urol J 2021 Nov 13;19(2):138-143. doi: 10.22037/uj.v18i.6644. PMID: 34773634
Fiala L, Lenz J, Konecna P, Zajicova M, Cerna J, Sajdlova R
Andrologia 2021 Aug;53(7):e14093. Epub 2021 May 1 doi: 10.1111/and.14093. PMID: 33932044
Jiang M, Yan G, Deng H, Liang H, Lin Y, Zhang X
Andrologia 2020 Feb;52(1):e13473. Epub 2019 Nov 20 doi: 10.1111/and.13473. PMID: 31746051
Ma GC, Zou ZJ, Lai YF, Zhang X, Zhang Y
Asian J Androl 2019 Nov-Dec;21(6):631-634. doi: 10.4103/aja.aja_34_19. PMID: 31115366Free PMC Article

Recent systematic reviews

Arshad A, Irfan M, Inam M, Hussain NHN, Ismail SB
Am J Mens Health 2022 Sep-Oct;16(5):15579883221124832. doi: 10.1177/15579883221124832. PMID: 36154321Free PMC Article
Salonia A, Bettocchi C, Boeri L, Capogrosso P, Carvalho J, Cilesiz NC, Cocci A, Corona G, Dimitropoulos K, Gül M, Hatzichristodoulou G, Jones TH, Kadioglu A, Martínez Salamanca JI, Milenkovic U, Modgil V, Russo GI, Serefoglu EC, Tharakan T, Verze P, Minhas S; EAU Working Group on Male Sexual and Reproductive Health
Eur Urol 2021 Sep;80(3):333-357. Epub 2021 Jun 26 doi: 10.1016/j.eururo.2021.06.007. PMID: 34183196
Myers C, Smith M
Physiotherapy 2019 Jun;105(2):235-243. Epub 2019 Jan 14 doi: 10.1016/j.physio.2019.01.002. PMID: 30979506
Cooper K, Martyn-St James M, Kaltenthaler E, Dickinson K, Cantrell A
Health Technol Assess 2015 Mar;19(21):1-180, v-vi. doi: 10.3310/hta19210. PMID: 25768099Free PMC Article
Martyn-St James M, Cooper K, Kaltenthaler E, Dickinson K, Cantrell A, Wylie K, Frodsham L, Hood C
BMC Urol 2015 Jan 30;15:6. doi: 10.1186/1471-2490-15-6. PMID: 25636495Free PMC Article

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